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Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors

  • Authors:
    • Suresh Prajapati
    • Bhoomi Prajapati
    • Mansi Patel
    • Reeshu Gupta
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    Affiliations: Parul Institute of Applied Sciences, Parul University, Vadodara, Gujarat 391760, India, Department of Biochemistry, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India
    Copyright: © Prajapati et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 63
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    Published online on: September 12, 2024
       https://doi.org/10.3892/wasj.2024.278
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Abstract

Anti‑angiogenic therapies have several clinical benefits for patients with tumors. The acidic environment of tumor cells degrades the extracellular matrix, releases several growth factors, such as vascular endothelial growth factor (VEGF), and induces angiogenesis. By contrast, a high‑salt diet induces osmotic stress and salt‑sensitive hypertension in patients treated with anti‑angiogenic drugs. However, the consequences of various salinity conditions in combination with the pH of the tumor microenvironment have not yet been characterized, at least to the best of our knowledge, and are thus the focus of the present study. Herein, molecular dynamics simulations were performed between lenvatinib and VEGF receptor 2 (VEGFR2) at two different pH levels (acidic pH, 6.5; basic pH, 7.5) and three different salinity conditions (0.15, 030 and 0.45 M). The results suggested that, compared with the basic pH, the acidic pH reduced the binding affinity of lenvatinib to VEGFR2 and induced tumor cell viability by enhancing the expression of cyclin‑dependent kinase 2 (CDK2), fatty acid synthase (FASN), DnaJ heat shock protein family (Hsp40) member C9 (DNAJC9), c‑JUN, Bcl‑xL and dual specificity phosphatase 6 (DUSP6). It was also observed that physiological salinity (0.15 M) reversed the tumorigenic effect of the acidic pH by enhancing the binding affinity of lenvatinib, decreasing cell viability and migration, inhibiting the expression of CDK2, FASN, DNAJC9, c‑JUN, Bcl‑XL, BAX and DUSP6, and increasing the expression of VEGFR2 in MDA‑MB‑231 breast cancer cells. However, opposite results were obtained under the same salinity conditions at a basic pH. These results suggest that physiological salinity conditions at an acidic pH enhance the antitumor efficacy of antiangiogenic drugs targeting VEGFR2. Overall, the present study suggests that the salinity and pH of the tumor environment play a crucial role in the antitumor efficacy of therapies targeting VEGFR2‑mediated angiogenesis.
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1 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024.PubMed/NCBI View Article : Google Scholar

2 

Oguntade AS, Al-Amodi F, Alrumayh A, Alobaida M and Bwalya M: Anti-angiogenesis in cancer therapeutics: The magic bullet. J Egypt Natl Canc Inst. 33(15)2021.PubMed/NCBI View Article : Google Scholar

3 

Al-Abd AM, Alamoudi AJ, Abdel-Naim AB, Neamatallah TA and Ashour OM: Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies-a review. J Adv Res. 8:591–605. 2017.PubMed/NCBI View Article : Google Scholar

4 

Ghalehbandi S, Yuzugulen J, Pranjol MZI and Pourgholami MH: The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF. Eur J Pharmacol. 949(175586)2023.PubMed/NCBI View Article : Google Scholar

5 

Jung WY, Min KW and Oh YH: Increased VEGF-A in solid type of lung adenocarcinoma reduces the patients' survival. Sci Rep. 11(1321)2021.PubMed/NCBI View Article : Google Scholar

6 

Seo Y, Baba H, Fukuda T, Takashima M and Sugimachi K: High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer. 88:2239–2245. 2000.PubMed/NCBI View Article : Google Scholar

7 

Sindhura N and Kaumudi K: Vascular endothelial growth factor expression by immunohistochemistry as a possible indicator of prognosis in invasive breast carcinoma of no special type. Int J Appl Basic Med Res. 14:124–130. 2024.PubMed/NCBI View Article : Google Scholar

8 

Zirlik K and Duyster J: Anti-angiogenics: Current situation and future perspectives. Oncol Res Treat. 41:166–171. 2018.PubMed/NCBI View Article : Google Scholar

9 

Rizzo A, Dadduzio V, Ricci AD, Massari F, Di Federico A, Gadaleta-Caldarola G and Brandi G: Lenvatinib plus pembrolizumab: The next frontier for the treatment of hepatocellular carcinoma? Expert Opin Investig Drugs. 31:371–378. 2022.PubMed/NCBI View Article : Google Scholar

