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Efficacy of a novel high‑risk HPV‑16/18 therapeutic vaccine in treating cervical intraepithelial neoplasia and cervical cancer in a clinical trial: A systematic review and meta‑analysis

  • Authors:
    • Zigale Hibstu Teffera
    • Wubetu Yihunie
    • Bantayehu Addis Tegegne
    • Bewuket Misganaw
    • Desalegn Abebaw
    • Mekuriaw Belayineh
    • Yibeltal Akelew
    • Tebelay Dilnesa
    • Adane Adugna
    • Banteizie Silabat
    • Samrawit Tefera
    • Habtamu Belew
    • Lealem Gedefaw Bimrew
  • View Affiliations / Copyright

    Affiliations: Department of Medical Laboratory science, Debre Markos University, Debre Markos, P.O. Box 269, Ethiopia, School of Medical Laboratory Sciences, Institute of Healths, Jimma University, Jimma P.O. Box 378, Ethiopia
    Copyright: © Teffera et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 52
    |
    Published online on: July 22, 2024
       https://doi.org/10.3892/wasj.2024.267
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Abstract

Human papillomavirus (HPV) therapeutic vaccine development and ongoing clinical trials have revealed viral elimination and the waning of cervical intraepithelial neoplasia (CIN) and cervical cancer. HPV therapeutic vaccines are aimed at treating advanced cancers and pre‑cancerous lesions by generating antibodies and cell‑mediated immunity. The efficacy of a novel high‑risk HPV‑16/18 therapeutic vaccine in treating CIN and cervical cancer was systematically assessed. A total of three databases from 2012 to 2022 were systematically searched. Scopus (https://www.scopus.com/home.uri), PubMed (https://pubmed.ncbi.nlm.nih.gov/), Hinari (https://portal.research4life.org/) and Google Scholar were searched. Original articles conducted in human clinical trials were included based on a predefined inclusion criterion. The Joanna Briggs Institute (JBI) Critical Appraisal tools was utilized for use in the JBI Systematic Reviews Checklist for Systematic Reviews and Research Syntheses (http://joannabriggs.org/research/critical‑appraisal‑tools.html) to assess the risk of bias (RoB). Moreover, five authors worked independently during evidence searching and reached a consensus on all included studies to avoid the RoB. Data were extracted and synthesized from the included studies using an Excel spread sheet. The Preferred Reporting Items for Systematic Reviews and Meta‑Analyses (PRISMA) guidelines were used to select studies and a random model effect was also used to analyze the outcome of the review [I2=0.00%, P=0.93, confidence interval 95%(CI)]. Only eight evidences were included out of 555 studies searched. The efficacy of the novel HR‑HPV 16/18 therapeutic vaccine among 377 women suffering from high‑grade CIN and cervical cancer was 88.33% (333/377). Vaccination was most efficacious (33%, 126/377) and least efficacious (23%, 87/377) in complete lesion regression and partial lesion regression, respectively. However, 12% of the women progressed to cancer. Additionally, 33% (126/377) and 23% (87/377) of women demonstrated complete viral clearance and viral load reduction, respectively. Complete lesion regression and progression of lesion to cancer have the highest and lowest effect sizes: 33% (I2=0.00%, P=0.93, 95% CI=0.60‑60.67), 22% (I2=0.00%, P=0.93, 95% CI=11.40‑55.40), and respectively. The overall effect size of the clinical trial outcome is 27.67% (I2=0.00%, P=0.93, 95% CI=14.30‑41.03). The efficacy of a novel HR‑HPV 16/18 therapeutic vaccine is very promising for high‑grade CIN and cervical cancer therapy. Further studies are urgently required to boost the efficacy of a novel HR‑HPV 16/18 therapeutic vaccine, reduce women's health burden, and improve the quality of human life.
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1 

Khallouf H, Grabowska AK and Riemer AB: Therapeutic vaccine strategies against human papillomavirus. Vaccines (Basel). 2:422–462. 2014.PubMed/NCBI View Article : Google Scholar

2 

Stanley MA: Epithelial cell responses to infection with human papillomavirus. Clin Microbiol Rev. 25:215–222. 2012.PubMed/NCBI View Article : Google Scholar

