Biological roles of hepatocyte growth factor‑Met signaling from genetically modified animals (Review)
- Authors:
- Takashi Kato
-
Affiliations: Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA - Published online on: October 18, 2017 https://doi.org/10.3892/br.2017.1001
- Pages: 495-503
This article is mentioned in:
Abstract
 |
|
Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A, Tashiro K and Shimizu S: Molecular cloning and expression of human hepatocyte growth factor. Nature. 342:440–443. 1989. View Article : Google Scholar : PubMed/NCBI | |
|
Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N, Nakayama H, Hirono S, Sakiyama O, Takahashi K, et al: Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem Biophys Res Commun. 163:967–973. 1989. View Article : Google Scholar : PubMed/NCBI | |
|
Stoker M, Gherardi E, Perryman M and Gray J: Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature. 327:239–242. 1987. View Article : Google Scholar : PubMed/NCBI | |
|
Zarnegar R, Petersen B, DeFrances MC and Michalopoulos G: Localization of hepatocyte growth factor (HGF) gene on human chromosome 7. Genomics. 12:147–150. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Fukuyama R, Ichijoh Y, Minoshima S, Kitamura N and Shimizu N: Regional localization of the hepatocyte growth factor (HGF) gene to human chromosome 7 band q21.1. Genomics. 11:410–415. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Seki T, Hagiya M, Shimonishi M, Nakamura T and Shimizu S: Organization of the human hepatocyte growth factor-encoding gene. Gene. 102:213–219. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Andermarcher E, Surani MA and Gherardi E: Co-expression of the HGF/SF and c-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis. Dev Genet. 18:254–266. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Matsumoto K, Funakoshi H, Takahashi H and Sakai K: HGF-Met pathway in regeneration and drug discovery. Biomedicines. 2:275–300. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Fajardo-Puerta AB, Mato Prado M, Frampton AE and Jiao LR: Gene of the month: HGF. J Clin Pathol. 69:575–579. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Matsumoto K, Tajima H, Okazaki H and Nakamura T: Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-beta 1 and glucocorticoids. J Biol Chem. 267:24917–24920. 1992.PubMed/NCBI | |
|
Harrison P, Bradley L and Bomford A: Mechanism of regulation of HGF/SF gene expression in fibroblasts by TGF-beta1. Biochem Biophys Res Commun. 271:203–211. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Han S, Stuart LA and Degen SJ: Characterization of the DNF15S2 locus on human chromosome 3: Identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. Biochemistry. 30:9768–9780. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Leonard EJ and Skeel A: A serum protein that stimulates macrophage movement, chemotaxis and spreading. Exp Cell Res. 102:434–438. 1976. View Article : Google Scholar : PubMed/NCBI | |
|
Skeel A, Yoshimura T, Showalter SD, Tanaka S, Appella E and Leonard EJ: Macrophage stimulating protein: Purification, partial amino acid sequence, and cellular activity. J Exp Med. 173:1227–1234. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Shimamoto A, Kimura T, Matsumoto K and Nakamura T: Hepatocyte growth factor-like protein is identical to macrophage stimulating protein. FEBS Lett. 333:61–66. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF and Aaronson SA: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science. 251:802–804. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Naldini L, Vigna E, Narsimhan RP, Gaudino G, Zarnegar R, Michalopoulos GK and Comoglio PM: Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene. 6:501–504. 1991.PubMed/NCBI | |
|
Liu Y: The human hepatocyte growth factor receptor gene: Complete structural organization and promoter characterization. Gene. 215:159–169. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Niemann HH: Structural insights into Met receptor activation. Eur J Cell Biol. 90:972–981. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Stamos J, Lazarus RA, Yao X, Kirchhofer D and Wiesmann C: Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. EMBO J. 23:2325–2335. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Rodrigues GA and Park M: Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase. Oncogene. 9:2019–2027. 1994.PubMed/NCBI | |
|
