Neuroblastoma in childhood and its potential viral involvement: A webinar by the Paediatric Virology Study Group

Rovigatti,Ugo; Papaioannou,Georgia; Mammas,Ioannis N.; Koutsaftiki,Chryssie; Papatheodoropoulou,Alexia; Theodoridou,Maria; Spandidos,Demetrios A.

doi:10.3892/wasj.2022.151

Neuroblastoma in childhood and its potential viral involvement: A webinar by the Paediatric Virology Study Group

Authors:
- Ugo Rovigatti
- Georgia Papaioannou
- Ioannis N. Mammas
- Chryssie Koutsaftiki
- Alexia Papatheodoropoulou
- Maria Theodoridou
- Demetrios A. Spandidos
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Affiliations: Department of Experimental and Clinical Medicine (DMSC), University of Florence Medical School, I‑50139 Florence, Italy, Department of Paediatric Radiology, ‘Mitera’ Children's Hospital, 15123 Athens, Greece, Paediatric Clinic, Aliveri, 34500 Island of Euboea, Greece, COVID-19 Reference Centre, ‘Rafina’ Health Care Centre, 19009 Rafina, Greece, Paediatric Intensive Care Unit (PICU), University Hospital of Patras, 26504 Rio, Greece, First Department of Paediatrics, University of Athens School of Medicine, 11527 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece
Published online on: March 14, 2022 https://doi.org/10.3892/wasj.2022.151
Article Number: 16
Copyright: © Rovigatti et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Neuroblastoma represents the most common and lethal solid tumour of early childhood. In view of variations in genetic elements, MYCN amplification is certainly the most prominent genetic factor occurring in 1/4 or 1/5 of children with neuroblastoma; however, overall, the pathogenesis of neuroblastoma remains to be resolved. Rare, sporadic infections with Epstein‑Barr, hepatis C virus and varicella‑zoster virus have been detected in children with neuroblastoma, while the presence of BK virus was initially claimed, but later falsified as a triggering factor for the development of high‑risk neuroblastoma. The proposed model by Professor Ugo Rovigatti, Professor of Molecular Biology at the University of Florence in Italy, is based upon infection with micro‑foci inducing virus and its potential tumorigenic role as trigger of i) high and persistent inflammation; ii) chromothripsis and genetic instability; and iii) in vitro cell transformation and in vivo carcinogenesis. Modelling is still under‑utilized and under-developed in clinical virology and cancer research; however, it is expected to play a significant role in the future, aiming to elucidate the cancer enigma. This article is based on a webinar on neuroblastoma in children, which was organised virtually on December 12, 2020, by the Institute of Paediatric Virology.

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