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High TCTP expression as prognostic factor in different cancer types

  • Authors:
    • Nicolas Fischer
    • Mohamed E.M. Saeed
    • Elena Lippe
    • Wilfried Roth
    • Thomas Efferth
  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, D‑55128 Mainz, Germany, Department of Pathology, University Medical Center, D‑55131 Mainz, Germany
    Copyright: © Fischer et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 3
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    Published online on: November 9, 2020
       https://doi.org/10.3892/wasj.2020.74
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Abstract

The translationally controlled tumor protein (TCTP) has been linked to a number of fundamental biological processes, including tumorigenesis and cancer progression. Due to its role in tumor reversion, the interest in TCTP as a therapeutic target is constantly increasing. TCTP has also been discussed as a prognostic factor. However, evaluations of large numbers of different cancer types are still not available. The present study thus investigated the role of TCTP mRNA and protein expression as prognostic factors in different cancer types. The Oncomine database was analyzed for statistical associations between TCTP mRNA and the survival times of 5,651 cancer patients. Additionally, immunohistochemical analyses of 495 tissue samples covering 26 tumor types was performed. The associations between nuclear and cytoplasmic TCTP protein expression and tumor stage, grade, nodal status and metastatic status were also analyzed. Significant associations between a high TCTP mRNA expression and a decreased overall survival were observed in breast, lung, ovarian and prostate cancer. Nuclear and cytoplasmic TCTP protein expression was elevated in 24 cancer types. In kidney cancer, a high TCTP expression was associated with a higher tumor grade, stage, metastatic and nodal status. On the whole, the present study demonstrates that TCTP may serve as a prognostic factor in different tumor types.
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View References

1 

Acunzo J, Baylot V, So A and Rocchi P: TCTP as therapeutic target in cancers. Cancer Treat Rev. 40:760–769. 2014.PubMed/NCBI View Article : Google Scholar

2 

Bommer UA and Thiele BJ: The translationally controlled tumour protein (TCTP). Int J Biochem Cell Biol. 36:379–385. 2004.PubMed/NCBI View Article : Google Scholar

3 

Li S and Ge F: Current understanding of the TCTP interactome. Results Probl Cell Differ. 64:127–136. 2017.PubMed/NCBI View Article : Google Scholar

4 

Assrir N, Malard F and Lescop E: Structural Insights into TCTP and its interactions with ligands and proteins. Results Probl Cell Differ. 64:9–46. 2017.PubMed/NCBI View Article : Google Scholar

5 

Seo EJ, Fischer N and Efferth T: Role of TCTP for cellular differentiation and cancer therapy. Results Probl Cell Differ. 64:263–281. 2017.PubMed/NCBI View Article : Google Scholar

6 

Kubiak JZ and Kloc M: Elusive role of TCTP protein and mRNA in cell cycle and cytoskeleton regulation. Results Probl Cell Differ. 64:217–225. 2017.PubMed/NCBI View Article : Google Scholar

7 

Betsch L, Boltz V, Brioudes F, Pontier G, Girard V, Savarin J, Wipperman B, Chambrier P, Tissot N, Benhamed M, et al: TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals. PLoS Genet. 15(e1007899)2019.PubMed/NCBI View Article : Google Scholar

8 

Jojic B, Amodeo S and Ochsenreiter T: The translationally controlled tumor protein TCTP is involved in cell cycle progression and heat stress response in the bloodstream form of Trypanosoma brucei. Microb Cell. 5:460–468. 2018.PubMed/NCBI View Article : Google Scholar

9 

Koziol MJ and Gurdon JB: TCTP in development and cancer. Biochem Res Int. 2012(105203)2012.PubMed/NCBI View Article : Google Scholar

10 

Chen SH, Wu PS, Chou CH, Yan YT, Liu H, Weng SY and Yang-Yen HF: A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner. Mol Biol Cell. 18:2525–2532. 2007.PubMed/NCBI View Article : Google Scholar

11 

Kubiak JZ, Bazile F, Pascal A, Richard-Parpaillon L, Polanski Z, Ciemerych MA and Chesnel F: Temporal regulation of embryonic M-phases. Folia Histochem Cytobiol. 46:5–9. 2008.PubMed/NCBI View Article : Google Scholar

12 

Hsu YC, Chern JJ, Cai Y, Liu M and Choi KW: Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature. 445:785–788. 2007.PubMed/NCBI View Article : Google Scholar