Maina F, Casagranda F, Audero E, Simeone A, Comoglio PM, Klein R and Ponzetto C: Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell. 87:531–542. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Ponzetto C, Bardelli A, Zhen Z, Maina F, dalla Zonca P, Giordano S, Graziani A, Panayotou G and Comoglio PM: A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell. 77:261–271. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Sachs M, Weidner KM, Brinkmann V, Walther I, Obermeier A, Ullrich A and Birchmeier W: Motogenic and morphogenic activity of epithelial receptor tyrosine kinases. J Cell Biol. 133:1095–1107. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S and Comoglio PM: Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell. 3:347–361. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Palka HL, Park M and Tonks NK: Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. J Biol Chem. 278:5728–5735. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Sangwan V, Paliouras GN, Cheng A, Dubé N, Tremblay ML and Park M: Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure. J Biol Chem. 281:221–228. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Peschard P and Park M: Escape from Cbl-mediated downregulation: A recurrent theme for oncogenic deregulation of receptor tyrosine kinases. Cancer Cell. 3:519–523. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Abella JV, Peschard P, Naujokas MA, Lin T, Saucier C, Urbé S and Park M: Met/hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Mol Cell Biol. 25:9632–9645. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Schmidt C, Bladt F, Goedecke S, Brinkmann V, Zschiesche W, Sharpe M, Gherardi E and Birchmeier C: Scatter factor/hepatocyte growth factor is essential for liver development. Nature. 373:699–702. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Uehara Y, Minowa O, Mori C, Shiota K, Kuno J, Noda T and Kitamura N: Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature. 373:702–705. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Bladt F, Riethmacher D, Isenmann S, Aguzzi A and Birchmeier C: Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature. 376:768–771. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Borowiak M, Garratt AN, Wüstefeld T, Strehle M, Trautwein C and Birchmeier C: Met provides essential signals for liver regeneration. Proc Natl Acad Sci USA. 101:pp. 10608–10613. 2004, View Article : Google Scholar : PubMed/NCBI | |
|
Huh CG, Factor VM, Sánchez A, Uchida K, Conner EA and Thorgeirsson SS: Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci USA. 101:pp. 4477–4482. 2004, View Article : Google Scholar : PubMed/NCBI | |
|
Factor VM, Seo D, Ishikawa T, Kaposi-Novak P, Marquardt JU, Andersen JB, Conner EA and Thorgeirsson SS: Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice. PLoS One. 5:e127392010. View Article : Google Scholar : PubMed/NCBI | |
|
Gómez-Quiroz LE, Factor VM, Kaposi-Novak P, Coulouarn C, Conner EA and Thorgeirsson SS: Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis. J Biol Chem. 283:14581–14589. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kroy DC, Schumacher F, Ramadori P, Hatting M, Bergheim I, Gassler N, Boekschoten MV, Müller M, Streetz KL and Trautwein C: Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice. J Hepatol. 61:883–890. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Takami T, Kaposi-Novak P, Uchida K, Gomez-Quiroz LE, Conner EA, Factor VM and Thorgeirsson SS: Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Res. 67:9844–9851. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Ishikawa T, Factor VM, Marquardt JU, Raggi C, Seo D, Kitade M, Conner EA and Thorgeirsson SS: Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice. Hepatology. 55:1215–1226. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Ishibe S, Karihaloo A, Ma H, Zhang J, Marlier A, Mitobe M, Togawa A, Schmitt R, Czyczk J, Kashgarian M, et al: Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology. Development. 136:337–345. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Ma H, Saenko M, Opuko A, Togawa A, Soda K, Marlier A, Moeckel GW, Cantley LG and Ishibe S: Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction. Kidney Int. 76:868–876. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Dai C, Saleem MA, Holzman LB, Mathieson P and Liu Y: Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuria. Kidney Int. 77:962–973. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Finisguerra V, Di Conza G, Di Matteo M, Serneels J, Costa S, Thompson AA, Wauters E, Walmsley S, Prenen H, Granot Z, et al: MET is required for the recruitment of anti-tumoural neutrophils. Nature. 522:349–353. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Song Y, Su M, Panchatsharam P, Rood D and Lai L: c-Met signalling is required for efficient postnatal thymic regeneration and repair. Immunology. 144:245–253. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Thompson BL and Levitt P: Complete or partial reduction of the Met receptor tyrosine kinase in distinct circuits differentially impacts mouse behavior. J Neurodev Disord. 7:352015. View Article : Google Scholar : PubMed/NCBI | |
