Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
World Academy of Sciences Journal
Join Editorial Board Propose a Special Issue
Print ISSN: 2632-2900 Online ISSN: 2632-2919
Journal Cover
May-June 2024 Volume 6 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-June 2024 Volume 6 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Implications and considerations of V179D mutation in a patient with HIV treated with cabotegravir/rilpivirine: A case report and mini‑review of the literature

  • Authors:
    • Serena Spampinato
    • Andrea Marino
    • Benedetto Maurizio Celesia
    • Emmanuele Venanzi Rullo
    • Fabrizio Condorelli
    • Bruno Cacopardo
    • Giuseppe Nunnari
  • View Affiliations / Copyright

    Affiliations: Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Catania, ARNAS Garibaldi Hospital, I‑95122 Catania, Italy, Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, I‑98124 Messina, Italy, Department of Pharmacological Sciences, Università del Piemonte Orientale ‘A. Avogadro’, I‑28100 Novara, Italy
    Copyright: © Spampinato et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 19
    |
    Published online on: March 4, 2024
       https://doi.org/10.3892/wasj.2024.234
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The management of antiretroviral therapy is intricately associated with the evaluation of the viral genetic profile, a process in which infectious disease specialists play a pivotal role in both the selection and fine‑tuning of treatment protocols. The V179D aminoacidic variation within the reverse transcriptase of the human immunodeficiency virus (HIV), while not considered among major mutations, carries the potential to exert a notable effect on resistance to antiretroviral agents. Notably, this influence extends specifically to the class of non‑nucleoside reverse transcriptase inhibitors, suggesting that the presence of the V179D mutation may diminish the susceptibility of the virus to certain antiretroviral drugs within this classification. The present study describes the case of a patient which delineates the management trajectory of an HIV‑positive individual, commencing from the initial diagnosis in November, 2017. A genotypic resistance test revealed the presence of the V179D mutation. Of note, notwithstanding the existence of this mutation, the patient underwent a transition to a cabotegravir and rilpivirine injectable combination regimen, resulting in a favorable treatment response characterized by comprehensive and sustained viral suppression, coupled with enhancements in the immunological profile. The case described herein underscores the critical significance of a tailored approach in the management of HIV, wherein therapeutic strategies are adeptly tailored to the unique exigencies of people living with HIV.
View Figures
View References

1 

Yeo JY, Goh GR, Su TTT and Gan SKE: The determination of HIV-1 RT mutation rate, its possible allosteric effects, and its implications on drug resistance. Viruses. 12(297)2020.PubMed/NCBI View Article : Google Scholar

2 

Li JZ, Paredes R, Ribaudo HJ, Svarovskaia ES, Metzner KJ, Kozal MJ, Hullsiek KH, Balduin M, Jakobsen MR, Geretti AM, et al: Low-Frequency HIV-1 drug resistance mutations and risk of NNRTI-Based antiretroviral treatment failure: A systematic review and pooled analysis. JAMA. 305:1327–1335. 2015.PubMed/NCBI View Article : Google Scholar

3 

Fisicaro V, Campanella E, Marino A, Guarneri A, Franzò A, Pistarà E, Spampinato S, Bandiera A, Boscia V, Celesia BM, et al: Laryngeal leishmaniasis in a HIV positive Patient: A case report and review of the literature. World Acad Sci J 5: doi:10.3892/WASJ.2023.201, 2023.

4 

Soltani S, Farahani A, Zebardast A, Dowran R, Zandi M, Rafat Z, Sasani E, Zarandi B, Fallahy MP and Didehdar M: Human immunodeficiency virus and Candida albicans co-infection in Iran: A systematic review. HIV AIDS Rev. 22:181–188. 2023.

5 

Holtz CM and Mansky LM: Variation of HIV-1 mutation spectra among cell types. J Virol. 87:5296–5299. 2013.PubMed/NCBI View Article : Google Scholar

6 

Chen R, Yokoyama M, Sato H, Reilly C and Mansky LM: Human immunodeficiency virus mutagenesis during antiviral therapy: Impact of drug-resistant reverse transcriptase and nucleoside and nonnucleoside reverse transcriptase inhibitors on human immunodeficiency virus type 1 mutation frequencies. J Virol. 79:12045–12057. 2005.PubMed/NCBI View Article : Google Scholar

7 

Gupta S, Lataillade M, Kyriakides TC, Chiarella J, John EPS, Webb S, Moreno EA, Simen BB and Kozal MJ: Low-Frequency NNRTI-resistant HIV-1 variants and relationship to mutational load in antiretroviral-naïve subjects. Viruses. 6:3428–3437. 2014.PubMed/NCBI View Article : Google Scholar

