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Effects of interleukin‑6 genetic variation on hepatitis B virus infection and susceptibility to hepatocellular carcinoma: A systematic review and meta‑analysis

  • Authors:
    • Bibin Savio Antony
    • Karthikeyan Murugesan
    • Anjuna Radhakrishnan
    • Yupa Min
    • Gowtham Kumar Subbaraj
  • View Affiliations / Copyright

    Affiliations: Faculty of Allied Health Science, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chennai, Tamil Nadu 603103, India, Department of Microbiology, Faculty of Medicine, Quest International University, 30250 Ipoh, Perak, Malaysia, Department of Pathology, Faculty of Medicine, Quest International University, 30250 Ipoh, Perak, Malaysia
    Copyright: © Antony et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 63
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    Published online on: May 12, 2025
       https://doi.org/10.3892/wasj.2025.351
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Abstract

The present systematic review and meta‑analysis was conducted to assess the overall effects and ethnically specific effects of the interleukin (IL)‑6 single nucleotide polymorphism (SNP) rs1800796 on the susceptibility of hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). For this purpose, data were searched in the PubMed, Embase and Google Scholar databases using ‘interleukin 6’, ‘IL‑6 polymorphism’, ‘hepatitis B virus’, ‘HBV’, ‘hepatocellular carcinoma’, and ‘HCC’, and a meta‑analysis was performed on rs1800796 in Asian and Caucasian populations under the genetic model. The present meta‑analysis included eight studies totaling 1,960 patients with HBV, 877 patients with HCC and 3,630 healthy controls. The IL‑6 rs1800796 polymorphism and HBV persistence in all four genetic models exhibited no appreciable association in the present study. However, this polymorphism was revealed to be particularly associated with HCC persistence in the recessive model in particular. Furthermore, there was no statistically significant association between IL‑6 polymorphisms and HBV or HCC infection in neither the Asian nor Caucasian populations. On the whole, the present study demonstrates that IL‑6 polymorphisms are not associated with the outcome of HBV infection, and only the recessive genetic model was associated with HCC susceptibility, in the Asians and the Caucasians population.
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Spandidos Publications style
Antony BS, Murugesan K, Radhakrishnan A, Min Y and Subbaraj GK: Effects of interleukin‑6 genetic variation on hepatitis B virus infection and susceptibility to hepatocellular carcinoma: A systematic review and meta‑analysis. World Acad Sci J 7: 63, 2025.
APA
Antony, B.S., Murugesan, K., Radhakrishnan, A., Min, Y., & Subbaraj, G.K. (2025). Effects of interleukin‑6 genetic variation on hepatitis B virus infection and susceptibility to hepatocellular carcinoma: A systematic review and meta‑analysis. World Academy of Sciences Journal, 7, 63. https://doi.org/10.3892/wasj.2025.351
MLA
Antony, B. S., Murugesan, K., Radhakrishnan, A., Min, Y., Subbaraj, G. K."Effects of interleukin‑6 genetic variation on hepatitis B virus infection and susceptibility to hepatocellular carcinoma: A systematic review and meta‑analysis". World Academy of Sciences Journal 7.4 (2025): 63.
Chicago
Antony, B. S., Murugesan, K., Radhakrishnan, A., Min, Y., Subbaraj, G. K."Effects of interleukin‑6 genetic variation on hepatitis B virus infection and susceptibility to hepatocellular carcinoma: A systematic review and meta‑analysis". World Academy of Sciences Journal 7, no. 4 (2025): 63. https://doi.org/10.3892/wasj.2025.351
Copy and paste a formatted citation
x
Spandidos Publications style
Antony BS, Murugesan K, Radhakrishnan A, Min Y and Subbaraj GK: Effects of interleukin‑6 genetic variation on hepatitis B virus infection and susceptibility to hepatocellular carcinoma: A systematic review and meta‑analysis. World Acad Sci J 7: 63, 2025.
APA
Antony, B.S., Murugesan, K., Radhakrishnan, A., Min, Y., & Subbaraj, G.K. (2025). Effects of interleukin‑6 genetic variation on hepatitis B virus infection and susceptibility to hepatocellular carcinoma: A systematic review and meta‑analysis. World Academy of Sciences Journal, 7, 63. https://doi.org/10.3892/wasj.2025.351
MLA
Antony, B. S., Murugesan, K., Radhakrishnan, A., Min, Y., Subbaraj, G. K."Effects of interleukin‑6 genetic variation on hepatitis B virus infection and susceptibility to hepatocellular carcinoma: A systematic review and meta‑analysis". World Academy of Sciences Journal 7.4 (2025): 63.
Chicago
Antony, B. S., Murugesan, K., Radhakrishnan, A., Min, Y., Subbaraj, G. K."Effects of interleukin‑6 genetic variation on hepatitis B virus infection and susceptibility to hepatocellular carcinoma: A systematic review and meta‑analysis". World Academy of Sciences Journal 7, no. 4 (2025): 63. https://doi.org/10.3892/wasj.2025.351
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