Long‑term outcomes in patients with benign central airway stenosis or obstruction following stenting

Iyoda,Akira; Azuma,Yoko; Sano,Atsushi; Sakai,Takashi; Koezuka,Satoshi; Otsuka,Hajime; Isobe,Kazutoshi; Sakamoto,Susumu; Hata,Yoshinobu; Takagi,Keigo

doi:10.3892/wasj.2020.61

November-December 2020 Volume 2 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

November-December 2020 Volume 2 Issue 6

Full Size Image

Article Open Access

Long‑term outcomes in patients with benign central airway stenosis or obstruction following stenting

Authors:
- Akira Iyoda
- Yoko Azuma
- Atsushi Sano
- Takashi Sakai
- Satoshi Koezuka
- Hajime Otsuka
- Kazutoshi Isobe
- Susumu Sakamoto
- Yoshinobu Hata
- Keigo Takagi
View Affiliations / Copyright

Affiliations: Division of Chest Surgery, Department of Surgery, Toho University School of Medicine, Tokyo 143‑8541, Japan, Division of Respiratory Medicine, Toho University School of Medicine, Tokyo 143‑8541, Japan, Nishiyokohama International Hospital, Yokohama, Kanagawa 245‑8560, Japan

Copyright: © Iyoda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 20
|
Published online on: July 17, 2020

https://doi.org/10.3892/wasj.2020.61
Expand metrics +

Abstract

Although an airway stent is used for central airway stenosis or obstruction due to benign diseases, the long‑term outcomes of stenting are unknown. The aim of the present study was to identify the clinical features and outcomes of patients with airway stenosis or obstruction due to benign disease who underwent stenting procedures. For this purpose, clinical data from 136 patients with stents for central airway stenosis or obstruction who underwent treatment at Toho University Omori Medical Center from 1998 to 2018 were retrospectively analyzed. The clinical features, outcomes and complications associated with stenting were evaluated. The clinical features of patients with stents for benign central airway stenosis or obstruction were compared to those of patients with stents for malignant disease. Of the 136 patients with stents, 19 patients had benign disease and 117 had malignant disease. The difference between complications in patients with benign disease compared with those with malignant disease was not significant. The median follow‑up time of patients with stents due to benign central airway stenosis or obstruction was 51 (range, 0.164‑239) months. Patients with benign disease had a significantly better outcome than patients with malignant disease. For the 19 patients with benign disease, 35 stent procedures were performed as follows: A total of 18 placements, 6 replacements, 3 additional stent placements, 6 removals and 2 stents were repositioned. Patients with benign disease underwent significantly more (≥2) stent‑related procedures than patients with malignant disease. On the whole, the findings of the present study indicate that patients with benign central airway stenosis or obstruction who undergo stenting may require multiple procedures, and that physicians should plan for multiple treatments following the first stent placement as patients with benign airway disease have good long‑term outcomes.

View Figures

View References

1	Husain SA, Finch D, Ahmed M, Morgan A and Hetzel MR: Long-term follow-up of ultraflex metallic stents in benign and malignant central airway obstruction. Ann Thorac Surg. 83:1251–1256. 2007.PubMed/NCBI View Article : Google Scholar
2	Oviatt PL, Stather DR, Michaud G, Maceachern P and Tremblay A: Exercise capacity, lung function, and quality of life after interventional bronchoscopy. J Thorac Oncol. 6:38–42. 2011.PubMed/NCBI View Article : Google Scholar
3	Ferrell B, Koczywas M, Grannis F and Harrington A: Palliative care in lung cancer. Surg Clin North Am. 91:403–417. 2011.PubMed/NCBI View Article : Google Scholar
4	Sökücü SN, Özdemir C, Tural Önür S, Dalar L and Altın S: Comparison of silicon and metallic bifurcated stents in patients with malignant airway lesions. Clin Respir J. 14:198–204. 2020.PubMed/NCBI View Article : Google Scholar
5	Folch E and Keyes C: Airway stents. Ann Cardiothorac Surg. 7:273–283. 2018.PubMed/NCBI View Article : Google Scholar
6	Ost DE, Shah AM, Lei X, Godoy MCB, Jimenez CA, Eapen GA, Jani P, Larson AJ, Sarkiss MG and Morice RC: Respiratory infections increase the risk of granulation tissue formation following airway stenting in patients with malignant airway obstruction. Chest. 141:1473–1481. 2012.PubMed/NCBI View Article : Google Scholar
7	Saad CP, Murthy S, Krizmanich G and Mehta AC: Self-expandable metallic airway stents and flexible bronchoscopy: Long-term outcomes analysis. Chest. 124:1993–1999. 2003.PubMed/NCBI View Article : Google Scholar
8	Murgu SD, Egressy K, Laxmanan B, Doblare G, Ortiz-Comino R and Hogarth DK: Central airway obstruction: Benign strictures, tracheobronchomalacia, and malignancy-related obstruction. Chest. 150:426–441. 2016.PubMed/NCBI View Article : Google Scholar
9	Saji H, Furukawa K, Tsutsui H, Tsuboi M, Ichinose S, Usuda J, Ohira T and Ikeda N: Outcomes of airway stenting for advanced lung cancer with central airway obstruction. Interact Cardiovasc Thorac Surg. 11:425–428. 2010.PubMed/NCBI View Article : Google Scholar
10	Furukawa K, Ishida J, Yamaguchi G, Usuda J, Tsutsui H, Saito M, Konaka C and Kato H: The role of airway stent placement in the management of tracheobronchial stenosis caused by inoperable advanced lung cancer. Surg Today. 40:315–320. 2010.PubMed/NCBI View Article : Google Scholar
11	Lemaire A, Burfeind WR, Toloza E, Balderson S, Petersen RP, Harpole DH Jr and D'Amico TA: Outcomes of tracheobronchial stents in patients with malignant airway disease. Ann Thorac Surg. 80:434–438. 2005.PubMed/NCBI View Article : Google Scholar
12	Chung FT, Chen HC, Chou CL, Yu CT, Kuo CH, Kuo HP and Lin SM: An outcome analysis of self-expandable metallic stents in central airway obstruction: A cohort study. J Cardiothorac Surg. 6(46)2011.PubMed/NCBI View Article : Google Scholar
13	Guibert N, Saka H and Dutau H: Airway stenting: Technological advancements and its role in interventional pulmonology. Respirology: Mar 11, 2020 doi: 10.1111/resp.13801 (Epub ahead of print).
14	Serrano C, Laborda A, Lozano JM, Caballero H, Sebastián A, Lopera J and de Gregorio MÁ: Metallic stents for tracheobronchial pathology treatment. Cardiovasc Intervent Radiol. 36:1614–1623. 2013.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Long‑term outcomes in patients with benign central airway stenosis or obstruction following stenting

This article is mentioned in:

Abstract

Figure 1

Related Articles