Incisal margin condition after LEEP for cervical intraepithelial neoplasia patients and prognosis

Chen,Hong; Liu,Xiufeang; Xu,Lina

doi:10.3892/etm.2016.3338

Incisal margin condition after LEEP for cervical intraepithelial neoplasia patients and prognosis

Authors:
- Hong Chen
- Xiufeang Liu
- Lina Xu
View Affiliations

Affiliations: Department of Gynaecology, Binzhou City Center Hospital, Binzhou, Shandong 251700, P.R. China, Department of Science and Education, Binzhou City Center Hospital, Binzhou, Shandong 251700, P.R. China, Department of Gynaecology, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China
Published online on: May 12, 2016 https://doi.org/10.3892/etm.2016.3338
Pages: 1019-1021
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The aim of the study was to examine the relationship between incisal condition after loop electrosurgical excision procedure (LEEP) operation for cervical intraepithelial neoplasia (CIN) patients and prognosis. A study of high‑risk incisal margin positive cases was also performed. We compared the differences in the prognosis of the 1‑year follow‑up visit in the 120 CIN patients admitted to the hospital during the period from April 2013 to April 2014. A total of 43 cases of positive incisal margin (35.8%), and 77 negative cases were included in the study. The differences in age, course of disease, and CIN level between the two groups showed no statistical significance (P>0.05). In the positive group, the positive ratio was significantly higher than that of the negative group (P<0.05). The positive incisal margin showed a significant positive correlation with human papillomavirus (HPV) positivity (r=0.327, P=0.035). The condition of most patients with positive incisal margin and HPV was critical, which was followed by positive incisal margin and negative HPV. The patients with the best prognosis were those with significant negative incisal margin as well as HPV (P<0.05). In conclusion, the positive incisal margin after LEEP operation was associated with relapse of the disease. Thus, considering the HPV test into consideration is valuable for the prognosis of the disease.

View Figures

View References

1	Santesso N, Mustafa RA, Wiercioch W, Kehar R, Gandhi S, Chen Y, Cheung A, Hopkins J, Khatib R, Ma B, et al: Systematic reviews and meta-analyses of benefits and harms of cryotherapy, LEEP, and cold knife conization to treat cervical intraepithelial neoplasia. Int J Gynaecol Obstet. 132:266–271. 2016. View Article : Google Scholar : PubMed/NCBI
2	Wong AS, Li WH and Cheung TH: Predictive factors for residual disease in hysterectomy specimens after conization in early-stage cervical cancer. Eur J Obstet Gynecol Reprod Biol. 199:21–26. 2016. View Article : Google Scholar : PubMed/NCBI
3	Fallala MS and Mash R: Cervical cancer screening: Safety, acceptability, and feasibility of a single-visit approach in Bulawayo, Zimbabwe. Afr J Prim Health Care Fam Med. 7:3–4. 2015. View Article : Google Scholar
4	Elit L, Levine MN, Julian JA, Sellors JW, Lytwyn A, Chong S, Mahony JB, Gu C, Finch T and Zeferino LC: Expectant management versus immediate treatment for low-grade cervical intraepithelial neoplasia: a randomized trial in Canada and Brazil. Cancer. 117:1438–1445. 2011. View Article : Google Scholar : PubMed/NCBI
5	Song JS, Hwang I and Gong G: Outcome of ‘atypical squamous cells’ in cervical cytology: Follow-up assessment by loop electrical excision procedure. Korean J Pathol. 46:359–364. 2012. View Article : Google Scholar : PubMed/NCBI
6	Wu J, Jia Y, Luo M and Duan Z: Analysis of residual/recurrent disease and its risk factors after loop electrosurgical excision procedure for high-grade cervical intraepithelial neoplasia. Gynecol Obstet Invest. Sep 3–2015.(Epub ahead of Print). View Article : Google Scholar
7	Liverani CA, Di Giuseppe J, Clemente N, Delli Carpini G, Monti E, Fanetti F, Bolis G and Ciavattini A: Length but not transverse diameter of the excision specimen for high-grade cervical intraepithelial neoplasia (CIN 2-3) is a predictor of pregnancy outcome. Eur J Cancer Prev. Aug 27–2015.(Epub ahead of Print). View Article : Google Scholar : PubMed/NCBI
8	Ruano Y, Torrents M and Ferrer FJ: Human papillomavirus combined with cytology and margin status identifies patients at risk for recurrence after conization for high-grade cervical intraepithelial neoplasia. Eur J Gynaecol Oncol. 36:245–251. 2015.PubMed/NCBI
9	Malapati R, Chaparala S and Cejtin HE: Factors influencing persistence or recurrence of cervical intraepithelial neoplasia after loop electrosurgical excision procedure. J Low Genit Tract Dis. 15:177–179. 2011. View Article : Google Scholar : PubMed/NCBI
10	Monsonego J, Pintos J, Semaille C, Beumont M, Dachez R, Zerat L, Bianchi A and Franco E: Human papillomavirus testing improves the accuracy of colposcopy in detection of cervical intraepithelial neoplasia. Int J Gynecol Cancer. 16:591–598. 2006. View Article : Google Scholar : PubMed/NCBI
11	Alvarez RD, Huh WK, Bae S, Lamb LS Jr, Conner MG, Boyer J, Wang C, Hung CF, Sauter E, Paradis M, et al: A pilot study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16 cervical intraepithelial neoplasia 2/3 (CIN2/3). Gynecol Oncol. 140:245–252. 2016. View Article : Google Scholar : PubMed/NCBI
12	Kang WD, Ju UC and Kim SM: A human papillomavirus (HPV)-16 or HPV-18 genotype is a reliable predictor of residual disease in a subsequent hysterectomy following a loop electrosurgical excision procedure for cervical intraepithelial neoplasia 3. J Gynecol Oncol. 27:e22016. View Article : Google Scholar : PubMed/NCBI
13	Kang WD and Kim SM: Human papillomavirus genotyping as a reliable prognostic marker of recurrence after loop electrosurgical excision procedure for high-grade cervical intraepithelial neoplasia (CIN2-3) especially in postmenopausal women. Menopause. 23:81–86. 2016. View Article : Google Scholar : PubMed/NCBI
14	Mo LZ, Song HL, Wang JL, He Q, Qiu ZC and Li F: Pap smear combined with hpv testing: A reasonable tool for women with high-grade cervical intraepithelial neoplasia treated by LEEP. Asian Pac J Cancer Prev. 16:4297–4302. 2015. View Article : Google Scholar : PubMed/NCBI