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Review Open Access

Effects of bisphenol A and its chemical analogues on the microenvironment and female breast cancer development (Review)

  • Authors:
    • Shreeja Tripathi
    • Katharina Kusserow
    • Kerri Palmer
    • Abigail Dodson
    • Dylan Peter Mcclurg
    • Valerie Speirs
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK
    Copyright: © Tripathi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 66
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    Published online on: May 26, 2025
       https://doi.org/10.3892/wasj.2025.354
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Abstract

Female breast cancer (BC) is the fourth most commonly diagnosed malignancy globally and its incidence is rising. Endocrine‑disrupting chemicals can bind to and activate oestrogen receptors, disrupt the microenvironment and promote oncogenic pathways. Consequently, bisphenols have been associated with the potential onset of breast carcinogenesis. The present narrative review discusses bisphenol A (BPA) and three of its chemical analogues, bisphenol AF (BPAF), bisphenol S (BPS) and bisphenol S (BPF), as well as their potential role in altering the breast microenvironment. In doing so, the present review highlights the effects that BPA, and its analogues may have in driving carcinogenesis in the microenvironment through endocrine disruption, epigenetic changes, and the modulation of immune and inflammatory pathways. Further studies are required to better understand these interactions in order to develop preventative strategies and regulatory policies to mitigate the potential risk of BC development through environmental exposure to BPA, BPAF, BPS and BPF.
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Copy and paste a formatted citation
Spandidos Publications style
Tripathi S, Kusserow K, Palmer K, Dodson A, Mcclurg DP and Speirs V: Effects of bisphenol A and its chemical analogues on the microenvironment and female breast cancer development (Review). World Acad Sci J 7: 66, 2025.
APA
Tripathi, S., Kusserow, K., Palmer, K., Dodson, A., Mcclurg, D.P., & Speirs, V. (2025). Effects of bisphenol A and its chemical analogues on the microenvironment and female breast cancer development (Review). World Academy of Sciences Journal, 7, 66. https://doi.org/10.3892/wasj.2025.354
MLA
Tripathi, S., Kusserow, K., Palmer, K., Dodson, A., Mcclurg, D. P., Speirs, V."Effects of bisphenol A and its chemical analogues on the microenvironment and female breast cancer development (Review)". World Academy of Sciences Journal 7.4 (2025): 66.
Chicago
Tripathi, S., Kusserow, K., Palmer, K., Dodson, A., Mcclurg, D. P., Speirs, V."Effects of bisphenol A and its chemical analogues on the microenvironment and female breast cancer development (Review)". World Academy of Sciences Journal 7, no. 4 (2025): 66. https://doi.org/10.3892/wasj.2025.354
Copy and paste a formatted citation
x
Spandidos Publications style
Tripathi S, Kusserow K, Palmer K, Dodson A, Mcclurg DP and Speirs V: Effects of bisphenol A and its chemical analogues on the microenvironment and female breast cancer development (Review). World Acad Sci J 7: 66, 2025.
APA
Tripathi, S., Kusserow, K., Palmer, K., Dodson, A., Mcclurg, D.P., & Speirs, V. (2025). Effects of bisphenol A and its chemical analogues on the microenvironment and female breast cancer development (Review). World Academy of Sciences Journal, 7, 66. https://doi.org/10.3892/wasj.2025.354
MLA
Tripathi, S., Kusserow, K., Palmer, K., Dodson, A., Mcclurg, D. P., Speirs, V."Effects of bisphenol A and its chemical analogues on the microenvironment and female breast cancer development (Review)". World Academy of Sciences Journal 7.4 (2025): 66.
Chicago
Tripathi, S., Kusserow, K., Palmer, K., Dodson, A., Mcclurg, D. P., Speirs, V."Effects of bisphenol A and its chemical analogues on the microenvironment and female breast cancer development (Review)". World Academy of Sciences Journal 7, no. 4 (2025): 66. https://doi.org/10.3892/wasj.2025.354
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