Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
World Academy of Sciences Journal
Join Editorial Board Propose a Special Issue
Print ISSN: 2632-2900 Online ISSN: 2632-2919
Journal Cover
July-August 2021 Volume 3 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-August 2021 Volume 3 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Clear cell atypical fibroxanthoma: A case report and review of the literature

  • Authors:
    • Patroklos Katafygiotis
  • View Affiliations / Copyright

    Affiliations: First Department of Pathology National and Kapodistrian University of Athens, 11527 Athens, Greece
    Copyright: © Katafygiotis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 38
    |
    Published online on: May 20, 2021
       https://doi.org/10.3892/wasj.2021.109
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Clear cell atypical fibroxanthoma (CCAFX) is a rare tumor of uncertain differentiation first described in 1987, of which 20 cases have thus far been studied in detail and reported in the English literature. CCAFX is regarded as a skin tumor and without a wide‑range immunohistochemical application, it is relatively impossible to differentiate it from other well‑known malignancies with a clear cell phenotype. In the majority of cases, CCAFX has a rather indolent course; however, it can produce local recurrences, particularly if an incomplete excision has been made and in more rare cases, it can lead to regional lymph node metastases. The present study describes the case of a male patient with a rapidly growing CCAFX highlighting the vast clinicopathological differential diagnosis of this tumor and describing its course one year following its surgical excision. The tumor was examined immunohistochemically and was found to express several fibrohistiocytic antigens (such as CD68, α1‑antichymotrypsin and FactorXIIIa, as well as CD10, D2‑40 and CD99); however, it did not express melanocytic, hormonal receptors or cytokeratins. In addition, the current study reviews and discusses the most prominent clinicopathologic features of this rare cutaneous tumor of uncertain differentiation.
View Figures
View References

1 

Helwig EB: Atypical fibroxandioma: Proceedings of 18th annual tumor seminar of San Antonio society of pathologists. Tex State J Med. 59:664–667. 1961.

2 

Patterson JW, Konerding H and Kramer WM: ‘Clear cell’ atypical fibroxanthoma. J Dertmatol Surg Oncol. 13:1109–1114. 1987.PubMed/NCBI View Article : Google Scholar

3 

Longacre TA, Smoller BR and Rouse RV: Atypical fibroxanthoma: Multiple immunohistologic profiles. Am J Surg Pathol. 17(1199)1993.PubMed/NCBI View Article : Google Scholar

4 

Tardío JC, Pinedo F, Aramburu J, Martínez-González MÁ, Arias D, Khedaoui R, Suárez-Massa D and Santonja C: Clear cell atypical fibroxanthoma: Clinicopathological study of 6 cases and review of the literature with special emphasis on the differential diagnosis. Am J Dermatopathol. 38:586–592. 2016.PubMed/NCBI View Article : Google Scholar

5 

Kemmerling R, Dietze O, Müller S and Neureiter D: Aspects of the differential diagnosis of clear-cell lesions of the skin in connection with the rare case of a clear-cell atypical fibroxanthoma. Pathol Res Pract. 205:365–370. 2009.PubMed/NCBI View Article : Google Scholar

6 

Murali R and Palfreeman S: Clear cell atypical fibroxanthoma-report of a case with review of the literature. J Cutan Pathol. 33:343–348. 2006.PubMed/NCBI View Article : Google Scholar

7 

Cai JP and Randall B: HMB-45 expression in a clear cell variant of atypical fibroxanthoma. J Cutan Pathol. 33:186–188. 2006.PubMed/NCBI View Article : Google Scholar

8 

Crowson AN, Carlson-Sweet K, Macinnis C, Taylor JR, Battaglia T, LaMar WL, Minor D, Sutter S and Hill T: Clear cell atypical fibroxanthoma: A clinicopathologic study. J Cutan Pathol. 29:374–381. 2002.PubMed/NCBI View Article : Google Scholar

9 

Lazaro-Santander R, Andres-Gozalbo C, Rodriguez-Pereira C and Vera-Román JM: Clear cell atypical fibroxanthoma. Histopathology. 35:484–485. 1999.PubMed/NCBI View Article : Google Scholar

