Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
World Academy of Sciences Journal
Join Editorial Board Propose a Special Issue
Print ISSN: 2632-2900 Online ISSN: 2632-2919
Journal Cover
January-February 2025 Volume 7 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-February 2025 Volume 7 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Integrating expression profiling and computational modeling to elucidate PTEN‑miR‑141 interactions in oral squamous cell carcinoma

  • Authors:
    • Annanya Arora
    • Ashikha Shirin Usman Puthiya Purayil
    • Ameya Kizhakke Parambath
    • Durairaj Sekar
  • View Affiliations / Copyright

    Affiliations: Department of Prosthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai, Tamil Nadu 600077, India, RNA Biology Laboratory, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai, Tamil Nadu 600077, India
    Copyright: © Arora et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 12
    |
    Published online on: December 2, 2024
       https://doi.org/10.3892/wasj.2024.300
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

With a limited number of therapeutic options available, oral squamous cell carcinoma (OSCC) continues to pose a severe health burden, contributing to it high mortality rate. The tumor suppressor, phosphatase and tensin homolog (PTEN), is typically downregulated in OSCC, which aids in tumor growth. PTEN expression can be regulated by microRNAs (miRNAs/miRs), affecting the course of illness. In the present study, a possible PTEN regulator, miR‑141, was found by computational analysis. PTEN and miR‑141 expression profiling was performed on the samples of patients with OSCC and compared to that of healthy controls. The results revealed a significant inverse correlation between PTEN and miR‑141 expression in OSCC tissues. Specifically, miR‑141 levels were elevated, while PTEN expression was markedly downregulated in cancerous samples compared with the controls. This inverse correlation suggests that miR‑141 may play a regulatory role in silencing PTEN, contributing to the progression of OSCC. These findings provide valuable insight into the molecular mechanisms underlying OSCC and suggest that miR‑141 functions as an oncogenic miRNA in this context by targeting PTEN. The findings presented herein may have broad significance, since they may prove to be valuable for the development of new treatment approaches through the miR‑141/PTEN axis. Restoring PTEN expression by targeting miR‑141 may provide a novel treatment strategy for OSCC. PTEN and miR‑141 may also function as prospective biomarkers for early diagnosis, providing chances to enhance patient outcomes via individualized treatment plans. However, further research is required to further determine the therapeutic potential of this regulatory axis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Arumugam P, M SM and Jayaseelan VP: A novel m6A reader RBFOX2 expression is increased in oral squamous cell carcinoma and promotes tumorigenesis. J Stomatol Oral Maxillofac Surg. 102041:2024.PubMed/NCBI View Article : Google Scholar

2 

Murugesan D, Kannan B, As SG, Jayaseelan VP and Arumugam P: Alteration of SERPINH1 is associated with elevated expression in head and neck squamous cell carcinomas and its clinicopathological significance. J Stomatol Oral Maxillofac Surg. 125(101811)2024.PubMed/NCBI View Article : Google Scholar

3 

Miguelanez-Medran BC, Pozo-Kreilinger JJ, Cebrian-Carretero JL, Martinez-Garcia MA and Lopez-Sanchez AF: Oral squamous cell carcinoma of tongue: Histological risk assessment. A pilot study. Med Oral Patol Oral Cir Bucal. 24:e603–e609. 2019.PubMed/NCBI View Article : Google Scholar

4 

Sri S, Ramani P, Premkumar P, Ramshankar V, Ramasubramanian A and Krishnan R: Prevalence of Human Papillomavirus (HPV) 16 and 18 in oral malignant and potentially malignant disorders: A polymerase chain reaction analysis-A comparative study. Ann Maxillofac Surg. 11:6–11. 2021.PubMed/NCBI View Article : Google Scholar

5 

Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, Nice EC, Tang J and Huang C: Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci. 15(44)2023.PubMed/NCBI View Article : Google Scholar

6 

Shetty SS, Sharma M, Fonseca FP, Jayaram P, Tanwar AS, Kabekkodu SP, Kapaettu S and Radhakrishnan R: Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma. Jpn Dent Sci Rev. 56:97–108. 2020.PubMed/NCBI View Article : Google Scholar

7 

Liu M, Song H, Xing Z, Lu G, Li J and Chen D: Correlation between PTEN gene polymorphism and oral squamous cell carcinoma. Oncol Lett. 18:1755–1760. 2019.PubMed/NCBI View Article : Google Scholar

8 

Fusco N, Sajjadi E, Venetis K, Gaudioso G, Lopez G, Corti C, Rocco EG, Criscitiello C, Malapelle U and Invernizzi M: PTEN alterations and their role in cancer management: Are we making headway on precision medicine? Genes (Basel). 11(719)2020.PubMed/NCBI View Article : Google Scholar

9 

Travis G, McGowan EM, Simpson AM, Marsh DJ and Nassif NT: PTEN, PTENP1, microRNAs, and ceRNA Networks: Precision targeting in cancer therapeutics. Cancers (Basel). 15(4954)2023.PubMed/NCBI View Article : Google Scholar

10 

Diener C, Keller A and Meese E: The miRNA-target interactions: An underestimated intricacy. Nucleic Acids Res. 52:1544–1557. 2024.PubMed/NCBI View Article : Google Scholar

11 

Chakrabortty A, Patton DJ, Smith BF and Agarwal P: miRNAs: Potential as biomarkers and therapeutic targets for cancer. Genes (Basel). 14(1375)2023.PubMed/NCBI View Article : Google Scholar

12 

Gu Y, Tang S, Wang Z, Cai L, Shen Y and Zhou Y: Identification of key miRNAs and targeted genes involved in the progression of oral squamous cell carcinoma. J Dent Sci. 17:666–676. 2022.PubMed/NCBI View Article : Google Scholar

13 

Ahsan M, K P A, Usman P P AS and Sekar D: Computational and expression analysis of microRNA-149-5p and its target, interleukin-6, in chronic kidney disease. Biomed Res Ther. 10:6103–6109. 2023.

