Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
World Academy of Sciences Journal
Join Editorial Board Propose a Special Issue
Print ISSN: 2632-2900 Online ISSN: 2632-2919
Journal Cover
May-June 2021 Volume 3 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-June 2021 Volume 3 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Characteristics of patients unaware of their chronic hepatitis virus infection

  • Authors:
    • Hiroshi Okano
    • Hiroki Asakawa
    • Kenji Nose
    • Satomi Tsuruga
    • Tomomasa Tochio
    • Hiroaki Kumazawa
    • Takashi Sakuno
    • Yoshiaki Isono
    • Hiroki Tanaka
    • Shimpei Matsusaki
    • Tomohiro Sase
    • Tomonori Saito
    • Katsumi Mukai
    • Akira Nishimura
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Suzuka General Hospital, Suzuka, Mie 513‑8630, Japan
    Copyright: © Okano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 29
    |
    Published online on: April 14, 2021
       https://doi.org/10.3892/wasj.2021.100
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

A number of patients do not benefit from advancements made in the treatment of chronic hepatitis B virus (HBV) and chronic hepatitis C virus (HCV) infection due to a lack of awareness of their infection. Therefore, the present study aimed to investigate the reason for this and to identify strategies to resolve this issue. Data were retrospectively collected from medical records for the period between 2009 and 2019. Patients with chronic HBV or HCV infection who had been referred to the hospital and were unaware of their infection prior to their referral were eligible to participate in the present study. Overall, 282 and 259 patients with chronic HBV and HCV infection, respectively, were referred to the hospital. Of these patients, 63 in each group had been unaware of their infection. Moreover, of the 63 patients, seven already had hepatocellular carcinoma at diagnosis. The female patients with HCV were older than the other patients, including the male patients and the female patients with HBV (P=0.02), and the patients in the HBV group were younger than those in the HCV group (P=0.02). The majority of the patients (96/126) had become aware of their infection by chance. In the HBV group, patients whose infection had been detected during a health checkup were significantly younger than those whose infection had been detected by chance (P=0.016), but not in the HCV group. On the whole, these findings suggest that, in order to identify greater numbers of patients with chronic hepatitis infection who are unaware of their infection, the necessity of screening for hepatitis virus in primary care, particularly among women and elderly individuals, should be emphasized and promoted.
View Figures
View References

1 

Schweitzer A, Horn J, Mikolajczyk RT, Krause G and Ott JJ: Estimations of worldwide prevalence of chronic hepatitis B virus infection: A systematic review of data published between 1965 and 2013. Lancet. 386:1546–1555. 2015.PubMed/NCBI View Article : Google Scholar

2 

Mohd Hanafiah K, Groeger J, Flaxman AD and Wiersma ST: Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence. Hepatology. 57:1333–1342. 2013.PubMed/NCBI View Article : Google Scholar

3 

Chung H, Ueda T and Kudo M: Changing trends in hepatitis C infection over the past 50 years in Japan. Intervirology. 53:39–43. 2010.PubMed/NCBI View Article : Google Scholar

4 

de Martel C, Maucort-Boulch D, Plummer M and Franceschi S: World-wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma. Hepatology. 62:1190–1200. 2015.PubMed/NCBI View Article : Google Scholar

5 

Su TH and Kao JH: Improving clinical outcomes of chronic hepatitis B virus infection. Expert Rev Gastroenterol Hepatol. 9:141–154. 2015.PubMed/NCBI View Article : Google Scholar

6 

Yokosuka O, Takaguchi K, Fujioka S, Shindo M, Chayama K, Kobashi H, Hayashi N, Sato C, Kiyosawa K, Tanikawa K, et al: Long-term use of entecavir in nucleoside-naïve Japanese patients with chronic hepatitis B infection. J Hepatol. 52:791–799. 2010.PubMed/NCBI View Article : Google Scholar

7 

Ono A, Suzuki F, Kawamura Y, Sezaki H, Hosaka T, Akuta N, Kobayashi M, Suzuki Y, Saitou S, Arase Y, et al: Long-term continuous entecavir therapy in nucleos(t)ide-naïve chronic hepatitis B patients. J Hepatol. 57:508–514. 2012.PubMed/NCBI View Article : Google Scholar

8 

Sugiyama A, Ohisa M, Nagashima S, Yamamoto C, Chuon C, Fujii T, Akita T, Katayama K, Kudo Y and Tanaka J: Reduced prevalence of hepatitis B surface antigen positivity among pregnant women born after the national implementation of immunoprophylaxis for babies born to hepatitis B virus-carrier mothers in Japan. Hepatol Res. 47:1329–1334. 2017.PubMed/NCBI View Article : Google Scholar

