Efficacy of nutritional interventions in patients with hypopharyngeal‑laryngeal and esophageal cancers treated with radiotherapy&nbsp;

Hoang,Bach Viet; Nguyen,Hoa Thi Thanh; Nguyen,Diu Duc; Nguyen,Thu Ha; Nguyen,Lieu Thi Thu; Le,Huong Thi

doi:10.3892/wasj.2024.236

Efficacy of nutritional interventions in patients with hypopharyngeal‑laryngeal and esophageal cancers treated with radiotherapy

Authors:
- Bach Viet Hoang
- Hoa Thi Thanh Nguyen
- Diu Duc Nguyen
- Thu Ha Nguyen
- Lieu Thi Thu Nguyen
- Huong Thi Le
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Affiliations: Clinical Nutrition Center, Vietnam National Cancer Hospital, Hanoi 100000, Vietnam, School of Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, Vietnam
Published online on: March 19, 2024 https://doi.org/10.3892/wasj.2024.236
Article Number: 21
Copyright : © Hoang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

The aim of the present study was to evaluate the effects of nutritional interventions in patients with hypopharyngeal‑laryngeal and esophageal cancers treated with radiotherapy. Patients who received clinical intervention were compared with a control group. The intervention group received active nutritional support according to the regimen developed by the study team, while the control group followed a normal diet at the hospital or at home. After 1 month, in the intervention group, the patients' weight increased by 0.5±1.7 kg, while in the control group, the patients weight decreased by 1.6±1.9 kg. In addition, body mass index in the intervention group increased by 0.2±0.6 kg/m², whereas this decreased by 0.6±0.7 kg/m² in the control group. Significant differences between the groups were observed for both parameters (P<0.001). As regards the quality of life, the general symptoms of the patients in the intervention group improved (a decrease of 3.4±11.9 points), while those in the control group tended to worsen (an increase of 5.5±12.6 points). Specifically, fatigue, and vomiting and nausea decreased by 2.4±18.0 and 7.3±23.9 points in the intervention group, respectively, whereas these increased by 8.0±16.5 and 9.9±26.4 points, respectively in the control group, with differences between groups being statistically significant for both parameters (P<0.05). On the whole, the present study demonstrates that for patients with hypopharyngeal‑laryngeal and esophageal cancers who are at a high risk of developing malnutrition, active nutritional interventions during radiotherapy improve the nutritional status and, ultimately, the quality of life of the patients.

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