8 

Li JZ, Paredes R, Ribaudo HJ, Svarovskaia ES, Kozal MJ, Hullsiek KH, Miller MD, Bangsberg DR and Kuritzkes DR: Relationship between minority nonnucleoside reverse transcriptase inhibitor resistance mutations, adherence, and the risk of virologic failure. AIDS. 26:185–192. 2012.PubMed/NCBI View Article : Google Scholar

9 

Paredes R, Lalama CM, Ribaudo HJ, Schackman BR, Shikuma C, Gigue F, Meyer WA III, Johnson VA, Fiscus SA, D'Aquila RT, et al: Pre-existing minority drug-resistant HIV-1 variants, adherence, and risk of antiretroviral treatment failure. J Infect Dis. 201:662–671. 2010.PubMed/NCBI View Article : Google Scholar

10 

Wensing AM, Calvez V, Ceccherini-Silberstein F, Charpentier C, Günthard HF, Paredes R, Shafer RW and Richman DD: 2019 update of the drug resistance mutations in HIV-1. Top Antivir Med. 27:111–121. 2019.PubMed/NCBI

11 

Jiao L, Li H, Li L, Zhuang D, Liu Y, Bao Z, Liu S and Li J: Impact of novel resistance profiles in HIV-1 reverse transcriptase on phenotypic resistance to NVP. AIDS Res Treat. 2012(637263)2012.PubMed/NCBI View Article : Google Scholar

12 

2022 Update of HIV Drug Resistance Mutations in HIV-1 Is Now Available Online-IAS-USA Available online: https://www.iasusa.org/2022/09/23/2022-update-of-hiv-drug-resistance-mutations-now-available/ (accessed on 26 December 2023).

13 

Wang Z, Zhang M, Wang J, Liu L, Chen J, Zhang R, Tang Y, Shen Y, Qi T, Song W, et al: Efficacy of Efavirenz-Based regimen in Antiretroviral-Naïve PAtients with HIV-1 V179D/E mutations in Shanghai, China. Infect Dis Ther. 12:245–255. 2023.PubMed/NCBI View Article : Google Scholar

14 

Liu Y, Zhang Y, Li H, Wang X, Jia L, Han J, Li T, Li J and Li L: Natural presence of the V179D and K103R/V179D mutations associated with resistance to nonnucleoside reverse transcriptase inhibitors in HIV-1 CRF65_cpx strains. BMC Infect Dis. 20(313)2020.PubMed/NCBI View Article : Google Scholar

15 

Obasa AE, Mikasi SG, Brado D, Cloete R, Singh K, Neogi U and Jacobs GB: Drug resistance mutations against protease, reverse transcriptase and integrase inhibitors in people living with HIV-1 receiving boosted protease inhibitors in South Africa. Front Microbiol. 11(438)2020.PubMed/NCBI View Article : Google Scholar

16 

SeyedAlinaghi SA, Afsahi AM, Moradi A, Parmoon Z, Habibi P, Mirzapour P, Dashti M, Ghasemzadeh A, Karimi E, Sanaati F, et al: Current ART, determinants for virologic failure and implications for HIV drug resistance: An umbrella review. AIDS Res Ther. 20(74)2023.PubMed/NCBI View Article : Google Scholar

17 

Mittelholzer C and Klimkait T: Advances in molecular genetics enabling studies of highly pathogenic RNA viruses. Viruses. 14(2682)2022.PubMed/NCBI View Article : Google Scholar

18 

Krishnan S, Lippincott CK, Bjerrum S, Rivera MB and Shah M: A national HIV provider survey of antiretroviral therapy preferences for management of treatment-naive and experienced individuals with drug resistance. Open Forum Infect Dis. 10(ofad541)2023.PubMed/NCBI View Article : Google Scholar

19 

Celesia BM, Marino A, Del Vecchio RF, Bruno R, Palermo F, Gussio M, Nunnari G and Cacopardo B: Is it safe and cost saving to defer the CD4+ cell count monitoring in stable patients on ART with more than 350 or 500 cells/ΜL? Mediterr J Hematol Infect Dis. 11(e2019063)2019.PubMed/NCBI View Article : Google Scholar

20 

Marino A, Zafarana G, Ceccarelli M, Cosentino F, Moscatt V, Bruno G, Bruno R, Benanti F, Cacopardo B and Celesia BM: Immunological and clinical impact of DAA-mediated HCV eradication in a cohort of HIV/HCV coinfected patients: Monocentric Italian experience. Diagnostics (Basel). 11(2336)2021.PubMed/NCBI View Article : Google Scholar

21 

Marino A, Caltabiano E, Zagami A, Onorante A, Zappalà C, Locatelli ME, Pampaloni A, Scuderi D, Bruno R and Cacopardo B: Rapid emergence of cryptococcal fungemia, mycobacterium chelonae vertebral osteomyelitis and gastro intestinal stromal tumor in a young HIV late presenter: A case report. BMC Infect Dis. 18(693)2018.PubMed/NCBI View Article : Google Scholar

