Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
World Academy of Sciences Journal
Join Editorial Board Propose a Special Issue
Print ISSN: 2632-2900 Online ISSN: 2632-2919
Journal Cover
September-October 2024 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-October 2024 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)

  • Authors:
    • Ritu Raina
    • Ravinder Bhatt
    • Arif Hussain
  • View Affiliations / Copyright

    Affiliations: School of Life Sciences, Manipal Academy of Higher Education‑Dubai Campus, P.O. Box 345050, Dubai, United Arab Emirates, Prime Healthcare, Dubai, P.O. Box 7162, United Arab Emirates, School of Life Sciences, Manipal Academy of Higher Education‑Dubai Campus, P.O. Box 345050, Dubai, United Arab Emirates
    Copyright: © Raina et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 45
    |
    Published online on: June 26, 2024
       https://doi.org/10.3892/wasj.2024.260
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

One of the most extensively used herbal medicines is chrysin, a naturally occurring flavone commonly detected in several natural products, including propolis and honey. Due to its various biological properties, such as antioxidant, anti‑estrogenic, anti‑inflammatory, anti‑allergic, antibacterial and anticancer activities, chrysin has emerged as the leading contender for health benefits. Amongst the several pharmacological effects exhibited by chrysin, its anticancer activity is the most attractive. Several studies have demonstrated that chrysin suppresses tumor progression in cell lines and animal models by inducing apoptosis, disrupting the cell cycle and inhibiting migration without generating toxicity or undesired side‑effects in normal cells. Furthermore, chrysin also inhibits multi‑drug resistant proteins and is effective in combination therapy. The present review comprehensively discusses the research developments in the understanding of the potential of chrysin as a potent anticancer agent achieved by modulating various cell targets and signaling pathways involved in inflammation, cell survival, apoptosis, growth, angiogenesis, invasion and metastasis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Hsieh YS, Yang SF, Sethi G and Hu DN: Natural bioactives in cancer treatment and prevention. Biomed Res Int. 2015(182835)2015.PubMed/NCBI View Article : Google Scholar

2 

Montané X, Kowalczyk O, Reig-Vano B, Bajek A, Roszkowski K, Tomczyk R, Pawliszak W, Giamberini M, Mocek-Płóciniak A and Tylkowski B: Current perspectives of the applications of polyphenols and flavonoids in cancer therapy. Molecules. 25(3342)2020.PubMed/NCBI View Article : Google Scholar

3 

Raina R, Hussain A and Sharma R: Molecular insight into apoptosis mediated by flavones in cancer (review). World Acad Sci J. 2(6)2020.

4 

Raina R, Afroze N, Sundaram MK, Haque S, Bajbouj K, Hamad M and Hussain A: Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways. Eur Rev Med Pharmacol Sci. 25:2206–2220. 2021.PubMed/NCBI View Article : Google Scholar

5 

Muthusami S, Prabakaran DS, An Z, Yu JR and Park WY: EGCG suppresses fused toes homolog protein through p53 in cervical cancer cells. Mol Biol Rep. 40:5587–5596. 2013.PubMed/NCBI View Article : Google Scholar

6 

Pratheeshkumar P, Sreekala C, Zhang Z, Budhraja A, Ding S, Son YO, Wang X, Hitron A, Hyun-Jung K, Wang L, et al: Cancer prevention with promising natural products: Mechanisms of action and molecular targets. Anticancer Agents Med Chem. 12:1159–1584. 2012.PubMed/NCBI View Article : Google Scholar

7 

Kasala ER, Bodduluru LN, Barua CC, Madhana RM, Dahiya V, Budhani MK, Mallugari RR, Maramreddy SR and Gogoi R: Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Pharmacol Rep. 68:310–318. 2016.PubMed/NCBI View Article : Google Scholar

8 

Singh P, Tomar RS and Rath SK: Anticancer potential of the histone deacetylase inhibitor-like effects of flavones, a subclass of polyphenolic compounds: A review. Mol Biol Rep. 42:1515–1531. 2015.PubMed/NCBI View Article : Google Scholar

9 

Abdal Dayem A, Choi HY, Yang GM, Kim K, Saha SK and Cho SG: The anti-cancer effect of polyphenols against breast cancer and cancer stem cells: Molecular mechanisms. Nutrients. 8(581)2016.PubMed/NCBI View Article : Google Scholar

10 

Kasala ER, Bodduluru LN, Madana RM, V AK, Gogoi R and Barua CC: Chemopreventive and therapeutic potential of chrysin in cancer: Mechanistic perspectives. Toxicol Lett. 233:214–225. 2015.PubMed/NCBI View Article : Google Scholar

11 

Sak K: Characteristic features of cytotoxic activity of flavonoids on human cervical cancer cells. Asian Pacific J Cancer Prev. 15:8007–8019. 2014.PubMed/NCBI View Article : Google Scholar

12 

Zhou Y, Zheng J, Li Y, Xu DP, Li S, Chen YM and Li H: Natural polyphenols for prevention and treatment of cancer. Nutrients. 8(515)2016.PubMed/NCBI View Article : Google Scholar

13 

Wu X, Li M, Xiao Z, Daglia M, Dragan S, Delmas D, Vong T, Wang Y, Zhao Y, Shen J, et al: Dietary polyphenols for managing cancers: What have we ignored? Trends Food Sci Technol. 101:150–164. 2020.