9 

de Fraga RS, Van Vaisberg V, Mendes LCA, Carrilho FJ and Ono SK: Adverse events of nucleos(t)ide analogues for chronic hepatitis B: A systematic review. J Gastroenterol. 55:496–514. 2020.PubMed/NCBI View Article : Google Scholar

10 

Kumada H, Suzuki Y, Ikeda K, Toyota J, Karino Y, Chayama K, Kawakami Y, Ido A, Yamamoto K, Takaguchi K, et al: Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection. Hepatology. 59:2083–2091. 2014.PubMed/NCBI View Article : Google Scholar

11 

Omata M, Nishiguchi S, Ueno Y, Mochizuki H, Izumi N, Ikeda F, Toyoda H, Yokosuka O, Nirei K, Genda T, et al: Sofosbuvir plus ribavirin in Japanese patients with chronic genotype 2 HCV infection: An open-label, phase 3 trial. J Viral Hepat. 21:762–768. 2014.PubMed/NCBI View Article : Google Scholar

12 

Chayama K, Notsumata K, Kurosaki M, Sato K, Rodrigues L Jr, Setze C, Badri P, Pilot-Matias T, Vilchez RA and Kumada H: Randomized trial of interferon- and ribavirin-free Ombitasvir/paritaprevir/ritonavir in treatment-experienced hepatitis C virus-infected patients. Hepatology. 61:1523–1532. 2015.PubMed/NCBI View Article : Google Scholar

13 

Mizokami M, Yokosuka O, Takehara T, Sakamoto N, Korenaga M, Mochizuki H, Nakane K, Enomoto H, Ikeda F, Yanase M, et al: Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: An open-label, randomised, phase 3 trial. Lancet Infect Dis. 15:645–653. 2015.PubMed/NCBI View Article : Google Scholar

14 

Suda G, Furusyo N, Toyoda H, Kawakami Y, Ikeda H, Suzuki M, Arataki K, Mori N, Tsuji K, Katamura Y, et al: Daclatasvir and asunaprevir in hemodialysis patients with hepatitis C virus infection: A nationwide retrospective study in Japan. J Gastroenterol. 53:119–128. 2018.PubMed/NCBI View Article : Google Scholar

15 

Akuta N, Sezaki H, Suzuki F, Kawamura Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Suzuki Y, Arase Y, et al: Favorable efficacy of daclatasvir plus asunaprevir in treatment of elderly Japanese patients infected with HCV genotype 1b aged 70 and older. J Med Virol. 89:91–98. 2017.PubMed/NCBI View Article : Google Scholar

16 

Heathcote EJ, Marcellin P, Buti M, Gane E, De Man RA, Krastev Z, Germanidis G, Lee SS, Flisiak R, Kaita K, et al: Three-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B. Gastroenterology. 140:132–143. 2011.PubMed/NCBI View Article : Google Scholar

17 

Marcellin P, Gane E, Buti M, Afdhal N, Sievert W, Jacobson IM, Washington MK, Germanidis G, Flaherty JF, Aguilar Schall R, et al: Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: A 5-year open-label follow-up study. Lancet. 381:468–475. 2013.PubMed/NCBI View Article : Google Scholar

18 

Backus LI, Belperio PS, Shahoumian TA and Mole LA: Impact of sustained virologic response with direct-acting antiviral treatment on mortality in patients with advanced liver disease. Hepatology. 69:487–497. 2019.PubMed/NCBI View Article : Google Scholar

19 

Nagai K, Ide K, Kawasaki Y, Tanaka-Mizuno S, Seto K, Iwane S, Eguchi Y and Kawakami K: Estimating the cost-effectiveness of screening for hepatitis C virus infection in Japan. Hepatol Res. 50:542–556. 2020.PubMed/NCBI View Article : Google Scholar

20 

El-Serag HB, Kanwal F, Richardson P and Kramer J: Risk of hepatocellular carcinoma after sustained virological response in Veterans with hepatitis C virus infection. Hepatology. 64:130–137. 2016.PubMed/NCBI View Article : Google Scholar

21 

Orito E, Ichida T, Sakugawa H, Sata M, Horiike N, Hino K, Okita K, Okanoue T, Iino S, Tanaka E, et al: Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan. Hepatology. 34:590–594. 2001.PubMed/NCBI View Article : Google Scholar

22 

Toyoda H, Kumada T, Takaguchi K, Shimada N and Tanaka J: Changes in hepatitis C virus genotype distribution in Japan. Epidemiol Infect. 142:2624–2628. 2014.PubMed/NCBI View Article : Google Scholar

