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Association between TSH and creatinine levels in patients with hypothyroidism

  • Authors:
    • Sara A. Hwisa
    • Namat A. Soliman
    • Mofeda M. Faraj
    • Ghada M. Salem
    • Anaya M. Alosta
    • Salsabiel O. Alshoshan
    • Retag F. Alfituri
    • Zaid A. Aziez
  • View Affiliations / Copyright

    Affiliations: Department of Medical and Basic Sciences, Faculty of Dentistry, University of Zawia, Zawia 16418, Libya, Department of Medical Technology, Faculty of Health Sciences University of Zawia, Zawia 16418, Libya, Libyan Authority for Scientific Research, Tripoli 80045, Libya, Department of Medical Technology, Higher Institute of Medical Sciences and Technologies, Tripoli 16418, Libya
    Copyright: © Hwisa et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 73
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    Published online on: October 10, 2024
       https://doi.org/10.3892/wasj.2024.288
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Abstract

Thyroid hormones play a crucial role in regulating renal function, and hypothyroidism ranks among the most prevalent endocrine disorders worldwide. The present study aimed to investigate the association between thyroid stimulating hormone (TSH) levels and creatinine levels in patients with hypothyroidism. A descriptive cross‑sectional study design was applied, and a cohort of patients with hypothyroidism was recruited from medical centers. The age range of the participants was between 13 to 84 years. The patients were categorized into four groups based on their TSH values as follows: Group 1, patients with a TSH level >4.00 µIU/l; group 2, patients with a TSH level <0.46 µIU/l; group 3, patients with a TSH level ranging from 0.60 to 2.8 µIU/l; and group 4, patients with a TSH level ranging from 2.94 to 3.60 µIU/l. Among the 120 participants, consisting of 30 control subjects and 90 patients with hypothyroidism, 74 subjects not undergoing dialysis exhibited statistically significant differences in TSH and creatinine levels across the four hypothyroid groups (P<0.05). Correlation analysis revealed positive correlations between TSH and creatinine levels in groups 1 (r=0.446, P=0.043), 3 (r=0.541, P=0.001) and 4 (r=0.748, P=0.005). Conversely, a negative correlation was observed between TSH and creatinine levels in group 2 (r=‑0.892, P=0.001). The control group displayed a weak negative correlation between TSH and creatinine (r=‑0.367, P=0.046). The TSH levels exhibited positive correlations with creatinine levels in all groups, with the exception of group 2, where a negative correlation was observed. These findings suggest a potential association between thyroid function and kidney dysfunction. This observation highlights a complex interaction between thyroid function and kidney health. The positive correlation between TSH and creatinine levels in the majority of the groups suggests that higher TSH levels are associated with higher creatinine levels, indicating potential thyroid dysfunction and impaired kidney function. However, the negative correlation in group 2 suggests a different or even opposite relationship in that specific group.
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Copy and paste a formatted citation
Spandidos Publications style
Hwisa SA, Soliman NA, Faraj MM, Salem GM, Alosta AM, Alshoshan SO, Alfituri RF and Aziez ZA: Association between TSH and creatinine levels in patients with hypothyroidism. World Acad Sci J 6: 73, 2024.
APA
Hwisa, S.A., Soliman, N.A., Faraj, M.M., Salem, G.M., Alosta, A.M., Alshoshan, S.O. ... Aziez, Z.A. (2024). Association between TSH and creatinine levels in patients with hypothyroidism. World Academy of Sciences Journal, 6, 73. https://doi.org/10.3892/wasj.2024.288
MLA
Hwisa, S. A., Soliman, N. A., Faraj, M. M., Salem, G. M., Alosta, A. M., Alshoshan, S. O., Alfituri, R. F., Aziez, Z. A."Association between TSH and creatinine levels in patients with hypothyroidism". World Academy of Sciences Journal 6.6 (2024): 73.
Chicago
Hwisa, S. A., Soliman, N. A., Faraj, M. M., Salem, G. M., Alosta, A. M., Alshoshan, S. O., Alfituri, R. F., Aziez, Z. A."Association between TSH and creatinine levels in patients with hypothyroidism". World Academy of Sciences Journal 6, no. 6 (2024): 73. https://doi.org/10.3892/wasj.2024.288
Copy and paste a formatted citation
x
Spandidos Publications style
Hwisa SA, Soliman NA, Faraj MM, Salem GM, Alosta AM, Alshoshan SO, Alfituri RF and Aziez ZA: Association between TSH and creatinine levels in patients with hypothyroidism. World Acad Sci J 6: 73, 2024.
APA
Hwisa, S.A., Soliman, N.A., Faraj, M.M., Salem, G.M., Alosta, A.M., Alshoshan, S.O. ... Aziez, Z.A. (2024). Association between TSH and creatinine levels in patients with hypothyroidism. World Academy of Sciences Journal, 6, 73. https://doi.org/10.3892/wasj.2024.288
MLA
Hwisa, S. A., Soliman, N. A., Faraj, M. M., Salem, G. M., Alosta, A. M., Alshoshan, S. O., Alfituri, R. F., Aziez, Z. A."Association between TSH and creatinine levels in patients with hypothyroidism". World Academy of Sciences Journal 6.6 (2024): 73.
Chicago
Hwisa, S. A., Soliman, N. A., Faraj, M. M., Salem, G. M., Alosta, A. M., Alshoshan, S. O., Alfituri, R. F., Aziez, Z. A."Association between TSH and creatinine levels in patients with hypothyroidism". World Academy of Sciences Journal 6, no. 6 (2024): 73. https://doi.org/10.3892/wasj.2024.288
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