Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review)

Dong,Xianglin; Mao,Shaolin; Wen,Hao

doi:10.3892/br.2013.169

Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review)

Authors:
- Xianglin Dong
- Shaolin Mao
- Hao Wen
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Affiliations: Department of Burns and Plastic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China, Department of Hydatid Hepatobiliary, Digestive and Vascular Surgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
Published online on: September 25, 2013 https://doi.org/10.3892/br.2013.169
Pages: 833-836

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Abstract

It was previously demonstrated that the main cause behind keloid formation may be keloid fibroblast abnormalities, which are closely associated with the microenvironment of the keloid lesion. The post‑traumatic and chronic inflammation of the keloid lesion area suggest that inflammatory mediators play an important role in the keloid microenvironment and are crucial for keloid fibroblast abnormalities. In this study, we hypothesized that the mechanism underlying keloid formation may involve the continuous upregulation of proinflammatory gene expression in keloid lesions. This hypothesis may explain the inflammatory response, invasive growth and recurrence following resection of keloids, as well as the selective localization of keloids in specific parts of a patient's body and the differences in localization among different patients.

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