23 

Ikeda K, Saitoh S, Koida I, Arase Y, Tsubota A, Chayama K, Kumada H and Kawanishi M: A multivariate analysis of risk factors for hepatocellular carcinogenesis: A prospective observation of 795 patients with viral and alcoholic cirrhosis. Hepatology. 18:47–53. 1993.PubMed/NCBI

24 

Ministry of Health, Labour and Welfare: Basic guidelines for promotion of control measures for hepatitis. http://www.mhlw.go.jp/bunya/kenkou/kekkakukansenshou09/pdf/hourei-17e.pdf. Accessed August 21, 2017.

25 

Tatemichi M, Furuya H, Nagahama S, Takaya N, Shida Y, Fukai K, Owada S, Endo H, Kinoue T and Korenaga M: A nationwide cross-sectional survey on hepatitis B and C screening among workers in Japan. Sci Rep. 10(11435)2020.PubMed/NCBI View Article : Google Scholar

26 

Gender Equality Bureau, Cabinet Office, Government of Japan: White Paper on Gender Equality 2020-Summary. 2020. https://www.gender.go.jp/english_contents/about_danjo/whitepaper/pdf/ewp2020.pdf. Accessed July 31. 2020.

27 

Sasaki T, Izawa M and Okada Y: Current trends in health insurance systems: OECD countries vs. Japan. Neurol Med Chir (Tokyo). 55:267–275. 2015.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Okano H, Asakawa H, Nose K, Tsuruga S, Tochio T, Kumazawa H, Sakuno T, Isono Y, Tanaka H, Matsusaki S, Matsusaki S, et al: Characteristics of patients unaware of their chronic hepatitis virus infection. World Acad Sci J 3: 29, 2021.
APA
Okano, H., Asakawa, H., Nose, K., Tsuruga, S., Tochio, T., Kumazawa, H. ... Nishimura, A. (2021). Characteristics of patients unaware of their chronic hepatitis virus infection. World Academy of Sciences Journal, 3, 29. https://doi.org/10.3892/wasj.2021.100
MLA
Okano, H., Asakawa, H., Nose, K., Tsuruga, S., Tochio, T., Kumazawa, H., Sakuno, T., Isono, Y., Tanaka, H., Matsusaki, S., Sase, T., Saito, T., Mukai, K., Nishimura, A."Characteristics of patients unaware of their chronic hepatitis virus infection". World Academy of Sciences Journal 3.3 (2021): 29.
Chicago
Okano, H., Asakawa, H., Nose, K., Tsuruga, S., Tochio, T., Kumazawa, H., Sakuno, T., Isono, Y., Tanaka, H., Matsusaki, S., Sase, T., Saito, T., Mukai, K., Nishimura, A."Characteristics of patients unaware of their chronic hepatitis virus infection". World Academy of Sciences Journal 3, no. 3 (2021): 29. https://doi.org/10.3892/wasj.2021.100
Copy and paste a formatted citation
x
Spandidos Publications style
Okano H, Asakawa H, Nose K, Tsuruga S, Tochio T, Kumazawa H, Sakuno T, Isono Y, Tanaka H, Matsusaki S, Matsusaki S, et al: Characteristics of patients unaware of their chronic hepatitis virus infection. World Acad Sci J 3: 29, 2021.
APA
Okano, H., Asakawa, H., Nose, K., Tsuruga, S., Tochio, T., Kumazawa, H. ... Nishimura, A. (2021). Characteristics of patients unaware of their chronic hepatitis virus infection. World Academy of Sciences Journal, 3, 29. https://doi.org/10.3892/wasj.2021.100
MLA
Okano, H., Asakawa, H., Nose, K., Tsuruga, S., Tochio, T., Kumazawa, H., Sakuno, T., Isono, Y., Tanaka, H., Matsusaki, S., Sase, T., Saito, T., Mukai, K., Nishimura, A."Characteristics of patients unaware of their chronic hepatitis virus infection". World Academy of Sciences Journal 3.3 (2021): 29.
Chicago
Okano, H., Asakawa, H., Nose, K., Tsuruga, S., Tochio, T., Kumazawa, H., Sakuno, T., Isono, Y., Tanaka, H., Matsusaki, S., Sase, T., Saito, T., Mukai, K., Nishimura, A."Characteristics of patients unaware of their chronic hepatitis virus infection". World Academy of Sciences Journal 3, no. 3 (2021): 29. https://doi.org/10.3892/wasj.2021.100
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team