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Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review)

  • Authors:
    • Ajitha Kumari Jeyachandran
    • Srinidhi Rai
    • Sujal Kumar Shetty
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, KS Hegde Medical Academy (KSHEMA), Nitte (Deemed to be University), Mangaluru, Karnataka 575018, India, Department of Cardiology, KS Hegde Medical Academy (KSHEMA), Nitte (Deemed to be University), Mangaluru, Karnataka 575018, India
    Copyright: © Jeyachandran et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 104
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    Published online on: October 20, 2026
       https://doi.org/10.3892/wasj.2026.519
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Abstract

Coronary artery disease (CAD) is characterized by the atherosclerotic narrowing of the coronary arteries. Sortilin regulates lipid metabolism, inflammation and vascular function, including hepatic very‑low‑density lipoprotein secretion and low‑density lipoprotein receptor degradation. In vascular tissues, sortilin increases inflammatory cytokine release and macrophage cholesterol accumulation, leading to foam cell formation and plaque progression. It also promotes vascular calcification by increasing pro‑calcific vesicle release from vascular smooth muscle cells. In adipose tissue, altered sortilin activity contributes to inflammation and insulin resistance through changes in adipokine secretion and ceramide production. Increased circulating sortilin levels have been reported in conditions, such as polycystic ovary syndrome and preeclampsia, suggesting a role in early cardiovascular risk in women. The present review describes the structure, expression and cellular functions of sortilin, and discusses its roles in lipid metabolism, insulin resistance, glucose metabolism and atherosclerosis. Sortilin may serve as a biomarker and therapeutic target in CAD by regulating lipid metabolism and vascular inflammation.
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Copy and paste a formatted citation
Spandidos Publications style
Jeyachandran AK, Rai S and Shetty SK: Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review). World Acad Sci J 8: 104, 2026.
APA
Jeyachandran, A.K., Rai, S., & Shetty, S.K. (2026). Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review). World Academy of Sciences Journal, 8, 104. https://doi.org/10.3892/wasj.2026.519
MLA
Jeyachandran, A. K., Rai, S., Shetty, S. K."Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review)". World Academy of Sciences Journal 8.6 (2026): 104.
Chicago
Jeyachandran, A. K., Rai, S., Shetty, S. K."Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review)". World Academy of Sciences Journal 8, no. 6 (2026): 104. https://doi.org/10.3892/wasj.2026.519
Copy and paste a formatted citation
x
Spandidos Publications style
Jeyachandran AK, Rai S and Shetty SK: Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review). World Acad Sci J 8: 104, 2026.
APA
Jeyachandran, A.K., Rai, S., & Shetty, S.K. (2026). Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review). World Academy of Sciences Journal, 8, 104. https://doi.org/10.3892/wasj.2026.519
MLA
Jeyachandran, A. K., Rai, S., Shetty, S. K."Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review)". World Academy of Sciences Journal 8.6 (2026): 104.
Chicago
Jeyachandran, A. K., Rai, S., Shetty, S. K."Multifaceted role of sortilin in coronary artery disease: Insight with sex‑based implication (Review)". World Academy of Sciences Journal 8, no. 6 (2026): 104. https://doi.org/10.3892/wasj.2026.519
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