Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
World Academy of Sciences Journal
Join Editorial Board Propose a Special Issue
Print ISSN: 2632-2900 Online ISSN: 2632-2919
Journal Cover
November-December 2024 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-December 2024 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus

  • Authors:
    • Junior Carbajal
    • Carlos Ballon‑Salcedo
    • Leonardo J. Uribe‑Cavero
    • Gabriel G. Saravia
    • Sthefany S. Cuadros‑Aguilar
    • Maria J. Lopez
    • Alfredo Rebaza
    • Jhon Ausejo
    • Joseph A. Pinto
    • Kevin J. Paez
    • Luis G. Saravia‑Huarca
  • View Affiliations / Copyright

    Affiliations: Faculty of Biology, San Luis Gonzaga National University, Ica 11004, Peru, Professional School of Nutrition Sciences, National University of San Agustín de Arequipa, Cercado, Arequipa 04001, Peru, Faculty of Human Medicine, San Luis Gonzaga National University, Ica 11004, Peru, Medicine School‑Ica Branch, San Juan Bautista Private University, Ica 11004, Peru
    Copyright: © Carbajal et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 62
    |
    Published online on: September 3, 2024
       https://doi.org/10.3892/wasj.2024.277
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the risk factors associated with the in‑hospital mortality of patients with coronavirus disease 2019 (COVID‑19) and type 2 diabetes mellitus (T2DM). Therefore, a cross‑sectional study of the medical records of patients hospitalized between April, 2020 and February, 2021 was performed. The demographic, clinical, laboratory and treatment data were compared between COVID‑19 survivors and non‑survivors. Furthermore, multivariate logistic regression and principal component analyses (PCA) were carried out to identify risk factors associated with mortality in these patients. Among the 287 patients included, 132 (46%) did not survive. The multivariate regression analysis revealed that dyspnea [odds ratio (OR), 7.68; 95% confidence interval (CI), 1.77‑40.89; P=0.010], neutrophil count >6.3x109/l (OR, 8.17; 95% CI, 3.16‑26.62; P<0.001), hemoglobin levels of ≤12 g/dl (OR, =3.24; 95% CI, 1.30‑8.56; P=0.014) and a partial pressure of oxygen (PaO2) of <60 mmHg (OR, 7.46; 95% CI, 2.83‑21.86; P<0.001) were independent risk factors for in‑hospital mortality. By contrast, lung crackles were associated with lower risk of in‑hospital mortality (OR, 0.21; 95% CI, 0.08‑0.55). In addition, PCA revealed that elevated levels of fraction of inspired oxygen (FiO2), blood urea nitrogen, serum creatinine and neutrophil count, and a low PaO2/FiO2 ratio considerably contributed to the first principal components of the non‑survivor group. Overall, the results of the present study demonstrated that patients with COVID‑19 and T2DM exhibit a high mortality rate, while several factors in these patients contribute independently to in‑hospital mortality.
View Figures

Figure 1

Figure 2

View References

1 

World Health Organization: COVID-19 Epidemiological update-27 October 2023. Available from: https://www.who.int/publications/m/item/covid-19-epidemiological-update-27-october-2023.

2 

Minsa. Cocid-19 Situation Room. COVID-19 situation. 2022. Available from: https://www.dge.gob.pe/covid19.html.

3 

Huang I, Lim MA and Pranata R: Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia-A systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr. 14:395–403. 2020.PubMed/NCBI View Article : Google Scholar

4 

Kumar A, Arora A, Sharma P, Anikhindi SA, Bansal N, Singla V, Khare S and Srivastava A: Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis. Diabetes Metab Syndr. 14:535–545. 2020.PubMed/NCBI View Article : Google Scholar

5 

Guo L, Shi Z, Zhang Y, Wang C, Do Vale Moreira NC, Zuo H and Hussain A: Comorbid diabetes and the risk of disease severity or death among 8807 COVID-19 patients in China: A meta-analysis. Diabetes Res Clin Pract. 166(108346)2020.PubMed/NCBI View Article : Google Scholar

6 

Wargny M, Potier L, Gourdy P, Pichelin M, Amadou C, Benhamou PY, Bonnet JB, Bordier L, Bourron O, Chaumeil C, et al: Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: Updated results from the nationwide CORONADO study. Diabetologia. 64:778–794. 2021.PubMed/NCBI View Article : Google Scholar

7 

Corona G, Pizzocaro A, Vena W, Rastrelli G, Semeraro F, Isidori AM, Pivonello R, Salonia A, Sforza A and Maggi M: Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis. Rev Endocr Metab Disord. 22:275–296. 2021.PubMed/NCBI View Article : Google Scholar

8 

GBD 2021 Diabetes Collaborators. Global, regional, and national burden of diabetes from 1990 to. 2021, with projections of prevalence to 2050: A systematic analysis for the global burden of disease study 2021. Lancet. 402:203–234. 2023.PubMed/NCBI View Article : Google Scholar

9 

Lei F, George K and Michael R: Coronavirus spike protein and receptor, illustration. Lancet Respir Med. 8(e21)2019.

