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Association of ABCA1 R219K and C69T single nucleotide polymorphisms with type 2 diabetes mellitus: A case control study

  • Authors:
    • Dhanalakshmi Balasundararaj
    • Gayathri Balasubramaniam
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu 641004, India
    Copyright: © Balasundararaj et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 41
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    Published online on: November 7, 2022
       https://doi.org/10.3892/wasj.2022.176
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Abstract

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder associated with alterations in the metabolism of carbohydrates, proteins and lipids. ATP binding cassette transporter 1 (ABCA1) encoding the ABCA1 protein plays a critical role in the reverse cholesterol transport of high‑density lipoprotein-cholesterol (HDL-c) metabolism. ABCA1 gene single nucleotide polymorphisms (SNPs) have been found to be associated with abnormalities in the serum levels of HDL‑c, thereby disrupting the cholesterol removing ability of cells. The aim of the present study was to determine the association between the R219K and C69T SNPs of ABCA1 gene variants and T2DM. For this purpose, a case control study was conducted among 50 patients with T2DM who were selected as cases, and 50 age‑ and sex‑matched patients without comorbidities were selected as the controls. Venous blood samples were collected from all participants following overnight fasting. Plasma glucose, glycated hemoglobin (HbA1c) and lipid profile estimations were performed using an autoanalyzer with standard methods. ABCA1 gene polymorphisms were determined using the polymerase chain reaction‑restriction fragment length polymorphism method. The body mass index for both the case and control groups was found to be above the revised cut‑off value for obesity. HDL‑c levels were below the optimum level in the case and control group. The distribution of genotype and dominant alleles of the C69T and R219K SNPs of the ABCA1 gene did not differ significantly between the case and control groups. The present study suggests the existence of a defective ABCA1 genotype in the studied population, predisposing these individuals to a decrease in serum HDL‑c levels. This interferes with cholesterol sequestration from foam cells and creates an inflammatory state, which is aggravated by obesity. Thus, HDL‑c becomes dysfunctional from inflammation‑mediated structural modifications and paves the way for atherogenic dyslipidemia associated with T2DM.
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1 

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 32 (Suppl 1):S62–S67. 2009.PubMed/NCBI View Article : Google Scholar

2 

Mohan V, Venkatraman JV and Pradeepa R: Epidemiology of cardiovascular disease in type 2 diabetes: The Indian scenario. J Diabetes Sci Technol. 4:158–170. 2010.PubMed/NCBI View Article : Google Scholar

3 

Bilen O, Kamal A and Virani SS: Lipoprotein abnormalities in South Asians and its association with cardiovascular disease: Current state and future directions. World J Cardiol. 8:247–257. 2016.PubMed/NCBI View Article : Google Scholar

4 

Joshi SR, Anjana RM, Deepa M, Pradeepa R, Bhansali A, Dhandania VK, Joshi PP, Unnikrishnan R, Nirmal E, Subashini R, et al: Prevalence of dyslipidemia in urban and rural India: The ICMR-INDIAB study. PLoS One. 9(e96808)2014.PubMed/NCBI View Article : Google Scholar

5 

Ohashi R, Mu H, Wang X, Yao Q and Chen C: Reverse cholesterol transport and cholesterol efflux in atherosclerosis. QJM. 98:845–856. 2005.PubMed/NCBI View Article : Google Scholar

6 

Dean M: The genetics of ATP-binding cassette transporters. Methods Enzymol. 400:409–429. 2005.PubMed/NCBI View Article : Google Scholar

7 

Qian H, Zhao X, Cao P, Lei J, Yan N and Gong X: Structure of the human lipid exporter ABCA1. Cell. 169:1228–1239.e10. 2017.PubMed/NCBI View Article : Google Scholar

8 

Yoon HY, Lee MH, Song Y, Yee J, Song G and Gwak HS: ABCA1 69C>T polymorphism and the risk of type 2 diabetes mellitus: A systematic review and updated meta-analysis. Front Endocrinol (Lausanne). 12(639524)2021.PubMed/NCBI View Article : Google Scholar

9 

Martín-Timón I, Sevillano-Collantes C, Segura-Galindo A and Del Cañizo-Gómez FJ: Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength? World J Diabetes. 5:444–470. 2014.PubMed/NCBI View Article : Google Scholar

10 

Jacobo-Albavera L, Domínguez-Pérez M, Medina-Leyte DJ, González-Garrido A and Villarreal-Molina T: The role of the ATP-binding cassette A1 (ABCA1) in human disease. Int J Mol Sci. 22(1593)2021.PubMed/NCBI View Article : Google Scholar

11 

Shim SY, Yoon HY, Yee J, Han JM and Gwak HS: Association between ABCA1 gene polymorphisms and plasma lipid concentration: A systematic review and meta-analysis. J Pers Med. 11(883)2021.PubMed/NCBI View Article : Google Scholar

12 

Mahajan K and Batra A: Obesity in adult Asian Indians-the ideal BMI cut-off. Indian Heart J. 70(195)2018.PubMed/NCBI View Article : Google Scholar

13 

Waist circumference and waist-hip ratio: Report of a WHO expert consultation. (2011, May 16). https://www.who.int/publications/i/item/9789241501491.

