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Expression of microRNAs following radiation therapy and association with severity of radiotherapy‑induced toxicity among patients with prostate adenocarcinoma: A systematic review and meta‑analysis

  • Authors:
    • Jagtar Singh
    • Thanuja Thachil
    • Sema Misir
    • Diler Us Altay
    • Serap Ozer Yaman
    • Gurpreet Singh
    • Mathew Suji Eapen
    • Kielan Darcy McAlinden
    • Nina Petrovic
    • Sukhwinder Singh Sohal
  • View Affiliations / Copyright

    Affiliations: Genesis Care Pty Ltd., Alexandria, New South Wales 2015, Australia, Austin Radiation Oncology Centre, Ballarat Central, Victoria 3350, Australia, Department of Biochemistry, Faculty of Pharmacy, Campus Sivas Cumhuriyet University, Sivas 58140, Turkey, Department of Nutrition and Dietetics, Faculty of Health Sciences, Ordu University Cumhuriyet Campus, Ordu 52200, Turkey, Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey, Department of Mental Health, Monash Health, Clayton, Melbourne, Victoria 3168, Australia, Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7250, Australia, Laboratory for Radiobiology and Molecular Genetics, VINČA ‘Institute of Nuclear Sciences‑National Institute of the Republic of Serbia’, University of Belgrade, Belgrade 11000, Serbia
    Copyright: © Singh et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 27
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    Published online on: April 4, 2024
       https://doi.org/10.3892/wasj.2024.242
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Abstract

Radiation‑induced normal tissue toxicity is a common acute and chronic outcome of radiotherapy (RT) for prostate cancer (PCa). There are currently no existing pre‑assessments before treatment to predict acute and late RT‑induced toxicity. Novel predictive blood biomarkers in radiation oncology may improve treatment decision‑making and therapeutic monitoring for patients with PCa. A comprehensive systematic search of microRNA (miRNA/miR) profiling studies published in PubMed, Science Direct and Google Scholar was performed. The present systematic review, supported by meta‑analysis, summarises key findings and discusses the results of prospective clinical studies investigating miRNA expression levels and their association with RT‑induced toxicity in PCa. Out of seven clinical studies, six highlighted levels of 10 miRNAs changing in plasma, serum or peripheral blood mononuclear cells during RT. The post‑RT expression levels of miRNA‑132‑5p, miRNA‑1‑3p, miRNA‑410 and miRNA‑221 were increased, and miRNA‑23a‑3p expression was decreased among patients with low‑grade RT‑induced toxicity. Furthermore, in patients with high‑grade RT toxicity, miRNA‑197‑3p, miRNA‑151a‑5p, miRNA‑18b‑5p, miRNA‑99a and miRNA‑21 expression was increased, while miRNA‑132‑5p expression was decreased. The present miRNA meta‑analysis could be the focus of future studies to identify their potential clinical value as PCa biomarkers and therapeutic mediators in RT‑induced toxicity. The variations in miRNA levels post‑RT could be used as predictive biomarkers of RT‑induced toxicity. However, further extensive validation is required to establish the relationship between miRNA expression levels and RT‑induced toxicity in PCa and to confirm their predictive value.
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Copy and paste a formatted citation
Spandidos Publications style
Singh J, Thachil T, Misir S, Altay DU, Yaman SO, Singh G, Eapen MS, McAlinden KD, Petrovic N, Sohal SS, Sohal SS, et al: Expression of microRNAs following radiation therapy and association with severity of radiotherapy‑induced toxicity among patients with prostate adenocarcinoma: A systematic review and meta‑analysis. World Acad Sci J 6: 27, 2024.
APA
Singh, J., Thachil, T., Misir, S., Altay, D.U., Yaman, S.O., Singh, G. ... Sohal, S.S. (2024). Expression of microRNAs following radiation therapy and association with severity of radiotherapy‑induced toxicity among patients with prostate adenocarcinoma: A systematic review and meta‑analysis. World Academy of Sciences Journal, 6, 27. https://doi.org/10.3892/wasj.2024.242
MLA
Singh, J., Thachil, T., Misir, S., Altay, D. U., Yaman, S. O., Singh, G., Eapen, M. S., McAlinden, K. D., Petrovic, N., Sohal, S. S."Expression of microRNAs following radiation therapy and association with severity of radiotherapy‑induced toxicity among patients with prostate adenocarcinoma: A systematic review and meta‑analysis". World Academy of Sciences Journal 6.3 (2024): 27.
Chicago
Singh, J., Thachil, T., Misir, S., Altay, D. U., Yaman, S. O., Singh, G., Eapen, M. S., McAlinden, K. D., Petrovic, N., Sohal, S. S."Expression of microRNAs following radiation therapy and association with severity of radiotherapy‑induced toxicity among patients with prostate adenocarcinoma: A systematic review and meta‑analysis". World Academy of Sciences Journal 6, no. 3 (2024): 27. https://doi.org/10.3892/wasj.2024.242
Copy and paste a formatted citation
x
Spandidos Publications style
Singh J, Thachil T, Misir S, Altay DU, Yaman SO, Singh G, Eapen MS, McAlinden KD, Petrovic N, Sohal SS, Sohal SS, et al: Expression of microRNAs following radiation therapy and association with severity of radiotherapy‑induced toxicity among patients with prostate adenocarcinoma: A systematic review and meta‑analysis. World Acad Sci J 6: 27, 2024.
APA
Singh, J., Thachil, T., Misir, S., Altay, D.U., Yaman, S.O., Singh, G. ... Sohal, S.S. (2024). Expression of microRNAs following radiation therapy and association with severity of radiotherapy‑induced toxicity among patients with prostate adenocarcinoma: A systematic review and meta‑analysis. World Academy of Sciences Journal, 6, 27. https://doi.org/10.3892/wasj.2024.242
MLA
Singh, J., Thachil, T., Misir, S., Altay, D. U., Yaman, S. O., Singh, G., Eapen, M. S., McAlinden, K. D., Petrovic, N., Sohal, S. S."Expression of microRNAs following radiation therapy and association with severity of radiotherapy‑induced toxicity among patients with prostate adenocarcinoma: A systematic review and meta‑analysis". World Academy of Sciences Journal 6.3 (2024): 27.
Chicago
Singh, J., Thachil, T., Misir, S., Altay, D. U., Yaman, S. O., Singh, G., Eapen, M. S., McAlinden, K. D., Petrovic, N., Sohal, S. S."Expression of microRNAs following radiation therapy and association with severity of radiotherapy‑induced toxicity among patients with prostate adenocarcinoma: A systematic review and meta‑analysis". World Academy of Sciences Journal 6, no. 3 (2024): 27. https://doi.org/10.3892/wasj.2024.242
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