Advanced diabetic kidney disease complicated by acute interstitial nephritis: A case report and literature review

He,Jin; Chen,Shubei; Huang,Weihong

doi:10.3892/wasj.2021.108

Advanced diabetic kidney disease complicated by acute interstitial nephritis: A case report and literature review

Authors:
- Jin He
- Shubei Chen
- Weihong Huang
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Affiliations: Division of Nephrology and Endocrinology, Chonggang General Hospital, Chongqing 400016, P.R. China
Published online on: May 19, 2021 https://doi.org/10.3892/wasj.2021.108
Article Number: 37
Copyright : © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Currently, diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD) and end‑stage renal disease (ESRD) worldwide. The condition of advanced DKD is severe and is often accompanied by a number of complications, such as heart failure and pulmonary infection, requiring multiple‑drug treatment. However, any type of medicine has the potential to cause acute interstitial nephritis (AIN). In addition, as renal fibrosis in advanced DKD is already severe without taking any complications, such as AIN into account, it remains unclear whether steroidal therapy can benefit the condition. The present study describes the case of a patient with advanced DKD complicated by AIN, who was administered steroidal therapy. Ultimately, the patient's renal function partially improved. The present study also presents a brief review, discussing past experience on DKD with complications. On the whole, it is demonstrated that even patients with advanced DKD may still benefit from steroid therapy.

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