13 

Cans C, Passer BJ, Shalak V, Nancy-Portebois V, Crible V, Amzallag N, Allanic D, Tufino R, Argentini M, Moras D, et al: Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A. Proc Natl Acad Sci USA. 100:13892–13897. 2003.PubMed/NCBI View Article : Google Scholar

14 

Bazile F, Pascal A, Arnal I, Le Clainche C, Chesnel F and Kubiak JZ: Complex relationship between TCTP, microtubules and actin microfilaments regulates cell shape in normal and cancer cells. Carcinogenesis. 30:555–565. 2009.PubMed/NCBI View Article : Google Scholar

15 

Tsarova K, Yarmola EG and Bubb MR: Identification of a cofilin-like actin-binding site on translationally controlled tumor protein (TCTP). FEBS Lett. 584:4756–4760. 2010.PubMed/NCBI View Article : Google Scholar

16 

Mishra DK, Srivastava P, Sharma A, Prasad R, Bhuyan SK, Malage R, Kumar P and Yadava PK: Translationally controlled tumor protein (TCTP) is required for TGF-β1 induced epithelial to mesenchymal transition and influences cytoskeletal reorganization. Biochim Biophys Acta Mol Cell Res. 1865:67–75. 2018.PubMed/NCBI View Article : Google Scholar

17 

Wu W, Wu B, Ye T, Huang H, Dai C, Yuan J and Wang W: TCTP is a critical factor in shrimp immune response to virus infection. PLoS One. 8(e74460)2013.PubMed/NCBI View Article : Google Scholar

18 

Taylor KJ, Van TT, MacDonald SM, Meshnick SR, Fernley RT, Macreadie IG and Smooker PM: Immunization of mice with plasmodium TCTP delays establishment of plasmodium infection. Parasite Immunol. 37:23–31. 2015.PubMed/NCBI View Article : Google Scholar

19 

MacDonald SM, Rafnar T, Langdon J and Lichtenstein LM: Molecular identification of an IgE-dependent histamine-releasing factor. Science. 269:688–690. 1995.PubMed/NCBI View Article : Google Scholar

20 

Li F, Zhang D and Fujise K: Characterization of fortilin, a novel antiapoptotic protein. J Biol Chem. 276:47542–47549. 2001.PubMed/NCBI View Article : Google Scholar

21 

Yang Y, Yang F, Xiong Z, Yan Y, Wang X, Nishino M, Mirkovic D, Nguyen J, Wang H and Yang XF: An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity. Oncogene. 24:4778–4788. 2005.PubMed/NCBI View Article : Google Scholar

22 

Bommer UA, Vine KL, Puri P, Engel M, Belfiore L, Fildes K, Batterham M, Lochhead A and Aghmesheh M: Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin. Cell Commun Signal. 15(9)2017.PubMed/NCBI View Article : Google Scholar

23 

Li S, Chen M, Xiong Q, Zhang J, Cui Z and Ge F: Characterization of the translationally controlled tumor protein (TCTP) interactome reveals novel binding partners in human cancer cells. J Proteome Res. 15:3741–3751. 2016.PubMed/NCBI View Article : Google Scholar

24 

Tuynder M, Susini L, Prieur S, Besse S, Fiucci G, Amson R and Telerman A: Biological models and genes of tumor reversion: Cellular reprogramming through tpt1/TCTP and SIAH-1. Proc Natl Acad Sci USA. 99:14976–14981. 2002.PubMed/NCBI View Article : Google Scholar

25 

Amson R, Karp JE and Telerman A: Lessons from tumor reversion for cancer treatment. Curr Opin Oncol. 25:59–65. 2013.PubMed/NCBI View Article : Google Scholar

26 

Tuynder M, Fiucci G, Prieur S, Lespagnol A, Géant A, Beaucourt S, Duflaut D, Besse S, Susini L, Cavarelli J, et al: Translationally controlled tumor protein is a target of tumor reversion. Proc Natl Acad Sci USA. 101:15364–15369. 2004.PubMed/NCBI View Article : Google Scholar

27 

Telerman A and Amson R: The molecular programme of tumour reversion: The steps beyond malignant transformation. Nat Rev Cancer. 9:206–216. 2009.PubMed/NCBI View Article : Google Scholar

