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HPV and cervical cancer:  From molecular diagnostics to emerging treatment approaches (Review)

  • Authors:
    • Imam Malik Kabir
    • Rosy Iara Maciel De Azambuja Ribeiro
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    Affiliations: Department of Medical Laboratory Science, Aminu Kano Teaching Hospital, Bayero University, 700213 Kano, Nigeria, Laboratory of Experimental Pathology, Federal University of São João del Rei (UFSJ), Divinópolis, MG 35501‑296, Brazil
    Copyright: © Kabir et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 58
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    Published online on: April 22, 2025
       https://doi.org/10.3892/wasj.2025.346
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Abstract

Cervical cancer remains a significant global health challenge, being the fourth most common type of cancer among women and disproportionately affecting those in low‑ and middle‑income countries. Persistent infection with high‑risk human papillomavirus (HR‑HPV), particularly types 16 and 18, is a critical etiological factor in the pathogenesis of cervical cancer. The present review comprehensively explores the molecular biology of HR‑HPV, its role in cervical carcinogenesis, and the anatomical and histological predispositions of the transformation zone. HPV is associated with warts, cervical cancer and other pre‑cancerous lesions. The association between HPV and the development of cervical cancer follows a pattern: Sexual exposure, persistent infection, the development of pre‑cancerous lesions, and progression to invasive disease. Advances in understanding the interplay of genetic polymorphisms, immune evasion strategies and epigenetic modifications, including DNA methylation and histone modifications, have led to the development of novel strategies for diagnostics and therapeutic interventions. While prophylactic HPV vaccination holds promise in mitigating the disease burden, barriers to accessibility, particularly in low‑resource settings, hinder widespread adoption. Vaccination is targeted towards preventing infection; however, the goal of public health is preventing cervical cancer. The present review underscores the need for integrating genomic, immunological and epidemiological perspectives to develop equitable prevention and treatment strategies. The present review advocates for the inclusion of HPV vaccines in national immunization programs and highlights emerging epigenetic biomarkers as potential tools for early detection. In addition to the available prophylactic vaccines, there is a need for the development of therapeutic vaccines that will target cancer cells.
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1 

Buskwofie A, David-West G and Clare CA: A review of cervical cancer: Incidence and disparities. J Natl Med Assoc. 112:229–232. 2020.PubMed/NCBI View Article : Google Scholar

2 

Malik KI, Aliyu DU, Abubakar BJ, Lukman Y, Sale KA, Alkali BH, Saidu A, Bala DA, Umoru A, Lawal N and Abubakar AI: Identification of high-risk human papillomavirus isolates circulating in Nigeria and phylogenetic analysis based on the virus essential protein. Indian J Gynecol Oncol. 19(87)2021.

3 

Singh D, Vignat J, Lorenzoni V, Eslahi M, Ginsburg O, Lauby-Secretan B, Arbyn M, Basu P, Bray F and Vaccarella S: Global estimates of incidence and mortality of cervical cancer in 2020: A baseline analysis of the WHO global cervical cancer elimination initiative. Lancet Glob Heal. 11:e197–e206. 2023.PubMed/NCBI View Article : Google Scholar

4 

Vu M, Yu J, Awolude OA and Chuang L: Cervical cancer worldwide. Curr Probl Cancer. 42:457–465. 2018.PubMed/NCBI View Article : Google Scholar

5 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA Cancer J Clin. 70:7–30. 2020.PubMed/NCBI View Article : Google Scholar

6 

Collins Y, Holcomb K, Chapman-Davis E, Khabele D and Farley JH: Gynecologic cancer disparities: A report from the health disparities taskforce of the society of gynecologic oncology. Gynecol Oncol. 133:353–361. 2014.PubMed/NCBI View Article : Google Scholar

7 

Siegel RL, Kratzer TB, Giaquinto AN, Sung H and Jemal A: Cancer statistics, 2025. CA Cancer J Clin. 75:10–45. 2025.PubMed/NCBI View Article : Google Scholar

8 

Wu J, Jin Q, Zhang Y, Ji J, Li J, Liu X, Duan H, Feng Z, Liu Y, Zhang Y, et al: Global burden of cervical cancer: Current estimates, temporal trend and future projections based on the GLOBOCAN 2022. J Natl Cancer Cent. 23:1–24. 2025.