10 

World Health Organization: Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases: Interim guidance, 2 March 2020.

11 

ElSayed NA, Aleppo G, Bannuru RR, Bruemmer D, Collins BS, Ekhlaspour L, Gaglia JL, Hilliard ME, Johnson EL, Khunt K, et al: Diagnosis and classification of diabetes: Standards of care in diabetes-2024. Diabetes Care. 47 (Suppl 1):S20–S42. 2024.PubMed/NCBI View Article : Google Scholar

12 

Rhee MK, Ho YL, Raghavan S, Vassy JL, Cho K, Gagnon D, Staimez LR, Ford CN, Wilson PWF and Phillips LS: Random plasma glucose predicts the diagnosis of diabetes. PLoS One. 14(e0219964)2019.PubMed/NCBI View Article : Google Scholar

13 

Association American Diabetes. 2. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2021. Diabetes Care. 44 (Suppl 1):S15–S33. 2021.PubMed/NCBI View Article : Google Scholar

14 

Wickham H, Averick M, Bryan J, Chang W, McGowan L, François R, Grolemund G, Hayes A, Henry L, Hester J, et al: Welcome to the Tidyverse. J Open Source Softw. 4(1686)2019.

15 

Sjoberg DD, Whiting K, Curry M, Lavery JA and Larmarange J: Reproducible summary tables with the gtsummary package. R J. 13:570–580. 2021.

16 

Lüdecke D, Ben-Shachar M, Patil I, Waggoner P and Makowski D: Performance: An R package for assessment, comparison and testing of statistical models. J Open Source Softw. 6(3139)2021.

17 

Kassambara A and Mundt F: factoextra: Extract and visualize the results of multivariate data analyses. Package Version 1.0.7. R Packag version, 2020. Available from: https://cran.r-project.org/web/packages/factoextra/readme/README.html.

18 

Dessie ZG and Zewotir T: Mortality-related risk factors of COVID-19: A systematic review and meta-analysis of 42 studies and 423,117 patients. BMC Infect Dis. 21(855)2021.PubMed/NCBI View Article : Google Scholar

19 

Soto A, Quiñones-Laveriano DM, Azañero J, Chumpitaz R, Claros J, Salazar L, Rosales O, Nuñez L, Roca D and Alcantara A: Mortality and associated risk factors in patients hospitalized due to COVID-19 in a Peruvian reference hospital. PLoS One. 17(e0264789)2022.PubMed/NCBI View Article : Google Scholar

20 

Mejía F, Medina C, Cornejo E, Morello E, Vásquez S, Alave J, Schwalb A and Málaga G: Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru. PLoS One. 15(e0244171)2020.PubMed/NCBI View Article : Google Scholar

21 

Hueda-Zavaleta M, Copaja-Corzo C, Bardales-Silva F, Flores-Palacios R, Barreto-Rocchetti L and Benites-Zapata VA: Factors associated with mortality due to COVID-19 in patients from a public hospital in Tacna, Peru. Rev Peru Med Exp Salud Publica. 38:214–223. 2021.PubMed/NCBI View Article : Google Scholar : (In Spanish, English).

22 

COVID-19 Excess Mortality Collaborators. Estimating excess mortality due to the COVID-19 pandemic: A systematic analysis of COVID-19-related mortality, 2020-21. Lancet. 399:1513–1536. 2022.PubMed/NCBI View Article : Google Scholar

23 

Williamson EJ, Walker AJ, Bhaskaran K, Bacon S, Bates C, Morton CE, Curtis HJ, Mehrkar A, Evans D, Inglesby P, et al: Factors associated with COVID-19-related death using OpenSAFELY. Nature. 584:430–436. 2020.PubMed/NCBI View Article : Google Scholar

24 

Anyaypoma-Ocón W, Vásquez SÑ, Bustamante-Chávez HC, Sedano-De La Cruz E, Zavaleta-Gavidia V and Angulo-Bazán Y: Factors associated with covid-19 lethality in a hospital in the cajamarca region in peru. Rev Peru Med Exp Salud Publica. 38:501–511. 2021.PubMed/NCBI View Article : Google Scholar : (In Spanish, English).

