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Clinical efficacy of the use of myoinositol alone compared with clomiphene citrate alone and the combined use of both medications as regards the conception rates of patients with PCOS: A systematic review and meta‑analysis

  • Authors:
    • Zaheera Saadia
    • Muhammad Munir Memon
    • Mushhood Memon
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Buraydah, Al‑Qassim 52571, Kingdom of Saudi Arabia, Department of Medicine, SBH Health System, Bronx, NY 10457, USA
    Copyright: © Saadia et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 72
    |
    Published online on: June 12, 2025
       https://doi.org/10.3892/wasj.2025.360
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Abstract

Myoinositol and clomiphene citrate have been investigated for improving conception rates in patients with polycystic ovary syndrome (PCOS). However, the comparative efficacy of these treatments remains uncertain. The present study performed a systematic review and meta‑analysis in an aim to examine the efficacy of myoinositol and clomiphene citrate (CC), both as standalone treatments compared with a combination of myoinositol and CC, in enhancing fertility rates among patients with PCOS. For this purpose, a random‑effects model was used to calculate pooled odds ratios (ORs) with 95% confidence intervals for the efficacy of myoinositol alone, CC alone, compared with the combination of myoinositol and clomiphene citrate, in improving conception rates in patients with PCOS. The pooled OR indicated no significant differences in conception rates between myoinositol and CC. However, myoinositol treatment was associated with improvements in other parameters, such as weight control and insulin resistance. On the whole, the present study demonstrates that myoinositol alone or in combination with CC does not improve the conception rates in patients with PCOS compared to the use of CC alone. However, myoinositol provides additional benefits in terms of weight control and insulin resistance.
View Figures

Figure 1

PRISMA protocol representation for the
present review. The PECO protocol utilized for the present study is
listed as follows: i) P, patients with confirmed polycystic ovary
syndrome presenting for infertility treatment; ii) E, myoinositol,
clomiphene citrate or combination; iii) C, clomiphene citrate
alone; and iv) O, using the combination of myoinositol and
clomiphene citrate increase the pregnancy and ovulation rate.

Figure 2

Bias assessment in the included
articles.

Figure 3

Efficacy of myoinositol in improving
ovulation in comparison to clomiphene citrate.

Figure 4

Efficacy of myoinositol in improving
pregnancy rates in comparison to clomiphene citrate.

Figure 5

Association between moderator and
estimated effect size.
View References

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Spandidos Publications style
Saadia Z, Memon MM and Memon M: Clinical efficacy of the use of myoinositol alone compared with clomiphene citrate alone and the combined use of both medications as regards the conception rates of patients with PCOS: A systematic review and meta‑analysis. World Acad Sci J 7: 72, 2025.
APA
Saadia, Z., Memon, M.M., & Memon, M. (2025). Clinical efficacy of the use of myoinositol alone compared with clomiphene citrate alone and the combined use of both medications as regards the conception rates of patients with PCOS: A systematic review and meta‑analysis. World Academy of Sciences Journal, 7, 72. https://doi.org/10.3892/wasj.2025.360
MLA
Saadia, Z., Memon, M. M., Memon, M."Clinical efficacy of the use of myoinositol alone compared with clomiphene citrate alone and the combined use of both medications as regards the conception rates of patients with PCOS: A systematic review and meta‑analysis". World Academy of Sciences Journal 7.4 (2025): 72.
Chicago
Saadia, Z., Memon, M. M., Memon, M."Clinical efficacy of the use of myoinositol alone compared with clomiphene citrate alone and the combined use of both medications as regards the conception rates of patients with PCOS: A systematic review and meta‑analysis". World Academy of Sciences Journal 7, no. 4 (2025): 72. https://doi.org/10.3892/wasj.2025.360
Copy and paste a formatted citation
x
Spandidos Publications style
Saadia Z, Memon MM and Memon M: Clinical efficacy of the use of myoinositol alone compared with clomiphene citrate alone and the combined use of both medications as regards the conception rates of patients with PCOS: A systematic review and meta‑analysis. World Acad Sci J 7: 72, 2025.
APA
Saadia, Z., Memon, M.M., & Memon, M. (2025). Clinical efficacy of the use of myoinositol alone compared with clomiphene citrate alone and the combined use of both medications as regards the conception rates of patients with PCOS: A systematic review and meta‑analysis. World Academy of Sciences Journal, 7, 72. https://doi.org/10.3892/wasj.2025.360
MLA
Saadia, Z., Memon, M. M., Memon, M."Clinical efficacy of the use of myoinositol alone compared with clomiphene citrate alone and the combined use of both medications as regards the conception rates of patients with PCOS: A systematic review and meta‑analysis". World Academy of Sciences Journal 7.4 (2025): 72.
Chicago
Saadia, Z., Memon, M. M., Memon, M."Clinical efficacy of the use of myoinositol alone compared with clomiphene citrate alone and the combined use of both medications as regards the conception rates of patients with PCOS: A systematic review and meta‑analysis". World Academy of Sciences Journal 7, no. 4 (2025): 72. https://doi.org/10.3892/wasj.2025.360
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