9 

zur Hausen H: Papillomaviruses and cancer: From basic studies to clinical application. Nat Rev Cancer. 2:342–350. 2002.PubMed/NCBI View Article : Google Scholar

10 

Akinlotan M, Bolin JN, Helduser J, Ojinnaka C, Lichorad A and McClellan D: Cervical cancer screening barriers and risk factor knowledge among uninsured women. J Community Health. 42:770–778. 2017.PubMed/NCBI View Article : Google Scholar

11 

Johnson CA, James D, Marzan A and Armaos M: Cervical cancer: An overview of pathophysiology and management. Semin Oncol Nurs. 35:166–174. 2019.PubMed/NCBI View Article : Google Scholar

12 

Kabir IM, Dutsinma UA, Bala JA, Yusuf L, Abubakar SD, Kumurya AS, Bulama HA, Bello ZM and Aliyu IA: The need for therapeutic hpv vaccines as a means of curbing the menace of cervical cancer. Indian J Gynecol Oncol. 19(96)2021.

13 

Jenkin D: A brief history of cervical cancer. INC, 2019.

14 

Yousefi Z, Aria H, Ghaedrahmati F, Bakhtiari T, Azizi M, Bastan R, Hosseini R and Eskandari N: An update on human papilloma virus vaccines: History, types, protection, and efficacy. Front Immunol. 12(805695)2022.PubMed/NCBI View Article : Google Scholar

15 

Jain MA and Limaiem F: Human Papillomavirus and Related Diseases From Bench to Bedside A Diagnostic and Preventive Perspective. Treasure Island, FL, 2023.

16 

Broeck DV: Human papillomavirus and related diseases-from bench to bedside. Broeck DV (ed). IntechOpen, p336, 2012.

17 

Herfs M, Hubert P, Moutschen M and Delvenne P: Mucosal junctions: Open doors to HPV and HIV infections? Trends Microbiol. 19:114–120. 2011.PubMed/NCBI View Article : Google Scholar

18 

Yuan F, Auborn K and James C: Altered growth and viral gene expression in human papillomavirus type 16-containing cancer cell lines treated with progesterone. Cancer Invest. 17:19–29. 1999.PubMed/NCBI

19 

Jing Y, Wang T, Chen Z, Ding X, Xu J, Mu X, Cao M and Chen H: Phylogeny and polymorphism in the long control regions E6, E7, and L1 of HPV type 56 in women from Southwest China. Mol Med Rep. 17:7131–7141. 2018.PubMed/NCBI View Article : Google Scholar

20 

Kuguyo O, Tsikai N, Thomford NE, Magwali T, Madziyire MG, Nhachi CFB, Matimba A and Dandara C: Genetic susceptibility for cervical cancer in African populations: What are the host genetic drivers? OMICS. 22:468–483. 2018.PubMed/NCBI View Article : Google Scholar

21 

Zhang Y, Fan S, Meng Q, Ma Y, Katiyar P, Schlegel R and Rosen EM: BRCA1 interaction with human papillomavirus oncoproteins. J Biol Chem. 280:33165–33177. 2005.PubMed/NCBI View Article : Google Scholar

22 

Zhou X, Han S, Wang S, Chen X, Dong J, Shi X, Xia Y, Wang X, Hu Z and Shen H: Polymorphisms in HPV E6/E7 protein interacted genes and risk of cervical cancer in Chinese women: A case-control analysis. Gynecol Oncol. 114:327–331. 2009.PubMed/NCBI View Article : Google Scholar

23 

Bodily J and Laimins AL: Persistence of human papillomavirus infection: Keys to malignant progression. Trends Microbiol. 19:33–39. 2011.PubMed/NCBI View Article : Google Scholar

24 

Baseman JG and Koutsky LA: The epidemiology of human papillomavirus infections. J Clin Virol. 32:16–24. 2005.PubMed/NCBI View Article : Google Scholar

25 

Münger K, Baldwin A, Edwards KM, Hayakawa H, Nguyen CL, Owens M, Grace M and Huh K: Mechanisms of human papillomavirus-induced oncogenesis. J Virol. 78:11451–11460. 2004.PubMed/NCBI View Article : Google Scholar

26 

Schiffman M and Wentzensen N: Human papillomavirus (HPV) infection and the multi-stage carcinogenesis of cervical cancer introduction and historic context. Cancer Epidemiol Biomarkers Prev. 22:553–560. 2013.

