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Legionella pneumophila pneumonia: A 5‑year retrospective clinical evaluation and commentary

  • Authors:
    • Andrea Marino
    • Stefano Stracquadanio
    • Edoardo Campanella
    • Manuela Ceccarelli
    • Aldo Zagami
    • Maria Gussio
    • Licia Larocca
    • Giuseppe Nunnari
    • Bruno Cacopardo
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical and Biotechnological Sciences, University of Catania, I‑95123 Catania, Italy, Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, I‑98124 Messina, Italy, Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, ARNAS Garibaldi Hospital, University of Catania, I‑95122 Catania, Italy, Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, ARNAS Garibaldi Hospital, University of Catania, I‑95122 Catania, Italy
    Copyright: © Marino et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 18
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    Published online on: June 7, 2023
       https://doi.org/10.3892/wasj.2023.195
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Abstract

Although legionellosis represents a widely underestimated disease for various reasons, the rate of Legionella pneumophila infections has increased steadily over the past 30 years. The present study describes the characteristics of patients hospitalized due to legionellosis. The present study retrospectively reviewed 10 cases of legionellosis during the defined period and documented the epidemiological and clinical characteristics of the patients, as well as the methods used for diagnosis and therapeutic management. The majority of the patients were male (80%) with a mean age of 55.8 years. The most common comorbidities were hypertension (40%) and tumors (20%). Fever was present in all the cases (100%) and the most frequent imaging finding was lung consolidation. Half of the cases exhibited hyponatremia, 40% of them had leukocytosis, and 50% of the patients presented elevated procalcitonin levels, as well as elevated levels of transaminases. In total, 2 patients (20%) required non‑invasive oxygen support. All the cases presented a positive urinary antigen test for Legionella pneumophila serogroup 1. A total of 9 patients (90%) received levofloxacin‑based therapy for a mean duration of 17.7 days. All the cases described herein were successfully discharged without any complications. On the whole, the present study demonstrates that a prompt clinical diagnosis along with early testing and treatment represent the cornerstone for positive outcomes in patients affected by Legionnaire's disease.
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1 

Jomehzadeh N, Moosavian M, Saki M and Rashno M: Legionella and legionnaires' disease: An overview. J Acute Dis. 8:221–232. 2019.

2 

Engel MF, Van Manen L, Hoepelman AIM, Thijsen S and Oosterheert JJ: Diagnostic, therapeutic and economic consequences of a positive urinary antigen test for Legionella spp. in patients admitted with community-acquired pneumonia: A 7-year retrospective evaluation. J Clin Pathol. 66:797–802. 2013.PubMed/NCBI View Article : Google Scholar

3 

Brady MF and Sundareshan V: Legionnaires' Disease (Legionella Infection); StatPearls Publishing, 2018.

4 

Tossa P, Deloge-Abarkan M, Zmirou-Navier D, Hartemann P and Mathieu L: Pontiac fever: An operational definition for epidemiological studies. BMC Public Health. 6(112)2006.PubMed/NCBI View Article : Google Scholar

5 

United States Department of Labor: Occupational Safety and Health Administration: Legionellosis (Legionnaires' Disease and Pontiac Fever). https://www.osha.gov/legionnaires-disease. Accessed September 29, 2022.

6 

Centers for Disease Control and Prevention (CDC): Legionella (Legionnaires' Disease and Pontiac Fever): History, Burden, and Trends. https://www.cdc.gov/legionella/about/history.html. Accessed September 29, 2022.

7 

European Centre for Disease Prevention and Control (ECDC): Annual Epidemiological Report for 2020: Legionnaires' disease. https://www.ecdc.europa.eu/en/publications-data/legionnaires-disease-annual-epidemiological-report-2020. Accessed September 29, 2022.

8 

Rota MC, Caporali MG, Bella A, Scaturro M, Giannitelli S and Ricci ML: Istituto Superiore di Sanità nazionale e bollettino epidemiologico b n I risultati del sistema di sorveglianza della legionellosi in Italia nel 2020 durante la pandemia di COVID-19. Vol 2. 2021.

