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Chromosome region maintenance 1 expression and its association with clinical pathological features in primary carcinoma of the liver

  • Authors:
    • Qiao‑Ling Xie
    • Yue Liu
    • Ying Zhu
  • View Affiliations

  • Published online on: April 20, 2016     https://doi.org/10.3892/etm.2016.3283
  • Pages: 59-68
  • Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Liver cancer is the third leading cause of cancer‑associated mortality worldwide. Recurrence and metastasis are the major factors affecting the prognosis; thus, investigation of the underlying molecular mechanisms of invasion and metastasis, and detection of novel drug target may improve the mortality rate of liver cancer patients. Chromosome region maintenance 1 (CRM1) recognizes specific leucine‑rich nuclear export signal sequences, and its overexpression is associated with tumor‑suppressor gene inactivation, proliferation, invasion and resistance to chemotherapy. The aim of the present study was to examine the association of CRM1 expression with the clinical and pathological features of primary liver cancer. In total, 152 cases diagnosed with liver cancer were included. CRM1 expression was detected in cancer tissues and adjacent normal tissues by immunohistochemical assay. No statistically significant difference was found between the CRM1 expression levels in tumor and adjacent normal tissues (P=0.106). However, CRM1 expression in adjacent normal tissues was higher compared with that in tumor tissues in the negative hepatitis B envelope antigen (HBeAg; P=0.029) and low differentiation (P=0.004) groups. In tumor tissues, CRM1 expression was significantly correlated with differentiation (P=0.045), whereas in adjacent normal tissues, CRM1 expression was significantly correlated with the tumor diameter (P=0.004). Therefore, it can be concluded that CRM1 is highly expressed in both tumor and adjacent normal tissues. Furthermore, CRM1 expression is associated with the tumor differentiation degree and diameter. Lower differentiation and larger tumor diameter resulted in higher CRM1 expression in adjacent normal tissues, and higher tendency for invasion and metastasis. In addition, the risk of invasion and metastasis remains in chronic hepatitis B patients with negative HBeAg.
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July-2016
Volume 12 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Xie QL, Liu Y and Zhu Y: Chromosome region maintenance 1 expression and its association with clinical pathological features in primary carcinoma of the liver. Exp Ther Med 12: 59-68, 2016
APA
Xie, Q., Liu, Y., & Zhu, Y. (2016). Chromosome region maintenance 1 expression and its association with clinical pathological features in primary carcinoma of the liver. Experimental and Therapeutic Medicine, 12, 59-68. https://doi.org/10.3892/etm.2016.3283
MLA
Xie, Q., Liu, Y., Zhu, Y."Chromosome region maintenance 1 expression and its association with clinical pathological features in primary carcinoma of the liver". Experimental and Therapeutic Medicine 12.1 (2016): 59-68.
Chicago
Xie, Q., Liu, Y., Zhu, Y."Chromosome region maintenance 1 expression and its association with clinical pathological features in primary carcinoma of the liver". Experimental and Therapeutic Medicine 12, no. 1 (2016): 59-68. https://doi.org/10.3892/etm.2016.3283