14 

Kopustinskiene DM, Jakstas V, Savickas A and Bernatoniene J: Flavonoids as anticancer agents. Nutrients. 12(457)2020.PubMed/NCBI View Article : Google Scholar

15 

Selvakumar P, Badgeley A, Murphy P, Anwar H, Sharma U, Lawrence K and Lakshmikuttyamma A: Flavonoids and other polyphenols act as epigenetic modifiers in breast cancer. Nutrients. 12(761)2020.PubMed/NCBI View Article : Google Scholar

16 

Bodduluru LN, Kasala ER, Thota N, Barua CC, Sistla R, Bodduluru LN, et al: Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Pharmacol Rep. 68:310–318. 2016.PubMed/NCBI View Article : Google Scholar

17 

Ramírez-Espinosa JJ, Saldaña-Ríos J, García-Jiménez S, Villalobos-Molina R, Ávila-Villarreal G, Rodríguez-Ocampo AN, Bernal-Fernández G and Estrada-Soto S: Chrysin induces antidiabetic, antidyslipidemic and anti-inflammatory effects in athymic nude diabetic mice. Molecules. 23(67)2017.PubMed/NCBI View Article : Google Scholar

18 

Naz S, Imran M, Rauf A, Orhan IE, Shariati MA, Iahtisham-Ul-Haq IqraYasmin, Shahbaz M, Qaisrani TB, Shah ZA, et al: Chrysin: Pharmacological and therapeutic properties. Life Sci. 235(116797)2019.PubMed/NCBI View Article : Google Scholar

19 

Balta C, Herman H, Boldura OM, Gasca I, Rosu M, Ardelean A and Hermenean A: Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway. Chem Biol Interact. 240:94–101. 2015.PubMed/NCBI View Article : Google Scholar

20 

Tsuji PA and Walle T: Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line. Chem Biol Interact. 171:37–44. 2008.PubMed/NCBI View Article : Google Scholar

21 

Talebi M, Talebi M, Farkhondeh T, Simal-Gandara J, Kopustinskiene DM, Bernatoniene J and Samarghandian S: Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin. Cancer Cell Int. 21(214)2021.PubMed/NCBI View Article : Google Scholar

22 

Galijatovic A, Otake Y, Walle UK and Walle T: Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. Xenobiotica. 29:1241–1256. 1999.PubMed/NCBI View Article : Google Scholar

23 

Ge S, Gao S, Yin T and Hu M: Determination of pharmacokinetics of chrysin and its conjugates in wild-type FVB and Bcrp1 knockout mice using a validated LC-MS/MS method. J Agric Food Chem. 63:2902–2910. 2015.PubMed/NCBI View Article : Google Scholar

24 

Lee JA, Jung BG, Kim TH, Kim YM, Park MH, Hyun PM, Jeon JW, Park JK, Cho CW, Suh GH and Lee BJ: Poly D,L-lactide-co-glycolide (PLGA) nanoparticle-encapsulated honeybee (Apis melifera) venom promotes clearance of Salmonella enterica serovar Typhimurium infection in experimentally challenged pigs through the up-regulation of T helper type 1 specific immune responses. Vet Immunol Immunopathol. 161:193–204. 2014.PubMed/NCBI View Article : Google Scholar

25 

Arafa MG, Ghalwash D, El-Kersh DM and Elmazar MM: Propolis-based niosomes as oromuco-adhesive films: A randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers. Sci Rep. 8(18056)2018.PubMed/NCBI View Article : Google Scholar

26 

Mohammadinejad S, Akbarzadeh A, Rahmati-Yamchi M, Hatam S, Kachalaki S, Zohreh S and Zarghami N: Preparation and evaluation of chrysin encapsulated in PLGA-PEG nanoparticles in the T47-D breast cancer cell line. Asian Pacific J Cancer Prev. 16:3753–3758. 2015.PubMed/NCBI View Article : Google Scholar

27 

Brown GA, Martini ER, Kohut ML, Franke WD, Jackson DA and King DS and King DS: Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old men. J Am Coll Nutr. 20:520–528. 2001.PubMed/NCBI View Article : Google Scholar

28 

Moghadam ER, Ang HL, Asnaf SE, Zabolian A, Saleki H, Yavari M, Esmaeili H, Zarrabi A, Ashrafizadeh M and Kumar AP: Broad-spectrum preclinical antitumor activity of chrysin: Current trends and future perspectives. Biomolecules. 10(1374)2020.PubMed/NCBI View Article : Google Scholar

29 

Slominski RM, Raman C, Chen JY and Slominski AT: How cancer hijacks the body's homeostasis through the neuroendocrine system. Trends Neurosci. 46:263–275. 2023.PubMed/NCBI View Article : Google Scholar

30 

Mishra A, Mishra PS, Bandopadhyay R, Khurana N, Angelopoulou E, Paudel YN and Piperi C: Neuroprotective potential of chrysin: Mechanistic insights and therapeutic potential for neurological disorders. Molecules. 26(6456)2021.PubMed/NCBI View Article : Google Scholar

31 

El-Sisi AE, El-Sayad ME and Abdelsalam NM: Protective effects of mirtazapine and chrysin on experimentally induced testicular damage in rats. Biomed Pharmacother. 95:1059–1066. 2017.PubMed/NCBI View Article : Google Scholar

32 

El-Bassossy HM, Abo-Warda SM and Fahmy A: Chrysin and luteolin attenuate diabetes-induced impairment in endothelial-dependent relaxation: Effect on lipid profile, AGEs and NO generation. Phyther Res. 27:1678–1684. 2013.PubMed/NCBI View Article : Google Scholar

33 

Satyanarayana K, Sravanthi K, Shaker I, Ponnulakshmi R and Selvaraj J: Role of chrysin on expression of insulin signaling molecules. J Ayurveda Integr Med. 6:248–258. 2015.PubMed/NCBI View Article : Google Scholar

34 

Samarghandian S, Farkhondeh T and Azimi-Nezhad M: Protective effects of chrysin against drugs and toxic agents. Dose Response. 15(1559325817711782)2017.PubMed/NCBI View Article : Google Scholar