14 

Suthagar P, Purayil ASUP, Parambath AK and Sekar D: In silico identification and gene expression of miR-148a-5p and IL-6 in hypothyroid patient blood samples. Biomed Res Ther. 11:6379–6386. 2024.

15 

Narayan RN, Parambath AK, Purayil ASUP and Sekar D: microRNA-9-5p and its target nuclear factor kappa B are differentially expressed in type-2 diabetes patients. Biomed Res Ther. 11:6183–6190. 2024.

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

17 

Oral cancer - the fight must go on against all odds. Evid Based Dent. 23:4–5. 2022.PubMed/NCBI View Article : Google Scholar

18 

Mesgari H, Esmaelian S, Nasiri K, Ghasemzadeh S, Doroudgar P and Payandeh Z: Epigenetic regulation in oral squamous cell carcinoma microenvironment: A comprehensive review. Cancers (Basel). 15(5600)2023.PubMed/NCBI View Article : Google Scholar

19 

Zedan AH, Osther PJS, Assenholt J, Madsen JS and Hansen TF: Circulating miR-141 and miR-375 are associated with treatment outcome in metastatic castration resistant prostate cancer. Sci Rep. 10(227)2020.PubMed/NCBI View Article : Google Scholar

20 

Guz M, Jeleniewicz W and Cybulski M: Interactions between circRNAs and miR-141 in Cancer: From pathogenesis to diagnosis and therapy. Int J Mol Sci. 24(11861)2023.PubMed/NCBI View Article : Google Scholar

21 

Khare S, Khare T, Ramanathan R and Ibdah JA: Hepatocellular Carcinoma: The Role of MicroRNAs. Biomolecules. 12(645)2022.PubMed/NCBI View Article : Google Scholar

22 

Yang H, Liu Y, Chen L, Zhao J, Guo M, Zhao X, Wen Z, He Z, Chen C and Xu L: MiRNA-based therapies for lung cancer: Opportunities and challenges? Biomolecules. 13(877)2023.PubMed/NCBI View Article : Google Scholar

23 

Bou Antoun N and Chioni AM: Dysregulated signalling pathways driving anticancer drug resistance. Int J Mol Sci. 24(12222)2023.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Arora A, Usman Puthiya Purayil A, Kizhakke Parambath A and Sekar D: Integrating expression profiling and computational modeling to elucidate PTEN‑miR‑141 interactions in oral squamous cell carcinoma. World Acad Sci J 7: 12, 2025.
APA
Arora, A., Usman Puthiya Purayil, A., Kizhakke Parambath, A., & Sekar, D. (2025). Integrating expression profiling and computational modeling to elucidate PTEN‑miR‑141 interactions in oral squamous cell carcinoma. World Academy of Sciences Journal, 7, 12. https://doi.org/10.3892/wasj.2024.300
MLA
Arora, A., Usman Puthiya Purayil, A., Kizhakke Parambath, A., Sekar, D."Integrating expression profiling and computational modeling to elucidate PTEN‑miR‑141 interactions in oral squamous cell carcinoma". World Academy of Sciences Journal 7.1 (2025): 12.
Chicago
Arora, A., Usman Puthiya Purayil, A., Kizhakke Parambath, A., Sekar, D."Integrating expression profiling and computational modeling to elucidate PTEN‑miR‑141 interactions in oral squamous cell carcinoma". World Academy of Sciences Journal 7, no. 1 (2025): 12. https://doi.org/10.3892/wasj.2024.300
Copy and paste a formatted citation
x
Spandidos Publications style
Arora A, Usman Puthiya Purayil A, Kizhakke Parambath A and Sekar D: Integrating expression profiling and computational modeling to elucidate PTEN‑miR‑141 interactions in oral squamous cell carcinoma. World Acad Sci J 7: 12, 2025.
APA
Arora, A., Usman Puthiya Purayil, A., Kizhakke Parambath, A., & Sekar, D. (2025). Integrating expression profiling and computational modeling to elucidate PTEN‑miR‑141 interactions in oral squamous cell carcinoma. World Academy of Sciences Journal, 7, 12. https://doi.org/10.3892/wasj.2024.300
MLA
Arora, A., Usman Puthiya Purayil, A., Kizhakke Parambath, A., Sekar, D."Integrating expression profiling and computational modeling to elucidate PTEN‑miR‑141 interactions in oral squamous cell carcinoma". World Academy of Sciences Journal 7.1 (2025): 12.
Chicago
Arora, A., Usman Puthiya Purayil, A., Kizhakke Parambath, A., Sekar, D."Integrating expression profiling and computational modeling to elucidate PTEN‑miR‑141 interactions in oral squamous cell carcinoma". World Academy of Sciences Journal 7, no. 1 (2025): 12. https://doi.org/10.3892/wasj.2024.300
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team