3 

Chabeda A, Yanez RJR, Lamprecht R, Meyers AE, Rybicki EP and Hitzeroth II: Therapeutic vaccines for high-risk HPV-associated diseases. Papillomavirus Res. 5:46–58. 2018.PubMed/NCBI View Article : Google Scholar

4 

Akhatova A, Chan CK, Azizan A and Aimagambetova G: The efficacy of therapeutic DNA vaccines expressing the human papillomavirus E6 and E7 oncoproteins for treatment of cervical cancer: Systematic review. Vaccines (Basel). 10(53)2021.PubMed/NCBI View Article : Google Scholar

5 

De Sanjose S, Quint WG, Alemany L, Geraets DT, Klaustermeier JE, Lloveras B, Tous S, Felix A, Bravo LE, Shin HR, et al: Human papillomavirus genotype attribution in invasive cervical cancer: A retrospective cross-sectional worldwide study. Lancet Oncol. 11:1048–1056. 2010.PubMed/NCBI View Article : Google Scholar

6 

Barrios K and Celis E: TriVax-HPV: An improved peptide-based therapeutic vaccination strategy against human papillomavirus-induced cancers. Cancer Immunol Immunother. 61:1307–1317. 2012.PubMed/NCBI View Article : Google Scholar

7 

Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P and Paraskevaidis E: Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: Systematic review and meta-analysis. BMJ. 354(i3633)2016.PubMed/NCBI View Article : Google Scholar

8 

Schiffman M and Wentzensen N: From human papillomavirus to cervical cancer. Obstet Gynecol. 116:177–185. 2010.PubMed/NCBI View Article : Google Scholar

9 

Çuburu N, Khan S, Thompson CD, Kim R, Vellinga J, Zahn R, Lowy DR, Scheper G and Schiller JT: Adenovirus vector-based prime-boost vaccination via heterologous routes induces cervicovaginal CD8+ T cell responses against HPV16 oncoproteins. Int J Cancer. 142:1467–1479. 2018.PubMed/NCBI View Article : Google Scholar

10 

Narisawa-Saito M and Kiyono T: Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: Roles of E6 and E7 proteins. Cancer Sci. 98:1505–1511. 2007.PubMed/NCBI View Article : Google Scholar

11 

Tindle RW: Immune evasion in human papillomavirus-associated cervical cancer. Nat Rev Cancer. 2:59–64. 2002.PubMed/NCBI View Article : Google Scholar

12 

Sewell DA, Pan ZK and Paterson Y: Listeria-based HPV-16 E7 vaccines limit autochthonous tumor growth in a transgenic mouse model for HPV-16 transformed tumors. Vaccine. 26:5315–5320. 2008.PubMed/NCBI View Article : Google Scholar

13 

Yang A, Farmer E, Lin J, Wu TC and Hung CF: The current state of therapeutic and T cell-based vaccines against human papillomaviruses. Virus Res. 231:148–165. 2017.PubMed/NCBI View Article : Google Scholar

14 

Kash N, Lee MA, Kollipara R, Downing C, Guidry J and Tyring SK: Safety and efficacy data on vaccines and immunization to human papillomavirus. J Clin Med. 4:614–633. 2015.PubMed/NCBI View Article : Google Scholar

15 

Di Bonito P, Accardi L, Galati L, Ferrantelli F and Federico M: Anti-cancer vaccine for HPV-associated neoplasms: Focus on a therapeutic HPV vaccine based on a novel tumor antigen delivery method using endogenously engineered exosomes. Cancers (Basel). 11(138)2019.PubMed/NCBI View Article : Google Scholar

16 

Kabir IM, Dutsinma UA, Bala JA, Yusuf L, Abubakar SD, Kumurya AS, Bulama HA, Bello ZM and Aliyu IA: The need for therapeutic HPV vaccines as a means of curbing the menace of cervical cancer. Indian J Gynecol Oncol. 19(96)2021.

