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One‑year cholecalciferol supplementation fails to improve bone mineral density or inflammation in patients with vitamin D deficiency undergoing hemodialysis

  • Authors:
    • Maria Divani
    • Panagiota Makri
    • Georgios Pissas
    • Maria Tziastoudi
    • Christina Poulianiti
    • Maria-Anna Polyzou‑konsta
    • Evangelos Lykotsetas
    • Ioannis Stefanidis
    • Theodoros Eleftheriadis
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece
    Copyright: © Divani et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 18
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    Published online on: December 24, 2024
       https://doi.org/10.3892/wasj.2024.306
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Abstract

Deficiency in 25‑hydroxyvitamin D [25(OH)D] is prevalent among patients undergoing hemodialysis (HD) and is associated with poorer clinical outcomes. The KDIGO guidelines advocate for 25(OH)D supplementation in these patients. In the present study, cholecalciferol was administered to patients undergoing HD exhibiting 25(OH)D deficiency over a period of 1 year. After excluding non‑compliant participants, 20 patients completed the study. Bone mineral density (BMD), as well as the T‑score and Z‑score of the lumbar spine and total hip were assessed pre‑ and post‑supplementation using dual‑energy X‑ray absorptiometry. Additionally, the serum levels of 25(OH)D, intact parathyroid hormone (iPTH), calcium, phosphorus, C‑reactive protein (CRP) and the neutrophil‑to‑lymphocyte ratio were evaluated. Cholecalciferol supplementation increased the 25(OH)D levels; however, it did not result in significant changes in lumbar spine T‑score, Z‑score or BMD. However, a decrease in the total hip T‑score and BMD was observed by the end of the study period. The serum levels of iPTH, calcium and phosphorus remained stable. Similarly, the levels of inflammation markers, including CRP and the neutrophil‑to‑lymphocyte ratio, did not exhibit any significant changes. Thus, the present study demonstrates that 1‑year cholecalciferol supplementation increases the 25(OH)D levels, but does not improve BMD or inflammation among patients with vitamin D deficiency undergoing HD. Further investigations with larger patient cohorts are required to confirm these findings and to potentially reconsider the relevant KDIGO guidelines.
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1 

Christakos S, Dhawan P, Verstuyf A, Verlinden L and Carmeliet G: Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev. 96:365–408. 2016.PubMed/NCBI View Article : Google Scholar

2 

Gil Á, Plaza-Diaz J and Mesa MD: Vitamin D: Classic and novel actions. Ann Nutr Metab. 72:87–95. 2018.PubMed/NCBI View Article : Google Scholar

3 

Jean G, Souberbielle J and Chazot C: Vitamin D in chronic kidney disease and dialysis patients. Nutrients. 9(328)2017.PubMed/NCBI View Article : Google Scholar

4 

Sreevani M, Rao BS and Srivanvani S: Vitamin D levels among chronic kidney disease patients at a tertiary care hospital: A cross-sectional study. Natl J Lab Med. 13:BO01–BO04. 2024.

5 

Franchi M, Gunnarsson J, Gonzales-Parra E, Ferreira A, Ström O and Corrao G: Paricalcitol and extended-release calcifediol for treatment of secondary hyperparathyroidism in non-dialysis chronic kidney disease: Results from a network meta-analysis. J Clin Endocrinol Metab. 108:e1424–e1432. 2023.PubMed/NCBI View Article : Google Scholar

6 

da Silva Canhos MM, de Oliveira RC, Modelli de Andrade LG, Caramori JCT, Barretti P and Martin LC: Association between vitamin D levels and mortality in hemodialysis patients: A cohort study. Ren Fail. 42:225–233. 2020.PubMed/NCBI View Article : Google Scholar

7 

Sutherland JP, Zhou A and Hyppönen E: Vitamin D deficiency increases mortality risk in the UK biobank: A nonlinear mendelian randomization study. Ann Intern Med. 175:1552–1559. 2022.PubMed/NCBI View Article : Google Scholar

8 

Kidney Disease, Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group. KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Suppl (2011). 7:1–59. 2017.PubMed/NCBI View Article : Google Scholar

9 

Bouillon R and Bikle D: Vitamin D metabolism revised: Fall of dogmas. J Bone Miner Res. 34:1985–1992. 2019.PubMed/NCBI View Article : Google Scholar

