Sleep duration and risk of obesity: A genome and epidemiological study

Kim,Hye Ok; Kang,Insug; Choe,Wonchae; Yoon,Kyung-Sik

doi:10.3892/wasj.2021.91

Sleep duration and risk of obesity: A genome and epidemiological study

Authors:
- Hye Ok Kim
- Insug Kang
- Wonchae Choe
- Kyung-Sik Yoon
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Affiliations: Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
Published online on: February 5, 2021 https://doi.org/10.3892/wasj.2021.91
Article Number: 20
Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Obesity is one of the risk factors for metabolic and cardiovascular diseases. Although numerous epidemiological studies have reported a possible causal association between sleep duration and the risk of obesity, evidence for an association in adults remains unclear. Accordingly, the present study aimed to evaluate the association between sleep duration and the risk of obesity in an adult group. To this end, 5,719 adults (2,876 males and 2,843 females) who participated in a genome and epidemiology study, were analyzed. Data were obtained on sleep duration, body mass index (BMI) and other demographic data including age, sex, waist circumference, alcohol consumption and smoking status. The association between sleep duration and obesity was investigated using a Chi‑squared test or logistic regression analysis. Multivariate logistic regression analysis revealed that a short sleep duration (≤6 h) was significantly associated with obesity after adjusting for various confounding factors (OR, 1.446; 95% CI, 1.254‑1.667; P<0.0001). Strong associations between a short sleep duration (≤6 h) and obesity were identified in males (OR, 1.567; 95% CI, 1.258‑1.953; P<0.0001) and the early midlife group (OR, 1.584; 95% CI, 1.320‑1.902; P<0.0001). Furthermore, the risk of obesity significantly increased with a short sleep duration (≤6 h) in participants without hypertension (OR, 1.534; 95% CI, 1.263‑1.863; P<0.0001) or diabetes (OR, 1.473; 95% CI, 1.272‑1.705; P<0.0001). A short sleep duration was positively related to a high prevalence of obesity, and this association varied with sex, age, and the presence of metabolic disease. On the whole, the findings of the present study provide evidence that sleep duration can affect obesity.

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1	Ning X, Lv J, Guo Y, Bian Z, Tan Y, Pei P, Chen J, Yan S, Li H, Fu Z, et al: China Kadoorie Biobank (CKB) Collaborative Group: Association of sleep duration with weight gain and general and central obesity risk in Chinese adults: A prospective study. Obesity (Silver Spring). 28:468–474. 2020.PubMed/NCBI View Article : Google Scholar
2	Yang L and Colditz GA: Prevalence of overweight and obesity in the United States, 2007-2012. JAMA Intern Med. 175:1412–1413. 2015.PubMed/NCBI View Article : Google Scholar
3	Kelly T, Yang W, Chen CS, Reynolds K and He J: Global burden of obesity in 2005 and projections to 2030. Int J Obes. 32:1431–1437. 2008.PubMed/NCBI View Article : Google Scholar
4	Kim CS, Ko SH, Kwon HS, Kim NH, Kim JH, Lim S, Choi SH, Song KH, Won JC, Kim DJ, et al: Taskforce Team of Diabetes Fact Sheet of the Korean Diabetes Association: Prevalence, awareness, and management of obesity in Korea: Data from the Korea national health and nutrition examination survey (1998-2011). Diabetes Metab J. 38:35–43. 2014.PubMed/NCBI View Article : Google Scholar
5	Rangaraj VR and Knutson KL: Association between sleep deficiency and cardiometabolic disease: Implications for health disparities. Sleep Med. 18:19–35. 2016.PubMed/NCBI View Article : Google Scholar
6	Taheri S, Lin L, Austin D, Young T and Mignot E: Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 1(e62)2004.PubMed/NCBI View Article : Google Scholar