17 

Gupta G, Glueck R and Patel PR: HPV vaccines: Global perspectives. Hum Vaccin Immunother. 13:1421–1424. 2017.PubMed/NCBI View Article : Google Scholar

18 

Rafael TS, Rotman J, Brouwer OR, van der Poel HG, Mom CH, Kenter GG, de Gruijl TD and Jordanova ES: Immunotherapeutic approaches for the treatment of HPV-associated (pre-)cancer of the cervix, vulva and penis. J Clin Med. 11(1101)2022.PubMed/NCBI View Article : Google Scholar

19 

Frazer IH, Leggatt GR and Mattarollo SR: Prevention and treatment of papillomavirus-related cancers through immunization. Annu Rev Immunol. 29:111–138. 2011.PubMed/NCBI View Article : Google Scholar

20 

Yang A, Jeang J, Cheng K, Cheng T, Yang B, Wu TC and Hung CF: Current state in the development of candidate therapeutic HPV vaccines. Expert Rev Vaccines. 15:989–1007. 2016.PubMed/NCBI View Article : Google Scholar

21 

Skeate JG, Woodham AW, Einstein MH, Da Silva DM and Kast WM: Current therapeutic vaccination and immunotherapy strategies for HPV-related diseases. Hum Vaccin Immunother. 12:1418–1429. 2016.PubMed/NCBI View Article : Google Scholar

22 

Yao Y, Huang W, Yang X, Sun W, Liu X, Cun W and Ma Y: HPV-16 E6 and E7 protein T cell epitopes prediction analysis based on distributions of HLA-A loci across populations: An in silico approach. Vaccine. 31:2289–2294. 2013.PubMed/NCBI View Article : Google Scholar

23 

Kumar A, Hussain S, Yadav IS, Gissmann L, Natarajan K, Das BC and Bharadwaj M: Identification of human papillomavirus-16 E6 variation in cervical cancer and their impact on T and B cell epitopes. J Virol Methods. 218:51–58. 2015.PubMed/NCBI View Article : Google Scholar

24 

Ma B, Maraj B, Tran NP, Knoff J, Chen A, Alvarez RD, Hung CF and Wu TC: Emerging human papillomavirus vaccines. Expert Opin Emerg Drugs. 17:469–492. 2012.PubMed/NCBI View Article : Google Scholar

25 

Bermúdez-Humarán LG, Cortes-Perez NG, Le Loir Y, Alcocer-González JM, Tamez-Guerra RS, de Oca-Luna RM and Langella P: An inducible surface presentation system improves cellular immunity against human papillomavirus type 16 E7 antigen in mice after nasal administration with recombinant lactococci. J Med Microbiol. 53:427–433. 2004.PubMed/NCBI View Article : Google Scholar

26 

Adachi K, Kawana K, Yokoyama T, Fujii T, Tomio A, Miura S, Tomio K, Kojima S, Oda K, Sewaki T, et al: Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7. Vaccine. 28:2810–2817. 2010.PubMed/NCBI View Article : Google Scholar

27 

Peters C and Paterson Y: Enhancing the immunogenicity of bioengineered Listeria monocytogenes by passaging through live animal hosts. Vaccine. 21:1187–1194. 2003.PubMed/NCBI View Article : Google Scholar

28 

Darji A, Guzmán CA, Gerstel B, Wachholz P, Timmis KN, Wehland J, Chakraborty T and Weiss S: Oral somatic transgene vaccination using attenuated S. typhimurium. Cell. 91:765–775. 1997.PubMed/NCBI View Article : Google Scholar

29 

Krul MR, Tijhaar EJ, Kleijne JA, Van Loon AM, Nievers MG, Schipper H, Geerse L, Van der Kolk M, Steerenberg PA, Mooi FR and Den Otter W: Induction of an antibody response in mice against human papillomavirus (HPV) type 16 after immunization with HPV recombinant Salmonella strains. Cancer Immunol Immunother. 43:44–48. 1996.PubMed/NCBI View Article : Google Scholar

30 

Liu DW, Tsao YP, Kung JT, Ding YA, Sytwu HK, Xiao X and Chen SL: Recombinant adeno-associated virus expressing human papillomavirus type 16 E7 peptide DNA fused with heat shock protein DNA as a potential vaccine for cervical cancer. J Virol. 74:2888–2894. 2000.PubMed/NCBI View Article : Google Scholar

31 

Hsieh CJ, Kim TW, Hung CF, Juang J, Moniz M, Boyd DA, He L, Chen PJ, Chen CH and Wu TC: Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin. Vaccine. 22:3993–4001. 2004.PubMed/NCBI View Article : Google Scholar