10 

Pike JW and Meyer MB: The unsettled science of nonrenal calcitriol production and its clinical relevance. J Clin Invest. 130:4519–4521. 2020.PubMed/NCBI View Article : Google Scholar

11 

van Driel M and van Leeuwen JPTM: Vitamin D and bone: A story of endocrine and auto/paracrine action in osteoblasts. Nutrients. 15(480)2023.PubMed/NCBI View Article : Google Scholar

12 

Verlinden L and Carmeliet G: Integrated view on the role of vitamin D actions on bone and growth plate homeostasis. JBMR Plus. 5(e10577)2021.PubMed/NCBI View Article : Google Scholar

13 

Segersten U, Correa P, Hewison M, Hellman P, Dralle H, Carling T, Akerström G and Westin G: 25-Hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands. J Clin Endocrinol Metab. 87:2967–2972. 2002.PubMed/NCBI View Article : Google Scholar

14 

Chen X, Chu C, Doebis C, Xiong Y, Cao Y, Krämer BK, von Baehr V and Hocher B: Vitamin D status and its association with parathyroid hormone in 23,134 outpatients. J Steroid Biochem Mol Biol. 220(106101)2022.PubMed/NCBI View Article : Google Scholar

15 

Eleftheriadis T, Antoniadi G, Liakopoulos V, Stefanidis I and Galaktidou G: Inverse association of serum 25-hydroxyvitamin D with markers of inflammation and suppression of osteoclastic activity in hemodialysis patients. Iran J Kidney Dis. 6:129–135. 2012.PubMed/NCBI

16 

Ghaseminejad-Raeini A, Ghaderi A, Sharafi A, Nematollahi-Sani B, Moossavi M, Derakhshani A and Sarab GA: Immunomodulatory actions of vitamin D in various immune-related disorders: A comprehensive review. Front Immunol. 14(950465)2023.PubMed/NCBI View Article : Google Scholar

17 

Eleftheriadis T, Antoniadi G, Liakopoulos V, Kartsios C, Stefanidis I and Galaktidou G: Paricalcitol reduces basal and lipopolysaccharide-induced (LPS) TNF-alpha and IL-8 production by human peripheral blood mononuclear cells. Int Urol Nephrol. 42:181–185. 2009.PubMed/NCBI View Article : Google Scholar

18 

Kara AV and Soylu YE: The relationship between vitamin D and inflammatory markers in maintenance hemodialysis patients. Int Urol Nephrol. 51:1659–1665. 2019.PubMed/NCBI View Article : Google Scholar

19 

Iimori S, Mori Y, Akita W, Kuyama T, Takada S, Asai T, Kuwahara M, Sasaki S and Tsukamoto Y: Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D patients-a single-center cohort study. Nephrol Dial Transplant. 27:345–351. 2011.PubMed/NCBI View Article : Google Scholar

20 

Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Köstenberger M, Tmava Berisha A, Martucci G, Pilz S and Malle O: Vitamin D deficiency 2.0: An update on the current status worldwide. Eur J Clin Nutr. 74:1498–1513. 2020.PubMed/NCBI View Article : Google Scholar

21 

Ravani P, Malberti F, Tripepi G, Pecchini P, Cutrupi S, Pizzini P, Mallamaci F and Zoccali C: Vitamin D levels and patient outcome in chronic kidney disease. Kidney Int. 75:88–95. 2009.PubMed/NCBI View Article : Google Scholar

22 

Williams S, Khan L and Licata AA: DXA and clinical challenges of fracture risk assessment in primary care. Cleve Clin J Med. 88:615–622. 2021.PubMed/NCBI View Article : Google Scholar

23 

Yucel Kocak S and Ozdemir A: Comparison of bone mineral density and biochemical factors in hemodialysis and peritoneal dialysis patients. Clin Nephrol. 98:115–122. 2022.PubMed/NCBI View Article : Google Scholar

24 

Yeung WCG, Toussaint ND, Lioufas N, Hawley CM, Pascoe EM, Elder GJ, Valks A and Badve SV: Vitamin D status and intermediate vascular and bone outcomes in chronic kidney disease: A secondary post hoc analysis of IMPROVE-CKD. Intern Med J. 54:1960–1969. 2024.PubMed/NCBI View Article : Google Scholar

