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Association between the CCR6/CCL20 axis and IL‑17A level in patients with rheumatoid arthritis

  • Authors:
    • Yaseen Kadhum Hamza
    • Batool Hassan Al‑Ghurabi
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    Affiliations: Department of Basic Science, College of Dentistry, University of Baghdad, 89XH+47Q, Baghdad, Iraq
    Copyright: © Hamza et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 65
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    Published online on: May 21, 2025
       https://doi.org/10.3892/wasj.2025.353
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Abstract

Rheumatoid arthritis (RA) is a common systemic autoimmune disease characterized by chronic inflammation. Accumulating evidence has established the pivotal role of the C‑C chemokine receptor type (CCR)6‑chemokine ligand 20 (CCL20) axis in the recruitment of IL‑17A to the arthritic joint. The aim of the present study was to investigate the association between the CCR6/CCL20 axis and IL‑17A production in patients with RA. The present study included 120 subjects aged 30‑65 years, 20 patients diagnosed as patients with RA who formerly did not receive steroids or any immune‑modulatory therapy, 30 patients on methotrexate (MTX) treatment, 30 patients receiving MTX + biological therapy and 40 healthy controls. ELISA was used to quantify the expression levels of CCR6, CCL20 and IL‑17A. The salivary concentration levels of IL‑17A, CCR6 and CCL20 were increased in patients with RA compared with those of the control subjects. Furthermore, the average salivary concentration levels of the biomarkers were markedly elevated in the newly diagnosed RA and in the MTX groups compared with those noted in the MTX + biological therapy group. By contrast, a significant decrease was noted in the mean ratio of CCR6/CCL20 among the patient groups in comparison to the control group. Furthermore, a substantial positive association was noted between the expression levels of IL‑17A and CCR6 in the newly diagnosed RA group, as well as between CCR6 and CCL20 in the MTX and newly RA groups, while a positive significant correlation (P<0.05) was noted between the expression levels of IL‑17A and CCL20 in each of the control groups, the MTX and the MTX + biological groups. On the whole, newly diagnosed RA indicated high levels of salivary biomarkers and a strong positive association was noted between the high expression levels of the chemokines CCR6 and CCL20 and the increased IL‑17A levels noted in the patients.
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Spandidos Publications style
Hamza YK and Al‑Ghurabi BH: Association between the CCR6/CCL20 axis and IL‑17A level in patients with rheumatoid arthritis. World Acad Sci J 7: 65, 2025.
APA
Hamza, Y.K., & Al‑Ghurabi, B.H. (2025). Association between the CCR6/CCL20 axis and IL‑17A level in patients with rheumatoid arthritis. World Academy of Sciences Journal, 7, 65. https://doi.org/10.3892/wasj.2025.353
MLA
Hamza, Y. K., Al‑Ghurabi, B. H."Association between the CCR6/CCL20 axis and IL‑17A level in patients with rheumatoid arthritis". World Academy of Sciences Journal 7.4 (2025): 65.
Chicago
Hamza, Y. K., Al‑Ghurabi, B. H."Association between the CCR6/CCL20 axis and IL‑17A level in patients with rheumatoid arthritis". World Academy of Sciences Journal 7, no. 4 (2025): 65. https://doi.org/10.3892/wasj.2025.353
Copy and paste a formatted citation
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Spandidos Publications style
Hamza YK and Al‑Ghurabi BH: Association between the CCR6/CCL20 axis and IL‑17A level in patients with rheumatoid arthritis. World Acad Sci J 7: 65, 2025.
APA
Hamza, Y.K., & Al‑Ghurabi, B.H. (2025). Association between the CCR6/CCL20 axis and IL‑17A level in patients with rheumatoid arthritis. World Academy of Sciences Journal, 7, 65. https://doi.org/10.3892/wasj.2025.353
MLA
Hamza, Y. K., Al‑Ghurabi, B. H."Association between the CCR6/CCL20 axis and IL‑17A level in patients with rheumatoid arthritis". World Academy of Sciences Journal 7.4 (2025): 65.
Chicago
Hamza, Y. K., Al‑Ghurabi, B. H."Association between the CCR6/CCL20 axis and IL‑17A level in patients with rheumatoid arthritis". World Academy of Sciences Journal 7, no. 4 (2025): 65. https://doi.org/10.3892/wasj.2025.353
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