32 

Gomez-Gutierrez JG, Elpek KG, Montes de Oca-Luna R, Shirwan H, Sam Zhou H and McMasters KM: Vaccination with an adenoviral vector expressing calreticulin-human papillomavirus 16 E7 fusion protein eradicates E7 expressing established tumors in mice. Cancer Immunol Immunother. 56:997–1007. 2007.PubMed/NCBI View Article : Google Scholar

33 

Cassetti MC, McElhiney SP, Shahabi V, Pullen JK, Le Poole IC, Eiben GL, Smith LR and Kast WM: Antitumor efficacy of Venezuelan equine encephalitis virus replicon particles encoding mutated HPV16 E6 and E7 genes. Vaccine. 22:520–527. 2004.PubMed/NCBI View Article : Google Scholar

34 

Borysiewicz LK, Fiander A, Nimako M, Man S, Wilkinson GW, Westmoreland D, Evans AS, Adams M, Stacey SN, Boursnell ME, et al: A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer. Lancet. 347:1523–1527. 1996.PubMed/NCBI View Article : Google Scholar

35 

Hsu KF, Hung CF, Cheng WF, He L, Slater LA, Ling M and Wu TC: Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen. Gene Ther. 8:376–383. 2001.PubMed/NCBI View Article : Google Scholar

36 

Lamikanra A, Pan ZK, Isaacs SN, Wu TC and Paterson Y: Regression of established human papillomavirus type 16 (HPV-16) immortalized tumors in vivo by vaccinia viruses expressing different forms of HPV-16 E7 correlates with enhanced CD8(+) T-cell responses that home to the tumor site. J Virol. 75:9654–9664. 2001.PubMed/NCBI View Article : Google Scholar

37 

Zurkova K, Babiarova K, Hainz P, Krystofova J, Kutinova L, Otahal P and Nemeckova S: The expression of the soluble isoform of hFlt3 ligand by recombinant vaccinia virus enhances immunogenicity of the vector. Oncol Rep. 21:1335–1343. 2009.PubMed/NCBI View Article : Google Scholar

38 

Chang CL, Ma B, Pang X, Wu TC and Hung CF: Treatment with cyclooxygenase-2 inhibitors enables repeated administration of vaccinia virus for control of ovarian cancer. Mol Ther. 17:1365–1372. 2009.PubMed/NCBI View Article : Google Scholar

39 

Ginaldi L, Loreto MF, Corsi MP, Modesti M and De Martinis M: Immunosenescence and infectious diseases. Microbes Infect. 3:851–857. 2001.PubMed/NCBI View Article : Google Scholar

40 

Lin K, Doolan K, Hung CF and Wu T: Perspectives for preventive and therapeutic HPV vaccines. J Formos Med Assoc. 109:4–24. 2010.PubMed/NCBI View Article : Google Scholar

41 

Rosales R and Rosales C: Immune therapy for human papillomaviruses-related cancers. World J Clin Oncol. 5:1002–1019. 2014.PubMed/NCBI View Article : Google Scholar

42 

Su JH, Wu A, Scotney E, Ma B, Monie A, Hung CF and Wu TC: Immunotherapy for cervical cancer: Research status and clinical potential. BioDrugs. 24:109–129. 2010.PubMed/NCBI View Article : Google Scholar

43 

Kim J, Hung C, Juang J, He L, Kim TW, Armstrong D, Pai SI, Chen PJ, Lin CT, Boyd DA and Wu TC: Comparison of HPV DNA vaccines employing intracellular targeting strategies. Gene Ther. 11:1011–1018. 2004.PubMed/NCBI View Article : Google Scholar

44 

Fu TM, Ulmer JB, Caulfield MJ, Deck RR, Friedman A, Wang S, Liu X, Donnelly JJ and Liu MA: Priming of cytotoxic T lymphocytes by DNA vaccines: Requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol Med. 3:362–371. 1997.PubMed/NCBI

45 

Porgador A, Irvine KR, Iwasaki A, Barber BH, Restifo NP and Germain RN: Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J Exp Med. 188:1075–1082. 1998.PubMed/NCBI View Article : Google Scholar

46 

Chattergoon MA, Robinson TM, Boyer JD and Weiner DB: Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages/antigen-presenting cells. J Immunol. 160:5707–5718. 1998.PubMed/NCBI