10 

Requena L, Sangueza OP, Yus ES and Furio V: Clear-cell atypical fibroxanthoma: An uncommon histopathologic variant of atypical fibroxanthoma. J Cutan Pathol. 24:176–182. 1997.PubMed/NCBI View Article : Google Scholar

11 

Javier CN, Colón DC, Sánchez JL and Sánchez JE: Clear-cell atypical fibroxanthoma: A combined immunohistochemistry analysis. Am J Dermatopathol. 38:775–779. 2016.PubMed/NCBI View Article : Google Scholar

12 

Nguyen CM, Chong K and Cassarino D: Clear cell atypical fibroxanthoma: A case report and review of the literature. J Cutan Pathol. 43:538–542. 2016.PubMed/NCBI View Article : Google Scholar

13 

Goldstein Z, Sarantopoulos G and Smart C: Clear-cell atypical fibroxanthoma: An unusual case in an unusual place. J Cutan Pathol. 44:951–953. 2017.PubMed/NCBI View Article : Google Scholar

14 

Bedir R, Agirbas S, Sehitoglu I, Yurdakul C and Elmas O: Clear cell atypical fibroxantoma: A rare variant of atypical fibroxanthoma and review of the literature. J Clin Diagn Res. 8:FD09–FD11. 2014.PubMed/NCBI View Article : Google Scholar

15 

Beer T, Calonje E and Wick M: Atypical fibroxanthoma and variants. In: Elder D, Massi D, Scolyer R, Willemze R (eds): WHO classification of skin tumors. IARC Press, Lyon, 2018, pp368-369.

16 

Helwig EB and May D: Atypical fibroxanthoma of the skin with metastasis. Cancer. 57:368–376. 1986.PubMed/NCBI View Article : Google Scholar

17 

Soleymani T and Hollmig ST: Conception and management of a poorly understood spectrum of dermatologic neoplasms: Atypical fibroxanthoma, pleomorphic dermal sarcoma, and undifferentiated pleomorphic sarcoma. Curr Treat Options Oncol. 18(50)2017.PubMed/NCBI View Article : Google Scholar

18 

Ang GC, Roenigk RK, Otley CC, Phillips PK and Weaver AL: More than 2 decades of treating atypical fibroxanthoma at mayo clinic: What have we learned from 91 patients? Dermatol Surg. 35:765–772. 2009.PubMed/NCBI View Article : Google Scholar

19 

Mohanty SK, Sharma S, Pradhan D, Kandukuri SR, Farahani N, Barry C, Wu JM, Frishberg D and Balzer B: Microphthalmia- associated transcription factor (MiTF): Promiscuous staining patterns in fibrohistiocytic lesions is a potential pitfall. Pathol Res Pract. 214:821–825. 2018.PubMed/NCBI View Article : Google Scholar

20 

Kanner WA, Brill LB II, Patterson JW and Wick MR: CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. J Cutan Pathol. 37:744–750. 2010.PubMed/NCBI View Article : Google Scholar

21 

Cesinaro AM, Gallo G, Tramontozzi S and Migaldi MJ: Atypical fibroxanthoma and pleomorphic dermal sarcoma: A reappraisal. J Cutan Pathol. 48:207–210. 2021.PubMed/NCBI View Article : Google Scholar

22 

Harding-Jackson N, Sangueza M, Mackinnon A, Suster S and Plaza JA: Spindle cell atypical fibroxanthoma: Myofibroblastic differentiation represents a diagnostic pitfall in this variant of AFX. Am J Dermatopathol. 370:509–514. 2015.PubMed/NCBI View Article : Google Scholar

23 

Soleymani T, Aasi SZ, Novoa R and Hollmig ST: Atypical fibroxanthoma and pleomorphic dermal sarcoma: Updates on classification and management. Dermatol Clin. 37:253–259. 2019.PubMed/NCBI View Article : Google Scholar

24 

Cooper JZ, Newman SR, Scott GA and Brown MD: Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): Report of five cases. Dermatol Surg. 31:221–225. 2005.PubMed/NCBI View Article : Google Scholar

25 

Miller K, Goodlad JR and Brenn T: Pleomorphic dermal sarcoma. Adverse histologic features predict aggressive behavior and allow distinction from atypical fibroxanthoma. Am J Surg Pathol. 36:1317–1326. 2012.PubMed/NCBI View Article : Google Scholar

