Open Access

Treatment of lentigo maligna (Review)

  • Authors:
    • Jean Kanitakis
  • View Affiliations

  • Published online on: February 26, 2021     https://doi.org/10.3892/wasj.2021.93
  • Article Number: 22
  • Copyright: © Kanitakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lentigo maligna (LM) is the most common type of in situ melanoma, usually appearing on chronically sun‑exposed skin (mostly the head and neck) of elderly patients. It manifests clinically as a macule with a heterogeneous pigmentation and irregular contours. LM grows gradually over the years in a radial pattern and may eventually progress with a vertical growth phase, thereby transforming into an invasive melanoma (LM melanoma) that has potential for metastasis and a lethal outcome; accordingly, LM is currently regarded as an authentic melanoma in situ, rather than a premalignant condition. To the best of my knowledge, no prospective, randomized controlled studies evaluating the efficacy of the various treatment modalities applied for the treatment of LM exist to date. Surgical excision with tumour‑free margins is regarded as the most effective treatment, achieving optimal rates of tumour clearance. Excision can be performed as traditional, one‑step tumour ablation with predefined safety margins or, preferably, with margin‑controlled techniques, such as staged excision or Mohs micrographic surgery, the latter methods achieving the highest cure rates. In the case of surgically‑unresectable tumours or in frail patients with severe comorbidities, alternative non‑surgical (off‑label) therapies can be applied, including namely radiotherapy and imiquimod, as monotherapy or in various combinations.
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May-June 2021
Volume 3 Issue 3

Print ISSN: 2632-2900
Online ISSN:2632-2919

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Spandidos Publications style
Kanitakis J: Treatment of lentigo maligna (Review). World Acad Sci J 3: 22, 2021
APA
Kanitakis, J. (2021). Treatment of lentigo maligna (Review). World Academy of Sciences Journal, 3, 22. https://doi.org/10.3892/wasj.2021.93
MLA
Kanitakis, J."Treatment of lentigo maligna (Review)". World Academy of Sciences Journal 3.3 (2021): 22.
Chicago
Kanitakis, J."Treatment of lentigo maligna (Review)". World Academy of Sciences Journal 3, no. 3 (2021): 22. https://doi.org/10.3892/wasj.2021.93