Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
World Academy of Sciences Journal
Join Editorial Board Propose a Special Issue
Print ISSN: 2632-2900 Online ISSN: 2632-2919
Journal Cover
November-December 2024 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-December 2024 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Blood pressure and insulin resistance in non‑diabetic and normotensive pregnant women

  • Authors:
    • Enaam Taj Elssir Elhaj
    • Duria A. Rayis
    • Ishag Adam
    • Ashwag Saleh Alsharidah
    • Hamdan Z. Hamdan
  • View Affiliations / Copyright

    Affiliations: Department of Medical Laboratories, College of Applied Medical Science, Shaqra University, Shaqra 15273, Saudi Arabia, Faculty of Medicine, University of Khartoum, Khartoum 11111, Sudan, Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Unaizah 51911, Qassim, Saudi Arabia, Department of Physiology, College of Medicine, Qassim University, Buraidah 52222, Qassim, Saudi Arabia, Department of Pathology, College of Medicine, Qassim University, Unaizah 51911, Qassim, Saudi Arabia
    Copyright: © Elhaj et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 60
    |
    Published online on: August 21, 2024
       https://doi.org/10.3892/wasj.2024.275
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Physiological and biochemical changes during normal pregnancy may precipitate a state of insulin resistance (IR) without disrupting the body's physiology. The present study aimed to investigate the association between the indices of insulin sensitivity and blood pressure among normotensive and euglycemic pregnant women. The present cross‑sectional study was conducted between February and December, 2021. It comprised 133 normal pregnant women who were non‑diabetic and had normal blood pressure. The oral glucose tolerance test and fasting insulin levels were assessed, and the indices of insulin sensitivity and β‑cell function were computed between the 24th and 28th weeks of gestation. A multivariate linear regression analysis was conducted to investigate the factors affecting systolic and diastolic blood pressure levels, including the indices of insulin sensitivity, β‑cell function and others. Univariate linear analysis revealed that fasting insulin levels (β=0.95, P=0.027), the quantitative insulin sensitivity check index (QUICKI; β=‑24.39, P=0.012) and diastolic blood pressure (β=0.76, P<0.001) were associated with systolic blood pressure. Of note, parity (β=0.83, P=0.031), fasting insulin levels (β=0.63, P=0.010), homeostasis model assessment of IR (HOMA‑IR; β=3.19, P=0.013) and QUICKI (β=‑11.97, P=0.029) were the factors that were associated with diastolic blood pressure. In the multivariate linear regression analysis, neither fasting insulin, nor QUICKI were found to be associated with systolic blood pressure. Fasting insulin levels (β=0.48; P=0.040), HOMA‑IR (β=2.51; P=0.043) were associated with diastolic blood pressure. On the whole, in the present study, fasting insulin levels and HOMA‑IR were associated with diastolic blood pressure levels without the emergence of high blood pressure readings or gestational diabetes. Further studies with a longitudinal approach are warranted to further identify associations with IR. 
View Figures
View References

1 

Lowe WL and Karban J: Genetics, genomics and metabolomics: New insights into maternal metabolism during pregnancy. Diabet Med. 31:254–262. 2014.PubMed/NCBI View Article : Google Scholar

2 

Wani K, Sabico S, Alnaami AM, Al-Musharaf S, Fouda MA, Turkestani IZ, Al-Ajlan A, Alshingetti NM, Alokail MS and Al-Daghri NM: Early-pregnancy metabolic syndrome and subsequent incidence in gestational diabetes mellitus in Arab women. Front Endocrinol (Lausanne). 11(98)2020.PubMed/NCBI View Article : Google Scholar

3 

Mohammed A, Aliyu IS and Manu M: Correlation between circulating level of tumor necrosis factor-alpha and insulin resistance in Nigerian women with gestational diabetes mellitus. Ann Afr Med. 17:168–171. 2018.PubMed/NCBI View Article : Google Scholar

4 

Balani J, Hyer S, Syngelaki A, Akolekar R, Nicolaides KH, Johnson A and Shehata H: Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin. Obstet Med. 10:170–173. 2017.PubMed/NCBI View Article : Google Scholar

5 

Laughon SK, Catov J and Roberts JM: Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women. Am J Obstet Gynecol. 201:582.e1–582.e6. 2009.PubMed/NCBI View Article : Google Scholar

6 

da Silva AA, do Carmo JM, Li X, Wang Z, Mouton AJ and Hall JE: Role of Hyperinsulinemia and insulin resistance in hypertension: Metabolic syndrome revisited. Can J Cardiol. 36:671–682. 2020.PubMed/NCBI View Article : Google Scholar

7 

Sowers JR, Standley PR, Ram JL, Jacober S, Simpson L and Rose K: Hyperinsulinemia, insulin resistance, and hyperglycemia: Contributing factors in the pathogenesis of hypertension and atherosclerosis. Am J Hypertens. 6 (Suppl):260S–270S. 1993.PubMed/NCBI View Article : Google Scholar

8 

Tarray R, Saleem S, Afroze D, Yousuf I, Gulnar A, Laway B and Verma S: Role of insulin resistance in essential hypertension. Cardiovasc Endocrinol. 3:129–133. 2014.