26 

Helbig D, Quaas A, Mauch C, Merkelbach-Bruse S, Büttner R, Emberger M, Wobser M, Rüsseler V, Pütz K, Binot E, et al: Copy number variations in atypical fibroxanthomas and pleomorphic dermal sarcomas. Oncotarget. 8:109457–109467. 2017.PubMed/NCBI View Article : Google Scholar

27 

Griewank KG, Murali R, Puig-Butille JA, Schilling B, Livingstone E, Potrony M, Carrera C, Schimming T, Möller I, Schwamborn M, et al: TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma. J Natl Cancer Inst. 106(dju246)2014.PubMed/NCBI View Article : Google Scholar

28 

Griewank KG, Wiesner T, Murali R, Pischler C, Müller H, Koelsche C, Möller I, Franklin C, Cosgarea I, Sucker A, et al: Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles. Mod Pathol. 31:418–428. 2018.PubMed/NCBI View Article : Google Scholar

29 

Helbig D, Ihle MA, Putz K, Tantcheva-Poor I, Mauch C, Büttner R and Quaas A: Oncogene and therapeutic target analyses in atypical fibroxanthomas and pleomorphic dermal scarcomas. Oncotarget. 7:21763–21774. 2016.PubMed/NCBI View Article : Google Scholar

30 

Dei Tos AP, Maestro R, Doglioni C, Gasparotto D, Boiocchi M, Laurino L and Fletcher CD: Ultraviolet-induced p53 mutations in atypical fibroxanthoma. Am J Pathol. 145:11–17. 1994.PubMed/NCBI

31 

Soufir N, Ribojad M, Magnaldo T, Thibaudeau O, Delestaing G, Daya-Grosjean L, Rivet J, Sarasin A and Basset-Seguin NJ: Germline and somatic mutations of the INK4a-ARF gene in a xeroderma pigmentosum group C patient. J Invest Dermatol. 119:1355–1360. 2002.PubMed/NCBI View Article : Google Scholar

32 

Lee SM, Zhang W and Fernandez MP: Atypical fibroxanthoma arising in a young patient with Li-Fraumeni syndrome. J Cutan Pathol. 41:303–307. 2014.PubMed/NCBI View Article : Google Scholar

33 

Suárez-Vilela D, Izquierdo-García F, Domínguez-Iglesias F and Méndez-Álvarez JR: Combined papillated bowen disease and clear cell atypical fibroxanthoma. Case Rep Dermatol. 2:69–75. 2010.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Katafygiotis P: Clear cell atypical fibroxanthoma: A case report and review of the literature. World Acad Sci J 3: 38, 2021.
APA
Katafygiotis, P. (2021). Clear cell atypical fibroxanthoma: A case report and review of the literature. World Academy of Sciences Journal, 3, 38. https://doi.org/10.3892/wasj.2021.109
MLA
Katafygiotis, P."Clear cell atypical fibroxanthoma: A case report and review of the literature". World Academy of Sciences Journal 3.4 (2021): 38.
Chicago
Katafygiotis, P."Clear cell atypical fibroxanthoma: A case report and review of the literature". World Academy of Sciences Journal 3, no. 4 (2021): 38. https://doi.org/10.3892/wasj.2021.109
Copy and paste a formatted citation
x
Spandidos Publications style
Katafygiotis P: Clear cell atypical fibroxanthoma: A case report and review of the literature. World Acad Sci J 3: 38, 2021.
APA
Katafygiotis, P. (2021). Clear cell atypical fibroxanthoma: A case report and review of the literature. World Academy of Sciences Journal, 3, 38. https://doi.org/10.3892/wasj.2021.109
MLA
Katafygiotis, P."Clear cell atypical fibroxanthoma: A case report and review of the literature". World Academy of Sciences Journal 3.4 (2021): 38.
Chicago
Katafygiotis, P."Clear cell atypical fibroxanthoma: A case report and review of the literature". World Academy of Sciences Journal 3, no. 4 (2021): 38. https://doi.org/10.3892/wasj.2021.109
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team