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Review Open Access

Understanding the Mpox outbreak: Advances in epidemiology, management and prevention (Review)

  • Authors:
    • Abdulellah Samer Alghamdi
    • Basheer Aldajani
    • Mohammed Ali Aljasim
    • Abdullah Hani Alotaibi
    • Ali Taleb Alsultan
    • Abdullah Abbas Alhussain
    • Abdulaziz Khalil Alswedan
    • Kamaluddin H. Motawei
    • Muhammad Iqbal
    • Shahid Bashir
  • View Affiliations / Copyright

    Affiliations: College of Medicine, Imam Abdulrahman Bin Faisal University, 34221 Dammam, Kingdom of Saudi Arabia, Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, 34221 Dammam, Kingdom of Saudi Arabia, Department of Physiology, College of Medicine, King Saud University, 11362 Riyadh, Kingdom of Saudi Arabia, Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam 32253, Kingdom of Saudi Arabia
    Copyright: © Alghamdi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 64
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    Published online on: May 15, 2025
       https://doi.org/10.3892/wasj.2025.352
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Abstract

Monkeypox (Mpox) is a zoonotic disease caused by the monkeypox virus (MPXV), a member of the Poxviridae family. Historically endemic to Central and West Africa, its spread beyond these regions in 2022 prompted the World Health Organization to declare it a public health emergency. Mpox is primarily transmitted through direct skin‑to‑skin contact with lesions, animal bites, or exposure to contaminated materials. The present review discusses the epidemiological, virological, immunological, clinical, diagnostic, and preventive aspects of Mpox infection. It highlights the two main viral clades (clade I and clade II), the role of APOBEC3‑driven mutations, and factors contributing to the resurgence of outbreaks, such as environmental changes, increased urbanization, air travel, and the prevalence of HIV/AIDS. Clinical manifestations range from localized rash and systemic symptoms to severe complications like encephalitis and sepsis. Diagnostic approaches including PCR, whole‑genome sequencing, and electron microscopy are explored, alongside preventive measures such as the JYNNEOS and ACAM2000 vaccines. Management primarily involves supportive care and antiviral therapy with tecovirimat, although recent clinical trials have raised concerns about its efficacy. Challenges in outbreak control include limited vaccine access, diagnostic resource gaps, stigma, particularly among high‑risk populations, and the potential emergence of antiviral resistance. The present review emphasizes the importance of the One Health approach, recognizing the interconnectedness of human, animal, and environmental health sectors, to ensure a coordinated and effective response. Furthermore, it underscores the need for ongoing research into viral evolution, novel therapeutic development, enhanced diagnostic methods, and understanding long‑term physical and psychosocial outcomes to strengthen global preparedness against Mpox outbreaks.
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Spandidos Publications style
Alghamdi AS, Aldajani B, Aljasim MA, Alotaibi AH, Alsultan AT, Alhussain AA, Alswedan AK, Motawei KH, Iqbal M, Bashir S, Bashir S, et al: Understanding the Mpox outbreak: Advances in epidemiology, management and prevention (Review). World Acad Sci J 7: 64, 2025.
APA
Alghamdi, A.S., Aldajani, B., Aljasim, M.A., Alotaibi, A.H., Alsultan, A.T., Alhussain, A.A. ... Bashir, S. (2025). Understanding the Mpox outbreak: Advances in epidemiology, management and prevention (Review). World Academy of Sciences Journal, 7, 64. https://doi.org/10.3892/wasj.2025.352
MLA
Alghamdi, A. S., Aldajani, B., Aljasim, M. A., Alotaibi, A. H., Alsultan, A. T., Alhussain, A. A., Alswedan, A. K., Motawei, K. H., Iqbal, M., Bashir, S."Understanding the Mpox outbreak: Advances in epidemiology, management and prevention (Review)". World Academy of Sciences Journal 7.4 (2025): 64.
Chicago
Alghamdi, A. S., Aldajani, B., Aljasim, M. A., Alotaibi, A. H., Alsultan, A. T., Alhussain, A. A., Alswedan, A. K., Motawei, K. H., Iqbal, M., Bashir, S."Understanding the Mpox outbreak: Advances in epidemiology, management and prevention (Review)". World Academy of Sciences Journal 7, no. 4 (2025): 64. https://doi.org/10.3892/wasj.2025.352
Copy and paste a formatted citation
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Spandidos Publications style
Alghamdi AS, Aldajani B, Aljasim MA, Alotaibi AH, Alsultan AT, Alhussain AA, Alswedan AK, Motawei KH, Iqbal M, Bashir S, Bashir S, et al: Understanding the Mpox outbreak: Advances in epidemiology, management and prevention (Review). World Acad Sci J 7: 64, 2025.
APA
Alghamdi, A.S., Aldajani, B., Aljasim, M.A., Alotaibi, A.H., Alsultan, A.T., Alhussain, A.A. ... Bashir, S. (2025). Understanding the Mpox outbreak: Advances in epidemiology, management and prevention (Review). World Academy of Sciences Journal, 7, 64. https://doi.org/10.3892/wasj.2025.352
MLA
Alghamdi, A. S., Aldajani, B., Aljasim, M. A., Alotaibi, A. H., Alsultan, A. T., Alhussain, A. A., Alswedan, A. K., Motawei, K. H., Iqbal, M., Bashir, S."Understanding the Mpox outbreak: Advances in epidemiology, management and prevention (Review)". World Academy of Sciences Journal 7.4 (2025): 64.
Chicago
Alghamdi, A. S., Aldajani, B., Aljasim, M. A., Alotaibi, A. H., Alsultan, A. T., Alhussain, A. A., Alswedan, A. K., Motawei, K. H., Iqbal, M., Bashir, S."Understanding the Mpox outbreak: Advances in epidemiology, management and prevention (Review)". World Academy of Sciences Journal 7, no. 4 (2025): 64. https://doi.org/10.3892/wasj.2025.352
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