25 

Díaz-Vélez C, Urrunaga-Pastor D, Romero-Cerdán A, Peña-Sánchez ER, Mogollon JL, Chafloque JD, Ascoy GC and Benites-Zapata VA: Risk factors for mortality in hospitalized patients with COVID-19 from three hospitals in Peru: A retrospective cohort study. F1000Res. 10(224)2021.PubMed/NCBI View Article : Google Scholar

26 

Holman N, Knighton P, Kar P, O'Keefe J, Curley M, Weaver A, Barron E, Bakhai C, Khunti K, Wareham NJ, et al: Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: A population-based cohort study. Lancet Diabetes Endocrinol. 8:823–833. 2020.PubMed/NCBI View Article : Google Scholar

27 

Galiero R, Loffredo G, Simeon V, Caturano A, Vetrano E, Medicamento G, Alfano M, Beccia D, Brin C, Colantuoni S, et al: Impact of liver fibrosis on COVID-19 in-hospital mortality in Southern Italy. PLoS One. 19(e0296495)2024.PubMed/NCBI View Article : Google Scholar

28 

Galiero R, Pafundi PC, Simeon V, Rinaldi L, Perrella A, Vetrano E, Caturano A, Alfano M, Beccia D, Nevola R, et al: Impact of chronic liver disease upon admission on COVID-19 in-hospital mortality: Findings from COVOCA study. PLoS One. 15(e0243700)2020.PubMed/NCBI View Article : Google Scholar

29 

Hu B, Guo H, Zhou P and Shi ZL: Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol. 19:141–154. 2021.PubMed/NCBI View Article : Google Scholar

30 

Muñoz-Rodríguez JR, Gómez-Romero FJ, Pérez-Ortiz JM, López-Juárez P, Santiago JL, Serrano-Oviedo L and Redondo-Calvo FJ: COVID-19 SESCAM Network. Characteristics and risk factors associated with mortality in a multicenter spanish cohort of patients with COVID-19 pneumonia. Arch Bronconeumol. 57:34–41. 2021.PubMed/NCBI View Article : Google Scholar

31 

Soares RCM, Mattos LR and Raposo LM: Risk factors for hospitalization and mortality due to COVID-19 in Espírito Santo State, Brazil. Am J Trop Med Hyg. 103:1184–1190. 2020.PubMed/NCBI View Article : Google Scholar

32 

Berenguer J, Ryan P, Rodríguez-Baño J, Jarrín I, Carratalà J, Pachón J, Yllescas M and Arriba JR: COVID-19@Spain Study Group; Fundación SEIMC-GESIDA et al. Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain. Clin Microbiol Infect. 26:1525–1536. 2020.PubMed/NCBI View Article : Google Scholar

33 

Aksel G, İslam MM, Algın AE, Emre S, Yaşar GB, Ademoğlu E and Dölek ÜC: Early predictors of mortality for moderate to severely ill patients with Covid-19. Am J Emerg Med. 45:290–296. 2021.PubMed/NCBI View Article : Google Scholar

34 

Rechtman E, Curtin P, Navarro E, Nirenberg S and Horton MK: Vital signs assessed in initial clinical encounters predict COVID-19 mortality in an NYC hospital system. Sci Rep. 10(21545)2020.PubMed/NCBI View Article : Google Scholar

35 

Mol MBA, Strous MTA, van Osch FHM, Vogelaar FJ, Barten DG, Farchi M, Foudraine NA and Gidron Y: Heart-rate-variability (HRV), predicts outcomes in COVID-19. PLoS One. 16(e0258841)2021.PubMed/NCBI View Article : Google Scholar

36 

Rastad H, Ejtahed HS, Mahdavi-Ghorabi A, Arzaghi M, Safari A, Shahrestanaki E, Rezaei M, Niksima MM, Zakani A, Manshadi SH, et al: Factors associated with the poor outcomes in diabetic patients with COVID-19. J Diabetes Metab Disord. 19:1293–1302. 2020.PubMed/NCBI View Article : Google Scholar

