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Case Report Open Access

Unrelated bone marrow transplantation improves Crohn's disease in a patient with myelodysplastic syndrome that developed from aplastic anemia: A case report

  • Authors:
    • Hideko Goto
    • Takeshi Hara
    • Kei Fujita
    • Yuto Kaneda
    • Kimihiro Yamaguchi
    • Yuhei Shibata
    • Senji Kasahara
    • Takeshi Takahashi
    • Hisashi Tsurumi
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Gifu Municipal Hospital, Gifu 500‑8513, Japan, Department of Hematology, Matsunami General Hospital, Gifu 501‑6062, Japan
    Copyright: © Goto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 12
    |
    Published online on: March 1, 2022
       https://doi.org/10.3892/wasj.2022.147
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Abstract

The present study describes the case of a 56‑year‑old male who was admitted to hospital due to pancytopenia. He was diagnosed as having acquired severe aplastic anemia (SAA). Immunosuppressive therapy with cyclosporine was transiently effective; however, the pancytopenia recurred. Bone marrow aspiration did not reveal an increased number of blasts, although it revealed trilineage dysplasia. Chromosomal analysis of the bone marrow demonstrated der(1;7) with abnormalities on chromosome 1. A diagnosis of a transformation from SAA to myelodysplastic syndrome (MDS) was made. High‑grade fever and lower abdominal pain developed at approximately the same time. The patient was diagnosed as having Crohn's disease (CD). Treatment consisting of mesalazine and adalimumab was commenced. After two courses of azacitidine treatment, allogeneic bone marrow transplantation was performed, preceded by a reduced‑intensity conditioning regimen, including fludarabine, cytarabine and cyclophosphamide. Tacrolimus and short‑term methotrexate were used as prophylaxis against graft‑versus‑host disease. Chromosomal analysis of the bone marrow revealed a 100% donor‑derived abnormal karyotype. The patient has since then remained in complete remission of both MDS and CD. On the whole, the present study demonstrates that allogeneic hematopoietic stem cell transplantation may be a promising treatment strategy for patients with combined MDS and CD. However, its use should be carefully considered.
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Copy and paste a formatted citation
Spandidos Publications style
Goto H, Hara T, Fujita K, Kaneda Y, Yamaguchi K, Shibata Y, Kasahara S, Takahashi T and Tsurumi H: Unrelated bone marrow transplantation improves Crohn's disease in a patient with myelodysplastic syndrome that developed from aplastic anemia: A case report. World Acad Sci J 4: 12, 2022.
APA
Goto, H., Hara, T., Fujita, K., Kaneda, Y., Yamaguchi, K., Shibata, Y. ... Tsurumi, H. (2022). Unrelated bone marrow transplantation improves Crohn's disease in a patient with myelodysplastic syndrome that developed from aplastic anemia: A case report. World Academy of Sciences Journal, 4, 12. https://doi.org/10.3892/wasj.2022.147
MLA
Goto, H., Hara, T., Fujita, K., Kaneda, Y., Yamaguchi, K., Shibata, Y., Kasahara, S., Takahashi, T., Tsurumi, H."Unrelated bone marrow transplantation improves Crohn's disease in a patient with myelodysplastic syndrome that developed from aplastic anemia: A case report". World Academy of Sciences Journal 4.2 (2022): 12.
Chicago
Goto, H., Hara, T., Fujita, K., Kaneda, Y., Yamaguchi, K., Shibata, Y., Kasahara, S., Takahashi, T., Tsurumi, H."Unrelated bone marrow transplantation improves Crohn's disease in a patient with myelodysplastic syndrome that developed from aplastic anemia: A case report". World Academy of Sciences Journal 4, no. 2 (2022): 12. https://doi.org/10.3892/wasj.2022.147
Copy and paste a formatted citation
x
Spandidos Publications style
Goto H, Hara T, Fujita K, Kaneda Y, Yamaguchi K, Shibata Y, Kasahara S, Takahashi T and Tsurumi H: Unrelated bone marrow transplantation improves Crohn's disease in a patient with myelodysplastic syndrome that developed from aplastic anemia: A case report. World Acad Sci J 4: 12, 2022.
APA
Goto, H., Hara, T., Fujita, K., Kaneda, Y., Yamaguchi, K., Shibata, Y. ... Tsurumi, H. (2022). Unrelated bone marrow transplantation improves Crohn's disease in a patient with myelodysplastic syndrome that developed from aplastic anemia: A case report. World Academy of Sciences Journal, 4, 12. https://doi.org/10.3892/wasj.2022.147
MLA
Goto, H., Hara, T., Fujita, K., Kaneda, Y., Yamaguchi, K., Shibata, Y., Kasahara, S., Takahashi, T., Tsurumi, H."Unrelated bone marrow transplantation improves Crohn's disease in a patient with myelodysplastic syndrome that developed from aplastic anemia: A case report". World Academy of Sciences Journal 4.2 (2022): 12.
Chicago
Goto, H., Hara, T., Fujita, K., Kaneda, Y., Yamaguchi, K., Shibata, Y., Kasahara, S., Takahashi, T., Tsurumi, H."Unrelated bone marrow transplantation improves Crohn's disease in a patient with myelodysplastic syndrome that developed from aplastic anemia: A case report". World Academy of Sciences Journal 4, no. 2 (2022): 12. https://doi.org/10.3892/wasj.2022.147
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