Therapeutic and toxicological effects of natural compounds: Data from HPV16-transgenic and ICR mice (Review)
- Tiago Ferreira
- Elisabete Nascimento-Gonçalves
- Rui Miguel Gil Da Costa
- Eduardo Rosa
- Paula Alexandra Oliveira
Affiliations: Centre for The Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal
- Published online on: April 30, 2020 https://doi.org/10.3892/wasj.2020.50
Copyright: © Ferreira
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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The aim of present mini-review was to highlight the effects of certain natural plant food compounds in animal models, analyzing their therapeutic effects and toxicological levels. Several natural compounds have been shown to promote health and to reduce the risk of disease due to their functional and nutraceutical properties. However, it has been observed that some diseases can still progress even in the presence of natural compounds. Thus, there is a need to conduct further research in order to elucidate the mechanisms underlying the functions and effects of natural compounds and to determine which products exert positive effects and which products have pharmacological potential to be applied in therapies.