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Early outcomes of hepatectomy for hepatocellular carcinoma: A retrospective cohort study

  • Authors:
    • Van Thoi Dang
    • Van Kham Le
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Da Nang University of Medical Technology and Pharmacy, Da Nang 550000, Vietnam, Department of Surgery, Hue University of Medicine and Pharmacy, Hue 530000, Vietnam
    Copyright: © Dang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 62
    |
    Published online on: May 15, 2026
       https://doi.org/10.3892/wasj.2026.477
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Abstract

Hepatectomy remains a potentially curative treatment for selected patients with hepatocellular carcinoma (HCC). The present retrospective observational study was conducted on a cohort of consecutive adults who underwent open hepatectomy with curative intent for primary HCC between January, 2021 to May, 2023. Preoperative characteristics, imaging findings, operative variables and early outcomes (in‑hospital/30‑day) were extracted from medical records. Post‑hepatectomy liver failure (PHLF) and bile leak were defined using the International Study Group of Liver Surgery criteria, and univariable associations with any post‑operative complications were assessed using the χ2 or Fisher's exact tests. In total, 57 patients were included (mean age, 57.0±12.1 years; 78.9% male); all had preserved liver function (Child‑Pugh A, 100%) and the majority were classified as Barcelona Clinic Liver Cancer stage B (89.5%). The mean operative time was 156.6±34.8 min and the mean estimated blood loss was 399.0±212.6 ml. A total of 9 patients (15.8%) developed ≥1 post‑operative complication, with no 30‑day mortality; the most frequent complications were PHLF (7.0%) and bile leak (5.3%). Complications were significantly associated with hypoalbuminemia (<35 g/l; P=0.0389), Barcelona Clinic Liver Cancer stage (P=0.0016) and major hepatectomy (P=0.0451). On the whole, the present study demonstrates that open hepatectomy for HCC is associated with acceptable early morbidity and no mortality in a carefully selected cohort. However, the identified risk factors should be interpreted cautiously, since the analyses were univariable and based on a limited number of events.
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Copy and paste a formatted citation
Spandidos Publications style
Dang VT and Le VK: Early outcomes of hepatectomy for hepatocellular carcinoma: A retrospective cohort study. World Acad Sci J 8: 62, 2026.
APA
Dang, V.T., & Le, V.K. (2026). Early outcomes of hepatectomy for hepatocellular carcinoma: A retrospective cohort study. World Academy of Sciences Journal, 8, 62. https://doi.org/10.3892/wasj.2026.477
MLA
Dang, V. T., Le, V. K."Early outcomes of hepatectomy for hepatocellular carcinoma: A retrospective cohort study". World Academy of Sciences Journal 8.4 (2026): 62.
Chicago
Dang, V. T., Le, V. K."Early outcomes of hepatectomy for hepatocellular carcinoma: A retrospective cohort study". World Academy of Sciences Journal 8, no. 4 (2026): 62. https://doi.org/10.3892/wasj.2026.477
Copy and paste a formatted citation
x
Spandidos Publications style
Dang VT and Le VK: Early outcomes of hepatectomy for hepatocellular carcinoma: A retrospective cohort study. World Acad Sci J 8: 62, 2026.
APA
Dang, V.T., & Le, V.K. (2026). Early outcomes of hepatectomy for hepatocellular carcinoma: A retrospective cohort study. World Academy of Sciences Journal, 8, 62. https://doi.org/10.3892/wasj.2026.477
MLA
Dang, V. T., Le, V. K."Early outcomes of hepatectomy for hepatocellular carcinoma: A retrospective cohort study". World Academy of Sciences Journal 8.4 (2026): 62.
Chicago
Dang, V. T., Le, V. K."Early outcomes of hepatectomy for hepatocellular carcinoma: A retrospective cohort study". World Academy of Sciences Journal 8, no. 4 (2026): 62. https://doi.org/10.3892/wasj.2026.477
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