47 

Dupuis M, Denis-Mize K, Woo C, Goldbeck C, Selby MJ, Chen M, Otten GR, Ulmer JB, Donnelly JJ, Ott G and McDonald DM: Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice. J Immunol. 165:2850–2858. 2000.PubMed/NCBI View Article : Google Scholar

48 

Tsen SWD, Paik AH, Hung CF and Wu TC: Enhancing DNA vaccine potency by modifying the properties of antigen-presenting cells. Expert Rev Vaccines. 6:227–239. 2007.PubMed/NCBI View Article : Google Scholar

49 

Berglund P, Quesada-Rolander M, Putkonen P, Biberfeld G, Thorstensson R and Liljeström P: Outcome of immunization of cynomolgus monkeys with recombinant Semliki Forest virus encoding human immunodeficiency virus type 1 envelope protein and challenge with a high dose of SHIV-4 virus. AIDS Res Hum Retroviruses. 13:1487–1495. 1997.PubMed/NCBI View Article : Google Scholar

50 

Cheng WF, Hung CF, Hsu KF, Chai CY, He L, Polo JM, Slater LA, Ling M and Wu TC: Cancer immunotherapy using Sindbis virus replicon particles encoding a VP22-antigen fusion. Hum Gene Ther. 13:553–568. 2002.PubMed/NCBI View Article : Google Scholar

51 

Varnavski AN, Young PR and Khromykh AA: Stable high-level expression of heterologous genes in vitro and in vivo by noncytopathic DNA-based Kunjin virus replicon vectors. J Virol. 74:4394–4403. 2000.PubMed/NCBI View Article : Google Scholar

52 

Mackova J, Kutinova L, Hainz P, Krystofova J, Sroller V, Otahal P, Gabriel P and Nemeckova S: Adjuvant effect of dendritic cells transduced with recombinant vaccinia virus expressing HPV16-E7 is inhibited by co-expression of IL12. Int J Oncol. 24:1581–1588. 2004.PubMed/NCBI

53 

Benencia F, Courrèges MC and Coukos G: Whole tumor antigen vaccination using dendritic cells: Comparison of RNA electroporation and pulsing with UV-irradiated tumor cells. J Transl Med. 6(21)2008.PubMed/NCBI View Article : Google Scholar

54 

Wang T, Ling M, Shih I, Pham T, Pai S, Lu Z, Kurman RJ, Pardoll DM and Wu TC: Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity. Gene Ther. 7:726–733. 2000.PubMed/NCBI View Article : Google Scholar

55 

Kim JH, Kang TH, Noh KH, Bae HC, Kim SH, Yoo YD, Seong SY and Kim TW: Enhancement of dendritic cell-based vaccine potency by anti-apoptotic siRNAs targeting key pro-apoptotic proteins in cytotoxic CD8(+) T cell-mediated cell death. Immunol Lett. 122:58–67. 2009.PubMed/NCBI View Article : Google Scholar

56 

Peng S, Kim TW, Lee JH, Yang M, He L, Hung CF and Wu TC: Vaccination with dendritic cells transfected with BAK and BAX siRNA enhances antigen-specific immune responses by prolonging dendritic cell life. Hum Gene Ther. 16:584–593. 2005.PubMed/NCBI View Article : Google Scholar

57 

Ahn YH, Hong SO, Kim JH, Noh KH, Song KH, Lee YH, Jeon JH, Kim DW, Seo JH and Kim TW: The siRNA cocktail targeting interleukin 10 receptor and transforming growth factor-β receptor on dendritic cells potentiates tumour antigen-specific CD8(+) T cell immunity. Clin Exp Immunol. 181:164–178. 2015.PubMed/NCBI View Article : Google Scholar

58 

Mikysková R, Indrová M, Símová J, Jandlová T, Bieblová J, Jinoch P, Bubeník J and Vonka V: Treatment of minimal residual disease after surgery or chemotherapy in mice carrying HPV16-associated tumours: Cytokine and gene therapy with IL-2 and GM-CSF. Int J Oncol. 24:161–167. 2004.PubMed/NCBI

59 

Chang EY, Chen CH, Ji H, Wang TL, Hung K, Lee BP, Huang AY, Kurman RJ, Pardoll DM and Wu T: Antigen-specific cancer immunotherapy using a GM-CSF secreting allogeneic tumor cell-based vaccine. Int J Cancer. 86:725–730. 2000.PubMed/NCBI View Article : Google Scholar

