|
1
|
Bartold PM and Van Dyke TE: Periodontitis:
A host-mediated disruption of microbial homeostasis. Unlearning
learned concepts. Periodontol 2000. 62:203–217. 2013.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Hajishengallis G: Immunomicrobial
pathogenesis of periodontitis: Keystones, pathobionts and host
response. Trends Immunol. 35:3–11. 2014.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Page RC: The pathobiology of periodontal
diseases may affect systemic disease: Inversion of a paradigm. Ann
Periodontol. 3:108–120. 1998.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Dodero VI, Morré SA and Behzadi P:
Editorial: Gut microbiota and immunity in health and disease:
Dysbiosis and eubiosis effects on the human body. Front Immunol.
15(1536258)2024.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Behzadi P, Dodero VI and Golubnitschaja O:
Systemic inflammation as the health-related communication tool
between the human host and gut microbiota in the framework of
predictive, preventive and personalised medicine. In: All Around
Suboptimal Health: Advanced Approaches by Predictive, Preventive
and Personalised Medicine for Healthy Populations. Wang W (ed).
Springer Nature Switzerland, Cham, pp203-241, 2024.
|
|
6
|
Petakh P, Duve K, Oksenych V, Behzadi P
and Kamyshnyi O: Molecular mechanisms and therapeutic possibilities
of short-chain fatty acids in posttraumatic stress disorder
patients: A mini-review. Front Neurosci. 18(1394953)2024.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Goodson JM, Offenbacher S, Farr DH and
Hogan PE: Periodontal disease treatment by local drug delivery. J
Periodontol. 56:265–272. 1985.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Evans RT, Klausen B, Sojar HT, Bedi GS,
Sfintescu C, Ramamurthy NS, Golub LM and Genco RJ: Immunisation
with a purified outer membrane antigen complex of Bacteroides
gingivalis protects against periodontal destruction in nonhuman
primates. Infect Immun. 60:2926–2935. 1992.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Choi JI and Seymour GJ: Vaccines against
periodontitis: a forward-looking review. J Periodontal Implant Sci.
40:153–163. 2010.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Hajishengallis G, Chavakis T and Lambris
JD: Current understanding of periodontal disease pathogenesis and
targets for host-modulation therapy. Periodontol 2000. 84:14–34.
2020.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Behzadi P, García-Perdomo HA and Karpiński
TM: Toll-like receptors: General molecular and structural biology.
J Immunol Res. 2021(9914854)2021.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Behzadi P, Sameer AS, Nissar S, Banday MZ,
Gajdács M, García-Perdomo HA, Akhtar K, Pinheiro M, Magnusson P,
Sarshar M and Ambrosi C: The interleukin-1 (IL-1) superfamily
cytokines and their single-nucleotide polymorphisms (SNPs). J
Immunol Res. 2022(2054431)2022.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Mukherjee S, Patra R, Behzadi P, Masotti
A, Paolini A and Sarshar M: Toll-like receptor-guided therapeutic
intervention of human cancers: Molecular and immunological
perspectives. Front Immunol. 14(1244345)2023.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Behzadi P, Chandran D, Chakraborty C,
Bhattacharya M, Saikumar G, Dhama K, Chakraborty A, Mukherjee S and
Sarshar M: The dual role of toll-like receptors in COVID-19:
Balancing protective immunity and immunopathogenesis. Int J Biol
Macromol. 284(Pt 2)(137836)2025.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Sharaf SS and Hijazi K: Modulatory
mechanisms of pathogenicity in Porphyromonas gingivalis and other
periodontal pathobionts. Microorganisms. 11(15)2022.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Nadaf R, Kumbar VM and Ghagane S:
Unravelling the intricacies of Porphyromonas gingivalis: Virulence
factors, lifecycle dynamics and phytochemical interventions for
periodontal disease management. APMIS. 132:611–624. 2024.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Shahoumi LA, Saleh MHA and Meghil MM:
Virulence factors of the periodontal pathogens: Tools to evade the
host immune response and promote carcinogenesis. Microorganisms.
11(115)2023.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Curtis MA, Aduse-Opoku J and Rangarajan M:
Cysteine proteases of Porphyromonas gingivalis. Crit Rev Oral Biol
Med. 12:192–216. 2001.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Pathirana RD, O'Brien-Simpson NM, Veith
PD, Riley PF and Reynolds EC: Characterization of
proteinase-adhesin complexes of Porphyromonas gingivalis.
