Clinical analysis and RNA findings in a family with SARS‑CoV‑2 infection: Case reports

Lin,Fen; Wu,Yong‑Hao; Deng,Wen-Jian; Wu,Pei‑Biao; Chen,Jian‑Yong; Tang,Shao‑Huang; Wen,Jin‑Zhou; Liu,Shao‑Qun; Lin,Zhuo‑Mao; Li,Deng‑Feng; Chen,Jin‑Sheng; Chen,Wei‑Zhao; Lu,Jiang‑Fang; Hong,Jian‑Wen; Gao,Jin‑Pei; Xu,Peng‑Fei; Yang,Li‑Ye

doi:10.3892/wasj.2020.58

Clinical analysis and RNA findings in a family with SARS‑CoV‑2 infection: Case reports

Authors:
- Fen Lin
- Yong‑Hao Wu
- Wen-Jian Deng
- Pei‑Biao Wu
- Jian‑Yong Chen
- Shao‑Huang Tang
- Jin‑Zhou Wen
- Shao‑Qun Liu
- Zhuo‑Mao Lin
- Deng‑Feng Li
- Jin‑Sheng Chen
- Wei‑Zhao Chen
- Jiang‑Fang Lu
- Jian‑Wen Hong
- Jin‑Pei Gao
- Peng‑Fei Xu
- Li‑Ye Yang
View Affiliations

Affiliations: Central Laboratory, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong 521021, P.R. China, Department of Infection, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong 521021, P.R. China, Chaozhou Center for Disease Control and Prevention, Chaozhou, Guangdong 521099, P.R. China, Department of Respiration, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong 521021, P.R. China, Department of Radiology, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong 521021, P.R. China, Department of Medicine, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong 521021, P.R. China
Published online on: June 24, 2020 https://doi.org/10.3892/wasj.2020.58
Article Number: 17
Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The present study reported the epidemiological, clinical features, laboratory data and management of a family of 5 members with COVID‑19. It was found that the initial clinical manifestations of the 3 adults were fever, cough and sore throat; they all exhibited a higher erythrocyte sedimentation rate (ESR) and higher serum glucose level. The 2 children only exhibited a mild dry cough. As regards the 2-month-old infant who was breast-fed, the possible infection source was close contact with family members or respiratory droplets. Her mother's breast milk was negative for SARS‑CoV‑2, as shown by RT‑PCR. The two children persisted to be positive for SARS‑CoV‑2 by anal swab after being released from the hospital, although they were negative for SARS‑CoV‑2 by a throat swab.

View Figures

View References

1	World Health Organization. Pneumonia of unknown cause-China. https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/. Accessed January 5, 2020.
2	WHO. Novel coronavirus-China. January 12, 2020. http://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/. Accessed January 19, 2020.
3	Tan WJ, Zhao X and Ma XJ: A novel coronavirus genome identified in a cluster of pneumonia cases: Wuhan, China 2019-2020. China CDC Weekly. 2:61–62. 2020.
4	Ahn DG, Shin HJ, Kim MH, Lee S, Kim HS, Myoung J, Kim BT and Kim SJ: Current status of epidemiology, diagnosis, therapeutics, and vaccines for novel coronavirus disease 2019 (COVID-19). J Microbiol Biotechnol. 30:313–324. 2020.PubMed/NCBI View Article : Google Scholar
5	Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S and Yuen KY: Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 9:221–236. 2020.PubMed/NCBI View Article : Google Scholar
6	Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 395:497–506. 2020.PubMed/NCBI View Article : Google Scholar
7	China National Health Commission: Diagnosis and treatment of pneumonitis caused by new coronavirus (trial version 6). Beijing: China National Health Commission, 2020. http://www.nhc.gov.cn/xcs/zhengcwj/202002/8334a8326dd94d329df351d7da8aefc2.shtm.
8	Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, et al: A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 382:727–733. 2020.PubMed/NCBI View Article : Google Scholar
9	http://wsjkw.gd.gov.cn/xxgzbdfk/content/post_2880738.html.
10	Special Expert Group for Control of the Epidemic of Novel Coronavirus Pneumonia of the Chinese Preventive Medicine Association. An update on the epidemiological characteristics of novel coronavirus pneumonia (COVID-19). Zhonghua Liu Xing Bing Xue Za Zhi. 41:139–144. 2020.PubMed/NCBI View Article : Google Scholar : (In Chinese).
11	Wei M, Yuan J, Liu Y, Fu T, Yu X and Zhang ZJ: Novel coronavirus infection in hospitalized infants under 1 year of age in China. JAMA. 323:1313–1314. 2020.PubMed/NCBI View Article : Google Scholar
12	Wang XF, Yuan J, Zheng YJ, Chen J, Bao YM, Wang YR, Wang LF, Li H, Zeng JX, Zhang YH, et al: Retracted: Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen. Zhonghua Er Ke Za Zhi. 58(E008)2020.PubMed/NCBI View Article : Google Scholar : (Epub ahead of print).
13	Li AM and Ng PC: Severe acute respiratory syndrome (SARS) in neonates and children. Arch Dis Child Fetal Neonatal Ed. 90:F461–F465. 2005.PubMed/NCBI View Article : Google Scholar
14	Hon KL, Leung CW, Cheng WT, Chan PK, Chu WC, Kwan YW, Li AM, Fong NC, Ng PC, Chiu MC, et al: Clinical presentations and outcome of severe acute respiratory syndrome in children. Lancet. 361:1701–1703. 2003.PubMed/NCBI View Article : Google Scholar
15	Wu JT, Leung K and Leung GM: Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study. Lancet. 395:689–697. 2020.PubMed/NCBI View Article : Google Scholar
16	Shek CC, Ng PC, Fung GP, Cheng FW, Chan PK, Peiris MJ, Lee KH, Wong SF, Cheung HM, Li AM, et al: Infants born to mothers with severe acute respiratory syndrome. Pediatrics. 112(e254)2003.PubMed/NCBI View Article : Google Scholar
17	Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A, et al: First case of 2019 novel coronavirus in the United States. N Engl J Med. 382:929–936. 2020.PubMed/NCBI View Article : Google Scholar
18	Chen W, Lan Y, Yuan X, Deng X, Li Y, Cai X, Li L, He R, Tan Y, Deng X, et al: Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerg Microbes Infect. 9:469–473. 2020.PubMed/NCBI View Article : Google Scholar
19	Zhang Y, Chen C, Zhu S, Shu C, Wang D, Song J, Song Y, Zhen W, Feng Z, Wu G, et al: Notes from the field: Isolation of 2019-nCoV from a stool specimen of a laboratory-confirmed case of the coronavirus disease 2019 (COVID-19). China CDC Weekly. 2:123–124. 2020.
20	Jean SS, Lee PI and Hsueh PR: Treatment options for COVID-19: The reality and challenges. J Microbiol Immunol Infect. 53:436–443. 2020.PubMed/NCBI View Article : Google Scholar
21	National Health Commission's briefing on the pneumonia epidemic situation. Released on May 4, 2020. http://www.nhc.gov.cn/xcs/yqfkdt/202005/9f8375d7ac9b4eda83515fcd5fd4adf4.shtml.