|
Judson MC, Eagleson KL, Wang L and Levitt P: Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain. J Comp Neurol. 518:4463–4478. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Qiu S, Anderson CT, Levitt P and Shepherd GM: Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase. J Neurosci. 31:5855–5864. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Qiu S, Lu Z and Levitt P: MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus. J Neurosci. 34:16166–16179. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Avetisyan M, Wang H, Schill EM, Bery S, Grider JR, Hassell JA, Stappenbeck T and Heuckeroth RO: Hepatocyte growth factor and met support mouse enteric nervous system development, the peristaltic response, and intestinal epithelial proliferation in response to injury. J Neurosci. 35:11543–11558. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yamamoto H, Yun EJ, Gerber HP, Ferrara N, Whitsett JA and Vu TH: Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 308:44–53. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Calvi C, Podowski M, Lopez-Mercado A, Metzger S, Misono K, Malinina A, Dikeman D, Poonyagariyon H, Ynalvez L, Derakhshandeh R, et al: Hepatocyte growth factor, a determinant of airspace homeostasis in the murine lung. PLoS Genet. 9:e10032282013. View Article : Google Scholar : PubMed/NCBI | |
|
Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA and Garcia-Ocaña A: Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass. Diabetes. 54:2090–2102. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Dai C, Huh CG, Thorgeirsson SS and Liu Y: Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am J Pathol. 167:429–436. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC and Garcia-Ocaña A: Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes. 60:525–536. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Alvarez-Perez JC, Ernst S, Demirci C, Casinelli GP, Mellado-Gil JM, Rausell-Palamos F, Vasavada RC and Garcia-Ocaña A: Hepatocyte growth factor/c-Met signaling is required for β-cell regeneration. Diabetes. 63:216–223. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Arechederra M, Carmona R, González-Nuñez M, Gutiérrez-Uzquiza A, Bragado P, Cruz-González I, Cano E, Guerrero C, Sánchez A, López-Novoa JM, et al: Met signaling in cardiomyocytes is required for normal cardiac function in adult mice. Biochim Biophys Acta. 1832:2204–2215. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Chmielowiec J, Borowiak M, Morkel M, Stradal T, Munz B, Werner S, Wehland J, Birchmeier C and Birchmeier W: c-Met is essential for wound healing in the skin. J Cell Biol. 177:151–162. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Weidner KM, Di Cesare S, Sachs M, Brinkmann V, Behrens J and Birchmeier W: Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature. 384:173–176. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Sachs M, Brohmann H, Zechner D, Müller T, Hülsken J, Walther I, Schaeper U, Birchmeier C and Birchmeier W: Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol. 150:1375–1384. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Maina F, Panté G, Helmbacher F, Andres R, Porthin A, Davies AM, Ponzetto C and Klein R: Coupling Met to specific pathways results in distinct developmental outcomes. Mol Cell. 7:1293–1306. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Sakata H, Takayama H, Sharp R, Rubin JS, Merlino G and LaRochelle WJ: Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Differ. 7:1513–1523. 1996.PubMed/NCBI | |
|
Shiota G, Wang TC, Nakamura T and Schmidt EV: Hepatocyte growth factor in transgenic mice: Effects on hepatocyte growth, liver regeneration and gene expression. Hepatology. 19:962–972. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Di Renzo MF, Olivero M, Martone T, Maffe A, Maggiora P, Stefani AD, Valente G, Giordano S, Cortesina G and Comoglio PM: Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas. Oncogene. 19:1547–1555. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Suzuki H, Toyoda M, Horiguchi N, Kakizaki S, Ohyama T, Takizawa D, Ichikawa T, Sato K, Takagi H and Mori M: Hepatocyte growth factor protects against Fas-mediated liver apoptosis in transgenic mice. Liver Int. 29:1562–1568. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Kosone T, Takagi H, Horiguchi N, Ariyama Y, Otsuka T, Sohara N, Kakizaki S, Sato K and Mori M: HGF ameliorates a high-fat diet-induced fatty liver. Am J Physiol Gastrointest Liver Physiol. 293:G204–G210. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