9 

Cosentino F, Moscatt V, Marino A, Pampaloni A, ScuderI D, Ceccarelli M, Benanti F, Gussio M, Larocca L, Boscia V, et al: Clinical characteristics and predictors of death among hospitalized patients infected with SARS-CoV-2 in Sicily, Italy: A retrospective observational study. Biomed Rep. 16(34)2022.PubMed/NCBI View Article : Google Scholar

10 

Musso N, Maugeri JG, Bongiorno D, Stracquadanio S, Bartoloni G, Stefani S and Di Stefano ED: SARS-CoV-2's high rate of genetic mutation under immune selective pressure: From oropharyngeal B.1.1.7 to intrapulmonary B.1.533 in a vaccinated patient. Int J Infect Dis. 118:169–172. 2022.PubMed/NCBI View Article : Google Scholar

11 

García MT, Pelaz C, Giménez MJ and Aguilar L: In vitro activities of gemifloxacin versus five quinolones and two macrolides against 271 Spanish isolates of Legionella pneumophila: Influence of charcoal on susceptibility test results. Antimicrob Agents Chemother. 44:2176–2178. 2000.PubMed/NCBI View Article : Google Scholar

12 

Brenner DJ, Steigerwalt AG, Epple P, Bibb WF, McKinney RM, Starnes RW, Colville JM, Selander RK, Edelstein PH and Moss CW: Legionella pneumophila serogroup Lansing 3 isolated from a patient with fatal pneumonia, and descriptions of L. pneumophila subsp. pneumophila subsp. nov., L. pneumophila subsp. fraseri subsp. nov., and L. pneumophila subsp. pascullei subsp. nov. J Clin Microbiol. 26:1695–1703. 1988.PubMed/NCBI View Article : Google Scholar

13 

Kim P, Deshpande A and Rothberg MB: Urinary antigen testing for respiratory infections: Current perspectives on utility and limitations. Infect Drug Resist. 15:2219–2228. 2022.PubMed/NCBI View Article : Google Scholar

14 

Avni T, Bieber A, Green H, Steinmetz T, Leibovici L and Paul M: Diagnostic accuracy of PCR alone and compared to urinary antigen testing for detection of Legionella spp: A systematic review. J Clin Microbiol. 54:401–411. 2016.PubMed/NCBI View Article : Google Scholar

15 

European Committee on Antimicrobial Susceptibility Testing (EUCAST): Antimicrobial susceptibility testing of Legionella pneumophila. In: EUCAST. Guidance document on Legionella. EUCAST, Växjö, 2016.

16 

Rota MC, Caporali MG, Bella A, Scaturro M, Giannitelli S and Ricci ML: I risultati del sistema di sorveglianza della legionellosi in Italia nel 2020 durante la pandemia di COVID-19. Boll Epidemiol Naz. 2:9–16. 2021.

17 

European Centre for Disease Prevention and Control (ECDC): Legionnaires’ disease. In: ECDC. Annual epidemiological report for 2019. ECDC, Stockholm, 2021.

18 

Williams A and Lever MS: Characterisation of Legionella pneumophila antigen in urine of guinea pigs and humans with Legionnaires' disease. J Infect. 30:13–16. 1995.PubMed/NCBI View Article : Google Scholar

19 

Kawasaki T, Nakagawa N, Murata M, Yasuo S, Yoshida T, Ando K, Okamori S and Okada Y: Diagnostic accuracy of urinary antigen tests for legionellosis: A systematic review and meta-analysis. Respir Investig. 60:205–214. 2022.PubMed/NCBI View Article : Google Scholar

20 

McDade JE: Legionella and the prevention of legionellosis. Emerg Infect Dis. 14:1006a–1006. 2008.

21 

Pierre DM, Baron J, Yu VL and Stout JE: Diagnostic testing for Legionnaires' disease. Ann Clin Microbiol Antimicrob. 16(59)2017.PubMed/NCBI View Article : Google Scholar

22 

Essig A, von Baum H, Gonser T, Haerter G and Lück C: Microbiological diagnosis and molecular typing of Legionella strains during an outbreak of legionellosis in Southern Germany. Int J Med Microbiol. 306:109–114. 2016.PubMed/NCBI View Article : Google Scholar

23 

Mercante JW and Winchell JM: Current and emerging Legionella diagnostics for laboratory and outbreak investigations. Clin Microbiol Rev. 28:95–133. 2015.PubMed/NCBI View Article : Google Scholar

24 

Viasus D, Gaia V, Manzur-Barbur C and Carratalà J: Legionnaires' Disease: Update on diagnosis and treatment. Infect Dis Ther. 11:973–986. 2022.PubMed/NCBI View Article : Google Scholar

25 

Robert S, Lhommet C, Brun CL, Garot D, Legras A, Mankikian J and Goudeau A: Diagnostic performance of multiplex PCR on pulmonary samples versus nasopharyngeal aspirates in community-acquired severe lower respiratory tract infections. J Clin Virol. 108:1–5. 2018.PubMed/NCBI View Article : Google Scholar

26 

Ricci ML, Grottola A, Serpini GF, Bella A, Rota MC, Frascaro F, Pegoraro E, Meacci M, Fabio A, Vecchi E, et al: Improvement of legionnaires' disease diagnosis using real-time PCR assay: A retrospective analysis, Italy, 2010 to 2015. Eurosurveillance. 23(1800032)2018.PubMed/NCBI View Article : Google Scholar

