Soluble VCAM-1 and its relation to disease progression in colorectal carcinoma

  • Authors:
    • Yoshinaga Okugawa
    • Chikao Miki
    • Yuji Toiyama
    • Yuki Koike
    • Takeshi Yokoe
    • Susumu Saigusa
    • Kouji Tanaka
    • Yasuhiro Inoue
    • Masato Kusunoki
  • View Affiliations

  • Published online on: May 1, 2010     https://doi.org/10.3892/etm_00000072
  • Pages: 463-469
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The membranous form of vascular cell adhesion molecule (VCAM)-1 supports metastasis, while its soluble forms may suppress cancer growth by competitive inhibition of ligand binding to VCAM-1 and/or by inducing chemotaxis of lymphocytes. Here, we investigated the biological kinetics of membranous and soluble forms of VCAM-1 in tumors, and evaluated their association with malignant potential in colorectal cancer. We measured tissue concentrations of soluble VCAM-1 (sVCAM-1) in tumors and normal mucosa from 150 colorectal cancer patients. VCAM-1 expression was detected immunohistochemically. Reduced levels of sVCAM-1 in cancer tissues were significantly associated with factors reflecting disease progression such as T classification, lymphatic duct and vessel involvement, lymph node metastasis and distant metastasis. In Cox multivariate analysis, distant metastasis and reduced sVCAM-1 levels in cancer tissues were independent risk factors for poor prognosis. Immunohistochemically, VCAM-1 was intensely expressed in cancer stroma, and its expression was associated with decreased sVCAM-1 concentrations and poor prognosis. Decreased tissue concentrations of sVCAM-1 in colorectal cancer patients were significantly correlated with clinicopathological parameters and prognosis. Suppressed shedding of membranous VCAM-1 in its soluble form into the cancer stroma might play a role in the progression of colorectal carcinoma.
View Figures
View References

Related Articles

Journal Cover

May-June 2010
Volume 1 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Okugawa Y, Miki C, Toiyama Y, Koike Y, Yokoe T, Saigusa S, Tanaka K, Inoue Y and Kusunoki M: Soluble VCAM-1 and its relation to disease progression in colorectal carcinoma . Exp Ther Med 1: 463-469, 2010
APA
Okugawa, Y., Miki, C., Toiyama, Y., Koike, Y., Yokoe, T., Saigusa, S. ... Kusunoki, M. (2010). Soluble VCAM-1 and its relation to disease progression in colorectal carcinoma . Experimental and Therapeutic Medicine, 1, 463-469. https://doi.org/10.3892/etm_00000072
MLA
Okugawa, Y., Miki, C., Toiyama, Y., Koike, Y., Yokoe, T., Saigusa, S., Tanaka, K., Inoue, Y., Kusunoki, M."Soluble VCAM-1 and its relation to disease progression in colorectal carcinoma ". Experimental and Therapeutic Medicine 1.3 (2010): 463-469.
Chicago
Okugawa, Y., Miki, C., Toiyama, Y., Koike, Y., Yokoe, T., Saigusa, S., Tanaka, K., Inoue, Y., Kusunoki, M."Soluble VCAM-1 and its relation to disease progression in colorectal carcinoma ". Experimental and Therapeutic Medicine 1, no. 3 (2010): 463-469. https://doi.org/10.3892/etm_00000072