Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies

  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
World Academy of Sciences Journal
Join Editorial Board Propose a Special Issue
Print ISSN: 2632-2900 Online ISSN: 2632-2919
Journal Cover
September-October 2020 Volume 2 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-October 2020 Volume 2 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Clinical analysis and RNA findings in a family with SARS‑CoV‑2 infection: Case reports

  • Authors:
    • Fen Lin
    • Yong‑Hao Wu
    • Wen-Jian Deng
    • Pei‑Biao Wu
    • Jian‑Yong Chen
    • Shao‑Huang Tang
    • Jin‑Zhou Wen
    • Shao‑Qun Liu
    • Zhuo‑Mao Lin
    • Deng‑Feng Li
    • Jin‑Sheng Chen
    • Wei‑Zhao Chen
    • Jiang‑Fang Lu
    • Jian‑Wen Hong
    • Jin‑Pei Gao
    • Peng‑Fei Xu
    • Li‑Ye Yang

  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong 521021, P.R. China, Department of Infection, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong 521021, P.R. China, Chaozhou Center for Disease Control and Prevention, Chaozhou, Guangdong 521099, P.R. China, Department of Respiration, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong 521021, P.R. China, Department of Radiology, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong 521021, P.R. China, Department of Medicine, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong 521021, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 17
    |
    Published online on: June 24, 2020
       https://doi.org/10.3892/wasj.2020.58
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study reported the epidemiological, clinical features, laboratory data and management of a family of 5 members with COVID‑19. It was found that the initial clinical manifestations of the 3 adults were fever, cough and sore throat; they all exhibited a higher erythrocyte sedimentation rate (ESR) and higher serum glucose level. The 2 children only exhibited a mild dry cough. As regards the 2-month-old infant who was breast-fed, the possible infection source was close contact with family members or respiratory droplets. Her mother's breast milk was negative for SARS‑CoV‑2, as shown by RT‑PCR. The two children persisted to be positive for SARS‑CoV‑2 by anal swab after being released from the hospital, although they were negative for SARS‑CoV‑2 by a throat swab.
View Figures

Figure 1

View References

1 

World Health Organization. Pneumonia of unknown cause-China. https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/. Accessed January 5, 2020.

2 

WHO. Novel coronavirus-China. January 12, 2020. http://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/. Accessed January 19, 2020.

3 

Tan WJ, Zhao X and Ma XJ: A novel coronavirus genome identified in a cluster of pneumonia cases: Wuhan, China 2019-2020. China CDC Weekly. 2:61–62. 2020.

4 

Ahn DG, Shin HJ, Kim MH, Lee S, Kim HS, Myoung J, Kim BT and Kim SJ: Current status of epidemiology, diagnosis, therapeutics, and vaccines for novel coronavirus disease 2019 (COVID-19). J Microbiol Biotechnol. 30:313–324. 2020.PubMed/NCBI View Article : Google Scholar

5 

Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S and Yuen KY: Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 9:221–236. 2020.PubMed/NCBI View Article : Google Scholar

6 

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 395:497–506. 2020.PubMed/NCBI View Article : Google Scholar

7 

China National Health Commission: Diagnosis and treatment of pneumonitis caused by new coronavirus (trial version 6). Beijing: China National Health Commission, 2020. http://www.nhc.gov.cn/xcs/zhengcwj/202002/8334a8326dd94d329df351d7da8aefc2.shtm.

8 

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, et al: A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 382:727–733. 2020.PubMed/NCBI View Article : Google Scholar

9 

http://wsjkw.gd.gov.cn/xxgzbdfk/content/post_2880738.html.

10 

Special Expert Group for Control of the Epidemic of Novel Coronavirus Pneumonia of the Chinese Preventive Medicine Association. An update on the epidemiological characteristics of novel coronavirus pneumonia (COVID-19). Zhonghua Liu Xing Bing Xue Za Zhi. 41:139–144. 2020.PubMed/NCBI View Article : Google Scholar : (In Chinese).

11 

Wei M, Yuan J, Liu Y, Fu T, Yu X and Zhang ZJ: Novel coronavirus infection in hospitalized infants under 1 year of age in China. JAMA. 323:1313–1314. 2020.PubMed/NCBI View Article : Google Scholar

12 

Wang XF, Yuan J, Zheng YJ, Chen J, Bao YM, Wang YR, Wang LF, Li H, Zeng JX, Zhang YH, et al: Retracted: Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen. Zhonghua Er Ke Za Zhi. 58(E008)2020.PubMed/NCBI View Article : Google Scholar : (Epub ahead of print).