35 

Mantawy EM, El-Bakly WM, Esmat A, Badr AM and El-Demerdash E: Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis. Eur J Pharmacol. 728:107–118. 2014.PubMed/NCBI View Article : Google Scholar

36 

Tahir M and Sultana S: Chrysin modulates ethanol metabolism in Wistar rats: A promising role against organ toxicities. Alcohol Alcohol. 46:383–392. 2011.PubMed/NCBI View Article : Google Scholar

37 

Raina R, Almutary AG, Bagabir SA, Afroze N, Fagoonee S, Haque S and Hussain A: Chrysin modulates aberrant epigenetic variations and hampers migratory behavior of human cervical (HeLa) cells. Front Genet. 12(768130)2022.PubMed/NCBI View Article : Google Scholar

38 

Bahadori M, Baharara J and Amini E: Anticancer properties of chrysin on colon cancer cells, in vitro and in vivo with modulation of caspase-3,-9, Bax and Sall4. Iran J Biotechnol. 14:177–184. 2016.PubMed/NCBI View Article : Google Scholar

39 

Zhang Q, Ma S, Liu B, Liu J, Zhu R and Li M: Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells. Exp Ther Med. 12:469–474. 2016.PubMed/NCBI View Article : Google Scholar

40 

Lim W, Ryu S, Bazer FW, Kim SM and Song G: Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction. J Cell Physiol. 233:3129–3140. 2018.PubMed/NCBI View Article : Google Scholar

41 

Zaric M, Mitrovic M, Nikolic I, Baskic D, Popovic S, Djurdjevic P, Milosavljevic Z and Zelen I: Chrysin induces apoptosis in peripheral blood lymphocytes isolated from human chronic lymphocytic leukemia. Anticancer Agents Med Chem. 15:189–195. 2015.PubMed/NCBI View Article : Google Scholar

42 

Ganai SA, Sheikh FA and Baba ZA: Plant flavone chrysin as an emerging histone deacetylase inhibitor for prosperous epigenetic-based anticancer therapy. Phyther Res. 35:823–834. 2021.PubMed/NCBI View Article : Google Scholar

43 

Lee S, Lee SK and Jung J: Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells. Oncol Lett. 21(24)2021.PubMed/NCBI View Article : Google Scholar

44 

Liu Y, Xie S, Wang Y, Luo K, Wang Y and Cai Y: Liquiritigenin inhibits tumor growth and vascularization in a mouse model of HeLa cells. Molecules. 17:7206–7216. 2012.PubMed/NCBI View Article : Google Scholar

45 

Jin YM, Xu TM, Zhao YH, Wang YC and Cui MH: In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa. Tumor Biol. 35:2279–2284. 2014.PubMed/NCBI View Article : Google Scholar

46 

Hussain A, Harish G, Prabhu SA, Mohsin J, Khan MA, Rizvi TA and Sharma C: Inhibitory effect of genistein on the invasive potential of human cervical cancer cells via modulation of matrix metalloproteinase-9 and tissue inhibitiors of matrix metalloproteinase-1 expression. Cancer Epidemiol. 36:e387–e393. 2012.PubMed/NCBI View Article : Google Scholar

47 

Chou RH, Hsieh SC, Yu YL, Huang MH, Huang YC and Hsieh YH: Fisetin inhibits migration and invasion of human cervical cancer cells by down-regulating urokinase plasminogen activator expression through suppressing the p38 MAPK-dependent NF-κB signaling pathway. PLoS One. 8(e71983)2013.PubMed/NCBI View Article : Google Scholar

48 

Chen YJ, Kay N, Yang JM, Lin CT, Chang HL, Wu YC, Fu CF, Chang Y, Lo S, Hou MF, et al: Total synthetic protoapigenone WYC02 inhibits cervical cancer cell proliferation and tumour growth through PIK3 signalling pathway. Basic Clin Pharmacol Toxicol. 113:8–18. 2013.PubMed/NCBI View Article : Google Scholar

49 

Stelzle D, Tanaka LF, Lee KK, Ibrahim Khalil A, Baussano I, Shah ASV, McAllister DA, Gottlieb SL, Klug SJ, Winkler AS, et al: Estimates of the global burden of cervical cancer associated with HIV. Lancet Glob Health. 9:e161–e169. 2021.PubMed/NCBI View Article : Google Scholar

50 

Ham S, Kim KH, Kwon TH, Bak Y, Lee DH, Song YS, Park SH, Park YS, Kim MS, Kang JW, et al: Luteolin induces intrinsic apoptosis via inhibition of E6/E7 oncogenes and activation of extrinsic and intrinsic signaling pathways in HPV-18-associated cells. Oncol Rep. 31:2683–2691. 2014.PubMed/NCBI View Article : Google Scholar

51 

Kim MS, Bak Y, Park YS, Lee DH, Kim JH, Kang JW, Song HH, Oh SR and Yoon DY: Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. Cell Biol Toxicol. 29:259–272. 2013.PubMed/NCBI View Article : Google Scholar

52 

Garcia FAR, Cornelison T, Nuño T, Greenspan DL, Byron JW, Hsu CH, Alberts DS and Chow HH: Results of a phase II randomized, double-blind, placebo-controlled trial of Polyphenon E in women with persistent high-risk HPV infection and low-grade cervical intraepithelial neoplasia. Gynecol Oncol. 132:377–382. 2014.PubMed/NCBI View Article : Google Scholar

53 

Cherry JJ, Rietz A, Malinkevich A, Liu Y, Xie M, Bartolowits M, Davisson VJ, Baleja JD and Androphy EJ: Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 function. PLoS One. 8(e84506)2013.PubMed/NCBI View Article : Google Scholar

54 

Berman TA and Schiller JT: Human papillomavirus in cervical cancer and oropharyngeal cancer: One cause, two diseases. Cancer. 123:2219–2229. 2017.PubMed/NCBI View Article : Google Scholar

55 

Yin KB: Chrysin in PI3K/AKT and other apoptosis signalling pathways, and its effect on HeLa cells, 2014.