7	Leibel RL: The role of leptin in the control of body weight. Nutr Rev. 60:S15–S19; discussion S68-87. 2002.
8	Cummings DE and Foster KE: Ghrelin-leptin tango in body-weight regulation. Gastroenterology. 124:1532–1535. 2003.PubMed/NCBI View Article : Google Scholar
9	Golem DL, Martin-Biggers JT, Koenings MM, Davis KF and Byrd-Bredbenner C: An integrative review of sleep for nutrition professionals. Adv Nutr. 5:742–759. 2014.PubMed/NCBI View Article : Google Scholar
10	Cappuccio FP, Taggart FM, Kandala NB, Currie A, Peile E, Stranges S and Miller MA: Meta-analysis of short sleep duration and obesity in children and adults. Sleep. 31:619–626. 2008.PubMed/NCBI View Article : Google Scholar
11	Wu Y, Zhai L and Zhang D: Sleep duration and obesity among adults: A meta-analysis of prospective studies. Sleep Med. 15:1456–1462. 2014.PubMed/NCBI View Article : Google Scholar
12	Lauderdale DS, Knutson KL, Rathouz PJ, Yan LL, Hulley SB and Liu K: Cross-sectional and longitudinal associations between objectively measured sleep duration and body mass index: The CARDIA Sleep Study. Am J Epidemiol. 170:805–813. 2009.PubMed/NCBI View Article : Google Scholar
13	Chaput JP, Després JP, Bouchard C and Tremblay A: The association between sleep duration and weight gain in adults: A 6-year prospective study from the Quebec Family Study. Sleep. 31:517–523. 2008.PubMed/NCBI View Article : Google Scholar
14	Gangwisch JE, Malaspina D, Boden-Albala B and Heymsfield SB: Inadequate sleep as a risk factor for obesity: Analyses of the NHANES I. Sleep. 28:1289–1296. 2005.PubMed/NCBI View Article : Google Scholar
15	Gutiérrez-Repiso C, Soriguer F, Rubio-Martín E, Esteva de Antonio I, Ruiz de Adana MS, Almaraz MC, Olveira-Fuster G, Morcillo S, Valdés S, Lago-Sampedro AM, et al: Night-time sleep duration and the incidence of obesity and type 2 diabetes. Findings from the prospective Pizarra study. Sleep Med. 15:1398–1404. 2014.PubMed/NCBI View Article : Google Scholar
16	Nishiura C and Hashimoto H: A 4-year study of the association between short sleep duration and change in body mass index in Japanese male workers. J Epidemiol. 20:385–390. 2010.PubMed/NCBI View Article : Google Scholar
17	Nagai M, Tomata Y, Watanabe T, Kakizaki M and Tsuji I: Association between sleep duration, weight gain, and obesity for long period. Sleep Med. 14:206–210. 2013.PubMed/NCBI View Article : Google Scholar
18	Vgontzas AN, Fernandez-Mendoza J, Miksiewicz T, Kritikou I, Shaffer ML, Liao D, Basta M and Bixler EO: Unveiling the longitudinal association between short sleep duration and the incidence of obesity: The Penn State Cohort. Int J Obes. 38:825–832. 2014.PubMed/NCBI View Article : Google Scholar
19	Sayón-Orea C, Bes-Rastrollo M, Carlos S, Beunza JJ, Basterra-Gortari FJ and Martínez-González MA: Association between sleeping hours and siesta and the risk of obesity: The SUN Mediterranean Cohort. Obes Facts. 6:337–347. 2013.PubMed/NCBI View Article : Google Scholar
20	Zhou Q, Wu X, Zhang D, Liu L, Wang J, Cheng R, Lin J, Liu Y, Sun X, Yin Z, et al: Age and sex differences in the association between sleep duration and general and abdominal obesity at 6-year follow-up: The rural Chinese cohort study. Sleep Med. 69:71–77. 2020.PubMed/NCBI View Article : Google Scholar
21	Kobayashi D, Takahashi O, Deshpande GA, Shimbo T and Fukui T: Association between weight gain, obesity, and sleep duration: A large-scale 3-year cohort study. Sleep Breath. 16:829–833. 2012.PubMed/NCBI View Article : Google Scholar
22	Sasaki N, Fujiwara S, Yamashita H, Ozono R, Monzen Y, Teramen K and Kihara Y: Association between obesity and self-reported sleep duration variability, sleep timing, and age in the Japanese population. Obes Res Clin Pract. 12:187–194. 2018.PubMed/NCBI View Article : Google Scholar