27 

Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, et al: Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American thoracic society and infectious diseases society of America. Am J Respir Crit Care Med. 200:e45–e67. 2019.PubMed/NCBI View Article : Google Scholar

28 

Menéndez R, Torres A, Aspa J, Capelastegui A, Prat C and de Castro FR: Community acquired pneumonia. New guidelines of the Spanish society of chest diseases and thoracic surgery (SEPAR). Arch Bronconeumol. 46:543–558. 2010.PubMed/NCBI View Article : Google Scholar

29 

Losier A and Cruz CS: New testing guidelines for community-acquired pneumonia. Curr Opin Infect Dis. 35:128–132. 2022.PubMed/NCBI View Article : Google Scholar

30 

Kim J, Park S, Yang E, Kim H, Seo H, Chung H, Jung J, Kim MJ, Chong YP, Lee SO, et al: Clinical features of patients with Legionnaires disease showing initial clinical improvement but radiological deterioration: A retrospective single-center analysis. Medicine (Baltimore). 100(e28402)2021.PubMed/NCBI View Article : Google Scholar

31 

Nakanishi M, Shiroshita A, Nakashima K, Takeshita M, Kiguchi T and Yamada H: Clinical and computed tomographic features of Legionella pneumonia with negative urine antigen test results. Respir Investig. 59:204–211. 2021.PubMed/NCBI View Article : Google Scholar

32 

Rajasurya V and Surani S: Legionnaires disease in immunocompromised host. In: hospital acquired infection and Legionnaires' disease. Surani S (ed). IntechOpen, London, 2020.

33 

Marino A, Zafarana G, Ceccarelli M, Cosentino F, Moscatt V, Bruno G, Bruno R, Benanti F, Cacopardo B and Celesia BM: Immunological and clinical impact of DAA-mediated HCV eradication in a cohort of HIV/HCV coinfected patients: Monocentric Italian experience. Diagnostics (Basel). 11(2336)2021.PubMed/NCBI View Article : Google Scholar

34 

Micali C, Russotto Y, Facciolà A, Marino A, Celesia BM, Pistarà E, Caci G, Nunnari G, Pellicanò GF and Rullo EV: Pulmonary kaposi sarcoma without respiratory symptoms and skin lesions in an HIV-naïve patient: A case report and literature review. Infect Dis Rep. 14:228–242. 2022.PubMed/NCBI View Article : Google Scholar

35 

Marino A, Caltabiano E, Zagami A, Onorante A, Zappalà C, Locatelli ME, Pampaloni A, Scuderi D, Bruno R and Cacopardo B: Rapid emergence of cryptococcal fungemia, Mycobacterium chelonae vertebral osteomyelitis and gastro intestinal stromal tumor in a young HIV late presenter: A case report. BMC Infect Dis. 18(693)2018.PubMed/NCBI View Article : Google Scholar

36 

Marino A, Munafò A, Augello E, Bellanca CM, Bonomo C, Ceccarelli M, Musso N, Cantarella G, Cacopardo B and Bernardini R: Sarilumab administration in COVID-19 patients: Literature review and considerations. Infect Dis Rep. 14:360–371. 2022.PubMed/NCBI View Article : Google Scholar

37 

Edelstein PH and Cianciotto NP: Legionella species and Legionnaires' Disease. The Prokaryotes; Springer, New York, NY, 2006; pp. 988-1033.

38 

Fernández JA, López P, Orozco D and Merino J: Clinical study of an outbreak of Legionnaire's disease in Alcoy, Southeastern Spain. Eur J Clin Microbiol Infect Dis. 21:729–735. 2002.PubMed/NCBI View Article : Google Scholar

39 

Gacouin A, Le Tulzo Y, Lavoue S, Camus C, Hoff J, Bassen R, Arvieux C, Heurtin C and Thomas R: Severe pneumonia due to Legionella pneumophila: Prognostic factors, impact of delayed appropriate antimicrobial therapy. Intensive Care Med. 28:686–691. 2002.PubMed/NCBI View Article : Google Scholar

40 

Heath CH, Grove DI and Looke DF: Delay in appropriate therapy of Legionella pneumonia associated with increased mortality. Eur J Clin Microbiol Infect Dis. 15:286–290. 1996.PubMed/NCBI View Article : Google Scholar

41 

Falcone M, Russo A, Tiseo G, Cesaretti M, Guarracino F and Menichetti F: Predictors of intensive care unit admission in patients with Legionella pneumonia: Role of the time to appropriate antibiotic therapy. Infection. 49:321–325. 2021.PubMed/NCBI View Article : Google Scholar

42 

Woodhead M, Blasi F, Ewig S, Garau J, Huchon G, Ieven M, Ortqvist A, Schaberg T, Torres A, van der Heijden G, et al: Guidelines for the management of adult lower respiratory tract infections-full version. Clin Microbiol Infect. 17:E1–E59. 2011.PubMed/NCBI View Article : Google Scholar