25 

Elder GJ and Mackun K: 25-Hydroxyvitamin D deficiency and diabetes predict reduced BMD in patients with chronic kidney disease. J Bone Miner Res. 21:1778–1784. 2006.PubMed/NCBI View Article : Google Scholar

26 

Bosworth C, de Boer IH, Targher G, Kendrick J, Smits G and Chonchol M: The effect of combined calcium and cholecalciferol supplementation on bone mineral density in elderly women with moderate chronic kidney disease. Clin Nephrol. 77:358–365. 2012.PubMed/NCBI View Article : Google Scholar

27 

Mieczkowski M, Żebrowski P, Wojtaszek E, Stompór T, Przedlacki J, Bartoszewicz Z, Sierdziński J, Wańkowicz Z, Niemczyk S and Matuszkiewicz-Rowińska J: Long-term cholecalciferol administration in hemodialysis patients: A single-center randomized pilot study. Med Sci Monit. 20:2228–2234. 2014.PubMed/NCBI View Article : Google Scholar

28 

Tsikliras N, Anagnostara A, Tsantekidou F and Kyrgialanis A: #495 effect of Vit D supplementation on bone mineral density in haemodialysis patients. A comparative study. Nephrol Dial Transplant. 39 (Suppl 1)(gfae069-1604-495)2024.

29 

Bhan I, Dobens D, Tamez H, Deferio JJ, Li YC, Warren HS, Ankers E, Wenger J, Tucker JK, Trottier C, et al: Nutritional vitamin D supplementation in dialysis: A randomized trial. Clin J Am Soc Nephrol. 10:611–619. 2015.PubMed/NCBI View Article : Google Scholar

30 

Fernández-Martín JL, Martínez-Camblor P, Dionisi MP, Floege J, Ketteler M, London G, Locatelli F, Gorriz JL, Rutkowski B, Ferreira A, et al: Improvement of mineral and bone metabolism markers is associated with better survival in haemodialysis patients: The COSMOS study. Nephrol Dial Transplant. 30:1542–1551. 2015.PubMed/NCBI View Article : Google Scholar

31 

Sasaki K, Shoji T, Kabata D, Shintani A, Okute Y, Tsuchikura S, Shimomura N, Tsujimoto Y, Nakatani S, Mori K, et al: Oxidative stress and inflammation as predictors of mortality and cardiovascular events in hemodialysis patients: The DREAM cohort. J Atheroscler Thromb. 28:249–260. 2021.PubMed/NCBI View Article : Google Scholar

32 

Osawa H, Nakamura N, Tsutaya C, Saitoh H, Shimada M, Murakami R, Fujita T, Narita-Kinjo I, Nagawa D, Nakata M, et al: Role of high-sensitivity C-reactive protein in future cardiovascular events in hemodialysis patients. In Vivo. 38:1351–1358. 2024.PubMed/NCBI View Article : Google Scholar

33 

Mulkareddy V, Bhalla V, Upadhye S and Siddam P: The diagnostic dilemma of sarcoidosis: A case of acute hypercalcemia. Cureus. 12(e10399)2020.PubMed/NCBI View Article : Google Scholar

34 

Pineault J, Lamarche C, Bell R, Lafrance JP, Ouellet G, Leblanc M, Pichette V, Bezzaoucha S and Vallée M: Association of neutrophil-to-lymphocyte ratio with inflammation and erythropoietin resistance in chronic dialysis patients. Can J Kidney Health Dis. 4(2054358117735563)2017.PubMed/NCBI View Article : Google Scholar

35 

Wang Y, Liu Y, Lian Y, Li N, Liu H and Li G: Efficacy of high-dose supplementation with oral vitamin d3 on depressive symptoms in dialysis patients with vitamin D3 insufficiency: A prospective, randomized, double-blind study. J Clin Psychopharmacol. 36:229–235. 2016.PubMed/NCBI View Article : Google Scholar

36 

Zhao L, Zhu G, Wu L and Xie D: Effects of vitamin D on inflammatory state in patients with chronic kidney disease: A controversial issue. Ther Apher Dial. 27:383–393. 2022.PubMed/NCBI View Article : Google Scholar