60 

Hibma MH: The immune response to papillomavirus during infection persistence and regression. Open Virol J. 6:241–248. 2012.PubMed/NCBI View Article : Google Scholar

61 

Vici P, Mariani L, Pizzuti L, Sergi D, Di Lauro L, Vizza E, Tomao F, Tomao S, Cavallotti C, Paolini F and Venuti A: Immunologic treatments for precancerous lesions and uterine cervical cancer. J Exp Clin Cancer Res. 33(29)2014.PubMed/NCBI View Article : Google Scholar

62 

de Freitas AC, de Oliveira THA, Barros MR and Venuti A: hrHPV E5 oncoprotein: Immune evasion and related immunotherapies. J Exp Clin Cancer Res. 36(71)2017.PubMed/NCBI View Article : Google Scholar

63 

Spurgeon ME and Lambert PF: Human papillomavirus and the stroma: Bidirectional crosstalk during the virus life cycle and carcinogenesis. Viruses. 9(219)2017.PubMed/NCBI View Article : Google Scholar

64 

Langers I, Renoux V, Reschner A, Touzé A, Coursaget P, Boniver J, Koch J, Delvenne P and Jacobs N: Natural killer and dendritic cells collaborate in the immune response induced by the vaccine against uterine cervical cancer. Eur J Immunol. 44:3585–3595. 2014.PubMed/NCBI View Article : Google Scholar

65 

Veluchamy JP, Heeren AM, Spanholtz J, van Eendenburg JDH, Heideman DA, Kenter GG, Verheul HM, van der Vliet HJ, Jordanova ES and de Gruijl TD: High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status. Cancer Immunol Immunother. 66:51–61. 2017.PubMed/NCBI View Article : Google Scholar

66 

Bergot AS, Kassianos A, Frazer IH and Mittal D: New approaches to immunotherapy for HPV associated cancers. Cancers (Basel). 3:3461–3495. 2011.PubMed/NCBI View Article : Google Scholar

67 

Barros MR Jr, de Melo CML, Barros MLCMGR, de Cássia Pereira de Lima R, de Freitas AC and Venuti A: Activities of stromal and immune cells in HPV-related cancers. J Exp Clin Cancer Res. 37(137)2018.PubMed/NCBI View Article : Google Scholar

68 

Park JS, Lee SJ, Hur SY, Kim TJ, Hong SR, Lee JK, Cho CH, Suh YS, Woo JW and Sung YC: 27 GX-188E, A therapeutic HPV vaccine, in combination with imiquimod or IL-7-HYFC for treatment of HPV-16 or HPV-18 related cin 3: Results from phase 2 study. Int J Gynecol Cancer. 29 (Suppl 3):A16.2–A16. 2019.

69 

Choi CH, Choi HJ, Lee JW, Kang ES, Cho D, Park BK, Kim YM, Kim DY, Seo H, Park M, et al: Phase I study of a B cell-based and monocyte-based immunotherapeutic vaccine, BVAC-C in human papillomavirus type 16-or 18-positive recurrent cervical cancer. J Clin Med. 9(147)2020.PubMed/NCBI View Article : Google Scholar

70 

Choi CG, Choi HJ, Lee JW, Kang ES, Cho D, Kim YM, Kim D, Seo H, Park M, Kim W, et al: 960PPhase I study of BVAC-C in HPV type 16 or 18 positive recurrent cervical carcinoma: Safety, clinical activity and immunologic correlates. Ann Oncol. 29 (Suppl 8)(viii343)2018.

71 

Harper DM, Nieminen P, Donders G, Einstein MH, Garcia F, Huh WK, Stoler MH, Glavini K, Attley G, Limacher JM, et al: The efficacy and safety of Tipapkinogen Sovacivec therapeutic HPV vaccine in cervical intraepithelial neoplasia grades 2 and 3: Randomized controlled phase II trial with 2.5 years of follow-up. Gynecol Oncol. 153:521–529. 2019.PubMed/NCBI View Article : Google Scholar