43 

Jasper AS, Musuuza JS, Tischendorf JS, Stevens VW, Gamage SD, Osman F and Safdar N: Are fluoroquinolones or macrolides better for treating Legionella pneumonia? A systematic review and meta-analysis. Clin Infect Dis. 72:1979–1989. 2021.PubMed/NCBI View Article : Google Scholar

44 

Kato H, Hagihara M, Asai N, Shibata Y, Koizumi Y, Yamagishi Y and Mikamo H: Meta-analysis of fluoroquinolones versus macrolides for treatment of Legionella pneumonia. J Infect Chemother. 27:424–433. 2021.PubMed/NCBI View Article : Google Scholar

45 

Martin SJ, Pendland SL, Chen C, Schreckenberger P and Danziger LH: In vitro synergy testing of macrolide-quinolone combinations against 41 clinical isolates of Legionella. Antimicrob Agents Chemother. 40:1419–1421. 1996.PubMed/NCBI View Article : Google Scholar

46 

Bivona DA, Mirabile A, Bonomo C, Bonacci PG, Stracquadanio S, Marino A, Campanile F, Bonaccorso C, Fortuna CG, Stefani S, et al: Heteroaryl-ethylenes as new effective agents for high priority gram-positive and gram-negative bacterial clinical isolates. Antibiotics (Basel). 11(767)2022.PubMed/NCBI View Article : Google Scholar

47 

Tansarli GS and Mylonakis E: Systematic review and meta-analysis of the efficacy of short-course antibiotic treatments for community-acquired pneumonia in adults. Antimicrob Agents Chemother. 62:e00635–e00618. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Marino A, Stracquadanio S, Campanella E, Ceccarelli M, Zagami A, Gussio M, Larocca L, Nunnari G and Cacopardo B: <em>Legionella pneumophila</em> pneumonia: A 5‑year retrospective clinical evaluation and commentary. World Acad Sci J 5: 18, 2023.
APA
Marino, A., Stracquadanio, S., Campanella, E., Ceccarelli, M., Zagami, A., Gussio, M. ... Cacopardo, B. (2023). <em>Legionella pneumophila</em> pneumonia: A 5‑year retrospective clinical evaluation and commentary. World Academy of Sciences Journal, 5, 18. https://doi.org/10.3892/wasj.2023.195
MLA
Marino, A., Stracquadanio, S., Campanella, E., Ceccarelli, M., Zagami, A., Gussio, M., Larocca, L., Nunnari, G., Cacopardo, B."<em>Legionella pneumophila</em> pneumonia: A 5‑year retrospective clinical evaluation and commentary". World Academy of Sciences Journal 5.3 (2023): 18.
Chicago
Marino, A., Stracquadanio, S., Campanella, E., Ceccarelli, M., Zagami, A., Gussio, M., Larocca, L., Nunnari, G., Cacopardo, B."<em>Legionella pneumophila</em> pneumonia: A 5‑year retrospective clinical evaluation and commentary". World Academy of Sciences Journal 5, no. 3 (2023): 18. https://doi.org/10.3892/wasj.2023.195
Copy and paste a formatted citation
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Spandidos Publications style
Marino A, Stracquadanio S, Campanella E, Ceccarelli M, Zagami A, Gussio M, Larocca L, Nunnari G and Cacopardo B: <em>Legionella pneumophila</em> pneumonia: A 5‑year retrospective clinical evaluation and commentary. World Acad Sci J 5: 18, 2023.
APA
Marino, A., Stracquadanio, S., Campanella, E., Ceccarelli, M., Zagami, A., Gussio, M. ... Cacopardo, B. (2023). <em>Legionella pneumophila</em> pneumonia: A 5‑year retrospective clinical evaluation and commentary. World Academy of Sciences Journal, 5, 18. https://doi.org/10.3892/wasj.2023.195
MLA
Marino, A., Stracquadanio, S., Campanella, E., Ceccarelli, M., Zagami, A., Gussio, M., Larocca, L., Nunnari, G., Cacopardo, B."<em>Legionella pneumophila</em> pneumonia: A 5‑year retrospective clinical evaluation and commentary". World Academy of Sciences Journal 5.3 (2023): 18.
Chicago
Marino, A., Stracquadanio, S., Campanella, E., Ceccarelli, M., Zagami, A., Gussio, M., Larocca, L., Nunnari, G., Cacopardo, B."<em>Legionella pneumophila</em> pneumonia: A 5‑year retrospective clinical evaluation and commentary". World Academy of Sciences Journal 5, no. 3 (2023): 18. https://doi.org/10.3892/wasj.2023.195
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