56 

Khoo BY, Chua SL and Balaram P: Apoptotic effects of chrysin in human cancer cell lines. Int J Mol Sci. 11:2188–2199. 2010.PubMed/NCBI View Article : Google Scholar

57 

von Brandenstein MG, Abety AN, Depping R, Roth T, Koehler M, Dienes HP and Fries JWU: A p38-p65 transcription complex induced by endothelin-1 mediates signal transduction in cancer cells. Biochim Biophys Acta. 1783:1613–1622. 2008.PubMed/NCBI View Article : Google Scholar

58 

Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Athikomkulchai S, Viriyaroj A, Awale S, Ruchirawat S, Svasti J and Saiki I: Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation. Int J Oncol. 43:329–337. 2013.PubMed/NCBI View Article : Google Scholar

59 

Kanwal R, Datt M, Liu X and Gupta S: Dietaryflavones as dual inhibitors of DNA methyltransferases and histone methyltransferases. PLoS One. 11(e0162956)2016.PubMed/NCBI View Article : Google Scholar

60 

Dong W, Chen A, Cao X, Li X, Cui YH, Xu C, Cao J and Ning Y: Chrysin inhibits proinflammatory factor-induced EMT phenotype and cancer stem cell-like features in HeLa cells by blocking the NF-κB/Twist axis. Cell Physiol Biochem. 52:1236–1250. 2019.PubMed/NCBI View Article : Google Scholar

61 

Pawar JS, Mustafa S and Ghosh I: Chrysin and Capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in Cervical cancer cells. Saudi J Biol Sci. 29:3838–3847. 2022.PubMed/NCBI View Article : Google Scholar

62 

Raina R, Hussain A, Almutary AG, Haque S, Raza T, D'Souza AC, Subramani S and Sajeevan A: Co-administration of chrysin and luteolin with cisplatin and topotecan exhibits a variable therapeutic value in human cancer cells, HeLa. ACS Omega. 8:41204–41213. 2023.PubMed/NCBI View Article : Google Scholar

63 

DeSantis CE, Ma J, Gaudet MM, Newman LA, Miller KD, Goding Sauer A, Jemal A and Siegel RL: Breast cancer statistics, 2019. CA Cancer J Clin. 69:438–451. 2019.PubMed/NCBI View Article : Google Scholar

64 

Pandey K, An HJ, Kim SK, Lee SA, Kim S, Lim SM, Kim GM, Sohn J and Moon YW: Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review. Int J Cancer. 145:1179–1188. 2019.PubMed/NCBI View Article : Google Scholar

65 

Pandey PR, Young KH, Kumar D and Jain N: RNA-mediated immunotherapy regulating tumor immune microenvironment: Next wave of cancer therapeutics. Mol Cancer. 21(58)2022.PubMed/NCBI View Article : Google Scholar

66 

Shanmugam MK, Ahn KS, Hsu A, Woo CC, Yuan Y, Tan KHB, Chinnathambi A, Alahmadi TA, Alharbi SA, Koh APF, et al: Thymoquinone inhibits bone metastasis of breast cancer cells through abrogation of the CXCR4 signaling axis. Front Pharmacol. 9(1294)2018.PubMed/NCBI View Article : Google Scholar

67 

Liu L, Ahn KS, Shanmugam MK, Wang H, Shen H, Arfuso F, Chinnathambi A, Alharbi SA, Chang Y, Sethi G and Tang FR: Oleuropein induces apoptosis via abrogating NF-κB activation cascade in estrogen receptor-negative breast cancer cells. J Cell Biochem. 120:4504–4513. 2019.PubMed/NCBI View Article : Google Scholar

68 

Yang B, Huang J, Xiang T, Yin X, Luo X, Huang J, Luo F, Li H, Li H and Ren G: Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway. J Appl Toxicol. 34:105–112. 2014.PubMed/NCBI View Article : Google Scholar

69 

Rasouli S and Zarghami N: Synergistic growth inhibitory effects of chrysin and metformin combination on breast cancer cells through hTERT and cyclin D1 suppression. Asian Pacific J Cancer Prev. 19:977–982. 2018.PubMed/NCBI View Article : Google Scholar

70 

Samarghandian S, Azimi-Nezhad M, Borji A, Hasanzadeh M, Jabbari F, Farkhondeh T and Samini M: Inhibitory and cytotoxic activities of Chrysin on human breast adenocarcinoma cells by induction of apoptosis. Pharmacogn Mag. 12 (Suppl 4):S436–S440. 2016.PubMed/NCBI View Article : Google Scholar

71 

Sun LP, Chen AL, Hung HC, Chien YH, Huang JS, Huang CY, Chen YW and Chen CN: Chrysin: A histone deacetylase 8 inhibitor with anticancer activity and a suitable candidate for the standardization of Chinese propolis. J Agric Food Chem. 60:11748–11758. 2012.PubMed/NCBI View Article : Google Scholar

72 

Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Maruyama T, Athikomkulchai S, Viriyaroj A, Awale S, Yagita H, Ruchirawat S, et al: A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncol Rep. 30:2357–2364. 2013.PubMed/NCBI View Article : Google Scholar

73 

Mohammadi Z, Sharif Zak M, Seidi K, Barati M, Akbarzadeh A and Zarghami N: The effect of chrysin loaded PLGA-PEG on metalloproteinase gene expression in mouse 4T1 tumor model. Drug Res (Stuttg). 67:211–216. 2017.PubMed/NCBI View Article : Google Scholar