28 

Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A and Bray F: Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 144:1941–1953. 2019.PubMed/NCBI View Article : Google Scholar

29 

Mattiuzzi C and Lippi G: Current cancer epidemiology. J Epidemiol Glob Health. 9:217–222. 2019.PubMed/NCBI View Article : Google Scholar

30 

Vasan N, Baselga J and Hyman DM: A view on drug resistance in cancer. Nature. 575:299–309. 2019.PubMed/NCBI View Article : Google Scholar

31 

Miao X, Chen YB, Xu SL, Zhao T, Liu JY, Li YR, Wang J, Zhang J and Guo GZ: TCTP overexpression is associated with the development and progression of glioma. Tumour Biol. 34:3357–3361. 2013.PubMed/NCBI View Article : Google Scholar

32 

Amson R, Pece S, Marine JC, Di Fiore PP and Telerman A: TPT1/ TCTP-regulated pathways in phenotypic reprogramming. Trends Cell Biol. 23:37–46. 2013.PubMed/NCBI View Article : Google Scholar

33 

Chen C, Deng Y, Hua M, Xi Q, Liu R, Yang S, Liu J, Zhong J, Tang M, Lu S, et al: Expression and clinical role of TCTP in epithelial ovarian cancer. J Mol Histol. 46:145–156. 2015.PubMed/NCBI View Article : Google Scholar

34 

Michaelsen FW, Saeed ME, Schwarzkopf J and Efferth T: Activity of Artemisia annua and artemisinin derivatives, in prostate carcinoma. Phytomedicine. 22:1223–1231. 2015.PubMed/NCBI View Article : Google Scholar

35 

Koo N, Shin AY, Oh S, Kim H, Hong S, Park SJ, Sim YM, Byeon I, Kim KY, Lim YP, et al: Comprehensive analysis of translationally controlled tumor protein (TCTP) provides insights for lineage-specific evolution and functional divergence. PLoS One. 15(e0232029)2020.PubMed/NCBI View Article : Google Scholar

36 

Brioudes F, Thierry AM, Chambrier P, Mollereau B and Bendahmane M: Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants. Proc Natl Acad Sci USA. 107:16384–16389. 2010.PubMed/NCBI View Article : Google Scholar

37 

Proietti S, Cucina A, Pensotti A, Biava PM, Minini M, Monti N, Catizone A, Ricci G, Leonetti E, Harrath AH, et al: Active fraction from embryo fish extracts induces reversion of the malignant invasive phenotype in breast cancer through down-regulation of TCTP and modulation of E-cadherin/β-catenin pathway. Int J Mol Sci. 20(2151)2019.PubMed/NCBI View Article : Google Scholar

38 

Phanthaphol N, Techasen A, Loilome W, Thongchot S, Thanan R, Sungkhamanon S, Khuntikeo N, Yongvanit P and Namwat N: Upregulation of TCTP is associated with cholangiocarcinoma progression and metastasis. Oncol Lett. 14:5973–5979. 2017.PubMed/NCBI View Article : Google Scholar

39 

Powers S and Pollack RE: Inducing stable reversion to achieve cancer control. Nat Rev Cancer. 16:266–270. 2016.PubMed/NCBI View Article : Google Scholar

40 

Gu X, Zheng R, Xia C, Zeng H, Zhang S, Zou X, Yang Z, Li H and Chen W: Interactions between life expectancy and the incidence and mortality rates of cancer in China: A population-based cluster analysis. Cancer Commun (Lond). 38(44)2018.PubMed/NCBI View Article : Google Scholar

41 

Luengo-Fernandez R, Leal J, Gray A and Sullivan R: Economic burden of cancer across the European Union: A population-based cost analysis. Lancet Oncol. 14:1165–1174. 2013.PubMed/NCBI View Article : Google Scholar

42 

Mariotto AB, Yabroff KR, Shao Y, Feuer EJ and Brown ML: Projections of the cost of cancer care in the United States: 2010-2020. J Natl Cancer Inst. 103:117–128. 2011.PubMed/NCBI View Article : Google Scholar

43 

Sankaranarayanan R, Ramadas K and Qiao Yl: Managing the changing burden of cancer in Asia. BMC Med. 12(3)2014.PubMed/NCBI View Article : Google Scholar

44 

Weber GF: DNA Damaging Drugs. In: Molecular Therapies of Cancer. Weber GF (ed). Springer, Cham, International Publishing, pp9-112, 2015.