27 

Yadav C, Yadav R, Chabbra R, Nanda S, Ranga S, Kadian L and Ahuja P: Overview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical cancer. Apoptosis. 28:683–701. 2023.PubMed/NCBI View Article : Google Scholar

28 

Smola S, Trimble C and Stern PL: Human papillomavirus-driven immune deviation: Challenge and novel opportunity for immunotherapy. Ther Adv Vaccines. 5:69–82. 2017.PubMed/NCBI View Article : Google Scholar

29 

Gutiérrez-Hoya A and Soto-Cruz I: NK cell regulation in cervical cancer and strategies for immunotherapy. Cells. 10(3104)2021.PubMed/NCBI View Article : Google Scholar

30 

Tamoutounour S, Han SJ, Deckers J, Constantinides MG, Hurabielle C, Harrison OJ, Bouladoux N, Linehan JL, Link VM, Vujkovic-Cvijin I, et al: Keratinocyte-intrinsic MHCII expression controls microbiota-induced Th1 cell responses. Proc Natl Acad Sci USA. 116:23643–23652. 2019.PubMed/NCBI View Article : Google Scholar

31 

Manzo-Merino J, Del-Toro-Arreola S, Rocha-Zavaleta L, Peralta-Zaragoza Ó, Jiménez-Lima R and Madrid-Marina V: Immunology of cervical cancer. Rev Invest Clin. 72:188–197. 2020.PubMed/NCBI View Article : Google Scholar

32 

Stanley MA: Immune responses to human papilloma viruses. Indian J Med Res. 130:266–276. 2009.PubMed/NCBI

33 

Stanley M: Immunobiology of HPV and HPV vaccines. Gynecol Oncol. 109 (Suppl 2):S15–S21. 2008.PubMed/NCBI View Article : Google Scholar

34 

Tindle RW: Cervical Cancer. StatPearls Publishing, Treasure Island, FL, pp1-7, 2002.

35 

Doorbar J, Egawa N, Griffin H, Kranjec C and Murakami I: Human papillomavirus molecular biology and disease association. Rev Med Virol. 25 (Suppl 1):S2–S23. 2015.PubMed/NCBI View Article : Google Scholar

36 

Siddiqa A, Sims-Mourtada JC, Guzman-Rojas L, Rangel R, Guret C, Madrid-Marina V, Sun Y and Martinez-Valdez H: Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA. Nature. 410:383–387. 2001.PubMed/NCBI View Article : Google Scholar

37 

Garcia-Iglesias T, Del Toro-Arreola A, Albarran-Somoza B, Del Toro-Arreola S, Sanchez-Hernandez PE, Ramirez-Dueñas MG, Balderas-Peña LM, Bravo-Cuellar A, Ortiz-Lazareno PC and Daneri-Navarro A: Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions. BMC Cancer. 9(186)2009.PubMed/NCBI View Article : Google Scholar

38 

Sasson IM, Haley NJ, Hoffmann D, Wynder EL, Hellberg D and Nilsson S: Cigarette smoking and neoplasia of the uterine cervix: Smoke constituents in cervical mucus. N Engl J Med. 312:315–316. 1985.PubMed/NCBI View Article : Google Scholar

39 

Roteli-Martins CM, Panetta K, Alves VA, Siqueira SA, Syrjänen KJ and Derchain SF: Cigarette smoking and high-risk HPV DNA as predisposing factors for high-grade cervical intraepithelial neoplasia (CIN) in young Brazilian women. Acta Obstet Gynecol Scand. 77:678–682. 1998.PubMed/NCBI View Article : Google Scholar

40 

Stumbar SE, Stevens M and Feld Z: Cervical cancer and its precursors: A preventative approach to screening, diagnosis, and management. Prim Care. 46:117–134. 2019.PubMed/NCBI View Article : Google Scholar

41 

International Collaboration of Epidemiological Studies of Cervical Cancer. Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: Collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J Cancer. 120:885–891. 2007.PubMed/NCBI View Article : Google Scholar

42 

Burd EM: Human papillomavirus and cervical cancer. Clin Microbiol Rev. 16:1–17. 2003.PubMed/NCBI View Article : Google Scholar

43 

Olusola P, Banerjee HN, Philley JV and Dasgupta S: Human papilloma virus-associated cervical cancer and health disparities. Cells. 8(622)2019.PubMed/NCBI View Article : Google Scholar

44 

Fowler JR, Maani EV, Dunton CJ and Jack BW: Cervical Cancer. StatPearls Publishing, Treasure Island, FL, 2023.

