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Case Report Open Access

Insular thyroid carcinoma in the background of follicular thyroid carcinoma: A report of a rare case and mini‑review of the literature

  • Authors:
    • Abdulwahid M. Salih
    • Ari M. Abdullah
    • Hiwa O. Baba
    • Goran L. Omer
    • Imad J. Habibullah
    • Aso S. Muhialdeen
    • Rebaz O. Mohammed
    • Hardi M. Dhahir
    • Marwan N. Hassan
    • Shko H. Hassan
    • Fahmi H. Kakamad
  • View Affiliations / Copyright

    Affiliations: Department of Scientific Affairs, Smart Health Tower, Sulaymaniyah, Kurdistan 46001, Iraq, College of Medicine, University of Sulaimani, Sulaymaniyah, Kurdistan 46001, Iraq
    Copyright: © Salih et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 32
    |
    Published online on: May 31, 2024
       https://doi.org/10.3892/wasj.2024.247
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Abstract

Follicular thyroid carcinoma (FTC) is a well‑differentiated malignancy, while insular thyroid carcinoma (ITC) is a very rare and poorly differentiated tumor. The present study reports a case of ITC arising within the background of FTC. A 52‑year‑old housewife presented with an anterior neck swelling for a duration of 6 months. An ultrasound examination revealed a well‑defined solid nodule measuring ~58x37x28 mm in the mid‑lower third of the right thyroid lobe, and two small nodules of <3 mm in size in the left lobe. Fine needle aspiration cytology of the lesion led to the suspicion of follicular neoplasm. A right thyroid lobectomy was performed, and the histopathological examination revealed poorly differentiated insular carcinoma arising in the background of FTC. As a result of this diagnosis, a completion thyroidectomy was performed. ITC is a rare and highly aggressive thyroid malignancy that is morphologically and biologically regarded as an intermediate between fully differentiated and undifferentiated/anaplastic thyroid carcinomas. In comparison to patients solely with follicular carcinoma, patients with insular carcinoma are older, more often male, have larger tumor sizes, are at greater risk of metastasis, and have a lower survival rate. Poorly differentiated ITC with follicular carcinoma is a very rare and aggressive condition that could be managed by thyroidectomy followed by radioiodine therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Salih AM, Abdullah AM, Baba HO, Omer GL, Habibullah IJ, Muhialdeen AS, Mohammed RO, Dhahir HM, Hassan MN, Hassan SH, Hassan SH, et al: Insular thyroid carcinoma in the background of follicular thyroid carcinoma: A report of a rare case and mini‑review of the literature. World Acad Sci J 6: 32, 2024.
APA
Salih, A.M., Abdullah, A.M., Baba, H.O., Omer, G.L., Habibullah, I.J., Muhialdeen, A.S. ... Kakamad, F.H. (2024). Insular thyroid carcinoma in the background of follicular thyroid carcinoma: A report of a rare case and mini‑review of the literature. World Academy of Sciences Journal, 6, 32. https://doi.org/10.3892/wasj.2024.247
MLA
Salih, A. M., Abdullah, A. M., Baba, H. O., Omer, G. L., Habibullah, I. J., Muhialdeen, A. S., Mohammed, R. O., Dhahir, H. M., Hassan, M. N., Hassan, S. H., Kakamad, F. H."Insular thyroid carcinoma in the background of follicular thyroid carcinoma: A report of a rare case and mini‑review of the literature". World Academy of Sciences Journal 6.4 (2024): 32.
Chicago
Salih, A. M., Abdullah, A. M., Baba, H. O., Omer, G. L., Habibullah, I. J., Muhialdeen, A. S., Mohammed, R. O., Dhahir, H. M., Hassan, M. N., Hassan, S. H., Kakamad, F. H."Insular thyroid carcinoma in the background of follicular thyroid carcinoma: A report of a rare case and mini‑review of the literature". World Academy of Sciences Journal 6, no. 4 (2024): 32. https://doi.org/10.3892/wasj.2024.247
Copy and paste a formatted citation
x
Spandidos Publications style
Salih AM, Abdullah AM, Baba HO, Omer GL, Habibullah IJ, Muhialdeen AS, Mohammed RO, Dhahir HM, Hassan MN, Hassan SH, Hassan SH, et al: Insular thyroid carcinoma in the background of follicular thyroid carcinoma: A report of a rare case and mini‑review of the literature. World Acad Sci J 6: 32, 2024.
APA
Salih, A.M., Abdullah, A.M., Baba, H.O., Omer, G.L., Habibullah, I.J., Muhialdeen, A.S. ... Kakamad, F.H. (2024). Insular thyroid carcinoma in the background of follicular thyroid carcinoma: A report of a rare case and mini‑review of the literature. World Academy of Sciences Journal, 6, 32. https://doi.org/10.3892/wasj.2024.247
MLA
Salih, A. M., Abdullah, A. M., Baba, H. O., Omer, G. L., Habibullah, I. J., Muhialdeen, A. S., Mohammed, R. O., Dhahir, H. M., Hassan, M. N., Hassan, S. H., Kakamad, F. H."Insular thyroid carcinoma in the background of follicular thyroid carcinoma: A report of a rare case and mini‑review of the literature". World Academy of Sciences Journal 6.4 (2024): 32.
Chicago
Salih, A. M., Abdullah, A. M., Baba, H. O., Omer, G. L., Habibullah, I. J., Muhialdeen, A. S., Mohammed, R. O., Dhahir, H. M., Hassan, M. N., Hassan, S. H., Kakamad, F. H."Insular thyroid carcinoma in the background of follicular thyroid carcinoma: A report of a rare case and mini‑review of the literature". World Academy of Sciences Journal 6, no. 4 (2024): 32. https://doi.org/10.3892/wasj.2024.247
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