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Review Open Access

Advanced drug delivery systems for wound healing and tissue regeneration: Current progress and translational perspectives (Review)

  • Authors:
    • Anup Kumar Dash
    • Dharmendra Prasad Kewat
    • Omprakash Mori
    • Vijay Kumar Singh
    • Khemraj Sahu
    • Ravi Parashar
    • Rakesh Sahu
    • Harish Bhardwaj
  • View Affiliations / Copyright

    Affiliations: Faculty of Pharmacy, Shri Rawatpura Sarkar University, Raipur, Chhattisgarh 492015, India, School of Studies in Biotechnology, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh 492010, India, University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh 492010, India, School of Pharmacy, Sharda University, Greater Noida, Uttar Pradesh 201310, India
    Copyright: © Dash et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 83
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    Published online on: July 24, 2026
       https://doi.org/10.3892/wasj.2026.498
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Abstract

Wound healing is a multifaceted and tightly regulated process involving four sequential, yet overlapping phases: Hemostasis, inflammation, proliferation and remodeling. Chronic wounds and extensive tissue injuries often remain unresolved due to the limitations of conventional therapies, including poor drug bioavailability, inadequate targeting and the lack of sustained release. Recent advances in drug delivery technologies have significantly improved therapeutic outcomes by enabling the precise, localized and temporally controlled delivery of regenerative agents. The present review explores the latest innovations in drug delivery systems, including nanoparticles, hydrogels, microneedles, exosomes and 3D‑printed scaffolds, that facilitate enhanced tissue regeneration. These systems improve the delivery of bioactive molecules, including growth factors, stem cells and small‑molecule drugs, thereby promoting angiogenesis, cellular proliferation and extracellular matrix remodeling, while reducing inflammation and the risk of infection. Furthermore, stimuli‑responsive delivery platforms that react to pH, enzymatic activity, or oxidative stress provide dynamic regulation of the wound microenvironment. The integration of innovative biomaterials with biologics and engineering solutions marks a transformative step in regenerative wound care. The present review provides a comprehensive discussion of emerging drug delivery strategies that hold promise for accelerating and managing wound healing.
View Figures

Figure 1

Schematic diagram illustrating the
phases of wound healing.

Figure 2

Schematic diagram illustrating the
various nanoparticles used in chronic wound management.

Figure 3

Schematic diagram illustrating smart
hydrogel-based drug delivery systems for diabetic wounds.
View References

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Copy and paste a formatted citation
Spandidos Publications style
Dash AK, Kewat DP, Mori O, Singh VK, Sahu K, Parashar R, Sahu R and Bhardwaj H: Advanced drug delivery systems for wound healing and tissue regeneration: Current progress and translational perspectives (Review). World Acad Sci J 8: 83, 2026.
APA
Dash, A.K., Kewat, D.P., Mori, O., Singh, V.K., Sahu, K., Parashar, R. ... Bhardwaj, H. (2026). Advanced drug delivery systems for wound healing and tissue regeneration: Current progress and translational perspectives (Review). World Academy of Sciences Journal, 8, 83. https://doi.org/10.3892/wasj.2026.498
MLA
Dash, A. K., Kewat, D. P., Mori, O., Singh, V. K., Sahu, K., Parashar, R., Sahu, R., Bhardwaj, H."Advanced drug delivery systems for wound healing and tissue regeneration: Current progress and translational perspectives (Review)". World Academy of Sciences Journal 8.5 (2026): 83.
Chicago
Dash, A. K., Kewat, D. P., Mori, O., Singh, V. K., Sahu, K., Parashar, R., Sahu, R., Bhardwaj, H."Advanced drug delivery systems for wound healing and tissue regeneration: Current progress and translational perspectives (Review)". World Academy of Sciences Journal 8, no. 5 (2026): 83. https://doi.org/10.3892/wasj.2026.498
Copy and paste a formatted citation
x
Spandidos Publications style
Dash AK, Kewat DP, Mori O, Singh VK, Sahu K, Parashar R, Sahu R and Bhardwaj H: Advanced drug delivery systems for wound healing and tissue regeneration: Current progress and translational perspectives (Review). World Acad Sci J 8: 83, 2026.
APA
Dash, A.K., Kewat, D.P., Mori, O., Singh, V.K., Sahu, K., Parashar, R. ... Bhardwaj, H. (2026). Advanced drug delivery systems for wound healing and tissue regeneration: Current progress and translational perspectives (Review). World Academy of Sciences Journal, 8, 83. https://doi.org/10.3892/wasj.2026.498
MLA
Dash, A. K., Kewat, D. P., Mori, O., Singh, V. K., Sahu, K., Parashar, R., Sahu, R., Bhardwaj, H."Advanced drug delivery systems for wound healing and tissue regeneration: Current progress and translational perspectives (Review)". World Academy of Sciences Journal 8.5 (2026): 83.
Chicago
Dash, A. K., Kewat, D. P., Mori, O., Singh, V. K., Sahu, K., Parashar, R., Sahu, R., Bhardwaj, H."Advanced drug delivery systems for wound healing and tissue regeneration: Current progress and translational perspectives (Review)". World Academy of Sciences Journal 8, no. 5 (2026): 83. https://doi.org/10.3892/wasj.2026.498
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