45 

Hwang SY, Chang SJ and Park BW: Does chemotherapy really affect the quality of life of women with breast cancer? J Breast Cancer. 16:229–235. 2013.PubMed/NCBI View Article : Google Scholar

46 

Lucibello M, Adanti S, Antelmi E, Dezi D, Ciafrè S, Carcangiu ML, Zonfrillo M, Nicotera G, Sica L, De Braud F and Pierimarchi P: Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells. Oncotarget. 6:5275–5291. 2015.PubMed/NCBI View Article : Google Scholar

47 

Ramani P, Nash R, Sowa-Avugrah E and Rogers C: High levels of polo-like kinase 1 and phosphorylated translationally controlled tumor protein indicate poor prognosis in neuroblastomas. J Neurooncol. 125:103–111. 2015.PubMed/NCBI View Article : Google Scholar

48 

Sun R, Lu X, Gong L and Jin F: TCTP promotes epithelial-mesenchymal transition in lung adenocarcinoma. Onco Targets Ther. 12:1641–1653. 2019.PubMed/NCBI View Article : Google Scholar

49 

Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, et al: The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 346:1937–1947. 2002.PubMed/NCBI View Article : Google Scholar

50 

Zhang F, Ma Q, Xu Z, Liang H, Li H, Ye Y, Xiang S, Zhang Y, Jiang L, Hu Y, et al: Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer. J Exp Clin Cancer Res. 36(68)2017.PubMed/NCBI View Article : Google Scholar

51 

Xiao B, Chen D, Luo S, Hao W, Jing F, Liu T, Wang S, Geng Y, Li L, Xu W, et al: Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/MMP9 signaling. Oncotarget. 7:50057–50073. 2016.PubMed/NCBI View Article : Google Scholar

52 

Bae SY, Kim HJ, Lee KJ and Lee K: Translationally controlled tumor protein induces epithelial to mesenchymal transition and promotes cell migration, invasion and metastasis. Sci Rep. 5(8061)2015.PubMed/NCBI View Article : Google Scholar

53 

Jin H, Zhang X, Su J, Teng Y, Ren H and Yang L: RNA interference-mediated knockdown of translationally controlled tumor protein induces apoptosis, and inhibits growth and invasion in glioma cells. Mol Med Rep. 12:6617–6625. 2015.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Fischer N, Saeed ME, Lippe E, Roth W and Efferth T: High TCTP expression as prognostic factor in different cancer types. World Acad Sci J 3: 3, 2021.
APA
Fischer, N., Saeed, M.E., Lippe, E., Roth, W., & Efferth, T. (2021). High TCTP expression as prognostic factor in different cancer types. World Academy of Sciences Journal, 3, 3. https://doi.org/10.3892/wasj.2020.74
MLA
Fischer, N., Saeed, M. E., Lippe, E., Roth, W., Efferth, T."High TCTP expression as prognostic factor in different cancer types". World Academy of Sciences Journal 3.1 (2021): 3.
Chicago
Fischer, N., Saeed, M. E., Lippe, E., Roth, W., Efferth, T."High TCTP expression as prognostic factor in different cancer types". World Academy of Sciences Journal 3, no. 1 (2021): 3. https://doi.org/10.3892/wasj.2020.74
Copy and paste a formatted citation
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Spandidos Publications style
Fischer N, Saeed ME, Lippe E, Roth W and Efferth T: High TCTP expression as prognostic factor in different cancer types. World Acad Sci J 3: 3, 2021.
APA
Fischer, N., Saeed, M.E., Lippe, E., Roth, W., & Efferth, T. (2021). High TCTP expression as prognostic factor in different cancer types. World Academy of Sciences Journal, 3, 3. https://doi.org/10.3892/wasj.2020.74
MLA
Fischer, N., Saeed, M. E., Lippe, E., Roth, W., Efferth, T."High TCTP expression as prognostic factor in different cancer types". World Academy of Sciences Journal 3.1 (2021): 3.
Chicago
Fischer, N., Saeed, M. E., Lippe, E., Roth, W., Efferth, T."High TCTP expression as prognostic factor in different cancer types". World Academy of Sciences Journal 3, no. 1 (2021): 3. https://doi.org/10.3892/wasj.2020.74
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