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Chyme refeeding therapy in pediatric patients with double enterostomy

  • Authors:
    • Hong Thi Thuy Nguyen
    • Nam Tung Hoang
    • Ngoc Thi Khanh Bui
    • Dat Tien Tran
    • Hoan Manh Vu
    • Du Quang Le
    • Lieu Thi Thu Nguyen
    • Thuc Thi My Luu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Hanoi Medical University, Hanoi 100000, Vietnam, Neurology Center, Vietnam National Children's Hospital, Hanoi 100000, Vietnam, Department of Nutrition, Vietnam National Children's Hospital, Hanoi 100000, Vietnam
    Copyright: © Nguyen et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 71
    |
    Published online on: June 23, 2026
       https://doi.org/10.3892/wasj.2026.486
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Abstract

Double enterostomy is a common surgical procedure performed in children that may result in a notable loss of nutrients, fluids and electrolytes from the proximal stoma, predisposing patients to malnutrition and intestinal failure‑associated complications. Chyme refeeding therapy (CRT) is a nutritional intervention that reinfuses chyme from the proximal stoma into the distal gut, aiming to preserve intestinal integrity and enhance nutritional status. However, it is still greatly underutilized in pediatric patients in developing countries. Therefore, in the present study, a combined retrospective‑prospective cohort study was conducted, which included 20 pediatric patients (aged 0‑12 years) who underwent CRT following double enterostomy. At the time of admission, the majority of the patients were suffering from wasting malnutrition. Following CRT, the weight gain velocity, weight‑for‑height Z‑score and body mass index‑for‑age Z‑score increased significantly and more than half of the patients were able to discontinue parenteral nutrition (PN). Infection was the leading indication for temporary CRT cessation; however, the association between infection and CRT was unclear. On the whole, the present study demonstrates that CRT may be an effective treatment that improves nutritional status and reduces PN requirement in children who have undergone a double enterostomy. However, further research with a larger sample size is required to further demonstrate the benefits of this therapy and promote its implementation in clinical practice.
View Figures

Figure 1

Weight-gain velocity before and after
CRT. Paired comparisons were performed using the Wilcoxon
signed-rank test (P=0.02). CRT, chyme refeeding therapy.

Figure 2

WHZ or BMIZ before and after CRT.
Paired comparisons were performed using the Wilcoxon signed-rank
test (P=0.04). BMIZ, body mass index-for-age Z-score; CRT, chyme
refeeding therapy; SD, standard deviation; WHZ, weight-for-height
Z-score.
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Copy and paste a formatted citation
Spandidos Publications style
Nguyen HT, Hoang NT, Bui NT, Tran DT, Vu HM, Le DQ, Nguyen LT and Luu TT: Chyme refeeding therapy in pediatric patients with double enterostomy. World Acad Sci J 8: 71, 2026.
APA
Nguyen, H.T., Hoang, N.T., Bui, N.T., Tran, D.T., Vu, H.M., Le, D.Q. ... Luu, T.T. (2026). Chyme refeeding therapy in pediatric patients with double enterostomy. World Academy of Sciences Journal, 8, 71. https://doi.org/10.3892/wasj.2026.486
MLA
Nguyen, H. T., Hoang, N. T., Bui, N. T., Tran, D. T., Vu, H. M., Le, D. Q., Nguyen, L. T., Luu, T. T."Chyme refeeding therapy in pediatric patients with double enterostomy". World Academy of Sciences Journal 8.4 (2026): 71.
Chicago
Nguyen, H. T., Hoang, N. T., Bui, N. T., Tran, D. T., Vu, H. M., Le, D. Q., Nguyen, L. T., Luu, T. T."Chyme refeeding therapy in pediatric patients with double enterostomy". World Academy of Sciences Journal 8, no. 4 (2026): 71. https://doi.org/10.3892/wasj.2026.486
Copy and paste a formatted citation
x
Spandidos Publications style
Nguyen HT, Hoang NT, Bui NT, Tran DT, Vu HM, Le DQ, Nguyen LT and Luu TT: Chyme refeeding therapy in pediatric patients with double enterostomy. World Acad Sci J 8: 71, 2026.
APA
Nguyen, H.T., Hoang, N.T., Bui, N.T., Tran, D.T., Vu, H.M., Le, D.Q. ... Luu, T.T. (2026). Chyme refeeding therapy in pediatric patients with double enterostomy. World Academy of Sciences Journal, 8, 71. https://doi.org/10.3892/wasj.2026.486
MLA
Nguyen, H. T., Hoang, N. T., Bui, N. T., Tran, D. T., Vu, H. M., Le, D. Q., Nguyen, L. T., Luu, T. T."Chyme refeeding therapy in pediatric patients with double enterostomy". World Academy of Sciences Journal 8.4 (2026): 71.
Chicago
Nguyen, H. T., Hoang, N. T., Bui, N. T., Tran, D. T., Vu, H. M., Le, D. Q., Nguyen, L. T., Luu, T. T."Chyme refeeding therapy in pediatric patients with double enterostomy". World Academy of Sciences Journal 8, no. 4 (2026): 71. https://doi.org/10.3892/wasj.2026.486
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