74 

Palakurthi S, Yellepeddi VK and Vangara KK: Recent trends in cancer drug resistance reversal strategies using nanoparticles. Expert Opin Drug Deliv. 9:287–301. 2012.PubMed/NCBI View Article : Google Scholar

75 

Javan Maasomi Z, Pilehvar Soltanahmadi Y, Dadashpour M, Alipour Sh, Abolhasani S and Zarghami N: Synergistic anticancer effects of silibinin and chrysin in T47D breast cancer cells. Asian Pacific J Cancer Prev. 18:1283–1287. 2017.PubMed/NCBI View Article : Google Scholar

76 

Roy S, Sil A and Chakraborty T: Potentiating apoptosis and modulation of p53, Bcl2, and Bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer. J Cell Physiol. 234:4888–4909. 2019.PubMed/NCBI View Article : Google Scholar

77 

Sulaiman GM, Jabir MS and Hameed AH: Nanoscale modification of chrysin for improved of therapeutic efficiency and cytotoxicity. Artif Cells Nanomed Biotechnol. 46 (Suppl 1):S708–S720. 2018.PubMed/NCBI View Article : Google Scholar

78 

Davaran S, Fazeli H, Ghamkhari A, Rahimi F, Molavi O, Anzabi M and Salehi R: Synthesis and characterization of novel P(HEMA-LA-MADQUAT) micelles for co-delivery of methotrexate and chrysin in combination cancer chemotherapy. J Biomater Sci Polym Ed. 29:1265–1286. 2018.PubMed/NCBI View Article : Google Scholar

79 

Anari E, Akbarzadeh A and Zarghami N: Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line. Artif Cells Nanomed Biotechnol. 44:1410–1416. 2016.PubMed/NCBI View Article : Google Scholar

80 

Javan N, Khadem Ansari MH, Dadashpour M, Khojastehfard M, Bastami M, Rahmati-Yamchi M and Zarghami N: Synergistic antiproliferative effects of co-nanoencapsulated curcumin and chrysin on MDA-MB-231 breast cancer cells through upregulating miR-132 and miR-502c. Nutr Cancer. 71:1201–1213. 2019.PubMed/NCBI View Article : Google Scholar

81 

Shao JJ, Zhang AP, Qin W, Zheng L, Zhu YF and Chen X: AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells. Biochem Biophys Res Commun. 423:448–453. 2012.PubMed/NCBI View Article : Google Scholar

82 

Zhang Y, Xu X, Li W, Miao H, Huang S, Zhou Y, Sun Y, Li Z, Guo Q and Zhao L: Activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway in human lung cancer cells by the new synthetic flavonoid, LZ-205. Oncotarget. 7:87257–87270. 2016.PubMed/NCBI View Article : Google Scholar

83 

Pinsolle J, Terzi N, Ferrer L, Giaj Levra M, Toffart AC and Moro-Sibilot D: Les avancées dans la prise en charge des cancers bronchopulmonaires: Ce qui change pour le réanimateur. Méd Intensive Réa. 28:290–299. 2019.

84 

Mehdi SH, Zafaryab M, Nafees S, Khan A, Ahmad I, Hafeez ZB and Rizvi MA: Chrysin sensitizes human lung cancer cells to tumour necrosis factor related apoptosis-inducing ligand (TRAIL) mediated apoptosis. Asian Pac J Cancer Biol. 4:27–33. 2019.

85 

Maruhashi R, Eguchi H, Akizuki R, Hamada S, Furuta T, Matsunaga T, Endo S, Ichihara K and Ikari A: Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells. Sci Rep. 9(13753)2019.PubMed/NCBI View Article : Google Scholar

86 

Lakshmi S, Suresh S, Rahul BS, Saikant R, Maya V, Gopi M, Padmaja G and Remani P: In vitro and in vivo studies of 5,7-dihydroxy flavones isolated from Alpinia galanga (L.) against human lung cancer and ascetic lymphoma. Med Chem Res. 28:39–51. 2019.

87 

Samarghandian S, Azimi Nezhad M and Mohammadi G: Role of caspases, Bax and Bcl-2 in chrysin-induced apoptosis in the A549 human lung adenocarcinoma epithelial cells. Anticancer Agents Med Chem. 14:901–909. 2014.PubMed/NCBI View Article : Google Scholar

88 

Wu TC, Chan ST, Chang CN, Yu PS, Chuang CH and Yeh SL: Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. Chem Biol Interact. 292:101–109. 2018.PubMed/NCBI View Article : Google Scholar

89 

Lim HK, Kim KM, Jeong SY, Choi EK and Jung J: Chrysin increases the therapeutic efficacy of docetaxel and mitigates docetaxel-induced edema. Integr Cancer Ther. 16:496–504. 2017.PubMed/NCBI View Article : Google Scholar

90 

Mohammad P, Nosratollah Z, Mohammad R, Abbas A and Javad R: The inhibitory effect of Curcuma longa extract on telomerase activity in A549 lung cancer cell line. Afr J Biotechnol. 9:912–919. 2010.

91 

Brechbuhl HM, Kachadourian R, Min E, Chan D and Day BJ: Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: The role of glutathione. Toxicol Appl Pharmacol. 258:1–9. 2012.PubMed/NCBI View Article : Google Scholar

92 

Shahbaz M, Naeem H, Imran M, Ul Hassan H, Alsagaby SA, Al Abdulmonem W, Waqar AB, Ghorab AH, Abdelgawad MA, Ghoneim MM, et al: Chrysin a promising anticancer agent: Recent perspectives. Int J Food Prop. 26:2294–2337. 2023.