García-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, López-Talavera JC and Stewart AF: Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes. 50:2752–2762. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Alvarez-Perez JC, Rosa TC, Casinelli GP, Valle SR, Lakshmipathi J, Rosselot C, Rausell-Palamos F, Vasavada RC and García-Ocaña A: Hepatocyte growth factor ameliorates hyperglycemia and corrects β-cell mass in IRS2-deficient mice. Mol Endocrinol. 28:2038–2048. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC and Stewart AF: Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem. 275:1226–1232. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Sun W, Funakoshi H and Nakamura T: Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS. J Neurosci. 22:6537–6548. 2002.PubMed/NCBI | |
|
Kadoyama K, Funakoshi H, Ohya W and Nakamura T: Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS. Neurosci Res. 59:446–456. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Ding Y, Adachi H, Katsuno M, Huang Z, Jiang YM, Kondo N, Iida M, Tohnai G, Nakatsuji H, Funakoshi H, et al: Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration. Biochem Biophys Res Commun. 468:677–683. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Kato T, Funakoshi H, Kadoyama K, Noma S, Kanai M, Ohya-Shimada W, Mizuno S, Doe N, Taniguchi T and Nakamura T: Hepatocyte growth factor overexpression in the nervous system enhances learning and memory performance in mice. J Neurosci Res. 90:1743–1755. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Yant J, Buluwela L, Niranjan B, Gusterson B and Kamalati T: In vivo effects of hepatocyte growth factor/scatter factor on mouse mammary gland development. Exp Cell Res. 241:476–481. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Fiaschi-Taesch NM, Santos S, Reddy V, Van Why SK, Philbrick WF, Ortega A, Esbrit P, Orloff JJ and Garcia-Ocaña A: Prevention of acute ischemic renal failure by targeted delivery of growth factors to the proximal tubule in transgenic mice: The efficacy of parathyroid hormone-related protein and hepatocyte growth factor. J Am Soc Nephrol. 15:112–125. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Toyoda M, Takayama H, Horiguchi N, Otsuka T, Fukusato T, Merlino G, Takagi H and Mori M: Overexpression of hepatocyte growth factor/scatter factor promotes vascularization and granulation tissue formation in vivo. FEBS Lett. 509:95–100. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Sanchez-Encinales V, Cozar-Castellano I, Garcia-Ocaña A and Perdomo G: Targeted delivery of HGF to the skeletal muscle improves glucose homeostasis in diet-induced obese mice. J Physiol Biochem. 71:795–805. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou D, Tan RJ, Lin L, Zhou L and Liu Y: Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury. Kidney Int. 84:509–520. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Mason S, Hader C, Marlier A, Moeckel G and Cantley LG: Met activation is required for early cytoprotection after ischemic kidney injury. J Am Soc Nephrol. 25:329–337. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, Casinelli GP, Alonso LC, Vasavada RC and García-Ocana A: Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus. Diabetes. 61:1143–1152. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Garner OB, Bush KT, Nigam KB, Yamaguchi Y, Xu D, Esko JD and Nigam SK: Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol. 355:394–403. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Webster MT and Fan CM: c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration. PLoS One. 8:e817572013. View Article : Google Scholar : PubMed/NCBI | |
|
Kasaoka M, Ma J and Lashkari K: c-Met modulates RPE migratory response to laser-induced retinal injury. PLoS One. 7:e407712012. View Article : Google Scholar : PubMed/NCBI | |
|
Baek JH, Birchmeier C, Zenke M and Hieronymus T: The HGF receptor/Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity. J Immunol. 189:1699–1707. 2012. View Article : Google Scholar : PubMed/NCBI |