45 

Burness JV, Schroeder JM and Warren JB: Cervical colposcopy: Indications and risk assessment. Am Fam Physician. 102:39–48. 2020.PubMed/NCBI

46 

Sachan P, Singh M, Patel M and Sachan R: A study on cervical cancer screening using pap smear test and clinical correlation. Asia Pac J Oncol Nurs. 5:337–341. 2018.PubMed/NCBI View Article : Google Scholar

47 

Turinetto M, Valsecchi AA, Tuninetti V, Scotto G, Borella F and Valabrega G: Immunotherapy for cervical cancer: Are we ready for prime time? Int J Mol Sci. 23(3559)2022.PubMed/NCBI View Article : Google Scholar

48 

Lazo PA: The molecular genetics of cervical carcinoma. Br J Cancer. 80:2008–2018. 1999.PubMed/NCBI View Article : Google Scholar

49 

Mezache L, Paniccia B, Nyinawabera A and Nuovo GJ: Enhanced expression of PD L1 in cervical intraepithelial neoplasia and cervical cancers. Mod Pathol. 28:1594–1602. 2015.PubMed/NCBI View Article : Google Scholar

50 

Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK and Sharpe AH: PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 206:3015–3029. 2009.PubMed/NCBI View Article : Google Scholar

51 

Jenkins RW, Barbie DA and Flaherty KT: Mechanisms of resistance to immune checkpoint inhibitors. Br J Cancer. 118:9–16. 2018.PubMed/NCBI View Article : Google Scholar

52 

Kakotkin VV, Semina EV, Zadorkina TG and Agapov MA: Prevention strategies and early diagnosis of cervical cancer: Current state and prospects. Diagnostics (Basel). 13(610)2023.PubMed/NCBI View Article : Google Scholar

53 

Mavundza EJ, Mmotsa TM and Ndwandwe D: Human papillomavirus (HPV) trials: A cross-sectional analysis of clinical trials registries. Hum Vaccin Immunother. 20(2393481)2024.PubMed/NCBI View Article : Google Scholar

54 

Saslow D, Andrews KS, Manassaram-Baptiste D, Smith RA and Fontham ETH: American Cancer Society Guideline Development Group. Human papillomavirus vaccination 2020 guideline update: American cancer society guideline adaptation. CA Cancer J Clin. 70:274–280. 2020.PubMed/NCBI View Article : Google Scholar

55 

Eun TJ and Perkins RB: Screening for cervical cancer. Med Clin North Am. 104:1063–1078. 2020.PubMed/NCBI View Article : Google Scholar

56 

Pardini B, De Maria D, Francavilla A, Di Gaetano C, Ronco G and Naccarati A: MicroRNAs as markers of progression in cervical cancer: A systematic review. BMC Cancer. 18(696)2018.PubMed/NCBI View Article : Google Scholar

57 

Gu Y, Feng X, Jin Y, Liu Y, Zeng L, Zhou D and Feng Y: Upregulation of miRNA-10a-5p promotes tumor progression in cervical cancer by suppressing UBE2I signaling. J Obstet Gynaecol. 43(2171283)2023.PubMed/NCBI View Article : Google Scholar

58 

Lev Maor G, Yearim A and Ast G: The alternative role of DNA methylation in splicing regulation. Trends Genet. 31:274–280. 2015.PubMed/NCBI View Article : Google Scholar

59 

Boland CR: Non-coding RNA: It's not junk. Dig Dis Sci. 62:1107–1109. 2017.PubMed/NCBI View Article : Google Scholar

60 

Gao P and Zheng J: High-risk HPV E5-induced cell fusion: A critical initiating event in the early stage of HPV-associated cervical cancer. Virol J. 7(238)2010.PubMed/NCBI View Article : Google Scholar

