Apparent excess of mineral corticoids and a point of view of an alternative statistical evaluation: A case report and mini-review of the literature

Zirino,Fortunata; Calabrese,Vincenzo; Siligato,Rossella; Lipari,Antonella; Vienna,Federica Giada; Santoro,Domenico

doi:10.3892/wasj.2023.216

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Apparent excess of mineral corticoids and a point of view of an alternative statistical evaluation: A case report and mini-review of the literature

Authors:
- Fortunata Zirino
- Vincenzo Calabrese
- Rossella Siligato
- Antonella Lipari
- Federica Giada Vienna
- Domenico Santoro
View Affiliations / Copyright

Affiliations: Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, A.O.U. ‘G. Martino’, University of Messina, I-93100 Messina, Italy

Copyright: © Zirino et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 1
|
Published online on: November 28, 2023

https://doi.org/10.3892/wasj.2023.216
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Abstract

The present study describes the case of a 71-year-old male patient with hypocalcemia, hypomagnesemia and hypokalemia. Following infusion therapy, the serum calcium and serum magnesium levels were normalized. Conversely, serum potassium did not respond to the infusion therapy, with the progressive reduction of the serum concentration, in spite of the high dose of potassium infusion. Although unusual, the present study analyzed how infusion treatment affects kalemia. The present study used, over time, the measurements of variables on a single patient as ‘cases’ and the set of measurements of the patient himself (single patient) as a ‘cohort’. One patient can be considered as one single cluster; thus, the independence assumption is not violated. The present study quantitatively analyzed the effect of one or more treatments and in finding unknown causes that may influence the therapeutic response, particularly in situations with a paradoxical response. Thus, it was found that only potassium canreonate was related to an increase in kalemia (β=0.03, P<0.01). Based on this finding, together with the low aldosterone concentration in hypokalemia, an apparent excess of mineral corticoids was assumed.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Apparent excess of mineral corticoids and a point of view of an alternative statistical evaluation: A case report and mini-review of the literature

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