93 

Khazaei Z, Ghorat F, Jarrahi AM, Adineh HA, Sohrabivafa M and Goodarzi E: Global incidence and mortality of skin cancer by histological subtype and its relationship with the human development index (HDI); an ecology study in 2018 2018. World Cancer Res J. 6(e1265)2019.

94 

Carr S, Smith C and Wernberg J: Epidemiology and risk factors of melanoma. Surg Clin North Am. 100:1–12. 2020.

95 

Islam MM, Nagaraja S, Hafsa NE, Meravanige G, Asdaq SMB and Anwer MK: Polyphenol chrysin for management of skin disorders: Current status and future opportunities. J King Saud Univ Sci. 34(102026)2022.

96 

Sassi A, Maatouk M, El gueder D, Bzéouich IM, Abdelkefi-Ben Hatira S, Jemni-Yacoub S, Ghedira K and Chekir-Ghedira L: Chrysin, a natural and biologically active flavonoid suppresses tumor growth of mouse B16F10 melanoma cells: In vitro and in vivo study. Chem Biol Interact. 283:10–19. 2018.PubMed/NCBI View Article : Google Scholar

97 

Bittner M, Meltzer P, Chen Y, Jiang Y, Seftor E, Hendrix M, Radmacher M, Simon R, Yakhini Z, Ben-Dor A, et al: Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature. 406:536–540. 2000.PubMed/NCBI View Article : Google Scholar

98 

Slominski RM, Sarna T, Płonka PM, Raman C, Brożyna AA and Slominski AT: Melanoma, melanin, and melanogenesis: The Yin and Yang relationship. Front Oncol. 12(842496)2022.PubMed/NCBI View Article : Google Scholar

99 

Slominski RM, Zmijewski MA and Slominski AT: The role of melanin pigment in melanoma. Exp Dermatol. 24:258–259. 2015.PubMed/NCBI View Article : Google Scholar

100 

Yang HZ, Zhang J, Zeng J, Liu S, Zhou F, Zhang F, Giampieri F, Cianciosi D, Forbes-Hernandez TY, Ansary J, et al: Resveratrol inhibits the proliferation of melanoma cells by modulating cell cycle. Int J Food Sci Nutr. 71:84–93. 2020.PubMed/NCBI View Article : Google Scholar

101 

Xue C, Chen Y, Hu D, Iacob C, Lu C and Huang Z: Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis. Oncol Lett. 12:4813–4820. 2016.PubMed/NCBI View Article : Google Scholar

102 

Folgueras AR, Pendás AM, Sánchez LM and López-Otín C: Matrix metalloproteinases in cancer: From new functions to improved inhibition strategies. Int J Dev Biol. 48:411–424. 2004.PubMed/NCBI View Article : Google Scholar

103 

Chen HY, Jiang YW, Kuo CL, Way T Der, Chou YC, Chang YS and Chung JG: Chrysin inhibit human melanoma A375.S2 cell migration and invasion via affecting MAPK signaling and NF-κB signaling pathway in vitro. Environ Toxicol. 34:434–442. 2019.PubMed/NCBI View Article : Google Scholar

104 

Yufei Z, Yuqi W, Binyue H, Lingchen T, Xi C, Hoffelt D and Fuliang H: Chrysin Inhibits melanoma tumor metastasis via interfering with the FOXM1/β-catenin signaling. J Agric Food Chem. 68:9358–9367. 2020.PubMed/NCBI View Article : Google Scholar

105 

Tavakoli F, Jahanban-Esfahlan R, Seidi K, Jabbari M, Behzadi R, Pilehvar-Soltanahmadi Y and Zarghami N: Effects of nano-encapsulated curcumin-chrysin on telomerase, MMPs and TIMPs gene expression in mouse B16F10 melanoma tumour model. Artif Cells Nanomed Biotechnol. 46 (Suppl 2):S75–S86. 2018.PubMed/NCBI View Article : Google Scholar

106 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI View Article : Google Scholar

107 

Cai Z, Zhang F, Chen W, Zhang J and Li H: Mirnas: A promising target in the chemoresistance of bladder cancer. Onco Targets Ther. 12:11805–11816. 2019.PubMed/NCBI View Article : Google Scholar

108 

Korac-Prlic J, Degoricija M, Vilović K, Haupt B, Ivanišević T, Franković L, Grivennikov S and Terzić J: Targeting Stat3 signaling impairs the progression of bladder cancer in a mouse model. Cancer Lett. 490:89–99. 2020.PubMed/NCBI View Article : Google Scholar

109 

Sun N, Liang Y, Chen Y, Wang L, Li D, Liang Z, Sun L, Wang Y and Niu H: Glutamine affects T24 bladder cancer cell proliferation by activating STAT3 through ROS and glutaminolysis. Int J Mol Med. 44:2189–2200. 2019.PubMed/NCBI View Article : Google Scholar

110 

Anand V, Khandelwal M, Appunni S, Gupta N, Seth A, Singh P, Mathur S and Sharma A: CD44 splice variant (CD44v3) promotes progression of urothelial carcinoma of bladder through Akt/ERK/STAT3 pathways: Novel therapeutic approach. J Cancer Res Clin Oncol. 145:2649–2661. 2019.PubMed/NCBI View Article : Google Scholar

111 

Nagavally RR: Inhibition of epithelial mesenchymal transition (EMT) and renal fibrosis by chrysin involves modulation of Akt signaling. PhD dissertation. St. John's University (New York) ProQuest Dissertations & Theses. Publication no. 10170226, 2016. https://www.proquest.com/openview/9d262b69f271cffaa41ea9e6901fe3d0/1?pq-origsite=gscholar&cbl=18750.

