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Review Open Access

Role of ethnic and genetic factors in the development of prostate cancer (Review)

  • Authors:
    • Timur Saliev
    • Nurgulim Akhmad
    • Saule Altynbekova
    • Maral Nogaeva
    • Aigul Tazhieva
    • Zaure Dushimova
  • View Affiliations / Copyright

    Affiliations: Institute for Fundamental and Applied Medical Research, S.D. Asfendiyarov Kazakh National Medical University, Almaty 050000, Kazakhstan, Department of Normal Anatomy, S.D. Asfendiyarov Kazakh National Medical University, Almaty 050000, Kazakhstan, Department of Endocrinology, S.D. Asfendiyarov Kazakh National Medical University, Almaty 050000, Kazakhstan, Department of Rheumatology, S.D. Asfendiyarov Kazakh National Medical University, Almaty 050000, Kazakhstan, Department of Science, S.D. Asfendiyarov Kazakh National Medical University, Almaty 050000, Kazakhstan, Department of Fundamental Medicine, Al‑Farabi Kazakh National University, Almaty 050040, Kazakhstan
    Copyright: © Saliev et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 13
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    Published online on: December 3, 2024
       https://doi.org/10.3892/wasj.2024.301
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Abstract

Prostate cancer (PCa) is one of the most common malignancies worldwide, particularly affecting older males. Genetic and ethnic factors play a critical role in the development, progression and mortality rate associated with PCa. The present review focuses on the influence of race and genetic predisposition, particularly the mutations in BRCA1 and BRCA2 genes, which markedly increase the risk of developing aggressive forms of PCa. African American males, in particular, are more susceptible to PCa, with a higher incidence of aggressive disease compared to other ethnic groups. These genetic disparities highlight the importance of targeted genetic screening and personalized healthcare strategies to mitigate the risk of developing PCa in vulnerable populations. The key conclusions from the present review emphasize the necessity of integrating genetic testing into routine PCa screening protocols, particularly for high‑risk groups, such as males with a family history of PCa or those of African descent. Personalized treatment options, such as the use of PARP inhibitors for patients with BRCA mutations, present a promising approach to improving the outcomes of patients with PCa. The present review calls for further research into the interactions between genetic and environmental factors in PCa and the development of tailored intervention programs to reduce incidence and mortality among high‑risk populations. Expanding access to genetic counselling and testing services is crucial to improving early detection and preventive care.
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Copy and paste a formatted citation
Spandidos Publications style
Saliev T, Akhmad N, Altynbekova S, Nogaeva M, Tazhieva A and Dushimova Z: Role of ethnic and genetic factors in the development of prostate cancer (Review). World Acad Sci J 7: 13, 2025.
APA
Saliev, T., Akhmad, N., Altynbekova, S., Nogaeva, M., Tazhieva, A., & Dushimova, Z. (2025). Role of ethnic and genetic factors in the development of prostate cancer (Review). World Academy of Sciences Journal, 7, 13. https://doi.org/10.3892/wasj.2024.301
MLA
Saliev, T., Akhmad, N., Altynbekova, S., Nogaeva, M., Tazhieva, A., Dushimova, Z."Role of ethnic and genetic factors in the development of prostate cancer (Review)". World Academy of Sciences Journal 7.1 (2025): 13.
Chicago
Saliev, T., Akhmad, N., Altynbekova, S., Nogaeva, M., Tazhieva, A., Dushimova, Z."Role of ethnic and genetic factors in the development of prostate cancer (Review)". World Academy of Sciences Journal 7, no. 1 (2025): 13. https://doi.org/10.3892/wasj.2024.301
Copy and paste a formatted citation
x
Spandidos Publications style
Saliev T, Akhmad N, Altynbekova S, Nogaeva M, Tazhieva A and Dushimova Z: Role of ethnic and genetic factors in the development of prostate cancer (Review). World Acad Sci J 7: 13, 2025.
APA
Saliev, T., Akhmad, N., Altynbekova, S., Nogaeva, M., Tazhieva, A., & Dushimova, Z. (2025). Role of ethnic and genetic factors in the development of prostate cancer (Review). World Academy of Sciences Journal, 7, 13. https://doi.org/10.3892/wasj.2024.301
MLA
Saliev, T., Akhmad, N., Altynbekova, S., Nogaeva, M., Tazhieva, A., Dushimova, Z."Role of ethnic and genetic factors in the development of prostate cancer (Review)". World Academy of Sciences Journal 7.1 (2025): 13.
Chicago
Saliev, T., Akhmad, N., Altynbekova, S., Nogaeva, M., Tazhieva, A., Dushimova, Z."Role of ethnic and genetic factors in the development of prostate cancer (Review)". World Academy of Sciences Journal 7, no. 1 (2025): 13. https://doi.org/10.3892/wasj.2024.301
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