9 

Taittonen L, Uhari M, Nuutinen M, Turtinen J, Pokka T and Åkerblom HK: Insulin and blood pressure among healthy children: Cardiovascular risk in young Finns. Am J Hypertens. 9:194–199. 1996.PubMed/NCBI View Article : Google Scholar

10 

Sinaiko AR, Gomez-Marin O and Prineas RJ: Relation of fasting insulin to blood pressure and lipids in adolescents and parents. Hypertension. 30:1554–1559. 1997.PubMed/NCBI View Article : Google Scholar

11 

Topouchian J, Hakobyan Z, Asmar J, Gurgenian S, Zelveian P and Asmar R: Clinical accuracy of the Omron M3 Comfort® and the Omron Evolv® for self-blood pressure measurements in pregnancy and pre-eclampsia-validation according to the Universal Standard Protocol. Vasc Health Risk Manag. 14:189–197. 2018.PubMed/NCBI View Article : Google Scholar

12 

Guadalupe Vargas M, Pazmiño Gomez BJ, Vera Lorenti FE, Álvarez Condo GM, Rodas Neira EI and Veron D, Fernández Veron M, Cercado AG, Bahar B, Tufro A and Veron D: Assessment of two glycated hemoglobin immunoassays. Endocrinol Diabetes Nutr (Engl Ed). 67:297–303. 2020.PubMed/NCBI View Article : Google Scholar

13 

Bujang MA and Baharum N: Sample size guideline for correlation analysis. World J Soc Sci Res. 3(37)2016.

14 

Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G and Quon MJ: Quantitative insulin sensitivity check index: A Simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 85:2402–2410. 2000.

15 

Reaven GM: HOMA-beta in the UKPDS and ADOPT. Is the natural history of type 2 diabetes characterised by a progressive and inexorable loss of insulin secretory function? Maybe? Maybe not? Diab Vasc Dis Res. 6:133–138. 2009.PubMed/NCBI View Article : Google Scholar

16 

Furugen M, Saitoh S, Ohnishi H, Akasaka H, Mitsumata K, Chiba M, Furukawa T, Miyazaki Y, Shimamoto K and Miura T: Matsuda-DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: The Tanno-Sobetsu study. J Hum Hypertens. 26:325–333. 2012.PubMed/NCBI View Article : Google Scholar

17 

Hivert MF, Cardenas A, Allard C, Doyon M, Powe CE, Catalano PM, Perron P and Bouchard L: Interplay of placental DNA methylation and maternal insulin sensitivity in pregnancy. Diabetes. 69:484–492. 2020.PubMed/NCBI View Article : Google Scholar

18 

Jacober SJ, Morris DA and Sowers JR: Postpartum blood pressure and insulin sensitivity in African-American women with recent preeclampsia. Am J Hypertens. 7:933–936. 1991.PubMed/NCBI View Article : Google Scholar

19 

Mary S, Kulkarni MJ, Malakar D, Joshi SR, Mehendale SS and Giri AP: Placental proteomics provides insights into pathophysiology of Pre-Eclampsia and predicts possible markers in plasma. J Proteome Res. 16:1050–1060. 2017.PubMed/NCBI View Article : Google Scholar

20 

Kazumi T, Kawaguchi A, Sakai K, Hirano T and Yoshino G: Young men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressure. Diabetes Care. 25:971–976. 2002.PubMed/NCBI View Article : Google Scholar

21 

van Niekerk G, Christowitz C and Engelbrecht AM: Insulin-mediated immune dysfunction in the development of preeclampsia. J Mol Med. 99:889–897. 2021.PubMed/NCBI View Article : Google Scholar

22 

Valdés E, Sepúlveda-Martínez Á, Manukián B and Parra-Cordero M: Assessment of pregestational insulin resistance as a risk factor of preeclampsia. Gynecol Obstet Invest. 77:111–116. 2014.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Elhaj ET, Rayis DA, Adam I, Alsharidah AS and Hamdan HZ: Blood pressure and insulin resistance in non‑diabetic and normotensive pregnant women. World Acad Sci J 6: 60, 2024.
APA
Elhaj, E.T., Rayis, D.A., Adam, I., Alsharidah, A.S., & Hamdan, H.Z. (2024). Blood pressure and insulin resistance in non‑diabetic and normotensive pregnant women. World Academy of Sciences Journal, 6, 60. https://doi.org/10.3892/wasj.2024.275
MLA
Elhaj, E. T., Rayis, D. A., Adam, I., Alsharidah, A. S., Hamdan, H. Z."Blood pressure and insulin resistance in non‑diabetic and normotensive pregnant women". World Academy of Sciences Journal 6.6 (2024): 60.
Chicago
Elhaj, E. T., Rayis, D. A., Adam, I., Alsharidah, A. S., Hamdan, H. Z."Blood pressure and insulin resistance in non‑diabetic and normotensive pregnant women". World Academy of Sciences Journal 6, no. 6 (2024): 60. https://doi.org/10.3892/wasj.2024.275
Copy and paste a formatted citation
x
Spandidos Publications style
Elhaj ET, Rayis DA, Adam I, Alsharidah AS and Hamdan HZ: Blood pressure and insulin resistance in non‑diabetic and normotensive pregnant women. World Acad Sci J 6: 60, 2024.
APA
Elhaj, E.T., Rayis, D.A., Adam, I., Alsharidah, A.S., & Hamdan, H.Z. (2024). Blood pressure and insulin resistance in non‑diabetic and normotensive pregnant women. World Academy of Sciences Journal, 6, 60. https://doi.org/10.3892/wasj.2024.275
MLA
Elhaj, E. T., Rayis, D. A., Adam, I., Alsharidah, A. S., Hamdan, H. Z."Blood pressure and insulin resistance in non‑diabetic and normotensive pregnant women". World Academy of Sciences Journal 6.6 (2024): 60.
Chicago
Elhaj, E. T., Rayis, D. A., Adam, I., Alsharidah, A. S., Hamdan, H. Z."Blood pressure and insulin resistance in non‑diabetic and normotensive pregnant women". World Academy of Sciences Journal 6, no. 6 (2024): 60. https://doi.org/10.3892/wasj.2024.275
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team