Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
February-2018 Volume 8 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 8 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Efficacy of vonoprazan for 24-week maintenance therapy of patients with healed reflux esophagitis refractory to proton pump inhibitors

  • Authors:
    • Hideki Mizuno
    • Kazutoshi Yamada
    • Keiji Minouchi
    • Shinji Kamiyamamoto
    • Yoshinobu Hinoue
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Toyama City Hospital, Toyama 939-8511, Japan
    Copyright: © Mizuno et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 148-155
    |
    Published online on: December 28, 2017
       https://doi.org/10.3892/br.2017.1035
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to evaluate the efficacy of a potassium‑competitive acid blocker (P‑CAB), vonoprazan, for the maintenance therapy of healed reflux esophagitis (RE). A total of 60 patients were enrolled in this open‑label, single‑center, prospective study. All patients were diagnosed with RE with a frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) total score ≥8 following treatment with standard proton pump inhibitors (PPIs) for a minimum of 8 weeks. Standard PPI treatment was switched to vonoprazan 20 mg once daily for 4 weeks. A total of 52 patients, who had no endoscopic evidence of erosive esophagitis following vonoprazan treatment, received maintenance therapy with vonoprazan 10 mg once daily for 24 weeks. Symptoms were evaluated using the FSSG and Gastrointestinal Symptom Rating Scale (GSRS). Upper gastrointestinal endoscopies were performed following 24 weeks of maintenance therapy. The primary endpoint was to determine the proportion of patients who exhibited maintenance of healed RE refractory to PPIs following 24 weeks of maintenance therapy with vonoprazan 10 mg once daily. Secondary endpoints included evaluation of the proportion of patients with symptomatic non‑relapse at 24 weeks. Maintenance therapy with vonoprazan 10 mg once daily prevented relapse of esophageal mucosal breaks in 37/43 (86.0%) patients at 24 weeks. However, the number of patients with symptomatic relapse was 1 (1.9%) and 4 (7.7%) at 4 and 8 weeks, respectively. A total of 4 patients were withdrawn due to loss to follow‑up. At the end of the 24‑week maintenance period, the symptomatic non‑relapse rate for acid reflux‑associated and dysmotility symptom FSSG scores were 86.5 and 80.8%, respectively. Furthermore, the symptomatic non‑relapse rate for reflux, abdominal pain, indigestion, diarrhea, and constipation GSRS scores at 24 weeks were 86.5, 80.8, 75.0, 71.2 and 76.9%, respectively. No serious adverse events were reported during the study. The mean gastrin level was 1,059 pg/ml. In conclusion, the results of the present study indicate that vonoprazan 10 mg once daily is effective for 24‑week maintenance therapy of healed RE refractory to PPIs.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Iwakiri K, Kinoshita Y, Habu Y, Oshima T, Manabe N, Fujiwara Y, Nagahara A, Kawamura O, Iwakiri R, Ozawa S, et al: Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015. J Gastroenterol. 51:751–767. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Fujiwara Y and Arakawa T: Epidemiology and clinical characteristics of GERD in the Japanese population. J Gastroenterol. 44:518–534. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Miwa H, Yokoyama T, Hori K, Sakagami T, Oshima T, Tomita T, Fujiwara Y, Saita H, Itou T, Ogawa H, et al: Interobserver agreement in endoscopic evaluation of reflux esophagitis using a modified Los Angeles classification incorporating grades N and M: A validation study in a cohort of Japanese endoscopists. Dis Esophagus. 21:355–363. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Kahrilas PJ, Shaheen NJ and Vaezi MF; American Gastroenterological Association Institute, ; Clinical Practice and Quality Management Committee, : American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux disease. Gastroenterology. 135:1392–1413, 1413.e1-1413.e5. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Joh T, Miwa H, Higuchi K, Shimatani T, Manabe N, Adachi K, Wada T, Sasaki M, Fujiwara Y, Hongo M, et al ARS Research Group, : Validity of endoscopic classification of nonerosive reflux disease. J Gastroenterol. 42:444–449. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Pace F, Negrini C, Wiklund I, Rossi C and Savarino V; ITALIAN ONE INVESTIGATORS STUDY GROUP, : Quality of life in acute and maintenance treatment of non-erosive and mild erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 22:349–356. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Wada T, Sasaki M, Kataoka H, Tanida S, Itoh K, Ogasawara N, Oshima T, Togawa S, Kubota E, Yamada T, et al: Efficacy of famotidine and omeprazole in healing symptoms of non-erosive gastro-oesophageal reflux disease: Randomized-controlled study of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 21 Suppl 2:2–9. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Fass R: Erosive esophagitis and nonerosive reflux disease (NERD): Comparison of epidemiologic, physiologic, and therapeutic characteristics. J Clin Gastroenterol. 41:131–137. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Fass R, Shapiro M, Dekel R and Sewell J: Systematic review: Proton-pump inhibitor failure in gastro-oesophageal reflux disease - where next? Aliment Pharmacol Ther. 22:79–94. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Mizuno H, Matsuhashi N, Sakaguchi M, Inoue S, Nakada K, Higuchi K, Haruma K and Joh T: Recent effectiveness of proton pump inhibitors for severe reflux esophagitis: The first multicenter prospective study in Japan. J Clin Biochem Nutr. 57:233–238. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Andersson K and Carlsson E: Potassium-competitive acid blockade: A new therapeutic strategy in acid-related diseases. Pharmacol Ther. 108:294–307. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Hori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M and Inatomi N: 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther. 335:231–238. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Ashida K, Sakurai Y, Nishimura A, Kudou K, Hiramatsu N, Umegaki E, Iwakiri K and Chiba T: Randomised clinical trial: A dose-ranging study of vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the treatment of erosive oesophagitis. Aliment Pharmacol Ther. 42:685–695. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Jenkins H, Sakurai Y, Nishimura A, Okamoto H, Hibberd M, Jenkins R, Yoneyama T, Ashida K, Ogama Y and Warrington S: Randomised clinical trial: Safety, tolerability, pharmacokinetics and pharmacodynamics of repeated doses of TAK-438 (vonoprazan), a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 41:636–648. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Sakurai Y, Mori Y, Okamoto H, Nishimura A, Komura E, Araki T and Shiramoto M: Acid-inhibitory effect of vonoprazan 20 mg compared with esomeprazole 20 mg or rabeprazole 10 mg in healthy adult male subjects - a randomised open-label cross-over study. Aliment Pharmacol Ther. 42:719–730. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Ashida K, Sakurai Y, Hori T, Kudou K, Nishimura A, Hiramatsu N, Umegaki E and Iwakiri K: Randomised clinical trial: Vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the healing of erosive oesophagitis. Aliment Pharmacol Ther. 43:240–251. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Hoshino S, Kawami N, Takenouchi N, Umezawa M, Hanada Y, Hoshikawa Y, Kawagoe T, Sano H, Hoshihara Y, Nomura T, et al: Efficacy of Vonoprazan for Proton Pump Inhibitor-Resistant Reflux Esophagitis. Digestion. 95:156–161. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Okuyama M, Nakahara K, Iwakura N, Hasegawa T, Oyama M, Inoue A, Ishizu H, Satoh H and Fujiwara Y: Factors associated with potassium-competitive acid blocker non-response in patients with proton pump inhibitor-refractory gastroesophageal reflux disease. Digestion. 95:281–287. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Iwakiri K, Sakurai Y, Shiino M, Okamoto H, Kudou K, Nishimura A, Hiramatsu N, Umegaki E and Ashida K: A randomized, double-blind study to evaluate the acid-inhibitory effect of vonoprazan (20 mg and 40 mg) in patients with proton-pump inhibitor-resistant erosive esophagitis. Therap Adv Gastroenterol. 10:439–451. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Kusano M, Shimoyama Y, Sugimoto S, Kawamura O, Maeda M, Minashi K, Kuribayashi S, Higuchi T, Zai H, Ino K, et al: Development and evaluation of FSSG: Frequency scale for the symptoms of GERD. J Gastroenterol. 39:888–891. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, et al: Endoscopic assessment of oesophagitis: Clinical and functional correlates and further validation of the Los Angeles classification. Gut. 45:172–180. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Kinoshita Y and Adachi K: Hiatal hernia and gastroesophageal flap valve as diagnostic indicators in patients with gastroesophageal reflux disease. J Gastroenterol. 41:720–721. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Kimura K and Takemoto T: An endoscopic recognition of the atrophic border and its significance in chronic gastritis. Endoscopy. 1:87–97. 1969. View Article : Google Scholar

24 

Hongo M, Fukuhara S and Green J: Gastrointestinal-related QOL-QOL assessment using the Japanese version of GSRS. Diagn Treat. 87:731–736. 1999.