23	Park SE, Kim HM, Kim DH, Kim J, Cha BS and Kim DJ: The association between sleep duration and general and abdominal obesity in Koreans: Data from the Korean National Health and Nutrition Examination Survey, 2001 and 2005. Obesity (Silver Spring). 17:767–771. 2009.PubMed/NCBI View Article : Google Scholar
24	Kim Y and Han BG: KoGES group: Cohort Profile. The Korean Genome and Epidemiology Study (KoGES) Consortium. Int J Epidemiol. 46(1350)2017.PubMed/NCBI View Article : Google Scholar
25	Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, Yoon D, Lee MH, Kim DJ, Park M, et al: A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet. 41:527–534. 2009.PubMed/NCBI View Article : Google Scholar
26	Oh SW, Shin SA, Yun YH, Yoo T and Huh BY: Cut-off point of BMI and obesity-related comorbidities and mortality in middle-aged Koreans. Obes Res. 12:2031–2040. 2004.PubMed/NCBI View Article : Google Scholar
27	Lim JE, Kim HO, Rhee SY, Kim MK, Kim YJ and Oh B: Gene-environment interactions related to blood pressure traits in two community-based Korean cohorts. Genet Epidemiol. 43:402–413. 2019.PubMed/NCBI View Article : Google Scholar
28	Hirshkowitz M, Whiton K, Albert SM, Alessi C, Bruni O, DonCarlos L, Hazen N, Herman J, Katz ES, Kheirandish-Gozal L, et al: National Sleep Foundation's sleep time duration recommendations: Methodology and results summary. Sleep Health. 1:40–43. 2015.PubMed/NCBI View Article : Google Scholar
29	Mamcarz A, Podolec P, Kopeć G, Czarnecka D, Rynkiewicz A, Stańczyk J, Undas A, Godycki-Cwirko M, Kozek E, Pajak A, et al: PFP Task Force on Guidelines: Polish forum for prevention guidelines on metabolic syndrome. Kardiol Pol. 68:121–124. 2010.PubMed/NCBI
30	National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Evaluation, Treatment of High Blood Cholesterol in Adults: Third report of the National cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation. 106:3143–3421. 2002.PubMed/NCBI
31	Gottlieb DJ, Punjabi NM, Newman AB, Resnick HE, Redline S, Baldwin CM and Nieto FJ: Association of sleep time with diabetes mellitus and impaired glucose tolerance. Arch Intern Med. 165:863–867. 2005.PubMed/NCBI View Article : Google Scholar
32	Bjorvatn B, Sagen IM, Øyane N, Waage S, Fetveit A, Pallesen S and Ursin R: The association between sleep duration, body mass index and metabolic measures in the Hordaland Health Study. J Sleep Res. 16:66–76. 2007.PubMed/NCBI View Article : Google Scholar
33	Bernsmeier C, Weisskopf DM, Pflueger MO, Mosimann J, Campana B, Terracciano L, Beglinger C, Heim MH and Cajochen C: Sleep disruption and daytime sleepiness correlating with disease severity and insulin resistance in non-alcoholic fatty liver disease: A comparison with healthy controls. PLoS One. 10(e0143293)2015.PubMed/NCBI View Article : Google Scholar
34	Hwang HR, Lee JG, Lee S, Cha KS, Choi JH, Jeong DW, Yi YH, Cho YH, Tak YJ and Kim YJ: The relationship between hypertension and sleep duration: An analysis of the fifth Korea National Health and Nutrition Examination Survey (KNHANES V-3). Clin Hypertens. 21(8)2015.PubMed/NCBI View Article : Google Scholar
35	Lee SA, Amis TC, Byth K, Larcos G, Kairaitis K, Robinson TD and Wheatley JR: Heavy snoring as a cause of carotid artery atherosclerosis. Sleep. 31:1207–1213. 2008.PubMed/NCBI
36	D'Agostino RB Sr, Vasan RS, Pencina MJ, Wolf PA, Cobain M, Massaro JM and Kannel WB: General cardiovascular risk profile for use in primary care: The Framingham Heart Study. Circulation. 117:743–753. 2008.PubMed/NCBI View Article : Google Scholar
37	Ikehara S, Iso H, Date C, Kikuchi S, Watanabe Y, Wada Y, Inaba Y and Tamakoshi A: JACC Study Group. Association of sleep duration with mortality from cardiovascular disease and other causes for Japanese men and women: The JACC study. Sleep. 32:295–301. 2009.PubMed/NCBI View Article : Google Scholar
38	Zhang S, Li L, Huang Y and Chen K: Meta-analysis of prospective cohort studies about sleep duration and risk of weight gain and obesity in adults. Zhonghua Liu Xing Bing Xue Za Zhi. 36:519–525. 2015.PubMed/NCBI(In Chinese).
