High TCTP expression as prognostic factor in different cancer types
- Nicolas Fischer
- Mohamed E.M. Saeed
- Elena Lippe
- Wilfried Roth
- Thomas Efferth
Affiliations: Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, D‑55128 Mainz, Germany, Department of Pathology, University Medical Center, D‑55131 Mainz, Germany
- Published online on: November 9, 2020 https://doi.org/10.3892/wasj.2020.74
Copyright: © Fischer
et al. This is an open access article distributed under the
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The translationally controlled tumor protein (TCTP) has been linked to a number of fundamental biological processes, including tumorigenesis and cancer progression. Due to its role in tumor reversion, the interest in TCTP as a therapeutic target is constantly increasing. TCTP has also been discussed as a prognostic factor. However, evaluations of large numbers of different cancer types are still not available. The present study thus investigated the role of TCTP mRNA and protein expression as prognostic factors in different cancer types. The Oncomine database was analyzed for statistical associations between TCTP mRNA and the survival times of 5,651 cancer patients. Additionally, immunohistochemical analyses of 495 tissue samples covering 26 tumor types was performed. The associations between nuclear and cytoplasmic TCTP protein expression and tumor stage, grade, nodal status and metastatic status were also analyzed. Significant associations between a high TCTP mRNA expression and a decreased overall survival were observed in breast, lung, ovarian and prostate cancer. Nuclear and cytoplasmic TCTP protein expression was elevated in 24 cancer types. In kidney cancer, a high TCTP expression was associated with a higher tumor grade, stage, metastatic and nodal status. On the whole, the present study demonstrates that TCTP may serve as a prognostic factor in different tumor types.