10 

Santoni M, Rizzo A, Mollica V, Rosellini M, Marchetti A, Fragomeno B, Battelli N and Massari F: Pembrolizumab plus lenvatinib or axitinib compared to nivolumab plus ipilimumab or cabozantinib in advanced renal cell carcinoma: A number needed to treat analysis. Expert Rev Pharmacoecon Outcomes Res. 22:45–51. 2022.PubMed/NCBI View Article : Google Scholar

11 

Rizzo A: Immune checkpoint inhibitors and mismatch repair status in advanced endometrial cancer: Elective affinities. J Clin Med. 11(3912)2022.PubMed/NCBI View Article : Google Scholar

12 

Rizzo A, Mollica V, Tateo V, Tassinari E, Marchetti A, Rosellini M, De Luca R, Santoni M and Massari F: Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: The MOUSEION-05 study. Cancer Immunol Immunother. 72:1381–1394. 2023.PubMed/NCBI View Article : Google Scholar

13 

Lopes-Coelho F, Martins F, Pereira SA and Serpa J: Anti-angiogenic therapy: Current challenges and future perspectives. Int J Mol Sci. 22(3765)2021.PubMed/NCBI View Article : Google Scholar

14 

Potter M, Newport E and Morten KJ: The Warburg effect: 80 Years on. Biochem Soc Trans. 44:1499–1505. 2016.PubMed/NCBI View Article : Google Scholar

15 

Ando H, Eshima K and Ishida T: Neutralization of acidic tumor microenvironment (TME) with daily oral dosing of sodium potassium citrate (K/Na Citrate) increases therapeutic effect of anti-cancer agent in pancreatic cancer xenograft mice model. Biol Pharm Bull. 44:266–270. 2021.PubMed/NCBI View Article : Google Scholar

16 

Saghiri MA, Asatourian A, Morgano SM, Wang S and Sheibani N: Moderately acidic pH promotes angiogenesis: An in vitro and in vivo study. J Endod. 46:1113–1119. 2020.PubMed/NCBI View Article : Google Scholar

17 

Rofstad EK, Mathiesen B, Kindem K and Galappathi K: Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res. 66:6699–6707. 2006.PubMed/NCBI View Article : Google Scholar

18 

Faes S, Uldry E, Planche A, Santoro T, Pythoud C, Demartines N and Dormond O: Acidic pH reduces VEGF-mediated endothelial cell responses by downregulation of VEGFR-2; relevance for anti-angiogenic therapies. Oncotarget. 7:86026–86038. 2016.PubMed/NCBI View Article : Google Scholar

19 

Lin YC, Chen JH, Han KW and Shen WC: Ablation of liver tumor by injection of hypertonic saline. AJR Am J Roentgenol. 184:212–219. 2005.PubMed/NCBI View Article : Google Scholar

20 

Shields CJ, Winter DC, Geibel JP, O'Sullivan GC, Wang JH and Redmond HP: Hypertonic saline attenuates colonic tumor cell metastatic potential by activating transmembrane sodium conductance. J Membr Biol. 211:35–42. 2006.PubMed/NCBI View Article : Google Scholar

21 

Wang Y, Peng C, Wang G, Xu Z, Luo Y, Wang J and Zhu W: Exploring binding mechanisms of VEGFR2 with three drugs lenvatinib, sorafenib, and sunitinib by molecular dynamics simulation and free energy calculation. Chem Biol Drug Des. 93:934–948. 2019.PubMed/NCBI View Article : Google Scholar

22 

Phillips JC, Braun R, Wang W, Gumbart J, Tajkhorshid E, Villa E, Chipot C, Skeel RD, Kalé L and Schulten K: Scalable molecular dynamics with NAMD. J Comput Chem. 26:1781–1802. 2005.PubMed/NCBI View Article : Google Scholar

23 

Lee J, Cheng X, Swails JM, Yeom MS, Eastman PK, Lemkul JA, Wei S, Buckner J, Jeong JC, Qi Y, et al: CHARMM-GUI input generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM simulations using the CHARMM36 additive force field. J Chem Theory Comput. 12:405–413. 2016.PubMed/NCBI View Article : Google Scholar

24 

Jo S, Kim T, Iyer VG and Im W: CHARMM-GUI: A web-based graphical user interface for CHARMM. J Comput Chem. 29:1859–1865. 2008.PubMed/NCBI View Article : Google Scholar

