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Article Open Access

Gut health of children with autism spectrum disorder

  • Authors:
    • Elene Kakabadze
    • Khatuna Makalatia
    • Nata Bakuradze
    • Nino Grdzelishvili
    • Sophie Kereselidze
    • Tamar Ediberidze
    • Veriko Berulava
    • Nana Sabauri
    • Nana Cholokashvili
    • Elene Javakhishvili
    • Gulnara Natroshvili
    • Tamar Tatrishvili
    • Mariam Motsikulashvili
    • Nina Chanishvili
    • Ivane Abiatari
  • View Affiliations / Copyright

    Affiliations: Research and Development Department, George Eliava Institute of Bacteriophages, Microbiology and Virology, 0160 Tbilisi, Georgia, School of Natural Sciences and Medicine, Ilia State University, 0162 Tbilisi, Georgia, Eliava Bacteriophage Analytical‑Diagnostic Centre, 0160 Tbilisi, Georgia
    Copyright: © Kakabadze et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 29
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    Published online on: July 14, 2022
       https://doi.org/10.3892/wasj.2022.164
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Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, frequently manifested by gastrointestinal symptoms. The investigation of alterations in the gut microbiome and its role in the gut‑brain axis communication is a promising field that may aid in the understanding of ASD symptoms. The present study thus focused on a preliminary investigation of the diversity, presence and drug‑resistance of particular bacterial species in the gut microbiota of ASD and neurotypical children. The study was performed in a case‑control manner and the relevant information of the participants was collected using dedicated questionnaires. Stool samples were collected from urban residents and the differences in microbial communities between the study and control groups were investigated and compared using culture‑dependent methods. Since phages are considered as alternatives to antibiotics, as well as a promising tool for the re‑instatement of disturbed microbiotas, antibiotic resistance and phage susceptibility profiles of the isolated intestinal pathogens were defined simultaneously. As a result, antibiotic resistant and phage susceptible β‑haemolytic Escherichia coli, but no Clostridioides difficile were detected in the collected sample. The differences in intestinal health and gut microbiota between the study groups were minor. On the whole, the findings of the present study may provide the basis for an extended metagenomics study of microbiota in the ASD population.
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Copy and paste a formatted citation
Spandidos Publications style
Kakabadze E, Makalatia K, Bakuradze N, Grdzelishvili N, Kereselidze S, Ediberidze T, Berulava V, Sabauri N, Cholokashvili N, Javakhishvili E, Javakhishvili E, et al: Gut health of children with autism spectrum disorder. World Acad Sci J 4: 29, 2022.
APA
Kakabadze, E., Makalatia, K., Bakuradze, N., Grdzelishvili, N., Kereselidze, S., Ediberidze, T. ... Abiatari, I. (2022). Gut health of children with autism spectrum disorder. World Academy of Sciences Journal, 4, 29. https://doi.org/10.3892/wasj.2022.164
MLA
Kakabadze, E., Makalatia, K., Bakuradze, N., Grdzelishvili, N., Kereselidze, S., Ediberidze, T., Berulava, V., Sabauri, N., Cholokashvili, N., Javakhishvili, E., Natroshvili, G., Tatrishvili, T., Motsikulashvili, M., Chanishvili, N., Abiatari, I."Gut health of children with autism spectrum disorder". World Academy of Sciences Journal 4.4 (2022): 29.
Chicago
Kakabadze, E., Makalatia, K., Bakuradze, N., Grdzelishvili, N., Kereselidze, S., Ediberidze, T., Berulava, V., Sabauri, N., Cholokashvili, N., Javakhishvili, E., Natroshvili, G., Tatrishvili, T., Motsikulashvili, M., Chanishvili, N., Abiatari, I."Gut health of children with autism spectrum disorder". World Academy of Sciences Journal 4, no. 4 (2022): 29. https://doi.org/10.3892/wasj.2022.164
Copy and paste a formatted citation
x
Spandidos Publications style
Kakabadze E, Makalatia K, Bakuradze N, Grdzelishvili N, Kereselidze S, Ediberidze T, Berulava V, Sabauri N, Cholokashvili N, Javakhishvili E, Javakhishvili E, et al: Gut health of children with autism spectrum disorder. World Acad Sci J 4: 29, 2022.
APA
Kakabadze, E., Makalatia, K., Bakuradze, N., Grdzelishvili, N., Kereselidze, S., Ediberidze, T. ... Abiatari, I. (2022). Gut health of children with autism spectrum disorder. World Academy of Sciences Journal, 4, 29. https://doi.org/10.3892/wasj.2022.164
MLA
Kakabadze, E., Makalatia, K., Bakuradze, N., Grdzelishvili, N., Kereselidze, S., Ediberidze, T., Berulava, V., Sabauri, N., Cholokashvili, N., Javakhishvili, E., Natroshvili, G., Tatrishvili, T., Motsikulashvili, M., Chanishvili, N., Abiatari, I."Gut health of children with autism spectrum disorder". World Academy of Sciences Journal 4.4 (2022): 29.
Chicago
Kakabadze, E., Makalatia, K., Bakuradze, N., Grdzelishvili, N., Kereselidze, S., Ediberidze, T., Berulava, V., Sabauri, N., Cholokashvili, N., Javakhishvili, E., Natroshvili, G., Tatrishvili, T., Motsikulashvili, M., Chanishvili, N., Abiatari, I."Gut health of children with autism spectrum disorder". World Academy of Sciences Journal 4, no. 4 (2022): 29. https://doi.org/10.3892/wasj.2022.164
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