Analysis of the association of diabetes mellitus with cancer using autopsy records

Wada,Ryuichi; Kimura,Sotai; Kure,Shoko; Ishino,Kousuke; Kudo,Mitsuhiro; Naito,Zenya

doi:10.3892/wasj.2020.52

July-August 2020 Volume 2 Issue 4

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July-August 2020 Volume 2 Issue 4

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Analysis of the association of diabetes mellitus with cancer using autopsy records

Authors:
- Ryuichi Wada
- Sotai Kimura
- Shoko Kure
- Kousuke Ishino
- Mitsuhiro Kudo
- Zenya Naito
View Affiliations / Copyright

Affiliations: Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo 113-8602, Japan, Faculty of Medicine, Hirosaki University School of Medicine, Hirosaki 036-8601, Japan

Copyright: © Wada et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 11
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Published online on: May 19, 2020

https://doi.org/10.3892/wasj.2020.52
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Abstract

In the present study, the association of diabetes mellitus (DM) with cancer was investigated using autopsy records. Among the 83,829 autopsy records between the years 2005 and 2009, 74,869 cases ≥40 years were eligible for the analysis. The cases with DM and cancers were selected, and the risk of cancer was estimated as the odds ratio (OR) by logistic regression analysis with the adjustment of age. Among the 74,869 cases, there were 49,676 males and 25,193 females. DM was noted in 4,901 males (9.9%) and 2,066 females (8.2%). In the liver, the OR for hepatocellular carcinoma (HCC) was increased to 1.25 (95% confidence interval (CI), 1.12-1.39, P<0.001) and to 1.22 (95% CI, 1.00-1.49, P<0.05) in males and females with DM, respectively. The ORs for invasive ductal carcinoma of the pancreas, cancers of the thyroid and kidney were not increased, and the ORs for cancers of the lung, stomach, colon/rectum, biliary tract, prostate, breast and uterus appeared to be decreased. The analyzed autopsy cases corresponded to only 1.4% of deceased individuals aged ≥40 years, and the ORs for cancers in DM estimated using the autopsy records may warrant a careful consideration. To the best of our knowledge, the present study is the first to confirm the increased OR for HCC in DM by a cross-sectional analysis using autopsy records.

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1	Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG and Ye D: Diabetes and cancer: A consensus report. Diabetes Care. 33:1674–1685. 2010.PubMed/NCBI View Article : Google Scholar
2	Kasuga M, Ueki K, Tajima N, Noda M, Ohashi K, Noto H, Goto A, Ogawa W, Sakai R, Tsugane S, et al: Report of the Japan diabetes society/Japanese cancer association joint committee on diabetes and cancer. Cancer Sci. 104:965–976. 2013.PubMed/NCBI View Article : Google Scholar
3	El-Serag HB, Hampel H and Javadi F: The association between diabetes and hepatocellular carcinoma: A systematic review of epidemiologic evidence. Clin Gastroenterol Hepatol. 4:369–380. 2006.PubMed/NCBI View Article : Google Scholar
4	Huxley R, Ansary-Moghaddam A, Berrington de González A and Woodward M: Type-II diabetes and pancreatic cancer: A meta-analysis of 36 studies. Br J Cancer. 92:2076–2083. 2005.PubMed/NCBI View Article : Google Scholar
5	Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M and Tsugane S: Diabetes mellitus and the risk of cancer: Results from a large-scale population-based cohort study in Japan. Arch Intern Med. 166:1871–1877. 2006.PubMed/NCBI View Article : Google Scholar
6	Khan M, Mori M, Fujino Y, Shibata A, Sakauchi F, Washio M and Tamakoshi A: Japan Collaborative Cohort Study G. Site-Specific cancer risk due to diabetes mellitus history: Evidence from the Japan collaborative cohort (JACC) study. Asian Pac J Cancer Prev. 7:253–259. 2006.PubMed/NCBI
7	Kuriki K, Hirose K and Tajima K: Diabetes and cancer risk for all and specific sites among Japanese men and women. Eur J Cancer Prev. 16:83–89. 2007.PubMed/NCBI View Article : Google Scholar
8	Matsuo M: Association between diabetes mellitus and hepatocellular carcinoma: Results of a hospital- and community-based case-control study. Kurume Med J. 50:91–98. 2003.PubMed/NCBI View Article : Google Scholar
9	Japanese Society of Pathology: Annual report of pathological autopsy cases in Japan 2005-2009. Japanese Society of Pathology, Tokyo, 2006-2010.
10	Japanese Ministry of Health Labour and Welfare: Vital statistics of Japan final data. General Mortality, 2009. https://www.e-stat.go.jp/.
11	Jing W, Jin G, Zhou X, Zhou Y, Zhang Y, Shao C, Liu R and Hu X: Diabetes mellitus and increased risk of cholangiocarcinoma: A meta-analysis. Eur J Cancer Prev. 21:24–31. 2012.PubMed/NCBI View Article : Google Scholar
12	Japanese Ministry of Health Labour and Welfare: The national health and nutrition survey in Japan, 2007. https://www.mhlw.go.jp/bunya/kenkou/eiyou09/01.html.
13	Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M and Butler PC: Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes. 62:2595–2604. 2013.PubMed/NCBI View Article : Google Scholar
14	Harja E, Lord J and Skyler JS: An analysis of characteristics of subjects examined for incretin effects on pancreatic pathology. Diabetes Technol Ther. 15:609–618. 2013.PubMed/NCBI View Article : Google Scholar
15	Giorda CB, Picariello R, Tartaglino B, Nada E, Costa G and Gnavi R: Incretin-based therapy and risk of cholangiocarcinoma: A nested case-control study in a population of subjects with type 2 diabetes. Acta Diabetol. 57:401–408. 2020.PubMed/NCBI View Article : Google Scholar
16	Goda M and Kadowaki T: Teneligliptin for the treatment of type 2 diabetes. Drugs Today (Barc). 49:615–629. 2013.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Analysis of the association of diabetes mellitus with cancer using autopsy records

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