25 

Anandakrishnan R, Aguilar B and Onufriev AV: H++ 3.0: Automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations. Nucleic Acids Res. 40 (Web Server Issue):W537–W541. 2012.PubMed/NCBI View Article : Google Scholar

26 

Bajbouj K, Qaisar R, Alshura MA, Ibrahim Z, Alebaji MB, Al Ani AW, Janajrah HM, Bilalaga MM, Omara AI, Assaleh RS, et al: Synergistic anti-angiogenic effect of combined VEGFR kinase inhibitors, lenvatinib, and regorafenib: A therapeutic potential for breast cancer. Int J Mol Sci. 23(4408)2022.PubMed/NCBI View Article : Google Scholar

27 

Lee S and Shanti A: Effect of exogenous pH on cell growth of breast cancer cells. Int J Mol Sci. 22(9910)2021.PubMed/NCBI View Article : Google Scholar

28 

Tan W, Zhang K, Chen X, Yang L, Zhu S, Wei Y, Xie Z, Chen Y and Shang C: GPX2 is a potential therapeutic target to induce cell apoptosis in lenvatinib against hepatocellular carcinoma. J Adv Res. 44:173–183. 2023.PubMed/NCBI View Article : Google Scholar

29 

Ye J, Qi L, Liang J, Zong K, Liu W, Li R, Feng R and Zhai W: Lenvatinib induces anticancer activity in gallbladder cancer by targeting AKT. J Cancer. 12:3548–3557. 2021.PubMed/NCBI View Article : Google Scholar

30 

Almeida VM, Bezerra MA Jr, Nascimento JC and Amorim LMF: Anticancer drug screening: Standardization of in vitro wound healing assay. J Bras Patol Med Lab. 55:606–619. 2019.

31 

Yu Z, Lou L and Zhao Y: Fibroblast growth factor 18 promotes the growth, migration and invasion of MDA-MB-231 cells. Oncol Rep. 40:704–714. 2018.PubMed/NCBI View Article : Google Scholar

32 

Razak NA, Abu N, Ho WY, Zamberi NR, Tan SW, Alitheen NB, Long K and Yeap SK: Cytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis. Sci Rep. 9(1514)2019.PubMed/NCBI View Article : Google Scholar

33 

Yin L, Gupta R, Vaught L, Grosche A, Okunieff P and Vidyasagar S: An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation. Sci Rep. 6(37220)2016.PubMed/NCBI View Article : Google Scholar

34 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

35 

Willebrand R, Hamad I, Van Zeebroeck L, Kiss M, Bruderek K, Geuzens A, Swinnen D, Côrte-Real BF, Markó L, Lebegge E, et al: High salt inhibits tumor growth by enhancing anti-tumor immunity. Front Immunol. 10(1141)2019.PubMed/NCBI View Article : Google Scholar

36 

Li T, Liu T, Zhu W, Xie S, Zhao Z, Feng B, Guo H and Yang R: Targeting MDSC for immune-checkpoint blockade in cancer immunotherapy: Current progress and new prospects. Clin Med Insights Oncol. 15(11795549211035540)2021.PubMed/NCBI View Article : Google Scholar

37 

Zhao Y, Du J and Shen X: Targeting myeloid-derived suppressor cells in tumor immunotherapy: Current, future and beyond. Front Immunol. 14(1157537)2023.PubMed/NCBI View Article : Google Scholar

38 

He W, Xu J, Mu R, Li Q, Lv DL, Huang Z, Zhang J, Wang C and Dong L: High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation. Nat Commun. 11(1732)2020.PubMed/NCBI View Article : Google Scholar

39 

Petersen MC and Greene AS: Inhibition of angiogenesis by high salt diet is associated with impaired muscle performance following chronic muscle stimulation. Microcirculation. 15:405–416. 2008.PubMed/NCBI View Article : Google Scholar

40 

Lankhorst S, Severs D, Markó L, Rakova N, Titze J, Müller DN, Danser AHJ and van den Meiracker AH: Salt sensitivity of angiogenesis inhibition-induced blood pressure rise: Role of interstitial sodium accumulation? Hypertension. 69:919–926. 2017.PubMed/NCBI View Article : Google Scholar

41 

Burbridge MF, West DC, Atassi G and Tucker GC: The effect of extracellular pH on angiogenesis in vitro. Angiogenesis. 3:281–288. 1999.PubMed/NCBI View Article : Google Scholar

42 

Loges S, Schmidt T and Carmeliet P: Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates. Genes Cancer. 1:12–25. 2010.PubMed/NCBI View Article : Google Scholar