61 

Hasan UA, Bates E, Takeshita F, Biliato A, Accardi R, Bouvard V, Mansour M, Vincent I, Gissmann L, Iftner T, et al: TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type 16. J Immunol. 178:3186–3197. 2007.PubMed/NCBI View Article : Google Scholar

62 

Howie HL, Katzenellenbogen RA and Galloway DA: Papillomavirus E6 proteins. Bone. 23:1–7. 2008.PubMed/NCBI View Article : Google Scholar

63 

Huh KW, DeMasi J, Ogawa H, Nakatani Y, Howley PM and Münger K: Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. Proc Natl Acad Sci USA. 102:11492–11497. 2005.PubMed/NCBI View Article : Google Scholar

64 

Zerfass K, Schulze A, Spitkovsky D, Friedman V, Henglein B and Jansen-Dürr P: Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation. J Virol. 69:6389–6399. 1995.PubMed/NCBI View Article : Google Scholar

65 

Eichten A, Rud DS, Grace M, Piboonniyom SO, Zacny V and Münger K: Molecular pathways executing the ‘trophic sentinel’ response in HPV-16 E7-expressing normal human diploid fibroblasts upon growth factor deprivation. Virology. 319:81–93. 2004.PubMed/NCBI View Article : Google Scholar

66 

McLaughlin-Daurbin ME: Oncogenic activities of human papillomaviruses margaret. Virus Res. 71:3831–3840. 2014.

67 

Spardy N, Duensing A, Charles D, Haines N, Nakahara T, Lambert PF and Duensing S: The human papillomavirus type 16 E7 oncoprotein activates the fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells. J Virol. 81:13265–13270. 2007.PubMed/NCBI View Article : Google Scholar

68 

Chen XF and Liu Y: MicroRNA-744 inhibited cervical cancer growth and progression through apoptosis induction by regulating Bcl-2. Biomed Pharmacother. 81:379–387. 2016.PubMed/NCBI View Article : Google Scholar

69 

Mou Z, Xu X, Dong M and Xu J: MicroRNA-148b acts as a tumor suppressor in cervical cancer by inducing G1/S-Phase cell cycle arrest and apoptosis in a caspase-3-dependent manner. Med Sci Monit. 22:2809–2815. 2016.PubMed/NCBI View Article : Google Scholar

70 

Liu S, Zhang P, Chen Z, Liu M, Li X and Tang H: MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells. FEBS Lett. 587:2247–2253. 2013.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Kabir I and Ribeiro RM: HPV and cervical cancer:  From molecular diagnostics to emerging treatment approaches (Review). World Acad Sci J 7: 58, 2025.
APA
Kabir, I., & Ribeiro, R.M. (2025). HPV and cervical cancer:  From molecular diagnostics to emerging treatment approaches (Review). World Academy of Sciences Journal, 7, 58. https://doi.org/10.3892/wasj.2025.346
MLA
Kabir, I., Ribeiro, R. M."HPV and cervical cancer:  From molecular diagnostics to emerging treatment approaches (Review)". World Academy of Sciences Journal 7.4 (2025): 58.
Chicago
Kabir, I., Ribeiro, R. M."HPV and cervical cancer:  From molecular diagnostics to emerging treatment approaches (Review)". World Academy of Sciences Journal 7, no. 4 (2025): 58. https://doi.org/10.3892/wasj.2025.346
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Spandidos Publications style
Kabir I and Ribeiro RM: HPV and cervical cancer:  From molecular diagnostics to emerging treatment approaches (Review). World Acad Sci J 7: 58, 2025.
APA
Kabir, I., & Ribeiro, R.M. (2025). HPV and cervical cancer:  From molecular diagnostics to emerging treatment approaches (Review). World Academy of Sciences Journal, 7, 58. https://doi.org/10.3892/wasj.2025.346
MLA
Kabir, I., Ribeiro, R. M."HPV and cervical cancer:  From molecular diagnostics to emerging treatment approaches (Review)". World Academy of Sciences Journal 7.4 (2025): 58.
Chicago
Kabir, I., Ribeiro, R. M."HPV and cervical cancer:  From molecular diagnostics to emerging treatment approaches (Review)". World Academy of Sciences Journal 7, no. 4 (2025): 58. https://doi.org/10.3892/wasj.2025.346
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