14 

Ahirwar R and Mondal PR: Prevalence of obesity in India: A systematic review. Diabetes Metab Syndr. 13:318–321. 2019.PubMed/NCBI View Article : Google Scholar

15 

Vergès B: Pathophysiology of diabetic dyslipidaemia: Where are we? Diabetologia. 58:886–899. 2015.PubMed/NCBI View Article : Google Scholar

16 

Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 285:2486–2497. 2001.PubMed/NCBI View Article : Google Scholar

17 

Haghvirdizadeh P, Ramachandran V, Etemad A, Heidari F, Ghodsian N, Bin Ismail N and Ismail P: Association of ATP-binding cassette transporter A1 gene polymorphisms in type 2 diabetes mellitus among malaysians. J Diabetes Res. 2015(289846)2015.PubMed/NCBI View Article : Google Scholar

18 

Vergès B: Lipid modification in type 2 diabetes: The role of LDL and HDL. Fundam Clin Pharmacol. 23:681–685. 2009.PubMed/NCBI View Article : Google Scholar

19 

Daimon M, Kido T, Baba M, Oizumi T, Jimbu Y, Kameda W, Yamaguchi H, Ohnuma H, Tominaga M, Muramatsu M and Kato T: Association of the ABCA1 gene polymorphisms with type 2 DM in a Japanese population. Biochem Biophys Res Commun. 329:205–210. 2005.PubMed/NCBI View Article : Google Scholar

20 

Alharbi KK, Khan IA, Al-Daghri NM, Munshi A, Sharma V, Mohammed AK, Wani KA, Al-Sheikh YA, Al-Nbaheen MS, Ansari MG and Syed R: ABCA1 C69T gene polymorphism and risk of type 2 diabetes mellitus in a Saudi population. J Biosci. 38:893–897. 2013.PubMed/NCBI View Article : Google Scholar

21 

Ergen HA, Zeybek U, Gök O and Karaali ZE: Investigation of ABCA1 C69T polymorphism in patients with type 2 diabetes mellitus. Biochem Med (Zagreb). 22:114–120. 2012.PubMed/NCBI View Article : Google Scholar

22 

Salinas CA, Cruz-Bautista I, Mehta R, Villarreal-Molina MT, Pérez FJ, Tusié-Luna MT and Canizales-Quinteros S: The ATP-binding cassette transporter subfamily A member 1 (ABC-A1) and type 2 diabetes: An association beyond HDL cholesterol. Curr Diabetes Rev. 3:264–267. 2007.PubMed/NCBI View Article : Google Scholar

23 

Zhao TY, Lei S, Huang L, Wang YN, Wang XN, Zhou PP, Xu XJ, Zhang L, Xu LW and Yang L: Associations of genetic variations in ABCA1 and lifestyle factors with coronary artery disease in a southern Chinese population with dyslipidemia: A nested case-control study. Int J Environ Res Public Health. 16(786)2019.PubMed/NCBI View Article : Google Scholar

24 

Feingold KR and Grunfeld C: Effect of inflammation on HDL structure and function. Curr Opin Lipidol. 27:521–530. 2016.PubMed/NCBI View Article : Google Scholar

25 

Ellulu MS, Patimah I, Khaza'ai H, Rahmat A and Abed Y: Obesity and inflammation: The linking mechanism and the complications. Arch Med Sci. 13:851–863. 2017.PubMed/NCBI View Article : Google Scholar

26 

Haerian BS, Haerian MS, Roohi A and Mehrad-Majd H: ABCA1 genetic polymorphisms and type 2 diabetes mellitus and its complications. Meta Gene. 13:104–114. 2017.

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Spandidos Publications style
Balasundararaj D and Balasubramaniam G: Association of ABCA1 R219K and C69T single nucleotide polymorphisms with type 2 diabetes mellitus: A case control study. World Acad Sci J 4: 41, 2022.
APA
Balasundararaj, D., & Balasubramaniam, G. (2022). Association of ABCA1 R219K and C69T single nucleotide polymorphisms with type 2 diabetes mellitus: A case control study. World Academy of Sciences Journal, 4, 41. https://doi.org/10.3892/wasj.2022.176
MLA
Balasundararaj, D., Balasubramaniam, G."Association of ABCA1 R219K and C69T single nucleotide polymorphisms with type 2 diabetes mellitus: A case control study". World Academy of Sciences Journal 4.6 (2022): 41.
Chicago
Balasundararaj, D., Balasubramaniam, G."Association of ABCA1 R219K and C69T single nucleotide polymorphisms with type 2 diabetes mellitus: A case control study". World Academy of Sciences Journal 4, no. 6 (2022): 41. https://doi.org/10.3892/wasj.2022.176
Copy and paste a formatted citation
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Spandidos Publications style
Balasundararaj D and Balasubramaniam G: Association of ABCA1 R219K and C69T single nucleotide polymorphisms with type 2 diabetes mellitus: A case control study. World Acad Sci J 4: 41, 2022.
APA
Balasundararaj, D., & Balasubramaniam, G. (2022). Association of ABCA1 R219K and C69T single nucleotide polymorphisms with type 2 diabetes mellitus: A case control study. World Academy of Sciences Journal, 4, 41. https://doi.org/10.3892/wasj.2022.176
MLA
Balasundararaj, D., Balasubramaniam, G."Association of ABCA1 R219K and C69T single nucleotide polymorphisms with type 2 diabetes mellitus: A case control study". World Academy of Sciences Journal 4.6 (2022): 41.
Chicago
Balasundararaj, D., Balasubramaniam, G."Association of ABCA1 R219K and C69T single nucleotide polymorphisms with type 2 diabetes mellitus: A case control study". World Academy of Sciences Journal 4, no. 6 (2022): 41. https://doi.org/10.3892/wasj.2022.176
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