37 

Shi L and Wang Y, Liang X, Xiao W, Duan G, Yang H and Wang Y: Is neutrophilia associated with mortality in COVID-19 patients? A meta-analysis and meta-regression. Int J Lab Hematol. 42:e244–e247. 2020.PubMed/NCBI View Article : Google Scholar

38 

Zhang L, Hou J, Ma FZ, Li J, Xue S and Xu ZG: The common risk factors for progression and mortality in COVID-19 patients: A meta-analysis. Arch Virol. 166:2071–2087. 2021.PubMed/NCBI View Article : Google Scholar

39 

Li J, Zhang K, Zhang Y, Gu Z and Huang C: Neutrophils in COVID-19: Recent insights and advances. Virol J. 20(169)2023.PubMed/NCBI View Article : Google Scholar

40 

Ali ET, Jabbar AS, Al Ali HS, Hamadi SS, Jabir MS and Albukhaty S: Extensive study on hematological, immunological, inflammatory markers, and biochemical profile to identify the risk factors in COVID-19 patients. Int J Inflam. 2022(5735546)2022.PubMed/NCBI View Article : Google Scholar

41 

Chen R, Sang L, Jiang M, Yang Z, Jia N, Fu W, Xie J, Guan W, Liang W, Ni Z, et al: Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China. J Allergy Clin Immunol. 146:89–100. 2020.PubMed/NCBI View Article : Google Scholar

42 

Novida H, Soelistyo SA, Cahyani C, Siagian N, Hadi U and Pranoto A: Factors associated with disease severity of COVID-19 in patients with type 2 diabetes mellitus. Biomed Rep. 18(8)2023.PubMed/NCBI View Article : Google Scholar

43 

Galiero R, Simeon V, Loffredo G, Caturano A, Rinaldi L, Vetrano E, Medicamento G, Alfano M, Beccia D, Brin C, et al: Association between renal function at admission and COVID-19 in-hospital mortality in Southern Italy: Findings from the prospective multicenter Italian COVOCA study. J Clin Med. 11(6121)2022.PubMed/NCBI View Article : Google Scholar

44 

ARDS Definition Task Force. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L and Slutsky AS: Acute respiratory distress syndrome: The Berlin definition. JAMA. 307:2526–2533. 2012.PubMed/NCBI View Article : Google Scholar

45 

Grasselli G, Greco M, Zanella A, Albano G, Antonelli M, Bellani G, Bonanomi E, Cabrini L, Carlesso E, Castelli G, et al: Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy. JAMA Intern Med. 180:1345–1355. 2020.PubMed/NCBI View Article : Google Scholar

46 

Gu Y, Wang D, Chen C, Lu W, Liu H, Lv T, Song Y and Zhang F: PaO2/FiO2 and IL-6 are risk factors of mortality for intensive care COVID-19 patients. Sci Rep. 11(7334)2021.PubMed/NCBI View Article : Google Scholar

47 

Gao J, Zhong L, Wu M, Ji J and Liu Z, Wang C, Xie Q and Liu Z: Risk factors for mortality in critically ill patients with COVID-19: A multicenter retrospective case-control study. BMC Infect Dis. 21(602)2021.PubMed/NCBI View Article : Google Scholar

48 

Tobin MJ, Laghi F and Jubran A: Why COVID-19 silent hypoxemia is baffling to physicians. Am J Respir Crit Care Med. 202:356–360. 2020.PubMed/NCBI View Article : Google Scholar

49 

Santus P, Radovanovic D, Saderi L, Marino P, Cogliati C, De Filippis G, Rizzi M, Franceschi E, Pini S, Giuliani F, et al: Severity of respiratory failure at admission and in-hospital mortality in patients with COVID-19: A prospective observational multicentre study. BMJ Open. 10(e043651)2020.PubMed/NCBI View Article : Google Scholar

50 

Rinaldi L, Lugarà M, Simeon V, Perrotta F, Romano C, Iadevaia C, Sagnelli C, Monaco L, Altruda C, Fascione MC, et al: Application and internal validation of lung ultrasound score in COVID-19 setting: The ECOVITA observational study. Pulmonology. 17(29)2024.PubMed/NCBI View Article : Google Scholar

51 

Soto-Becerra P, Culquichicón C, Hurtado-Roca Y and Araujo-Castillo RV: Real-world effectiveness of hydroxychloroquine, azithromycin, and ivermectin among hospitalized COVID-19 patients: Results of a target trial emulation using observational data from a nationwide healthcare system in Peru. medRxiv and bioRxiv. 51:191–192. 2020.