37 

Eleftheriadis T, Antoniadi G, Liakopoulos V, Kartsios C and Stefanidis I: Basic science and dialysis: Disturbances of acquired immunity in hemodialysis patients. Semin Dial. 20:440–451. 2007.PubMed/NCBI View Article : Google Scholar

38 

Hanna RM, Ghobry L, Wassef O, Rhee CM and Kalantar-Zadeh K: A practical approach to nutrition, protein-energy wasting, sarcopenia, and cachexia in patients with chronic kidney disease. Blood Purif. 49:202–211. 2020.PubMed/NCBI View Article : Google Scholar

39 

Visiedo L, Pérez Abud R, Rivas-Ruiz F, Payan JJ, Rey L, Tortajada B and Abilés J: Hypovitaminosis D and its relationship with nutritional status and quality of life in patients undergoing haemodialysis. Nutr Hosp. 40:144–150. 2023.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Divani M, Makri P, Pissas G, Tziastoudi M, Poulianiti C, Polyzou‑konsta M, Lykotsetas E, Stefanidis I and Eleftheriadis T: One‑year cholecalciferol supplementation fails to improve bone mineral density or inflammation in patients with vitamin D deficiency undergoing hemodialysis. World Acad Sci J 7: 18, 2025.
APA
Divani, M., Makri, P., Pissas, G., Tziastoudi, M., Poulianiti, C., Polyzou‑konsta, M. ... Eleftheriadis, T. (2025). One‑year cholecalciferol supplementation fails to improve bone mineral density or inflammation in patients with vitamin D deficiency undergoing hemodialysis. World Academy of Sciences Journal, 7, 18. https://doi.org/10.3892/wasj.2024.306
MLA
Divani, M., Makri, P., Pissas, G., Tziastoudi, M., Poulianiti, C., Polyzou‑konsta, M., Lykotsetas, E., Stefanidis, I., Eleftheriadis, T."One‑year cholecalciferol supplementation fails to improve bone mineral density or inflammation in patients with vitamin D deficiency undergoing hemodialysis". World Academy of Sciences Journal 7.2 (2025): 18.
Chicago
Divani, M., Makri, P., Pissas, G., Tziastoudi, M., Poulianiti, C., Polyzou‑konsta, M., Lykotsetas, E., Stefanidis, I., Eleftheriadis, T."One‑year cholecalciferol supplementation fails to improve bone mineral density or inflammation in patients with vitamin D deficiency undergoing hemodialysis". World Academy of Sciences Journal 7, no. 2 (2025): 18. https://doi.org/10.3892/wasj.2024.306
Copy and paste a formatted citation
x
Spandidos Publications style
Divani M, Makri P, Pissas G, Tziastoudi M, Poulianiti C, Polyzou‑konsta M, Lykotsetas E, Stefanidis I and Eleftheriadis T: One‑year cholecalciferol supplementation fails to improve bone mineral density or inflammation in patients with vitamin D deficiency undergoing hemodialysis. World Acad Sci J 7: 18, 2025.
APA
Divani, M., Makri, P., Pissas, G., Tziastoudi, M., Poulianiti, C., Polyzou‑konsta, M. ... Eleftheriadis, T. (2025). One‑year cholecalciferol supplementation fails to improve bone mineral density or inflammation in patients with vitamin D deficiency undergoing hemodialysis. World Academy of Sciences Journal, 7, 18. https://doi.org/10.3892/wasj.2024.306
MLA
Divani, M., Makri, P., Pissas, G., Tziastoudi, M., Poulianiti, C., Polyzou‑konsta, M., Lykotsetas, E., Stefanidis, I., Eleftheriadis, T."One‑year cholecalciferol supplementation fails to improve bone mineral density or inflammation in patients with vitamin D deficiency undergoing hemodialysis". World Academy of Sciences Journal 7.2 (2025): 18.
Chicago
Divani, M., Makri, P., Pissas, G., Tziastoudi, M., Poulianiti, C., Polyzou‑konsta, M., Lykotsetas, E., Stefanidis, I., Eleftheriadis, T."One‑year cholecalciferol supplementation fails to improve bone mineral density or inflammation in patients with vitamin D deficiency undergoing hemodialysis". World Academy of Sciences Journal 7, no. 2 (2025): 18. https://doi.org/10.3892/wasj.2024.306
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