22 

Celesia BM, Marino A, Borracino S, Arcadipane AF, Pantò G, Gussio M, Coniglio S, Pennisi A, Cacopardo B and Panarello G: Successful extracorporeal membrane oxygenation treatment in an acquired immune deficiency syndrome (AIDS) patient with acute respiratory distress syndrome (ARDS) complicating pneumocystis jirovecii pneumonia: A challenging case. Am J Case Rep. 21(e919570)2020.PubMed/NCBI View Article : Google Scholar

23 

Spampinato S, Saia AG, Russotto Y, Micali C, Marino A, Ceccarelli M, Rullo E, Pellicanò GF and Nunnari G: Real-life efficacy and satisfaction of long-acting ART Cabotegravir-Rilpivirine in HIV-infected individuals. Infectious Diseases and Tropical Medicine. 9(e1207)2023.

24 

Cosentino F, Marino A, Anile L, Moscatt V, Gussio M, Boscia V, Bruno R, Nunnari G, Pulvirenti A, Privitera GF, et al: Long-term survivors in a cohort of people living with HIV diagnosed between 1985 and 1994: Predictive factors associated with more than 25 years of survival. Infect Dis Rep. 15:70–83. 2023.PubMed/NCBI View Article : Google Scholar

25 

Rhee SY, Kassaye SG, Jordan MR, Kouamou V, Katzenstein D and Shafer RW: Public availability of HIV-1 drug resistance sequence and treatment data: A systematic review. Lancet Microbe. 3:e392–e398. 2022.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Spampinato S, Marino A, Celesia BM, Venanzi Rullo E, Condorelli F, Cacopardo B and Nunnari G: Implications and considerations of V179D mutation in a patient with HIV treated with cabotegravir/rilpivirine: A case report and mini‑review of the literature. World Acad Sci J 6: 19, 2024.
APA
Spampinato, S., Marino, A., Celesia, B.M., Venanzi Rullo, E., Condorelli, F., Cacopardo, B., & Nunnari, G. (2024). Implications and considerations of V179D mutation in a patient with HIV treated with cabotegravir/rilpivirine: A case report and mini‑review of the literature. World Academy of Sciences Journal, 6, 19. https://doi.org/10.3892/wasj.2024.234
MLA
Spampinato, S., Marino, A., Celesia, B. M., Venanzi Rullo, E., Condorelli, F., Cacopardo, B., Nunnari, G."Implications and considerations of V179D mutation in a patient with HIV treated with cabotegravir/rilpivirine: A case report and mini‑review of the literature". World Academy of Sciences Journal 6.3 (2024): 19.
Chicago
Spampinato, S., Marino, A., Celesia, B. M., Venanzi Rullo, E., Condorelli, F., Cacopardo, B., Nunnari, G."Implications and considerations of V179D mutation in a patient with HIV treated with cabotegravir/rilpivirine: A case report and mini‑review of the literature". World Academy of Sciences Journal 6, no. 3 (2024): 19. https://doi.org/10.3892/wasj.2024.234
Copy and paste a formatted citation
x
Spandidos Publications style
Spampinato S, Marino A, Celesia BM, Venanzi Rullo E, Condorelli F, Cacopardo B and Nunnari G: Implications and considerations of V179D mutation in a patient with HIV treated with cabotegravir/rilpivirine: A case report and mini‑review of the literature. World Acad Sci J 6: 19, 2024.
APA
Spampinato, S., Marino, A., Celesia, B.M., Venanzi Rullo, E., Condorelli, F., Cacopardo, B., & Nunnari, G. (2024). Implications and considerations of V179D mutation in a patient with HIV treated with cabotegravir/rilpivirine: A case report and mini‑review of the literature. World Academy of Sciences Journal, 6, 19. https://doi.org/10.3892/wasj.2024.234
MLA
Spampinato, S., Marino, A., Celesia, B. M., Venanzi Rullo, E., Condorelli, F., Cacopardo, B., Nunnari, G."Implications and considerations of V179D mutation in a patient with HIV treated with cabotegravir/rilpivirine: A case report and mini‑review of the literature". World Academy of Sciences Journal 6.3 (2024): 19.
Chicago
Spampinato, S., Marino, A., Celesia, B. M., Venanzi Rullo, E., Condorelli, F., Cacopardo, B., Nunnari, G."Implications and considerations of V179D mutation in a patient with HIV treated with cabotegravir/rilpivirine: A case report and mini‑review of the literature". World Academy of Sciences Journal 6, no. 3 (2024): 19. https://doi.org/10.3892/wasj.2024.234
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team