52 

Llanos-Cuentas A, Schwalb A, Quintana JL, Delfin B, Alvarez F, Ugarte-Gil C, Gronerth RI, Lucchetti A, Grogl M and Gotuzzo E: Hydroxychloroquine to prevent SARS-CoV-2 infection among healthcare workers: Early termination of a phase 3, randomised, open-label, controlled clinical trial. BMC Res Notes. 16(22)2023.PubMed/NCBI View Article : Google Scholar

53 

RECOVERY Collaborative Group. Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Brightling C, Ustianowski A, Elmahi E, et al: Dexamethasone in hospitalized patients with Covid-19. N Engl J Med. 384:693–704. 2021.PubMed/NCBI View Article : Google Scholar

54 

Rayman G, Lumb AN, Kennon B, Cottrell C, Nagi D, Page E, Voigt D, Courtney HC, Atkins H, Higgins K, et al: Dexamethasone therapy in COVID-19 patients: Implications and guidance for the management of blood glucose in people with and without diabetes. Diabet Med. 38(e14378)2021.PubMed/NCBI View Article : Google Scholar

55 

Marfella R, D'Onofrio N, Sardu C, Scisciola L, Maggi P, Coppola N, Romano C, Messina V, Turriziani F, Siniscalchi M, et al: Does poor glycaemic control affect the immunogenicity of the COVID-19 vaccination in patients with type 2 diabetes: The CAVEAT study. Diabetes Obes Metab. 24:160–165. 2022.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Carbajal J, Ballon‑Salcedo C, Uribe‑Cavero LJ, Saravia GG, Cuadros‑Aguilar SS, Lopez MJ, Rebaza A, Ausejo J, Pinto JA, Paez KJ, Paez KJ, et al: Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus. World Acad Sci J 6: 62, 2024.
APA
Carbajal, J., Ballon‑Salcedo, C., Uribe‑Cavero, L.J., Saravia, G.G., Cuadros‑Aguilar, S.S., Lopez, M.J. ... Saravia‑Huarca, L.G. (2024). Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus. World Academy of Sciences Journal, 6, 62. https://doi.org/10.3892/wasj.2024.277
MLA
Carbajal, J., Ballon‑Salcedo, C., Uribe‑Cavero, L. J., Saravia, G. G., Cuadros‑Aguilar, S. S., Lopez, M. J., Rebaza, A., Ausejo, J., Pinto, J. A., Paez, K. J., Saravia‑Huarca, L. G."Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus". World Academy of Sciences Journal 6.6 (2024): 62.
Chicago
Carbajal, J., Ballon‑Salcedo, C., Uribe‑Cavero, L. J., Saravia, G. G., Cuadros‑Aguilar, S. S., Lopez, M. J., Rebaza, A., Ausejo, J., Pinto, J. A., Paez, K. J., Saravia‑Huarca, L. G."Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus". World Academy of Sciences Journal 6, no. 6 (2024): 62. https://doi.org/10.3892/wasj.2024.277
Copy and paste a formatted citation
x
Spandidos Publications style
Carbajal J, Ballon‑Salcedo C, Uribe‑Cavero LJ, Saravia GG, Cuadros‑Aguilar SS, Lopez MJ, Rebaza A, Ausejo J, Pinto JA, Paez KJ, Paez KJ, et al: Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus. World Acad Sci J 6: 62, 2024.
APA
Carbajal, J., Ballon‑Salcedo, C., Uribe‑Cavero, L.J., Saravia, G.G., Cuadros‑Aguilar, S.S., Lopez, M.J. ... Saravia‑Huarca, L.G. (2024). Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus. World Academy of Sciences Journal, 6, 62. https://doi.org/10.3892/wasj.2024.277
MLA
Carbajal, J., Ballon‑Salcedo, C., Uribe‑Cavero, L. J., Saravia, G. G., Cuadros‑Aguilar, S. S., Lopez, M. J., Rebaza, A., Ausejo, J., Pinto, J. A., Paez, K. J., Saravia‑Huarca, L. G."Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus". World Academy of Sciences Journal 6.6 (2024): 62.
Chicago
Carbajal, J., Ballon‑Salcedo, C., Uribe‑Cavero, L. J., Saravia, G. G., Cuadros‑Aguilar, S. S., Lopez, M. J., Rebaza, A., Ausejo, J., Pinto, J. A., Paez, K. J., Saravia‑Huarca, L. G."Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus". World Academy of Sciences Journal 6, no. 6 (2024): 62. https://doi.org/10.3892/wasj.2024.277
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team