13 

Li AM and Ng PC: Severe acute respiratory syndrome (SARS) in neonates and children. Arch Dis Child Fetal Neonatal Ed. 90:F461–F465. 2005.PubMed/NCBI View Article : Google Scholar

14 

Hon KL, Leung CW, Cheng WT, Chan PK, Chu WC, Kwan YW, Li AM, Fong NC, Ng PC, Chiu MC, et al: Clinical presentations and outcome of severe acute respiratory syndrome in children. Lancet. 361:1701–1703. 2003.PubMed/NCBI View Article : Google Scholar

15 

Wu JT, Leung K and Leung GM: Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study. Lancet. 395:689–697. 2020.PubMed/NCBI View Article : Google Scholar

16 

Shek CC, Ng PC, Fung GP, Cheng FW, Chan PK, Peiris MJ, Lee KH, Wong SF, Cheung HM, Li AM, et al: Infants born to mothers with severe acute respiratory syndrome. Pediatrics. 112(e254)2003.PubMed/NCBI View Article : Google Scholar

17 

Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A, et al: First case of 2019 novel coronavirus in the United States. N Engl J Med. 382:929–936. 2020.PubMed/NCBI View Article : Google Scholar

18 

Chen W, Lan Y, Yuan X, Deng X, Li Y, Cai X, Li L, He R, Tan Y, Deng X, et al: Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerg Microbes Infect. 9:469–473. 2020.PubMed/NCBI View Article : Google Scholar

19 

Zhang Y, Chen C, Zhu S, Shu C, Wang D, Song J, Song Y, Zhen W, Feng Z, Wu G, et al: Notes from the field: Isolation of 2019-nCoV from a stool specimen of a laboratory-confirmed case of the coronavirus disease 2019 (COVID-19). China CDC Weekly. 2:123–124. 2020.

20 

Jean SS, Lee PI and Hsueh PR: Treatment options for COVID-19: The reality and challenges. J Microbiol Immunol Infect. 53:436–443. 2020.PubMed/NCBI View Article : Google Scholar

21 

National Health Commission's briefing on the pneumonia epidemic situation. Released on May 4, 2020. http://www.nhc.gov.cn/xcs/yqfkdt/202005/9f8375d7ac9b4eda83515fcd5fd4adf4.shtml.

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Lin F, Wu YH, Deng W, Wu PB, Chen JY, Tang SH, Wen JZ, Liu SQ, Lin ZM, Li DF, Li DF, et al: Clinical analysis and RNA findings in a family with SARS‑CoV‑2 infection: Case reports. World Acad Sci J 2: 17, 2020.
APA
Lin, F., Wu, Y., Deng, W., Wu, P., Chen, J., Tang, S. ... Yang, L. (2020). Clinical analysis and RNA findings in a family with SARS‑CoV‑2 infection: Case reports. World Academy of Sciences Journal, 2, 17. https://doi.org/10.3892/wasj.2020.58
MLA
Lin, F., Wu, Y., Deng, W., Wu, P., Chen, J., Tang, S., Wen, J., Liu, S., Lin, Z., Li, D., Chen, J., Chen, W., Lu, J., Hong, J., Gao, J., Xu, P., Yang, L."Clinical analysis and RNA findings in a family with SARS‑CoV‑2 infection: Case reports". World Academy of Sciences Journal 2.5 (2020): 17.
Chicago
Lin, F., Wu, Y., Deng, W., Wu, P., Chen, J., Tang, S., Wen, J., Liu, S., Lin, Z., Li, D., Chen, J., Chen, W., Lu, J., Hong, J., Gao, J., Xu, P., Yang, L."Clinical analysis and RNA findings in a family with SARS‑CoV‑2 infection: Case reports". World Academy of Sciences Journal 2, no. 5 (2020): 17. https://doi.org/10.3892/wasj.2020.58
Copy and paste a formatted citation
x
Spandidos Publications style
Lin F, Wu YH, Deng W, Wu PB, Chen JY, Tang SH, Wen JZ, Liu SQ, Lin ZM, Li DF, Li DF, et al: Clinical analysis and RNA findings in a family with SARS‑CoV‑2 infection: Case reports. World Acad Sci J 2: 17, 2020.
APA
Lin, F., Wu, Y., Deng, W., Wu, P., Chen, J., Tang, S. ... Yang, L. (2020). Clinical analysis and RNA findings in a family with SARS‑CoV‑2 infection: Case reports. World Academy of Sciences Journal, 2, 17. https://doi.org/10.3892/wasj.2020.58
MLA
Lin, F., Wu, Y., Deng, W., Wu, P., Chen, J., Tang, S., Wen, J., Liu, S., Lin, Z., Li, D., Chen, J., Chen, W., Lu, J., Hong, J., Gao, J., Xu, P., Yang, L."Clinical analysis and RNA findings in a family with SARS‑CoV‑2 infection: Case reports". World Academy of Sciences Journal 2.5 (2020): 17.
Chicago
Lin, F., Wu, Y., Deng, W., Wu, P., Chen, J., Tang, S., Wen, J., Liu, S., Lin, Z., Li, D., Chen, J., Chen, W., Lu, J., Hong, J., Gao, J., Xu, P., Yang, L."Clinical analysis and RNA findings in a family with SARS‑CoV‑2 infection: Case reports". World Academy of Sciences Journal 2, no. 5 (2020): 17. https://doi.org/10.3892/wasj.2020.58
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team