112 

Xu Y, Tong Y, Ying J, Lei Z, Wan L, Zhu X, Ye F, Mao P, Wu X, Pan R, et al: Chrysin induces cell growth arrest, apoptosis, and ER stress and inhibits the activation of STAT3 through the generation of ROS in bladder cancer cells. Oncol Lett. 15:9117–9125. 2018.PubMed/NCBI View Article : Google Scholar

113 

Lima APB, Almeida TC, Barros TMB, Rocha LCM, Garcia CCMH and Da Silva GN: Toxicogenetic and antiproliferative effects of chrysin in urinary bladder cancer cells. Mutagenesis. 35:361–371. 2020.PubMed/NCBI View Article : Google Scholar

114 

Talebi M, Talebi M, Kakouri E, Farkhondeh T, Pourbagher-Shahri AM, Tarantilis PA and Samarghandian S: Tantalizing role of p53 molecular pathways and its coherent medications in neurodegenerative diseases. Int J Biol Macromol. 172:93–103. 2021.PubMed/NCBI View Article : Google Scholar

115 

Szliszka E, Gebka J, Bronikowska J and Krol W: Dietary flavones enhance the effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on bladder cancer cells. Cent Eur J Urol. 63:138–143. 2010.

116 

Guo-Qing P, Yuan Y, Cai-Gao Z, Hongling Y, Gonghua H and Yan T: A study of association between expression of hOGG1, VDAC1, HK-2 and cervical carcinoma. J Exp Clin Cancer Res. 29(129)2010.PubMed/NCBI View Article : Google Scholar

117 

Khan MS, Devaraj H and Devaraj N: Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats. Toxicol Appl Pharmacol. 251:85–94. 2011.PubMed/NCBI View Article : Google Scholar

118 

Xu D, Jin J, Yu H, Zhao Z, Ma D, Zhang C and Jiang H: Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2. J Exp Clin Cancer Res. 36(44)2017.PubMed/NCBI View Article : Google Scholar

119 

Gao AM, Ke ZP, Shi F, Sun GC and Chen H: Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway. Chem Biol Interact. 206:100–108. 2013.PubMed/NCBI View Article : Google Scholar

120 

Li X, Huang JM, Wang JN, Xiong XK, Yang XF and Zou F: Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53. Chem Biol Interact. 232:12–20. 2015.PubMed/NCBI View Article : Google Scholar

121 

Xia Y, Lian S, Khoi PN, Yoon HJ, Han JY, Chay KO, Kim KK and Jung YD: Chrysin inhibits cell invasion by inhibition of recepteur d'origine Nantais via suppressing early growth response-1 and NF-κB transcription factor activities in gastric cancer cells. Int J Oncol. 46:1835–1843. 2015.PubMed/NCBI View Article : Google Scholar

122 

Xia Y, Lian S, Khoi PN, Yoon HJ, Joo YE, Chay KO, Kim KK and Do Jung Y: Chrysin inhibits tumor promoter-induced MMP-9 expression by blocking AP-1 via suppression of ERK and JNK pathways in gastric cancer cells. PLoS One. 10(e0124007)2015.PubMed/NCBI View Article : Google Scholar

123 

Zhong X, Liu D, Jiang Z, Li C, Chen L, Xia Y, Liu D, Yao Q and Wang D: Chrysin induced cell apoptosis and inhibited invasion through regulation of TET1 expression in gastric cancer cells. Onco Targets Ther. 13:3277–3287. 2020.PubMed/NCBI View Article : Google Scholar

124 

Wang J, Zhang L, Jiang W, Zhang R, Zhang B, Silayiding A and Duan X: MicroRNA-135a promotes proliferation, migration, invasion and induces chemoresistance of endometrial cancer cells. Eur J Obstet Gynecol Reprod Biol X. 5(100103)2019.PubMed/NCBI View Article : Google Scholar

125 

Xu C, Li B, Zhao S, Jin B, Jia R, Ge J and Xu H: MicroRNA-186-5p inhibits proliferation and metastasis of esophageal cancer by mediating HOXA9. Onco Targets Ther. 12:8905–8914. 2019.PubMed/NCBI View Article : Google Scholar

126 

Mohammadian F, Pilehvar-Soltanahmadi Y, Alipour S, Dadashpour M and Zarghami N: Chrysin alters microRNAs expression levels in gastric cancer cells: Possible molecular mechanism. Drug Res (Stuttg). 67:509–514. 2017.PubMed/NCBI View Article : Google Scholar

127 

Mohammadian F, Abhari A, Dariushnejad H, Nikanfar A, Pilehvar-Soltanahmadi Y and Zarghami N: Effects of chrysin-PLGA-PEG nanoparticles on proliferation and gene expression of miRNAs in gastric cancer cell line. Iran J Cancer Prev. 9(e4190)2016.PubMed/NCBI View Article : Google Scholar

128 

Mohammadian F, Pilehvar-Soltanahmadi Y, Mofarrah M, Dastani-Habashi M and Zarghami N: Down regulation of miR-18a, miR-21 and miR-221 genes in gastric cancer cell line by chrysin-loaded PLGA-PEG nanoparticles. Artif Cells Nanomed Biotechnol. 44:1972–1978. 2016.PubMed/NCBI View Article : Google Scholar

129 

Mohammadian F, Pilehvar-Soltanahmadi Y, Zarghami F, Akbarzadeh A and Zarghami N: Upregulation of miR-9 and Let-7a by nanoencapsulated chrysin in gastric cancer cells. Artif Cells Nanomed Biotechnol. 45:1–6. 2017.PubMed/NCBI View Article : Google Scholar

130 

Zhang MM, Huang SS, Long D and Lin X: Anti-proliferative action of chrysin in colon cancer cells and its effects on signaling pathways. Int J Clin Exp Med. 9:22784–22792. 2016.