25 

Drossman DA: The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 130:1377–1390. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Dent J, Brun J, Fendrick A, Fendrick M, Janssens J, Kahrilas P, Lauritsen K, Reynolds J, Shaw M, et al: An evidence-based appraisal of reflux disease management - the Genval Workshop Report. Gut. 44 Suppl 2:S1–S16. 1999. View Article : Google Scholar : PubMed/NCBI

27 

DeVault KR and Castell DO; American College of Gastroenterology, : Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. 100:190–200. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Röhss K, Lind T and Wilder-Smith C: Esomeprazole 40 mg provides more effective intragastric acid control than lansoprazole 30 mg, omeprazole 20 mg, pantoprazole 40 mg and rabeprazole 20 mg in patients with gastro-oesophageal reflux symptoms. Eur J Clin Pharmacol. 60:531–539. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Lauritsen K, Devière J, Bigard MA, Bayerdörffer E, Mózsik G, Murray F, Kristjánsdóttir S, Savarino V, Vetvik K, De Freitas D, et al: Metropole study results: Esomeprazole 20 mg and lansoprazole 15 mg in maintaining healed reflux oesophagitis: Metropole study results. Aliment Pharmacol Ther. 17:333–341. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Labenz J, Armstrong D, Lauritsen K, Katelaris P, Schmidt S, Schütze K, Wallner G, Juergens H, Preiksaitis H, Keeling N, et al: Esomeprazole 20 mg vs. pantoprazole 20 mg for maintenance therapy of healed erosive oesophagitis: Results from the EXPO study. Aliment Pharmacol Ther. 22:803–811. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Devault KR, Johanson JF, Johnson DA, Liu S and Sostek MB: Maintenance of healed erosive esophagitis: A randomized six-month comparison of esomeprazole twenty milligrams with lansoprazole fifteen milligrams. Clin Gastroenterol Hepatol. 4:852–859. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Vakil NB, Shaker R, Johnson DA, Kovacs T, Baerg RD, Hwang C, D'Amico D and Hamelin B: The new proton pump inhibitor esomeprazole is effective as a maintenance therapy in GERD patients with healed erosive oesophagitis: A 6-month, randomized, double-blind, placebo-controlled study of efficacy and safety. Aliment Pharmacol Ther. 15:927–935. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Atug O, Giral A, Kalayci C, Dolar E, Isitan F, Oguz D, Ovunc O, Ozgur O, Soykan I, Simsek I, et al Turkish HEMANEX Study Group, : Esomeprazole in acute and maintenance treatment of reflux oesophagitis: A multicentre prospective study. Adv Ther. 25:552–566. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Piche T and Galmiche JP: Pharmacological targets in gastro-oesophageal reflux disease. Basic Clin Pharmacol Toxicol. 97:333–341. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Sachs G, Shin JM and Howden CW: Review article: The clinical pharmacology of proton pump inhibitors. Aliment Pharmacol Ther. 23 Suppl 2:2–8. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Shimatani T, Inoue M, Kuroiwa T, Xu J, Mieno H, Nakamura M and Tazuma S: Acid-suppressive effects of rabeprazole, omeprazole, and lansoprazole at reduced and standard doses: A crossover comparative study in homozygous extensive metabolizers of cytochrome P450 2C19. Clin Pharmacol Ther. 79:144–152. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Norris V, Baisley K, Dunn K, Warrington S and Morocutti A: Combined analysis of three crossover clinical pharmacology studies of effects of rabeprazole and esomeprazole on 24-h intragastric pH in healthy volunteers. Aliment Pharmacol Ther. 25:501–510. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Yamasaki H, Kawaguchi N, Nonaka M, Takahashi J, Morohashi A, Hirabayashi H, Moriwaki T and Asahi S: In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 47:1027–1034. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Kusunoki H, Kusaka M, Kido S, Yamauchi R, Fujimura Y, Watanabe Y, Kobori M, Miwa H, Tomita T, Kin Y, et al: Comparison of the effects of omeprazole and famotidine in treatment of upper abdominal symptoms in patients with reflux esophagitis. J Gastroenterol. 44:261–270. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Hori K, Matsumoto T and Miwa H: Analysis of the gastrointestinal symptoms of uninvestigated dyspepsia and irritable bowel syndrome. Gut Liver. 3:192–196. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Locke GR III, Zinsmeister AR, Fett SL, Melton LJ III and Talley NJ: Overlap of gastrointestinal symptom complexes in a US community. Neurogastroenterol Motil. 17:29–34. 2005.Soleceperum esequi ut reperum autem es sequat. View Article : Google Scholar : PubMed/NCBI