Microbiology (Reading). 152:2381–2394. 2006.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Paramonov N, Bailey D, Rangarajan M,
Hashim A, Kelly G, Curtis MA and Hounsell EF: Structural analysis
of the polysaccharide from the lipopolysaccharide of
Porphyromonas gingivalis strain W50. Eur J Biochem.
268:4698–4707. 2001.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Dashper SG, Seers CA, Tan KH and Reynolds
EC: Virulence factors of the oral spirochete Treponema denticola. J
Dent Res. 90:691–703. 2011.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Tribble GD, Kerr JE and Wang BY: Genetic
diversity in the oral pathogen Porphyromonas gingivalis:
molecular mechanisms and biological consequences. Future Microbiol.
8:607–620. 2013.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Hajishengallis G and Lamont RJ: Beyond the
red complex and into more complexity: The polymicrobial synergy and
dysbiosis (PSD) model of periodontal disease aetiology. Mol Oral
Microbiol. 27:409–419. 2012.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Vernal R, Leon R, Herrera D, Garcia-Sanz
JA and Silva and Sanz M: Variability in the response of human
dendritic cells stimulated with Porphyromonas gingivalis or
Aggregatibacter actinomycetemcomitans. J Periodontal Res.
43:689–697. 2008.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Maekawa T, Krauss JL, Abe T, Jotwani R,
Triantafilou M, Triantafilou K, Hashim A, Hoch S, Curtis MA,
Nussbaum G, et al: Porphyromonas gingivalis manipulates
complement and TLR signaling to uncouple bacterial clearance from
inflammation and promote dysbiosis. Cell Host Microbe. 15:768–778.
2014.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Tada A and Senpuku H: The current status
and prospects of periodontal vaccine development. Vaccines (Basel).
9(254)2021.
|
|
27
|
Pulendran B, S Arunachalam P and O'Hagan
DT: Emerging concepts in the science of vaccine adjuvants. Nat Rev
Drug Discov. 20:454–475. 2021.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Hou X, Zaks T, Langer R and Dong Y: Lipid
nanoparticles for mRNA delivery. Nat Rev Mater. 6:1078–1094.
2021.
|
|
29
|
Prinindya KNN, Ashraf GM, Uddin S, Mahdi E
and Hasan A: Recent advances in engineering approaches for delivery
of mRNA-based therapeutics. Biomater Adv.
182(214667)2026.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Olawade DB, Teke J, Fapohunda O,
Weerasinghe K, Usman SO, Ige AO and Clement David-Olawade A:
Leveraging artificial intelligence in vaccine development: A
narrative review. J Microbiol Methods. 224(106998)2024.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Holmgren J and Czerkinsky C: Mucosal
immunity and vaccines. Nat Med. 11 (4 Suppl):S45–S53.
2005.PubMed/NCBI View
Article : Google Scholar
|
|
32
|
Neutra MR and Kozlowski PA: Mucosal
vaccines: The promise and the challenge. Nat Rev Immunol.
6:148–158. 2006.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Lycke N: Recent progress in mucosal
vaccine development: Potential and limitations. Nat Rev Immunol.
12:592–605. 2012.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Mestecky J, Moldoveanu Z and Russell MW:
Immunologic uniqueness of the genital tract: Challenge for vaccine
development. Am J Reprod Immunol. 53:208–214. 2005.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Wang S, Liu H, Zhang X and Qian F:
Intranasal and oral vaccination with protein-based antigens:
Advantages, challenges and formulation strategies. Protein Cell.
6:480–503. 2015.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Liu C, Hashizume T, Kurita-Ochiai T,
Fujihashi K and Yamamoto M: Oral immunization with Porphyromonas
gingivalis outer membrane protein and CpG oligodeoxynucleotides
elicits T helper 1 and 2 cytokines for enhanced protective
immunity. Mol Oral Microbiol. 25:178–189. 2010.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Toniolo A, Maccari G and Camussi G: mRNA
technology and mucosal immunisation. Vaccines (Basel).
12(670)2024.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Vasu M, Yadav P, Satyanarayana Y, Ahlawat
J, Sandeep D and Kumar KN: Golden threads of lipid nanoparticles
(LNPs) contributing to COVID-19 mRNA vaccine: A review. BioNanoSci.