39	Marshall NS, Glozier N and Grunstein RR: Is sleep duration related to obesity? A critical review of the epidemiological evidence. Sleep Med Rev. 12:289–298. 2008.PubMed/NCBI View Article : Google Scholar
40	Patel SR and Hu FB: Short sleep duration and weight gain: A systematic review. Obesity (Silver Spring). 16:643–653. 2008.PubMed/NCBI View Article : Google Scholar
41	Kohatsu ND, Tsai R, Young T, Vangilder R, Burmeister LF, Stromquist AM and Merchant JA: Sleep duration and body mass index in a rural population. Arch Intern Med. 166:1701–1705. 2006.PubMed/NCBI View Article : Google Scholar
42	Kripke DF, Garfinkel L, Wingard DL, Klauber MR and Marler MR: Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry. 59:131–136. 2002.PubMed/NCBI View Article : Google Scholar
43	Magee L and Hale L: Longitudinal associations between sleep duration and subsequent weight gain: A systematic review. Sleep Med Rev. 16:231–241. 2012.PubMed/NCBI View Article : Google Scholar
44	Nedeltcheva AV and Scheer FA: Metabolic effects of sleep disruption, links to obesity and diabetes. Curr Opin Endocrinol Diabetes Obes. 21:293–298. 2014.PubMed/NCBI View Article : Google Scholar
45	Yadav D and Cho KH: Total sleep duration and risk of type 2 diabetes: Evidence-based on clinical and epidemiological studies. Curr Drug Metab. 19:979–985. 2018.PubMed/NCBI View Article : Google Scholar
46	Spiegel K, Tasali E, Penev P and Van Cauter E: Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med. 141:846–850. 2004.PubMed/NCBI View Article : Google Scholar
47	Chaput JP, Després JP, Bouchard C and Tremblay A: Short sleep duration is associated with reduced leptin levels and increased adiposity: Results from the Quebec family study. Obesity (Silver Spring). 15:253–261. 2007.PubMed/NCBI View Article : Google Scholar
48	Schmid SM, Hallschmid M, Jauch-Chara K, Born J and Schultes B: A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men. J Sleep Res. 17:331–334. 2008.PubMed/NCBI View Article : Google Scholar
49	Ohida T, Kamal AM, Uchiyama M, Kim K, Takemura S, Sone T and Ishii T: The influence of lifestyle and health status factors on sleep loss among the Japanese general population. Sleep. 24:333–338. 2001.PubMed/NCBI View Article : Google Scholar
50	Stamatakis KA and Brownson RC: Sleep duration and obesity-related risk factors in the rural Midwest. Prev Med. 46:439–444. 2008.PubMed/NCBI View Article : Google Scholar
51	Tan DX, Manchester LC, Fuentes-Broto L, Paredes SD and Reiter RJ: Significance and application of melatonin in the regulation of brown adipose tissue metabolism: Relation to human obesity. Obes Rev. 12:167–188. 2011.PubMed/NCBI View Article : Google Scholar
52	Chambers JA and Swanson V: A health assessment tool for multiple risk factors for obesity: Age and sex differences in the prediction of body mass index. Br J Nutr. 104:298–307. 2010.PubMed/NCBI View Article : Google Scholar
53	Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F and Leibel RL: Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab. 81:3424–3427. 1996.PubMed/NCBI View Article : Google Scholar
54	Spaeth AM, Dinges DF and Goel N: Effects of experimental sleep restriction on weight gain, caloric intake, and meal timing in healthy adults. Sleep (Basel). 36:981–990. 2013.PubMed/NCBI View Article : Google Scholar
55	St-Onge MP, O'Keeffe M, Roberts AL, RoyChoudhury A and Laferrère B: Short sleep duration, glucose dysregulation and hormonal regulation of appetite in men and women. Sleep (Basel). 35:1503–1510. 2012.PubMed/NCBI View Article : Google Scholar