42 

Quat Nimusa: Umquid maios rerrore mporum evenis eaque sequam, nissitiae rem quam quuntusdae sequo te pro corionsequid magnisint quis duntis ellicae prehent estrume ndanda nonet, ut millace aquatur aspedi dolorro conessimust, a dis im fuga. Itatemq uissusc illatem sernatu saerum qui omniam, sinum fugitium alit facescient.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mizuno H, Yamada K, Minouchi K, Kamiyamamoto S and Hinoue Y: Efficacy of vonoprazan for 24-week maintenance therapy of patients with healed reflux esophagitis refractory to proton pump inhibitors. Biomed Rep 8: 148-155, 2018.
APA
Mizuno, H., Yamada, K., Minouchi, K., Kamiyamamoto, S., & Hinoue, Y. (2018). Efficacy of vonoprazan for 24-week maintenance therapy of patients with healed reflux esophagitis refractory to proton pump inhibitors. Biomedical Reports, 8, 148-155. https://doi.org/10.3892/br.2017.1035
MLA
Mizuno, H., Yamada, K., Minouchi, K., Kamiyamamoto, S., Hinoue, Y."Efficacy of vonoprazan for 24-week maintenance therapy of patients with healed reflux esophagitis refractory to proton pump inhibitors". Biomedical Reports 8.2 (2018): 148-155.
Chicago
Mizuno, H., Yamada, K., Minouchi, K., Kamiyamamoto, S., Hinoue, Y."Efficacy of vonoprazan for 24-week maintenance therapy of patients with healed reflux esophagitis refractory to proton pump inhibitors". Biomedical Reports 8, no. 2 (2018): 148-155. https://doi.org/10.3892/br.2017.1035
Copy and paste a formatted citation
x
Spandidos Publications style
Mizuno H, Yamada K, Minouchi K, Kamiyamamoto S and Hinoue Y: Efficacy of vonoprazan for 24-week maintenance therapy of patients with healed reflux esophagitis refractory to proton pump inhibitors. Biomed Rep 8: 148-155, 2018.
APA
Mizuno, H., Yamada, K., Minouchi, K., Kamiyamamoto, S., & Hinoue, Y. (2018). Efficacy of vonoprazan for 24-week maintenance therapy of patients with healed reflux esophagitis refractory to proton pump inhibitors. Biomedical Reports, 8, 148-155. https://doi.org/10.3892/br.2017.1035
MLA
Mizuno, H., Yamada, K., Minouchi, K., Kamiyamamoto, S., Hinoue, Y."Efficacy of vonoprazan for 24-week maintenance therapy of patients with healed reflux esophagitis refractory to proton pump inhibitors". Biomedical Reports 8.2 (2018): 148-155.
Chicago
Mizuno, H., Yamada, K., Minouchi, K., Kamiyamamoto, S., Hinoue, Y."Efficacy of vonoprazan for 24-week maintenance therapy of patients with healed reflux esophagitis refractory to proton pump inhibitors". Biomedical Reports 8, no. 2 (2018): 148-155. https://doi.org/10.3892/br.2017.1035
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team