14:3430–3439. 2024.
|
|
39
|
Wang S, Yan T, Zhang B, Chen Y and Li Z:
Porphyromonas gingivalis vaccine: Antigens and mucosal adjuvants.
Vaccines (Basel). 12(619)2024.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Qin X, Zhang Z, Wei T, Li M, Qin H, Xu X,
Song J and Lin Y: Mucosal gingipain vaccine based on framework
nucleic acid engineering for the treatment of periodontitis. ACS
Appl Mater Interfaces. 18:21562–21578. 2026.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Gibson FC III and Genco CA:
Porphyromonas gingivalis mediated periodontal disease and
atherosclerosis: disparate diseases with commonalities in
pathogenesis through TLRs. Curr Pharm Des. 13:3665–3675.
2007.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Kesavalu L, Sathishkumar S, Bakthavatchalu
V, Matthews C, Dawson D, Steffen M and Ebersole JL: Rat model of
polymicrobial infection, immunity and alveolar bone resorption in
periodontal disease. Infect Immun. 75:1704–1712. 2007.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Gopinath D, Pandiar D, Li Z and Panda S: .
Rodent models for oral microbiome research: Considerations and
challenges-a mini review. Front Oral Health.
5(1439091)2024.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Acqua YD, Hernández C, Fogacci M,
Barbirato D and Palioto D: Local and systemic effects produced in
different models of experimental periodontitis in mice: A
systematic review. Arch Oral Biol. 143(105528)2022.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Baker PJ, Evans RT and Roopenian DC: Oral
infection with Porphyromonas gingivalis induced alveolar bone loss
in immunocompetent and severe combined immunodeficient mice. Arch
Oral Biol. 39:1035–1040. 1994.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Kornman KS, Page RC and Tonetti MS: The
host response to the microbial challenge in periodontitis:
Assembling the players. Periodontol 2000. 14:33–53. 1997.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Preshaw PM, Seymour RA and Heasman PA:
Current concepts in periodontal pathogenesis. Dent Update.
31:570–578. 2004.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Myneni SR, Brocavich K and H Wang H:
Biological strategies for the prevention of periodontal disease:
Probiotics and vaccines. Periodontol 2000. 84:161–175.
2020.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Baddouri L and Hannig M: Probiotics as an
adjunctive therapy in periodontitis treatment-reality or illusion-a
clinical perspective. NPJ Biofilms Microbiomes.
10(148)2024.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Mendonça CD, Mata ADSPD, Azevedo LFR,
Marques JF, Silveira JML and Marques DNDS: Probiotics in the
non-surgical treatment of periodontitis: A systematic review and
network meta-analysis. BMC Oral Health. 24(1224)2024.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Van Dyke TE: Pro-resolving lipid
mediators: Potential for prevention and treatment of periodontitis.
J Clin Periodontol. 38 (Suppl 11):S119–S125. 2011.
|
|
52
|
Rappuoli R, Black S and Bloom DE: Vaccines
and global health: In search of a sustainable model for vaccine
development and delivery. Sci Transl Med.
11(eaaw2888)2019.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Plotkin SA: Vaccines: Past, present and
future. Nat Med. 11 (4 Suppl):S5–S11. 2005.
|
|
54
|
Seymour GJ, Ford PJ, Cullinan MP, Leishman
S and Yamazaki K: Relationship between periodontal infections and
systemic disease. Clin Microbiol Infect. 13 (Suppl 4):S3–S10.
2007.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Hajishengallis G: Periodontitis: From
microbial immune subversion to systemic inflammation. Nat Rev
Immunol. 15:30–44. 2015.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Nasiri O, Hajihassani M, Noori Goodarzi N,
Fereshteh S, Bolourchi N, Firoozeh F, Azizi O and Badmasti F:
Reverse vaccinology approach to identify novel and immunogenic
targets against Porphyromonas gingivalis: An in silico
study. PLoS One. 17(e0273770)2022.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Villanueva-Flores F, Sanchez-Villamil JI
and Garcia-Atutxa I: Publisher Correction: AI-driven epitope
prediction: A systematic review, comparative analysis, and
practical guide for vaccine development. NPJ Vaccines.
10(209)2025.PubMed/NCBI View Article : Google Scholar
|
