Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases

  • Authors:
    • Yan Jia
    • Yu Yue
    • Dan-Ning Hu
    • Ji-Li Chen
    • Ji-Bo Zhou
  • View Affiliations

  • Published online on: October 20, 2017     https://doi.org/10.3892/br.2017.1004
  • Pages:573-578
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Abstract

The present study aims to investigate the association of transforming growth factor-β2 (TGF-β2) and matrix metalloproteinases (MMPs), MMP-2 and MMP-3, and tissue inhibitors of matrix metalloproteinases (TIMPs), TIMP-1, TIMP-2 and TIMP-3 in the aqueous humor of patients with high myopia or cataracts. The levels of TGF-β2 and MMPs/TIMPs were measured with the Luminex xMAP Technology using commercially available Milliplex xMAP kits. The association between TGF-β2 and MMPs/TIMPs levels was analyzed using the Spearman's correlation test. The levels of TGF-β2 were identified to be positively correlated with the levels of TIMP-1 and TIMP-3 (TIMP-1: r=0.334; P=0.007; TIMP-3: r=0.309; P=0.012). The levels of MMP-2, MMP-3 and TIMP-2 did not significantly correlate with TGF-β2 levels (P>0.05). A positive correlation was identified between TGF-β2 and TIMPs in the aqueous humor of human eyes with elongated axial length. It appears that TGF-β2 stimulates the expression of TIMPs as a compensatory reaction to the development of high myopia.

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December 2017
Volume 7 Issue 6

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Jia, Y., Yue, Y., Hu, D., Chen, J., & Zhou, J. (2017). Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases. Biomedical Reports, 7, 573-578. https://doi.org/10.3892/br.2017.1004
MLA
Jia, Y., Yue, Y., Hu, D., Chen, J., Zhou, J."Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases". Biomedical Reports 7.6 (2017): 573-578.
Chicago
Jia, Y., Yue, Y., Hu, D., Chen, J., Zhou, J."Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases". Biomedical Reports 7, no. 6 (2017): 573-578. https://doi.org/10.3892/br.2017.1004