Palm dermatoglyphs and interleukin‑4 receptor polymorphisms in asthma

Sun,Lixin; Xue,Weilin; Li,Jun; Zhou,Zhaoshan; Han,Wei

doi:10.3892/br.2016.803

Palm dermatoglyphs and interleukin‑4 receptor polymorphisms in asthma

Authors:
- Lixin Sun
- Weilin Xue
- Jun Li
- Zhaoshan Zhou
- Wei Han
View Affiliations

Affiliations: Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China, Department of Respiratory Medicine, Qingdao Haici Hospital, Qingdao, Shandong 266033, P.R. China, Department of Respiratory Medicine, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China
Published online on: November 7, 2016 https://doi.org/10.3892/br.2016.803
Pages: 21-26
Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Single nucleotide polymorphisms (SNPs) in the interleukin‑4 receptor (IL‑4R) gene have been identified as having a close association with asthma severity in different populations. In our previous studies, a close association between asthma and a distinctive palm dermatoglyphic pattern was observed; however, the clinical implication and underlying genetic mechanisms of this particular palm pattern have not been clarified. Whether this particular palm pattern is associated with asthma severity and IL‑4R SNPs was assessed in the present study. A case cohort study was conducted in 400 patients with allergic asthma and in 200 healthy controls. DNA was extracted from peripheral blood leukocytes for analysis of 11 IL‑4R SNPs associated with asthma via polymerase chain reaction. There are two SNPs, rs1805012 and rs3024608, which are associated with asthma (rs1805012, dominant model; P=0.03 and rs3024608, codominant model; P=0.029), and two SNPs, rs1805010 and rs3024608, which are associated with the positive palm pattern (rs1805010, log‑additive model; P=0.031 and rs3024608, codominant model; P=0.016). The SNP of rs3024608 is associated with asthma and the positive palm pattern. Thus, genetic variation in IL‑4R may be associated with the development of asthma and the distinctive palm pattern; however, further investigations are required to identify the connection between asthma and palm dermatoglyphic patterns.

View Figures

View References

1	Global Initiative for Asthma, . Global Strategy for Asthma Management and Prevention. http://www.ginasthma.org
2	Zhu J: T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production. Cytokine. 75:14–24. 2015. View Article : Google Scholar : PubMed/NCBI
3	Zhu N, Gong Y, Chen XD, Zhang J, Long F, He J, Xia JW and Dong L: Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma. Chin Med J (Engl). 126:2943–2951. 2013.PubMed/NCBI
4	Soto-Ramírez N, Arshad SH, Holloway JW, Zhang H, Schauberger E, Ewart S, Patil V and Karmaus W: The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years. Clin Epigenetics. 5:1–5. 2013. View Article : Google Scholar : PubMed/NCBI
5	Zhou ZS, Ji ZQ, Zhu XJ, Wang YQ, Xue WL, Jiang HY and Liang WH: Study on objective and quantitative atopy of thenar eminence print and its correlation with asthma. Shanghai Journal of Traditional Chinese Medicine. 48:14–15. 2014.(In Chinese).
6	Mahajan AA, Gour KK and Thakare AE: The dermatoglyphic patterns in patients of bronchial asthma - a qualitative study. Int J Biol Med Res. 2:806–807. 2011.
7	Pakhale SV, Borole BS, Doshi MA and More VP: Study of the fingertip pattern as a tool for the identification of the dermatoglyphic trait in bronchial asthma. J Clin Diagn Res. 6:1397–1400. 2012.PubMed/NCBI
8	Singh S, Khurana AK, Harode HA, Tripathi A, Pakhare A and Chaware P: Study of fingerprint patterns to evaluate the role of dermatoglyphics in early detection of bronchial asthma. J Nat Sci Biol Med. 7:43–46. 2016. View Article : Google Scholar : PubMed/NCBI
9	Xue W, Han W and Zhou ZS: ADAM33 polymorphisms are associated with asthma and a distinctive palm dermatoglyphic pattern. Mol Med Rep. 8:1795–1800. 2013.PubMed/NCBI
10	Cazzoletti L, Marcon A, Corsico A, Janson C, Jarvis D, Pin I, Accordini S, Bugiani M, Cerveri I, Gislason D, et al: Therapy and Health Economics Group of the European Community Respiratory Health Survey: Asthma severity according to Global Initiative for Asthma and its determinants: An international study. Int Arch Allergy Immunol. 151:70–79. 2010. View Article : Google Scholar : PubMed/NCBI
11	Wenzel SE, Balzar S, Ampleford E, Hawkins GA, Busse WW, Calhoun WJ, Castro M, Chung KF, Erzurum S, Gaston B, et al: IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression. Am J Respir Crit Care Med. 175:570–576. 2007. View Article : Google Scholar : PubMed/NCBI
12	Narożna B, Hoffmann A, Sobkowiak P, Schoneich N, Bręborowicz A and Szczepankiewicz A: Polymorphisms in the interleukin 4, interleukin 4 receptor and interleukin 13 genes and allergic phenotype: A case control study. Adv Med Sci. 61:40–45. 2016. View Article : Google Scholar : PubMed/NCBI
13	Murk W, Walsh K, Hsu LI, Zhao L, Bracken MB and Dewan AT: Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma. Hum Hered. 71:97–105. 2011. View Article : Google Scholar : PubMed/NCBI
14	Chavarri-Guerra Y and Soto-Perez-de-Celis E: Images in clinical medicine. Loss of fingerprints. N Engl J Med. 372:e222015. View Article : Google Scholar : PubMed/NCBI
15	Kolgeci S, Kolgeci J, Azemi M, Daka A, Shala-Beqiraj R, Kurtishi I and Sopjani M: Dermatoglyphics and Reproductive Risk in a Family with Robertsonian Translocation 14q;21q. Acta Inform Med. 23:178–183. 2015. View Article : Google Scholar : PubMed/NCBI
16	Zvi Shamir E, Levy A, Cassan S Morris, Lifshitz T, Shefler G and Tarrasch R: Do biometric parameters of the hand differentiate schizophrenia from other psychiatric disorders? A comparative evaluation using three mental health modules. Psychiatry Res. 228:425–430. 2015. View Article : Google Scholar : PubMed/NCBI
17	Ezzati A, Batoei F, Jafari SA, Kiyani MA, Mahdavi-Shahri N, Ahanchian H, Tehranian S and Kianifar HR: Dermatoglyphic patterns in cystic fibrosis children. Iran J Pediatr. 24:609–616. 2014.PubMed/NCBI
18	Sen J, Kanchan T and Mondal N: A comparison of palmar dermatoglyphics in two ethnic Indian populations of north Bengal, India. J Forensic Sci. 56:109–117. 2011. View Article : Google Scholar : PubMed/NCBI
19	Navit S, Chadha D, Khan SA, Singh RK, Johri N, Navit P, Sharma A and Bahuguna R: The mystery of handprints: Assesment and correlation of dermatoglyphics with early childhood caries a case-control study. J Clin Diagn Res. 9:ZC44–ZC48. 2015.PubMed/NCBI
20	Eslami N, Jahanbin A, Ezzati A, Banihashemi E and Kianifar H: Can dermatoglyphics be used as a marker for predicting future malocclusions? Electron Physician. 8:1927–1932. 2016. View Article : Google Scholar : PubMed/NCBI
21	Kumasaka N, Yamaguchi-Kabata Y, Takahashi A, Kubo M, Nakamura Y and Kamatani N: Establishment of a standardized system to perform population structure analyses with limited sample size or with different sets of SNP genotypes. J Hum Genet. 55:525–533. 2010. View Article : Google Scholar : PubMed/NCBI