43 

Chen D, Walsh K and Wang J: Regulation of cdk2 activity in endothelial cells that are inhibited from growth by cell contact. Arterioscler Thromb Vasc Biol. 20:629–635. 2000.PubMed/NCBI View Article : Google Scholar

44 

Vleugel MM, Greijer AE, Bos R, van der Wall E and van Diest PJ: c-Jun activation is associated with proliferation and angiogenesis in invasive breast cancer. Hum Pathol. 37:668–674. 2006.PubMed/NCBI View Article : Google Scholar

45 

Vanauberg D, Schulz C and Lefebvre T: Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: A promising target in anti-cancer therapies. Oncogenesis. 12(16)2023.PubMed/NCBI View Article : Google Scholar

46 

Hsu SF, Lee YB, Lee YC, Chung AL, Apaya MK, Shyur LF, Cheng CF, Ho FM and Meng TC: Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1. FEBS J. 285:1593–1610. 2018.PubMed/NCBI View Article : Google Scholar

47 

Ran R, Lu A, Zhang L, Tang Y, Zhu H, Xu H, Feng Y, Han C, Zhou G and Sharp FR: Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling. Genes Dev. 18:1466–1481. 2004.PubMed/NCBI View Article : Google Scholar

48 

Hammond CM, Bao H, Hendriks IA, Carraro M, Garcia-Nieto A, Liu Y, Reverón-Gómez N, Spanos C, Chen L, Rappsilber J, et al: DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network. Mol Cell. 81:2533–2548.e9. 2021.PubMed/NCBI View Article : Google Scholar

49 

Ward C, Meehan J, Gray ME, Murray AF, Argyle DJ, Kunkler IH and Langdon SP: The impact of tumour pH on cancer progression: strategies for clinical intervention. Explor Target Antitumor Ther. 1:71–100. 2020.PubMed/NCBI View Article : Google Scholar

50 

Swietach P, Hulikova A, Vaughan-Jones RD and Harris AL: New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation. Oncogene. 29:6509–6521. 2010.PubMed/NCBI View Article : Google Scholar

51 

McIntyre A, Patiar S, Wigfield S, Li JL, Ledaki I, Turley H, Leek R, Snell C, Gatter K, Sly WS, et al: Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. Clin Cancer Res. 18:3100–3111. 2012.PubMed/NCBI View Article : Google Scholar

52 

Neri D and Supuran CT: Interfering with pH regulation in tumours as a therapeutic strategy. Nat Rev Drug Discov. 10:767–777. 2011.PubMed/NCBI View Article : Google Scholar

53 

Parks SK, Chiche J and Pouysségur J: Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer. 13:611–623. 2013.PubMed/NCBI View Article : Google Scholar

54 

Faes S, Duval AP, Planche A, Uldry E, Santoro T, Pythoud C, Stehle JC, Horlbeck J, Letovanec I, Riggi N, et al: Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors. Mol Cancer. 15(78)2016.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Prajapati S, Prajapati B, Patel M and Gupta R: Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors. World Acad Sci J 6: 63, 2024.
APA
Prajapati, S., Prajapati, B., Patel, M., & Gupta, R. (2024). Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors. World Academy of Sciences Journal, 6, 63. https://doi.org/10.3892/wasj.2024.278
MLA
Prajapati, S., Prajapati, B., Patel, M., Gupta, R."Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors". World Academy of Sciences Journal 6.6 (2024): 63.
Chicago
Prajapati, S., Prajapati, B., Patel, M., Gupta, R."Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors". World Academy of Sciences Journal 6, no. 6 (2024): 63. https://doi.org/10.3892/wasj.2024.278
Copy and paste a formatted citation
x
Spandidos Publications style
Prajapati S, Prajapati B, Patel M and Gupta R: Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors. World Acad Sci J 6: 63, 2024.
APA
Prajapati, S., Prajapati, B., Patel, M., & Gupta, R. (2024). Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors. World Academy of Sciences Journal, 6, 63. https://doi.org/10.3892/wasj.2024.278
MLA
Prajapati, S., Prajapati, B., Patel, M., Gupta, R."Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors". World Academy of Sciences Journal 6.6 (2024): 63.
Chicago
Prajapati, S., Prajapati, B., Patel, M., Gupta, R."Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors". World Academy of Sciences Journal 6, no. 6 (2024): 63. https://doi.org/10.3892/wasj.2024.278
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