Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice

  • Authors:
    • Krisana Asano
    • Emiko Takahashi
    • Sayuri Yoshimura
    • Akio Nakane
  • View Affiliations

  • Published online on: November 2, 2017     https://doi.org/10.3892/br.2017.1011
  • Pages:37-40
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Abstract

Proteoglycan (PG) is a complex glycohydrate that is widely distributed in the extracellular matrix. Oral administration of PG extracted from salmon nasal cartilage has been reported to attenuate the severity and proinflammatory cytokine responses in mouse experimental colitis, autoimmune encephalomyelitis, collagen-induced arthritis and obesity-induced inflammation. In the present study, the effects of salmon nasal cartilage PG on skin allografts were investigated in a mouse model. Oral administration of PG prolonged the survival of skin grafts within 10 days of transplantation. Although PG failed to inhibit allograft rejection at the final stage of transplantation, PG attenuated the cell infiltration in the skin under the transplanted site.

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January 2018
Volume 8 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Asano, K., Takahashi, E., Yoshimura, S., & Nakane, A. (2018). Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice. Biomedical Reports, 8, 37-40. https://doi.org/10.3892/br.2017.1011
MLA
Asano, K., Takahashi, E., Yoshimura, S., Nakane, A."Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice". Biomedical Reports 8.1 (2018): 37-40.
Chicago
Asano, K., Takahashi, E., Yoshimura, S., Nakane, A."Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice". Biomedical Reports 8, no. 1 (2018): 37-40. https://doi.org/10.3892/br.2017.1011