131 

Song HY, Kim HM, Mushtaq S, Kim WS, Kim YJ, Lim ST and Byun EB: Gamma-irradiated chrysin improves anticancer activity in HT-29 colon cancer cells through mitochondria-related pathway. J Med Food. 22:713–721. 2019.PubMed/NCBI View Article : Google Scholar

132 

Lee CS, Ryan EJ and Doherty GA: Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation. World J Gastroenterol. 20:3751–3761. 2014.PubMed/NCBI View Article : Google Scholar

133 

Crea F, Nobili S, Paolicchi E, Perrone G, Napoli C, Landini I, Danesi R and Mini E: Epigenetics and chemoresistance in colorectal cancer: An opportunity for treatment tailoring and novel therapeutic strategies. Drug Resist Updat. 14:280–296. 2011.PubMed/NCBI View Article : Google Scholar

134 

Lin YM, Chen CI, Hsiang YP, Hsu YC, Cheng KC, Chien PH, Pan HL, Lu CC and Chen YJ: Chrysin attenuates cell viability of human colorectal cancer cells through autophagy induction unlike 5-fluorouracil/oxaliplatin. Int J Mol Sci. 19(1763)2018.PubMed/NCBI View Article : Google Scholar

135 

Patra S, Mishra SR, Behera BP, Mahapatra KK, Panigrahi DP, Bhol CS, Praharaj PP, Sethi G, Patra SK and Bhutia SK: Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives. Semin Cancer Biol. 80:205–217. 2022.PubMed/NCBI View Article : Google Scholar

136 

Bagheri R, Sanaat Z and Zarghami N: Synergistic effect of free and nano-encapsulated chrysin-curcumin on inhibition of hTERT gene expression in SW480 colorectal cancer cell line. Drug Res (Stuttg). 68:335–343. 2018.PubMed/NCBI View Article : Google Scholar

137 

Zhang X, Zhang W, Chen F and Lu Z: Combined effect of chrysin and apigenin on inhibiting the development and progression of colorectal cancer by suppressing the activity of P38-MAPK/AKT pathway. IUBMB Life. 73:774–783. 2021.PubMed/NCBI View Article : Google Scholar

138 

Lotfi-Attari J, Pilehvar-Soltanahmadi Y, Dadashpour M, Alipour S, Farajzadeh R, Javidfar S and Zarghami N: Co-delivery of curcumin and chrysin by polymeric nanoparticles inhibit synergistically growth and hTERT gene expression in human colorectal cancer cells. Nutr Cancer. 69:1290–1299. 2017.PubMed/NCBI View Article : Google Scholar

139 

Casper AC, Parsons MW, Chipman J, Burt LM Jr, Suneja G, Maurer KA and Gaffney DK: Risk of secondary malignancies in ovarian cancer survivors: 52,680 Patients analyzed with over 40 years of follow-up. Gynecol Oncol. 162:454–460. 2021.PubMed/NCBI View Article : Google Scholar

140 

Jessmon P, Boulanger T, Zhou W and Patwardhan P: Epidemiology and treatment patterns of epithelial ovarian cancer. Expert Rev Anticancer Ther. 17:427–437. 2017.PubMed/NCBI View Article : Google Scholar

141 

Ulbright TM and Roth LM: Common epithelial tumors of the ovary: Proliferating and of low malignant potential. Semin Diagn Pathol. 2:2–15. 1985.PubMed/NCBI

142 

Guo X, Mei J, Jing Y and Wang S: Curcumin-loaded nanoparticles with low-intensity focused ultrasound-induced phase transformation as tumor-targeted and pH-sensitive theranostic nanoplatform of ovarian cancer. Nanoscale Res Lett. 15(73)2020.PubMed/NCBI View Article : Google Scholar

143 

Amini E, Baharara J, Nikdel N and Abdollahi FS: Cytotoxic and pro-apoptotic effects of honey bee venom and chrysin on human ovarian cancer cells. Asia Pacific J Med Toxicol. 4:68–73. 2015.

144 

Tewari D, Patni P and Bishayee A, Sah AN and Bishayee A: Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy. Semin Cancer Biol. 80:1–17. 2022.PubMed/NCBI View Article : Google Scholar

145 

Chang WC, Hsieh TC, Hsu WL, Chang FL, Tsai HR and He MS: Diabetes and further risk of cancer: A nationwide population-based study. BMC Med. 22(214)2024.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Raina R, Bhatt R and Hussain A: Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review). World Acad Sci J 6: 45, 2024.
APA
Raina, R., Bhatt, R., & Hussain, A. (2024). Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review). World Academy of Sciences Journal, 6, 45. https://doi.org/10.3892/wasj.2024.260
MLA
Raina, R., Bhatt, R., Hussain, A."Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)". World Academy of Sciences Journal 6.5 (2024): 45.
Chicago
Raina, R., Bhatt, R., Hussain, A."Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)". World Academy of Sciences Journal 6, no. 5 (2024): 45. https://doi.org/10.3892/wasj.2024.260
Copy and paste a formatted citation
x
Spandidos Publications style
Raina R, Bhatt R and Hussain A: Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review). World Acad Sci J 6: 45, 2024.
APA
Raina, R., Bhatt, R., & Hussain, A. (2024). Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review). World Academy of Sciences Journal, 6, 45. https://doi.org/10.3892/wasj.2024.260
MLA
Raina, R., Bhatt, R., Hussain, A."Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)". World Academy of Sciences Journal 6.5 (2024): 45.
Chicago
Raina, R., Bhatt, R., Hussain, A."Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)". World Academy of Sciences Journal 6, no. 5 (2024): 45. https://doi.org/10.3892/wasj.2024.260
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team