72 

Rahma OE, Herrin VE, Ibrahim RA, Toubaji A, Bernstein S, Dakheel O, Steinberg SM, Abu Eid R, Mkrtichyan M, Berzofsky JA and Khleif SN: Pre-immature dendritic cells (PIDC) pulsed with HPV16 E6 or E7 peptide are capable of eliciting specific immune response in patients with advanced cervical cancer. J Transl Med. 12(353)2014.PubMed/NCBI View Article : Google Scholar

73 

Trimble CL, Morrow MP, Kraynyak KA, Shen X, Dallas M, Yan J, Edwards L, Parker RL, Denny L, Giffear M, et al: Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: A randomised, double-blind, placebo-controlled phase 2b trial. Lancet. 386:2078–2088. 2015.PubMed/NCBI View Article : Google Scholar

74 

Kim TJ, Jin HT, Hur SY, Yang HG, Seo YB, Hong SR, Lee CW, Kim S, Woo JW, Park KS, et al: Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients. Nat Commun. 5(5317)2014.PubMed/NCBI View Article : Google Scholar

75 

Daayana S, Elkord E, Winters U, Pawlita M, Roden R, Stern PL and Kitchener HC: Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia. Br J Cancer. 102:1129–1136. 2010.PubMed/NCBI View Article : Google Scholar

76 

Kenter GG, Welters MJ, Valentijn AR, Lowik MJ, Berends-van der Meer DM, Vloon AP, Essahsah F, Fathers LM, Offringa R, Drijfhout JW, et al: Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N Engl J Med. 361:1838–1847. 2009.PubMed/NCBI View Article : Google Scholar

77 

Stevanović S, Draper LM, Langhan MM, Campbell TE, Kwong ML, Wunderlich JR, Dudley ME, Yang JC, Sherry RM, Kammula US, et al: Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumor-infiltrating T cells. J Clin Oncol. 33:1543–1550. 2015.PubMed/NCBI View Article : Google Scholar

78 

Mo Y, Ma J, Zhang H, Shen J, Chen J, Hong J, Xu Y and Qian C: Prophylactic and therapeutic HPV vaccines: Current scenario and perspectives. Front Cell Infect Microbiol. 12(909223)2022.PubMed/NCBI View Article : Google Scholar

79 

Maciag PC, Radulovic S and Rothman J: The first clinical use of a live-attenuated Listeria monocytogenes vaccine: A phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix. Vaccine. 27:3975–3983. 2009.PubMed/NCBI View Article : Google Scholar

80 

van Poelgeest MI, Welters MJ, van Esch EM, Stynenbosch LF, Kerpershoek G, van Persijn van Meerten EL, Van den Hende M, Löwik MJ, Berends-van der Meer DM, Fathers LM, et al: HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial. J Transl Med. 11(88)2013.PubMed/NCBI View Article : Google Scholar

81 

Santin AD, Bellone S, Palmieri M, Ravaggi A, Romani C, Tassi R, Roman JJ, Burnett A, Pecorelli S and Cannon MJ: HPV16/18 E7-pulsed dendritic cell vaccination in cervical cancer patients with recurrent disease refractory to standard treatment modalities. Gynecol Oncol. 100:469–478. 2006.PubMed/NCBI View Article : Google Scholar

82 

Komdeur FL, Singh A, van de Wall S, Meulenberg JJM, Boerma A, Hoogeboom BN, Paijens ST, Oyarce C, de Bruyn M, Schuuring E, et al: First-in-human phase I clinical trial of an SFV-based RNA replicon cancer vaccine against HPV-induced cancers. Mol Ther. 29:611–625. 2021.PubMed/NCBI View Article : Google Scholar

83 

Choi YJ, Hur SY, Kim TJ, Hong SR, Lee JK, Cho CH, Park KS, Woo JW, Sung YC, Suh YS and Park JS: A phase II, prospective, randomized, multicenter, open-label study of GX-188E, an HPV DNA vaccine, in patients with cervical intraepithelial neoplasia 3. Clin Cancer Res. 26:1616–1623. 2020.PubMed/NCBI View Article : Google Scholar

84 

Choi CH, Choi HJ, Lee JW, Kang ES, Cho D, Kim YM, Kim D, Seo H, Park M, Kim W, et al: Phase I study of BVAC-C in HPV type 16 or 18 positive recurrent cervical carcinoma: Safety, clinical activity and immunologic correlates. Ann Oncol. 29 (Suppl 8)(viii343)2018.

