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World Academy of Sciences Journal
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Print ISSN: 2632-2900 Online ISSN: 2632-2919
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November-December 2026 Volume 8 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Review Open Access

Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review)

  • Authors:
    • Ajitha Kumari Jeyachandran
    • Srinidhi Rai
    • Sujal Kumar Shetty
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, KS Hegde Medical Academy (KSHEMA), Nitte (Deemed to be University), Mangaluru, Karnataka 575018, India, Department of Cardiology, KS Hegde Medical Academy (KSHEMA), Nitte (Deemed to be University), Mangaluru, Karnataka 575018, India
    Copyright: © Jeyachandran et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 104
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    Published online on: October 20, 2026
       https://doi.org/10.3892/wasj.2026.519
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Abstract

Coronary artery disease (CAD) is characterized by the atherosclerotic narrowing of the coronary arteries. Sortilin regulates lipid metabolism, inflammation and vascular function, including hepatic very‑low‑density lipoprotein secretion and low‑density lipoprotein receptor degradation. In vascular tissues, sortilin increases inflammatory cytokine release and macrophage cholesterol accumulation, leading to foam cell formation and plaque progression. It also promotes vascular calcification by increasing pro‑calcific vesicle release from vascular smooth muscle cells. In adipose tissue, altered sortilin activity contributes to inflammation and insulin resistance through changes in adipokine secretion and ceramide production. Increased circulating sortilin levels have been reported in conditions, such as polycystic ovary syndrome and preeclampsia, suggesting a role in early cardiovascular risk in women. The present review describes the structure, expression and cellular functions of sortilin, and discusses its roles in lipid metabolism, insulin resistance, glucose metabolism and atherosclerosis. Sortilin may serve as a biomarker and therapeutic target in CAD by regulating lipid metabolism and vascular inflammation.

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Copy and paste a formatted citation
Spandidos Publications style
Jeyachandran AK, Rai S and Shetty SK: Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review). World Acad Sci J 8: 104, 2026.
APA
Jeyachandran, A.K., Rai, S., & Shetty, S.K. (2026). Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review). World Academy of Sciences Journal, 8, 104. https://doi.org/10.3892/wasj.2026.519
MLA
Jeyachandran, A. K., Rai, S., Shetty, S. K."Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review)". World Academy of Sciences Journal 8.6 (2026): 104.
Chicago
Jeyachandran, A. K., Rai, S., Shetty, S. K."Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review)". World Academy of Sciences Journal 8, no. 6 (2026): 104. https://doi.org/10.3892/wasj.2026.519
Copy and paste a formatted citation
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Spandidos Publications style
Jeyachandran AK, Rai S and Shetty SK: Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review). World Acad Sci J 8: 104, 2026.
APA
Jeyachandran, A.K., Rai, S., & Shetty, S.K. (2026). Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review). World Academy of Sciences Journal, 8, 104. https://doi.org/10.3892/wasj.2026.519
MLA
Jeyachandran, A. K., Rai, S., Shetty, S. K."Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review)". World Academy of Sciences Journal 8.6 (2026): 104.
Chicago
Jeyachandran, A. K., Rai, S., Shetty, S. K."Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review)". World Academy of Sciences Journal 8, no. 6 (2026): 104. https://doi.org/10.3892/wasj.2026.519
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