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Copy and paste a formatted citation
Spandidos Publications style
Teffera ZH, Yihunie W, Tegegne BA, Misganaw B, Abebaw D, Belayineh M, Akelew Y, Dilnesa T, Adugna A, Silabat B, Silabat B, et al: Efficacy of a novel high‑risk HPV‑16/18 therapeutic vaccine in treating cervical intraepithelial neoplasia and cervical cancer in a clinical trial: A systematic review and meta‑analysis. World Acad Sci J 6: 52, 2024.
APA
Teffera, Z.H., Yihunie, W., Tegegne, B.A., Misganaw, B., Abebaw, D., Belayineh, M. ... Bimrew, L.G. (2024). Efficacy of a novel high‑risk HPV‑16/18 therapeutic vaccine in treating cervical intraepithelial neoplasia and cervical cancer in a clinical trial: A systematic review and meta‑analysis. World Academy of Sciences Journal, 6, 52. https://doi.org/10.3892/wasj.2024.267
MLA
Teffera, Z. H., Yihunie, W., Tegegne, B. A., Misganaw, B., Abebaw, D., Belayineh, M., Akelew, Y., Dilnesa, T., Adugna, A., Silabat, B., Tefera, S., Belew, H., Bimrew, L. G."Efficacy of a novel high‑risk HPV‑16/18 therapeutic vaccine in treating cervical intraepithelial neoplasia and cervical cancer in a clinical trial: A systematic review and meta‑analysis". World Academy of Sciences Journal 6.6 (2024): 52.
Chicago
Teffera, Z. H., Yihunie, W., Tegegne, B. A., Misganaw, B., Abebaw, D., Belayineh, M., Akelew, Y., Dilnesa, T., Adugna, A., Silabat, B., Tefera, S., Belew, H., Bimrew, L. G."Efficacy of a novel high‑risk HPV‑16/18 therapeutic vaccine in treating cervical intraepithelial neoplasia and cervical cancer in a clinical trial: A systematic review and meta‑analysis". World Academy of Sciences Journal 6, no. 6 (2024): 52. https://doi.org/10.3892/wasj.2024.267
Copy and paste a formatted citation
x
Spandidos Publications style
Teffera ZH, Yihunie W, Tegegne BA, Misganaw B, Abebaw D, Belayineh M, Akelew Y, Dilnesa T, Adugna A, Silabat B, Silabat B, et al: Efficacy of a novel high‑risk HPV‑16/18 therapeutic vaccine in treating cervical intraepithelial neoplasia and cervical cancer in a clinical trial: A systematic review and meta‑analysis. World Acad Sci J 6: 52, 2024.
APA
Teffera, Z.H., Yihunie, W., Tegegne, B.A., Misganaw, B., Abebaw, D., Belayineh, M. ... Bimrew, L.G. (2024). Efficacy of a novel high‑risk HPV‑16/18 therapeutic vaccine in treating cervical intraepithelial neoplasia and cervical cancer in a clinical trial: A systematic review and meta‑analysis. World Academy of Sciences Journal, 6, 52. https://doi.org/10.3892/wasj.2024.267
MLA
Teffera, Z. H., Yihunie, W., Tegegne, B. A., Misganaw, B., Abebaw, D., Belayineh, M., Akelew, Y., Dilnesa, T., Adugna, A., Silabat, B., Tefera, S., Belew, H., Bimrew, L. G."Efficacy of a novel high‑risk HPV‑16/18 therapeutic vaccine in treating cervical intraepithelial neoplasia and cervical cancer in a clinical trial: A systematic review and meta‑analysis". World Academy of Sciences Journal 6.6 (2024): 52.
Chicago
Teffera, Z. H., Yihunie, W., Tegegne, B. A., Misganaw, B., Abebaw, D., Belayineh, M., Akelew, Y., Dilnesa, T., Adugna, A., Silabat, B., Tefera, S., Belew, H., Bimrew, L. G."Efficacy of a novel high‑risk HPV‑16/18 therapeutic vaccine in treating cervical intraepithelial neoplasia and cervical cancer in a clinical trial: A systematic review and meta‑analysis". World Academy of Sciences Journal 6, no. 6 (2024): 52. https://doi.org/10.3892/wasj.2024.267
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